Publication Information

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4033, 4311, 4318, 4351, 4455, 4507, 4531], 'a': [4, 53, 204, 254, 303, 454, 716, 1288, 1325, 1748, 1752, 1759, 2230, 2319, 2337, 2407, 2462, 2708, 2905, 2949, 2972, 3060, 3240, 3433, 3459, 4058, 4084, 4236, 4347, 4490, 4532, 4556], 'widely': [5, 255, 713, 3455, 4232], 'accepted': [6, 256, 714, 4233], 'bone': [7, 14, 257, 264, 511, 568, 596], 'marker.': [8, 258], 'Its': [9, 259, 577], 'expression': [10, 28, 38, 92, 177, 180, 260, 278, 288, 342, 427, 430, 865, 1039, 1047, 1172, 1190, 1243, 1250, 1279, 1293, 1378, 1448, 1567, 1572, 1812, 1854, 2367, 2431, 2440, 2563, 2595, 2598, 2647, 2728, 2924, 2989, 3283, 3290, 3530, 3544, 3652, 3689, 3781, 3833, 3852, 4521, 4575, 4587], 'stimulated': [12, 77, 262, 327, 1109, 1246, 2600, 2623, 2627, 2652, 2680, 2931, 2991, 3228, 3532, 3628, 3654, 3719, 3730], 'by': [13, 57, 125, 135, 229, 238, 263, 307, 375, 385, 479, 488, 541, 611, 627, 646, 652, 925, 931, 1099, 1110, 1196, 1280, 1299, 1337, 1385, 1391, 1451, 1628, 1670, 1680, 1816, 2015, 2021, 2154, 2197, 2405, 2477, 2481, 2578, 2588, 2729, 2992, 3059, 3128, 3154, 3215, 3533, 3861, 3877, 3994, 4037, 4046, 4088, 4105, 4126, 4305, 4362, 4377], 'morphogenetic': [15, 265, 512, 743], 'protein': [16, 266, 729, 1473, 2250, 2569, 3132, 3970, 4071, 4145, 4175, 4200], '(BMP)-2': [17, 267], 'treatment,': [18, 268], 'the': [19, 27, 45, 66, 70, 96, 114, 130, 140, 144, 195, 211, 215, 245, 269, 277, 295, 316, 320, 346, 364, 380, 390, 394, 445, 461, 465, 495, 559, 572, 589, 601, 604, 616, 629, 636, 658, 667, 686, 732, 749, 760, 916, 951, 1045, 1102, 1170, 1179, 1189, 1201, 1241, 1253, 1306, 1315, 1343, 1359, 1376, 1396, 1400, 1461, 1466, 1514, 1535, 1553, 1565, 1621, 1674, 1678, 1685, 1689, 1734, 1739, 1744, 1755, 1766, 1774, 1783, 1796, 1818, 1844, 1851, 1896, 1958, 2008, 2022, 2039, 2167, 2219, 2225, 2235, 2245, 2248, 2306, 2347, 2352, 2365, 2381, 2386, 2429, 2438, 2470, 2473, 2544, 2562, 2572, 2593, 2603, 2645, 2654, 2672, 2685, 2690, 2724, 2732, 2742, 2753, 2757, 2763, 2773, 2787, 2790, 2794, 2835, 2847, 2855, 2866, 2875, 2878, 2913, 2922, 2953, 2984, 3000, 3014, 3023, 3051, 3065, 3081, 3102, 3117, 3130, 3143, 3167, 3172, 3184, 3196, 3208, 3220, 3223, 3229, 3249, 3260, 3282, 3393, 3412, 3428, 3582, 3630, 3639, 3645, 3657, 3671, 3677, 3723, 3740, 3746, 3754, 3769, 3779, 3787, 3822, 3842, 3848, 3854, 3869, 3887, 3896, 3908, 3912, 3930, 3933, 3938, 3967, 3984, 3988, 4003, 4006, 4017, 4025, 4034, 4051, 4069, 4079, 4092, 4097, 4108, 4115, 4119, 4129, 4148, 4151, 4164, 4183, 4186, 4195, 4198, 4205, 4223, 4226, 4302, 4332, 4338, 4366, 4494, 4500, 4511, 4543, 4586], 'activation': [20, 270, 2471], 'of': [21, 29, 65, 72, 100, 104, 111, 120, 170, 198, 219, 248, 271, 279, 315, 322, 350, 354, 361, 370, 420, 448, 469, 498, 556, 574, 593, 603, 618, 638, 701, 718, 748, 763, 856, 919, 954, 1048, 1173, 1188, 1191, 1200, 1244, 1255, 1261, 1267, 1345, 1361, 1379, 1564, 1677, 1743, 1798, 1847, 1865, 1871, 1898, 1901, 2024, 2166, 2229, 2234, 2339, 2364, 2472, 2536, 2564, 2605, 2641, 2656, 2687, 2689, 2711, 2726, 2735, 2741, 2748, 2772, 2801, 2810, 2815, 2854, 2877, 2904, 3064, 3166, 3186, 3219, 3263, 3284, 3580, 3674, 3679, 3714, 3727, 3743, 3790, 3821, 3829, 3857, 3889, 3940, 4019, 4061, 4068, 4076, 4094, 4110, 4150, 4163, 4173, 4185, 4197, 4239, 4246, 4256, 4502, 4519, 4535, 4545, 4588], 'BMP': [22, 272, 1197, 2474, 2485, 2579], 