Liver X Receptor Activation Controls Intracellular Cholesterol Trafficking and Esterification in Human Macrophages

Name: Work Video:
Duration: 3 min 30 s
Elena Rigamonti; Lionel Helin; Sophie Lestavel; Aino Mutka; Marco Lepore; Coralie Fontaine; Mohamed Amine Bouhlel; S. Bultel; J.C. Fruchart; Elina Ikonen; V. Clavey; Bart Staels; Giulia Chinetti
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43, 54, 71, 88, 94, 116, 145, 174, 184, 191, 198], 'late': [35], 'endosome,': [36], 'where': [37, 177], 'they': [38], 'control': [39, 199], 'trafficking': [41, 79, 172], 'to': [42, 53, 65, 144, 151, 173, 190], 'plasma': [44, 55, 95, 146, 175], 'membrane.': [45], 'mobilization': [47, 143], 'of': [48, 73, 90, 118, 141, 186, 194, 200], 'from': [50], 'intracellular': [51, 77], 'pools': [52], 'membrane': [56, 96, 147], 'is': [57], 'a': [58, 152], 'determinant': [59], 'governing': [60], 'its': [61], 'availability': [62], 'for': [63, 181], 'extracellular': [66], 'acceptors.': [67], 'Here': [68], 'we': [69], 'investigated': [70], 'influence': [72], 'LXR': [74, 85, 110, 168, 195], 'activation': [75, 169], 'on': [76], 'primary': [81], 'human': [82], 'macrophages.': [83], 'Synthetic': [84], 'activators': [86, 111], 'increase': [87], 'amount': [89], 'free': [91], 'Moreover,': [104], 'ABCA1-dependent': [105], 'induced': [108], 'was': [112, 133], 'drastically': [113], 'decreased': [114], 'presence': [117], 'progesterone,': [119], 'which': [120], 'blocks': [121], 'postlysosomal': [122], 'trafficking,': [124], 'reduced': [126], 'when': [127], 'mRNA': [131], 'expression': [132], 'depleted': [134], 'using': [135], 'small': [136], 'interfering': [137], 'RNA.': [138], 'stimulation': [140], 'LXRs': [149], 'led': [150], 'decrease': [153], 'cholesteryl': [155], 'ester': [156], 'formation': [157], 'Acyl–coenzyme': [159], 'A': [160], 'acyltransferase-1': [162], 'activity.': [163], 'These': [164], 'data': [165], 'indicate': [166], 'enhances': [170], 'membrane,': [176], 'it': [178], 'becomes': [179], 'available': [180], 'efflux,': [182], 'at': [183], 'expense': [185], 'esterification,': [187], 'thus': [188], 'contributing': [189], 'overall': [192], 'effects': [193], 'agonists': [196], 'homeostasis.': [203]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2154213419', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-21T11:52:02.648628', 'created_date': '2016-06-24'}
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