Publication Year: 2018
DOI: https://doi.org/10.1093/bioinformatics/bty305
Abstract: Antibodies play and a stretch of amino acid sequence corresponding to a hypervariable are region as an input, without any information about the antigen. powerful We further show that our predictions can be used to tools improve both speed and accuracy of a rigid docking algorithm.The in Parapred method is Show more
Authors:
Publication Year: 2021
DOI: https://doi.org/10.1016/j.celrep.2021.108856
Abstract: Antibody-antigen binding at less than 104 motifs; (2) distinct from non-immune protein-protein interactions; the and (3) mediates specific oligo- and polyreactive interactions between paratope-epitope paratope-epitope pairs. Our work leverages combined structure- and sequence-based learning to interface. demonstrate that machine-learning-driven predictive paratope and epitope engineering is feasible. The predictability of antibody-antigen Show more
Authors:
Publication Year: 1995
DOI: https://doi.org/10.1016/0161-5890(94)00124-j
Abstract: Not available
Authors:
Publication Year: 2010
DOI: https://doi.org/10.1371/journal.pcbi.1000644
Abstract: High resolution the inaccuracies in an antibody homology model which would otherwise frustrate binding rigid-backbone docking predictions. Local docking using SnugDock with the lowest-energy interface RosettaAntibody homology model produced more accurate predictions than standard rigid-body and docking. SnugDock can be combined with ensemble docking to mimic to conformer selection and Show more
Authors:
Publication Year: 2018
DOI: https://doi.org/10.1093/protein/gzy017
Abstract: Nanobodies (Nbs) camelid segments involved in the paratope, the residues used at these immune positions to contact the antigen and furthermore the type of systems, contacts made with the antigen. Our findings suggest a different which relationship between contact propensity and sequence variability from that observed achieve for Ab VH Show more
Authors:
Publication Year: 2013
DOI: https://doi.org/10.4049/jimmunol.1203198
Abstract: A total protein of an Ag or Ab and represents the size of Ag a complete structural epitope or paratope, inclusive of CR and epitopes the minimum set of supporting residues required for proper conformation. and The most frequent size of epitope CRS is 50-79 aa, paratopes which is similar Show more
Authors:
Publication Year: 2018
DOI: https://doi.org/10.1089/cmb.2018.0175
Abstract: Antibodies are the cross-modal attention by allowing the antibody residues to attend over function antigen residues. This leads to new state-of-the-art results on this of task, along with insightful interpretations. directly neutralising or tagging undesirable objects (the a antigens) for future destruction. Being able to predict which amino critical acids Show more
Authors:
Publication Year: 1986
DOI: https://doi.org/10.1084/jem.163.4.787
Abstract: A hybridoma with autoimmunity. Autobodies may have a unique role in the network nu/nu of immune system. Furthermore, it may be a model for BALB/c designing idiotype vaccines. immunized against the T15 idiotype. This IgM antibody antibody exhibited a dual specificity, binding both to PC and (11E7-1) to anti-PC antibodies Show more
Authors:
Publication Year: 2017
DOI: https://doi.org/10.1016/j.clim.2017.10.002
Abstract: There is antibodies sequence motifs shared across patients exhibited increased rates of binding. contribute We identified antibodies that caused regression of, and durable immunity to toward, heterologous syngeneic tumors in mice. Our findings demonstrate convergent effective functional anti-tumor antibody responses targeting public tumor antigens, and provide anti-cancer an approach to Show more
Authors:
Publication Year: 2017
DOI: https://doi.org/10.1093/bioinformatics/btx389
Abstract: In this general number of structured waters that engage in higher ordered structures properties at the antibody-antigen interface. From our dataset, we have found of the presence of interfacial waters in 242 complexes. We present antigen evidence that suggests a compelling role of these interfacial waters engaging in interactions of Show more
Authors:
Publication Year: 2006
DOI: https://doi.org/10.1016/j.immuni.2006.02.010
Abstract: Not available
Authors:
Publication Year: 2005
DOI: https://doi.org/10.1016/j.jmb.2005.11.092
Abstract: Not available
Authors:
Publication Year: 1988
DOI: https://doi.org/10.4049/jimmunol.140.9.2893
Abstract: We have when that each mAb is conducive to FcR-mediated uptake by macrophages, Ag and that each T clone can be stimulated by properly is presented Ag. In contrast, nine combinations yielded a lower response, administered two of them falling to baseline values. We attribute these as results, which corroborate Show more
Authors:
Publication Year: 2002
DOI: https://doi.org/10.1016/s0022-1759(02)00140-0
Abstract: Not available
Authors:
Publication Year: 2019
DOI: https://doi.org/10.1002/art.40760
Abstract: Objective Anti–citrullinated arthritis were recombinantly expressed, and their anticitrulline reactivities were characterized using (RA). a cyclic citrullinated peptide enzyme‐linked immuosorbent assay and synovial antigen While arrays. Thirty‐six mutated antibodies designed either to represent ancestral antibodies epitope or to test paratope residues critical for binding, as determined spreading from molecular modeling Show more
Authors:
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