'receptors': [23, 273, 2486], 'and': [24, 26, 31, 49, 62, 69, 117, 128, 242, 274, 276, 281, 299, 312, 319, 367, 378, 492, 567, 655, 675, 710, 724, 766, 772, 866, 1043, 1248, 1269, 1301, 1320, 1445, 1480, 1488, 1503, 1511, 1517, 1534, 1569, 1701, 1776, 1791, 1793, 1863, 1869, 1874, 1881, 1940, 1957, 2010, 2042, 2094, 2137, 2170, 2192, 2201, 2328, 2371, 2385, 2400, 2546, 2684, 2715, 2722, 2746, 2765, 2779, 2793, 2808, 2817, 2823, 2825, 2830, 2852, 2868, 2883, 2900, 2907, 2941, 2959, 2980, 2994, 3034, 3054, 3072, 3091, 3191, 3202, 3213, 3253, 3403, 3542, 3565, 3616, 3644, 3662, 3694, 3705, 3751, 3793, 3819, 3923, 3942, 3956, 4065, 4136, 4138, 4140, 4215, 4242, 4328, 4342, 4385, 4497], 'R-Smads,': [25, 275], 'Dlx5': [30, 68, 87, 101, 138, 176, 199, 220, 224, 280, 318, 337, 351, 388, 426, 449, 470, 474, 1182, 1245, 1262, 1276, 1300, 1346, 1388, 1459, 1566, 1570, 2093, 2191, 2212, 2249, 2414, 2430, 2456, 2547, 2573, 2585, 2594, 2617, 2639, 2646, 2662, 2714, 2923, 2928, 3005, 3010, 3043, 3052, 3109, 3131, 3155, 3187, 3250, 3264, 3285, 3439, 3460, 3646, 3663, 3849, 3858, 3878, 3891, 3903, 3941, 3969, 3999, 4020, 4041, 4062, 4077, 4174, 4216, 4329, 4358, 4372, 4450, 4470, 4503, 4520, 4530, 4538, 4554, 4571], 'Runx2.': [32, 105, 282, 355, 1100], 'However,': [33, 85, 283, 335, 1101, 1439, 2551, 2660, 3095, 3576, 4301], 'how': [34, 284], 'BMP-2': [35, 126, 162, 168, 285, 376, 412, 418, 860, 926, 1035, 1111, 1256, 1472, 2478, 2534, 2559, 2606, 2619, 2730, 3276, 3548, 3563, 3598, 3623, 3634, 3704, 3718, 3962, 4307], 'induces': [36, 286, 759, 4308], 'ALP': [37, 47, 78, 91, 97, 121, 132, 145, 179, 216, 226, 287, 297, 328, 341, 347, 371, 382, 395, 429, 466, 476, 594, 642, 728, 863, 867, 933, 1054, 1094, 1105, 1249, 1270, 1278, 1292, 1318, 1331, 1354, 1369, 1447, 1467, 1555, 1664, 1807, 1875, 2043, 2143, 2146, 2149, 2157, 2459, 2492, 2545, 2565, 2597, 2624, 2649, 2673, 2681, 2706, 2720, 2727, 2744, 2759, 2767, 2802, 2856, 2890, 2954, 2988, 2996, 3197, 3231, 3256, 3266, 3279, 3289, 3413, 3543, 3625, 3651, 3680, 3706, 3720, 3732, 3748, 3756, 3823, 3832, 3974, 3989, 4007, 4023, 4227, 4229, 4309, 4333, 4340, 4356, 4360, 4367, 4459, 4474, 4495, 4512, 4524, 4536, 4540, 4561, 4574], 'not': [40, 290, 2935, 3099, 3416, 3595, 3627, 3798, 4313, 4565], 'clearly': [41, 291, 3048, 4314], 'understood.': [42, 292], 'We': [43, 106, 293, 356, 939, 1175, 1339, 2530, 3161, 3445, 3552, 3925, 4043, 4514], 'dissected': [44, 294, 1314], 'murine': [46, 296, 1317, 1878, 1883, 2758, 2764, 2816, 4339], 'promoter': [48, 79, 133, 298, 329, 383, 1055, 1319, 1403, 1617, 1665, 1679, 1687, 2674, 2682, 2803, 2844, 2857, 2879, 2891, 2917, 2955, 2997, 3174, 3198, 3225, 3232, 3397, 3414, 3775, 3844, 3898, 3935, 3990, 4341, 4496], 'found': [50, 108, 300, 358, 1033, 1177, 1321, 1341, 1441, 2531, 3163, 3385, 3553, 3927, 4343, 4498], 'within': [51, 301], 'it': [52, 302, 562, 584, 711, 758, 1031, 1090, 1323, 1394, 2302, 2628, 3141, 3448, 3593, 3796, 3977, 4317, 4345, 4563, 4578], 'Dlx5-binding': [54, 304], 'cis-acting': [55, 141, 305, 391, 1463], 'element': [56, 142, 235, 306, 392, 485, 1349, 1398, 1464, 2951, 2975, 3252, 3814, 3986, 4349, 4492, 4506], 'electrophoretic': [58, 308, 520], 'mobility': [59, 309, 521], 'shift': [60, 310, 522], 'assays': [61, 311], 'site-directed': [63, 313, 1760], 'mutagenesis': [64, 314], 'element.': [67, 317], 'product': [71, 321, 1781], 'its': [73, 232, 323, 482, 612, 936, 1454, 2011, 2749, 3946, 4582], 'target': [74, 324, 1401, 2710], 'gene,': [75, 325], 'Runx2,': [76, 326, 3872], 'activity': [80, 99, 119, 134, 197, 218, 330, 349, 369, 384, 447, 468, 868, 934, 1056, 1106, 2150, 2402, 2493, 2625, 2650, 2683, 2892, 3440, 3707, 3733, 3789, 3801, 3947], 'in': [81, 93, 143, 153, 174, 190, 200, 331, 343, 393, 403, 424, 440, 450, 539, 543, 564, 579, 595, 660, 692, 722, 725, 731, 754, 770, 773, 950, 1040, 1050, 1112, 1252, 1366, 1620, 1688, 1738, 1754, 1888, 1949, 2176, 2198, 2224, 2333, 2461, 2602, 2667, 2756, 2786, 2893, 2952, 3036, 3041, 3079, 3171, 3189, 3222, 3271, 3629, 3676, 3691, 3900, 3917, 3932, 3987, 4005, 4049, 4083, 4101, 4225, 4452, 4493, 4542, 4559], 'an': [82, 332, 947, 1184, 2156, 2254, 2391, 2694, 2886, 2908, 2995, 3020, 3037, 3122, 3134, 3813, 3882, 4089], 'additive': [83, 333, 2695], 'manner.': [84, 334], 'because': [86, 336, 1199, 2640, 3452, 4487], 'continued': [88, 338], 'to': [89, 210, 221, 231, 339, 460, 471, 481, 536, 614, 739, 1347, 1374, 1387, 1456, 1703, 1707, 1712, 1717, 1723, 2541, 2859, 3004, 3013, 3050, 3108, 3142, 3176, 3194, 3248, 3457, 3572, 3590, 3944, 4002, 4011, 4021, 4028, 4078, 4096, 4204, 4234, 4353, 4365, 4457, 4467, 4504, 4584], 'stimulate': [90, 340, 2936, 3195, 3973, 4458, 4585], 'Runx2–/–': [94, 344, 1893, 2416, 2424, 2636, 3192, 3901, 4453], 'cells,': [95, 345, 1939], 'stimulatory': [98, 217, 348, 467, 3855], 'independent': [103, 353], 'also': [107, 357, 945, 1295, 1340, 3077, 3162, 3246, 3811, 3926, 3982, 4515], 'that': [109, 122, 213, 359, 372, 463, 561, 588, 632, 649, 689, 859, 922, 943, 1034, 1044, 1093, 1104, 1161, 1168, 1178, 1193, 1275, 1290, 1322, 1330, 1342, 1443, 1750, 2418, 2433, 2469, 2533, 2561, 2704, 2834, 2888, 2927, 2946, 2964, 2969, 2982, 2998, 3116, 3164, 3207, 3236, 3244, 3274, 3386, 3419, 3430, 3437, 3447, 3554, 3566, 3806, 3835, 3871, 3914, 3928, 3979, 3991, 4014, 4201, 4320, 4344, 4350, 4371, 4449, 4469, 4482, 4499, 4517, 4529, 4553, 4568], 'overexpression': [110, 360, 2929, 3188, 3863, 3906, 4451], 'Msx2': [112, 148, 189, 243, 362, 398, 439, 493, 1371, 1452, 1811, 1852, 1857, 2193, 2214, 3258, 3453, 3555, 3583, 3640, 3658, 3675, 3685, 3715, 3728, 3744, 3780, 3783, 3830, 3851, 3862, 3893, 3905, 3943, 3951, 3980, 3996, 4015, 4039, 4064, 4095, 4144, 4199, 4214], 'suppressed': [113, 129, 363, 379, 3717, 3745, 3860], 'mRNA': [115, 365, 864, 937, 1038, 1872, 2044, 2548, 3280, 3556, 3584, 3610, 3749, 3757, 4460], 'level': [116, 366, 3750, 3758, 4117], 'enzyme': [118, 368], 'were': [123, 373, 1492, 1506, 1519, 1668, 1886, 1947, 1962, 2052, 2098, 2140, 2183, 2195, 2216, 2312, 2331, 2349, 2388, 2397, 2426, 2446, 2665, 2806, 3076, 3558, 3569, 3617, 3642, 3648, 3660, 3665, 3766, 3839, 4124, 4176, 4207], 'induced': [124, 374, 924, 2539, 3876], 'stimulation,': [127, 377, 3963], 'Dlx5-stimulated': [131, 381], 'competing': [136, 386, 1392], 'with': [137, 387, 600, 1393, 1458, 1695, 1765, 1782, 1789, 1795, 2185, 2218, 2253, 2305, 2351, 2361, 2422, 2428, 2448, 2555, 2592, 2644, 2671, 2912, 2921, 3040, 3101, 3133, 3392, 3401, 3703, 3710, 3737, 3768, 3778, 3841, 3847, 3895, 3998, 4057, 4219], 'for': [139, 389, 1352, 1395, 1460, 1500, 1773, 2238, 2295, 2390, 2864, 3106, 4000, 4222, 4509], 'promoter.': [146, 396, 1468, 3824, 4228, 4334, 4513], 'Moreover,': [147, 397, 757, 1030, 1356, 2583, 2846, 3976, 4182], 'levels': [149, 192, 202, 212, 399, 442, 452, 462, 3557, 3568, 3611, 3641, 3647, 3659, 3664, 3952, 3971, 4067, 4184], 'are': [150, 400, 650, 663, 2174, 2419, 2776, 3953], 'constitutively': [151, 401, 2483, 3954], 'high': [152, 191, 402, 441, 3560, 3619, 3643, 3955], 'C2C12': [154, 404, 956, 1041, 1879, 2537, 2590, 2613, 2668, 3190, 3390, 3692, 3764, 3837, 3918], 'myogenic': [155, 405, 955, 4247], 'cells': [156, 172, 406, 422, 768, 921, 957, 960, 1042, 1052, 1114, 1880, 1885, 1894, 1943, 2009, 2348, 2387, 2396, 2417, 2425, 2538, 2554, 2591, 2614, 2637, 2669, 2832, 2870, 2895, 3193, 3391, 3693, 3765, 3838, 3919, 4248, 4454], 'but': [157, 407, 583, 2933, 3600, 3795], 'decrease': [158, 408, 3957], 'over': [159, 409, 3545, 3614], 'time': [160, 410, 3420, 3546, 3615], 'after': [161, 411, 657, 2029, 2379, 3442, 3547, 3577, 3622, 3633, 3961], 'treatment.': [163, 413, 3444], 'This': [164, 414, 606, 3234, 3804], 'may': [165, 415, 1294, 1303, 3238, 3449, 3810, 3880, 3981, 4471], 'explain': [166, 416], 'why': [167, 417], 'treatment': [169, 419, 861, 927, 2479, 2535, 2607, 2620, 3549, 3564, 3599, 3635], 'these': [171, 421, 2553, 2736, 2811, 3096, 3567, 3738], 'results': [173, 423, 2944], 'immediate': [175, 425], 'yet': [178, 428], 'commences': [181, 431], 'only': [182, 432, 2629, 2896, 3293, 3655, 3958], '1–2': [183, 433, 3294], 'days': [184, 434, 3295, 3579, 3621], 'later.': [185, 435, 3575], 'In': [186, 436, 1284, 1310, 2610, 2873, 3761, 4160, 4445, 4476], 'other': [187, 437, 1165, 4221], 'words,': [188, 438], 'counteracts': [193, 244, 443, 494], 'initially': [194, 444], 'transcriptional': [196, 446], 'low': [201, 451], 'until': [203, 453], 'threshold': [205, 455], 'Dlx5:Msx2': [206, 456], 'ratio': [207, 457, 2023], 'reached': [209, 459], 'allow': [214, 464], 'prevail.': [222, 472], 'Thus,': [223, 473, 915, 1089, 1684, 3950, 4213], 'transactivates': [225, 475], 'expression,': [227, 241, 477, 491, 2721, 3281, 3681, 4562], 'directly': [228, 478, 1097, 1297, 1335, 2576, 4472, 4572], 'binding': [230, 480, 1344, 1386, 1785, 3056, 3107, 3118, 4075, 4093, 4166, 4501], 'cognate': [233, 483], 'response': [234, 484, 3251], 'and/or': [236, 486, 2213, 2663, 3850, 3892, 3904], 'indirectly': [237, 487], 'stimulating': [239, 489, 4378], 'Runx2': [240, 490, 944, 1037, 1049, 1192, 1247, 1268, 1282, 2657, 2664, 2716, 4327, 4384, 4589], 'direct': [246, 496], 'transactivation': [247, 497], 'Dlx5.': [249, 499, 1338, 3216, 3995], '(ALP': [502], '1The': [503], 'abbreviations': [504], 'used': [505, 1961, 2173, 3035, 4352], 'are:': [506], 'ALP,': [507], 'alkaline': [508, 531], 'phosphatase;': [509], 'BMP,': [510], 'protein;': [513], 'HDRE,': [514], 'homeodomain-response': [515, 2974], 'element;': [516], 'Osx,': [517], 'osterix;': [518], 'EMSA,': [519], 'assay;': [523], 'GAPDH,': [524], 'glyceraldehyde-3-phosphate': [525], 'dehydrogenase.;': [526], 'EC': [527], '3.1.3.1:': [528], 'orthophosphoricmonoester': [529], 'phosphohydrolase,': [530], 'optimum)': [532], 'was': [533, 1032, 1474, 1530, 1539, 1549, 1558, 1625, 1693, 1730, 1763, 1787, 1804, 1814, 1859, 2005, 2013, 2019, 2151, 2251, 2303, 2359, 2383, 2403, 2586, 2599, 2651, 3031, 3057, 3084, 3126, 3152, 3415, 3594, 3601, 3626, 3653, 3701, 3708, 3859, 3915, 4055, 4112, 4146, 4154, 4168, 4202, 4564], 'first': [534, 3602], 'suggested': [535], 'be': [537, 929, 1164, 1296, 1305, 1334, 3239, 3450, 3458, 4029, 4235], 'important': [538, 948, 1351], 'biomineralization': [540], 'Robison': [542], '1923': [544], '(1Robison': [545], 'R.': [546, 842, 1138, 3302], 'Biochem.': [547, 795, 903, 988, 4433], 'J.': [548, 826, 838, 843, 986, 1073, 1224, 1598, 1648, 1986, 2077, 2121, 2279, 2514, 3298, 3303, 3367, 4285, 4407, 4610], '1923;': [549], '17:': [550], '286-293Crossref': [551], 'PubMed': [552, 832, 849, 888, 910, 992, 1025, 1084, 1154, 1235, 1414, 1434, 1609, 1659, 1838, 1932, 1997, 2088, 2132, 2290, 2525, 3309, 3342, 3378, 3472, 3492, 4296, 4418, 4440], 'Google': [553, 804, 835, 852, 891, 913, 995, 1028, 1087, 1157, 1238, 1417, 1437, 1612, 1662, 1841, 1935, 2000, 2091, 2135, 2293, 2528, 3312, 3345, 3381, 3475, 3495, 3527, 4299, 4421, 4443], 'Scholar).': [554, 853, 914, 1029, 1088, 1239, 1438, 1613, 1663, 2001, 2092, 2529, 3382, 4300, 4444], 'Because': [555], 'this': [557, 735, 740, 1302, 1311, 1348, 2962, 3055, 3826, 4045, 4477, 4485, 4505], 'discovery,': [558], 'role': [560, 949, 1360, 4558], 'plays': [563, 946, 4555], 'osteoblast': [565, 755, 1380, 4240, 4375], 'differentiation': [566, 918, 4241, 4376], 'mineralization': [569], 'has': [570, 2465, 2983, 4230], 'been': [571, 1575, 2435, 2466, 4231], 'subject': [573], 'considerable': [575], 'research.': [576], 'function': [578, 592, 607], 'ossification': [580], 'remains': [581], 'controversial': [582], 'now': [586], 'known': [587, 3456, 4319], 'primary': [590, 1307], 'biological': [591], 'formation': [597, 4149, 4162], 'associated': [599], 'calcification': [602, 634], 'skeleton.': [605], 'exerted': [609], 'either': [610], 'ability': [613, 1455, 3185, 3939, 4018, 4583], 'catalyze': [615], 'hydrolysis': [617], 'organic': [619], 'phosphate': [620], 'esters,': [621], 'thereby': [622], 'providing': [623], 'inorganic': [624, 630], 'phosphate,': [625], 'or': [626, 678, 935, 1699, 1720, 2049, 2227, 2369, 2480, 2487, 2626, 2915, 3086, 3395, 3687, 3773, 4063, 4576], 'removing': [628], 'pyrophosphate': [631], 'inhibits': [633, 3438, 4016], 'at': [635, 2241, 2298, 2315, 2336, 3418, 3964, 4114, 4567], 'site': [637, 1786], 'active': [639, 2484], 'mineralization.': [640], 'The': [641, 727, 1495, 1524, 1545, 1614, 1779, 1802, 1809, 1953, 2190, 2211, 2309, 2395, 2454, 2769, 3045, 3148, 4074], 'family': [643], 'constituted': [645], 'several': [647, 2782], 'isoenzymes': [648], 'encoded': [651], 'four': [653], 'genes': [654, 1382], 'named': [656], 'tissues': [659], 'which': [661, 1328, 3080, 3637, 3873, 3965, 4038, 4050, 4111, 4306], 'they': [662], 'predominantly': [664], 'expressed,': [665], 'namely,': [666, 4383], 'intestinal': [668], '(IntALP),': [669], 'placental': [670], '(PALP),': [671], 'germ': [672], 'cell': [673, 1954, 2444, 2910, 3696, 3699], '(GALP),': [674], 'tissue': [676, 1900], 'nonspecific': [677], 'kidney/bone/liver': [679], '(TNSALP)': [680], 'isoenzymes.': [681], 'Of': [682], 'these,': [683], 'TNSALP': [684, 1616], 'major': [687], 'isoform': [688], 'expressed': [691, 2616, 3596, 3603], 'osteoblasts': [693, 720], '(2Bilezikian': [694, 4249], 'J.P.': [695, 4250], 'Raisz': [696, 4251], 'L.G.': [697, 4252], 'Rodan': [698, 4253], 'Q.A.': [699, 4254], 'Principles': [700, 4255], 'Bone': [702, 742, 4257], 'Biology.': [703, 4258], 'Academic': [704, 4259], 'Press,': [705, 4260], 'San': [706, 4261], 'Diego,': [707, 4262], 'CA1996Google': [708, 4263], 'Scholar)': [709, 1158, 1842, 2136, 2294, 3528], 'as': [715, 1963, 2054, 2141, 4118, 4194, 4326], 'marker': [717, 1381, 4238], 'differentiating': [719], 'both': [721, 769, 2543, 2677, 2688, 2718, 2780, 2865], 'vivo': [723, 774], 'vitro.': [726], 'described': [730, 1576, 1965, 2056, 2100], 'text': [733], 'from': [734, 1475, 1493, 1507, 1520, 1531, 1540, 1550, 1559, 1673, 1821, 1895, 1944, 2007, 4128], 'point': [736, 3421, 3638, 3966, 4569], 'onwards': [737], 'refers': [738], 'isoform.': [741], 'protein-2': [744], '(BMP-2)': [745], 'one': [747], 'most': [750], 'potent': [751], 'bone-inducing': [752], 'agents': [753], 'differentiation.': [756], 'osteogenic': [761, 917, 959, 2826, 2869, 2909, 4244], 'transdifferentiation': [762, 953, 4245], 'fibrogenic,': [764], 'myogenic,': [765], 'adipogenic': [767], 'vitro': [771, 2199], '(3Katagiri': [775], 'T.': [776, 780, 794, 807, 817, 825, 874, 1008, 1066, 1070, 1116, 1144, 1407, 1641, 1645, 1915, 3325, 3465], 'Yamaguchi': [777, 808, 1067, 1121, 1642], 'A.': [778, 809, 823, 964, 1068, 1122, 1643, 3500, 3510], 'Ikeda': [779, 816], 'Yoshiki': [781, 1141], 'S.': [782, 792, 870, 970, 1060, 1064, 1120, 1142, 1635, 1639], 'Wozney': [783, 820, 899, 1009, 1218, 1592, 1916, 1980, 2071, 2115, 2273, 2508, 3326, 3361, 4279, 4401, 4429, 4604], 'J.M.': [784, 821, 900, 1010, 1219, 1593, 1917, 1981, 2072, 2116, 2274, 2509, 3327, 3362, 4280, 4402, 4430, 4605], 'Rosen': [785, 818, 973], 'V.': [786, 819, 974], 'Wang': [787, 897, 1825], 'E.A.': [788, 898], 'Tanaka': [789], 'H.': [790, 876, 882, 1058, 1118, 1426, 1633, 1826, 3484], 'Omura': [791], 'Suda': [793, 824], 'Biophys.': [796, 904, 4434], 'Res.': [797, 905, 3523, 4435], 'Commun.': [798, 906, 4436], '1990;': [799], '15:': [800], '295-299Crossref': [801], 'Scopus': [802, 833, 850, 889, 911, 993, 1026, 1085, 1155, 1236, 1415, 1435, 1610, 1660, 1839, 1933, 1998, 2089, 2133, 2291, 2526, 3310, 3343, 3379, 3473, 3493, 4297, 4419, 4441], '(456)': [803], 'Scholar,': [805, 836, 892, 996, 1418, 3313, 3346, 3476, 3496, 4264, 4422], '4Katagiri': [806], 'Komaki': [810], 'M.': [811, 1062, 1072, 1134, 1136, 1637, 1647], 'Abe': [812], 'E.': [813, 1428, 3486], 'Takahashi': [814], 'N.': [815, 880], 'Fujisawa-Sehara': [822], 'Cell': [827, 844, 1867, 3304], 'Biol.': [828, 845, 1021, 1074, 1225, 1599, 1649, 1928, 1987, 2078, 2122, 2280, 2515, 3305, 3338, 3368, 4286, 4408, 4611], '1994;': [829], '127:': [830], '1755-1766Crossref': [831], '(1302)': [834], '5Skillington': [837], 'Choy': [839, 3299], 'L.': [840, 3300], 'Derynck': [841, 3301], '2002;': [846, 3306], '159:': [847, 3307], '135-146Crossref': [848, 3308], '(198)': [851, 3311], 'Several': [854], 'lines': [855], 'evidence': [857, 4481], 'indicate': [858, 3206, 4013, 4528], 'increases': [862], '(6Sakano': [869], 'Murata': [871], 'Y.': [872, 894, 1128, 1140], 'Miura': [873], 'Iwata': [875], 'Sato': [877, 1135], 'K.': [878, 902, 1124, 1126, 1420, 1422, 1424, 3478, 3480, 3482], 'Matsui': [879], 'Seo': [881], 'Clin.': [883], 'Orthop.': [884], '1993;': [885], '292:': [886], '337-344Crossref': [887], '(45)': [890], '7Takuwa': [893], 'Ohse': [895], 'C.': [896, 1006, 1832, 1913, 3323], 'Yamashita': [901], '1991;': [907], '174:': [908], '96-101Crossref': [909], '(267)': [912], 'various': [920, 2813, 4321], 'could': [928, 2934, 3098, 3784, 3797], 'determined': [930, 2153, 2404, 3539, 3709], 'measuring': [932], 'expression.': [938, 1271, 1283, 1355, 1370, 3257, 3975, 4357, 4461, 4475, 4525, 4537], 'have': [940, 1574, 3268, 3881], 'previously': [941, 1577, 1964, 2055, 2099, 2468, 4370, 4549], 'reported': [942], 'BMP-2-induced': [952, 1171, 1265, 1353, 1444, 3747, 3755, 4243, 4322, 4355, 4374, 4523, 4560], 'into': [958, 1733, 1843, 1861, 2437, 2812], '(8Lee': [961], 'M.H.': [962, 1205, 1579, 1967, 2058, 2102, 2260, 2495, 3348, 3504, 4266, 4388, 4424, 4591], 'Javed': [963, 3499], 'Kim': [965, 999, 1011, 1206, 1208, 1220, 1580, 1582, 1594, 1906, 1918, 1968, 1970, 1982, 2059, 2061, 2073, 2103, 2105, 2117, 2261, 2263, 2275, 2496, 2498, 2510, 3316, 3328, 3349, 3351, 3363, 4267, 4269, 4281, 4389, 4391, 4403, 4592, 4594, 4606], 'H.J.': [966, 1000, 1209, 1221, 1583, 1595, 1907, 1971, 1983, 2062, 2074, 2106, 2118, 2264, 2276, 2499, 2511, 3317, 3352, 3364, 4270, 4282, 4392, 4404, 4595, 4607], 'Shin': [967], 'H.I.': [968], 'Gutierrez': [969], 'Choi': [971, 1013, 1920, 3330], 'J.Y.': [972, 1014, 1921, 3331], 'Stein': [975, 980, 3518], 'J.L.': [976], 'van': [977], 'Wijnen': [978, 3512], 'A.J.': [979, 3513], 'G.S.': [981, 3519], 'Lian': [982, 3516], 'J.B.': [983, 3517], 'Ryoo': [984, 1015, 1222, 1596, 1922, 1984, 2075, 2119, 2277, 2512, 3332, 3365, 4283, 4405, 4431, 4608], 'H.M.': [985, 1016, 1215, 1223, 1589, 1597, 1923, 1977, 1985, 2068, 2076, 2112, 2120, 2270, 2278, 2505, 2513, 3333, 3358, 3366, 4276, 4284, 4398, 4406, 4432, 4601, 4609], 'Cell.': [987, 1020, 1145, 1927, 3337], '1999;': [989, 1076, 1651], '73:': [990], '114-125Crossref': [991], '(241)': [994], '9Lee': [997, 3314], 'K.S.': [998, 1905, 3315], 'Li': [1001, 1908, 3318], 'Q.L.': [1002, 1909, 3319], 'Chi': [1003, 1910, 3320], 'X.Z.': [1004, 1911, 3321], 'Ueta': [1005, 1912, 3322], 'Komori': [1007, 1069, 1644, 1914, 3324], 'E.G.': [1012, 1919, 3329], 'Bae': [1017, 1924, 3334], 'S.C.': [1018, 1925, 3335], 'Mol.': [1019, 1926, 3336], '2000;': [1022, 1929, 3339], '20:': [1023, 1930, 3340], '8783-8792Crossref': [1024, 1931, 3341], '(763)': [1027, 1934, 3344], 'stimulates': [1036, 1053, 2491, 2889, 3278], 'forced': [1046, 1242], 'C3H10T1/2': [1051, 1884], '(10Harada': [1057, 1632], 'Tagashira': [1059, 1634], 'Fujiwara': [1061, 1636], 'Ogawa': [1063, 1638], 'Katsumata': [1065, 1640], 'Nakatsuka': [1071, 1646], 'Chem.': [1075, 1226, 1600, 1650, 1988, 2079, 2123, 2281, 2516, 3369, 4287, 4409, 4612], '274:': [1077, 1652], '6972-6978Abstract': [1078, 1653], 'Full': [1079, 1081, 1149, 1151, 1230, 1232, 1604, 1606, 1654, 1656, 1992, 1994, 2083, 2085, 2127, 2129, 2285, 2287, 2520, 2522, 3373, 3375, 4291, 4293, 4413, 4415], 'Text': [1080, 1082, 1150, 1152, 1231, 1233, 1605, 1607, 1655, 1657, 1993, 1995, 2084, 2086, 2128, 2130, 2286, 2288, 2521, 2523, 3374, 3376, 4292, 4294, 4414, 4416], 'PDF': [1083, 1153, 1234, 1608, 1658, 1996, 2087, 2131, 2289, 2524, 3377, 4295, 4417], '(406)': [1086, 1661], 'speculated': [1092, 1287, 3446], 'transcription': [1095, 1502, 2200, 2678, 2691, 2738, 2783, 2796, 4310, 4323], 'regulated': [1098, 1298], 'observation': [1103], 'still': [1108, 2840, 3618, 4312], 'Runx2-deficient': [1113, 1902], '(11Komori': [1115], 'Yagi': [1117], 'Nomura': [1119], 'Sasaki': [1123], 'Deguchi': [1125], 'Shimizu': [1127], 'Bronson': [1129], 'R.T.': [1130], 'Gao': [1131], 'Y.H.': [1132], 'Inada': [1133], 'Okamoto': [1137], 'Kitamura': [1139], 'Kishimoto': [1143], '1997;': [1146], '89:': [1147], '755-764Abstract': [1148], '(3678)': [1156], 'strongly': [1159, 2490, 2702, 3227, 3277, 3426, 4483], 'suggests': [1160, 3235, 3805], 'there': [1162, 2947, 2970, 3237, 3431], 'must': [1163], 'upstream': [1166, 1186], 'mediators': [1167], 'regulate': [1169, 2719, 3945, 4331, 4354, 4473], 'ALP.': [1174], 'recently': [1176], 'homeobox': [1180, 1364], 'gene': [1181, 1402, 2574], 'indispensable': [1185], 'regulator': [1187, 3243, 3436], 'generated': [1195, 1669, 3179], 'signaling': [1198, 2475, 2580], 'following': [1202], 'observations': [1203, 1273, 2700, 3205, 3425, 4010, 4463, 4527, 4551], '(12Lee': [1204, 1578, 1966, 2057, 2101, 2259, 2494, 4387, 4590], 'Y.J.': [1207, 1581, 1969, 2060, 2104, 2262, 2497, 3350, 4268, 4390, 4593], 'Park': [1210, 1584, 1972, 2063, 2107, 2265, 2500, 3353, 4271, 4393, 4427, 4596], 'H.D.': [1211, 1585, 1973, 2064, 2108, 2266, 2501, 3354, 4272, 4394, 4597], 'Kang': [1212, 1586, 1974, 2065, 2109, 2267, 2502, 3355, 4273, 4395, 4598], 'A.R.': [1213, 1587, 1975, 2066, 2110, 2268, 2503, 3356, 4274, 4396, 4599], 'Kyung': [1214, 1588, 1976, 2067, 2111, 2269, 2504, 3357, 4275, 4397, 4600], 'Sung': [1216, 1590, 1978, 2069, 2113, 2271, 2506, 3359, 4277, 4399, 4602], 'J.H.': [1217, 1591, 1979, 2070, 2114, 2272, 2507, 3360, 4278, 4400, 4603], '2003;': [1227, 1601, 1989, 2080, 2124, 2282, 2517, 3370, 3524, 4288, 4410, 4437], '278:': [1228, 1602, 1990, 2081, 2125, 2283, 2518, 3371, 4289, 4411], '34387-34394Abstract': [1229, 1603, 1991, 2082, 2126, 2284, 2519, 3372, 4290, 4412], '(363)': [1237, 1611, 1999, 2090, 2134, 2292, 2527, 3380, 4298, 4420], 'First,': [1240], 'even': [1251, 1304, 2601, 3561], 'absence': [1254, 2228, 2604], 'stimulation.': [1257, 3624], 'Second,': [1258], 'antisense': [1259, 1571, 1853, 1856, 3688, 3725, 3752], 'blocking': [1260, 3726, 4518], 'completely': [1263, 3182], 'abrogated': [1264, 3183, 3937, 4522], 'stimulation': [1266, 2725], 'These': [1272, 2179, 2699, 2943, 3204, 3424, 3609, 4462, 4526], 'suggest': [1274, 2703, 2945], 'enhances': [1277], 'up-regulating': [1281], 'addition,': [1285, 2611, 3762, 4446], 'we': [1286, 1313, 1357, 1440, 2761, 3007, 3384, 3388, 3538, 3682, 3885, 4336, 4447, 4479, 4488], 'possibility': [1289, 3870], 'BMP-2-stimulated': [1291, 3731], 'regulatory': [1308], 'mechanism.': [1309], 'paper,': [1312, 4478], '1.9-kb': [1316], 'contains': [1324, 2885, 2999, 4346], 'Dlx5-response': [1326, 2750, 2754, 2950, 4348, 4491], 'element,': [1327], 'indicates': [1329, 2833, 2968], 'can': [1332, 2717, 3011, 3245, 3972, 4217, 4330], 'indeed': [1333, 3211], 'targeted': [1336, 2577], 'examined': [1358, 3886, 4044], 'Msx2,': [1362, 2041, 3451, 3540, 3807], 'another': [1363], 'protein,': [1365, 3053], 'regulating': [1367], 'Dlx5-induced': [1368, 1377], 'thought': [1373], 'reverse': [1375, 1501, 2050], 'like': [1383, 3808], 'osteocalcin': [1384], 'rather': [1389], 'than': [1390], 'same': [1397, 1462, 3909, 3985, 4116], 'on': [1399, 1465, 2031, 2318, 3265, 3831, 3911], '(13Newberry': [1404, 3462], 'E.P.': [1405, 3463], 'Latifi': [1406, 3464], 'Towler': [1408, 3466], 'D.A.': [1409, 3467], 'Biochemistry.': [1410, 3468], '1998;': [1411, 3469], '37:': [1412, 3470], '16360-16368Crossref': [1413, 3471], '(123)': [1416, 3474], '14Shirakabe': [1419, 3477], 'Terasawa': [1421, 3479], 'Miyama': [1423, 3481], 'Shibuya': [1425, 3483], 'Nishida': [1427, 3485], 'Genes': [1429, 3487], 'Cells.': [1430, 3488], '2001;': [1431, 3489], '6:': [1432, 3490], '851-856Crossref': [1433, 3491], '(159)': [1436, 3494], 'here': [1442, 2532], 'Dlx5-mediated': [1446], 'counteracted': [1450], 'through': [1453, 4581], 'compete': [1457, 3100, 4218], 'Materials—Bioactive': [1469], 'recombinant': [1470], 'human': [1471], 'Wyeth,': [1476], 'Inc.': [1477], '(Cambridge,': [1478], 'MA)': [1479], "Dulbecco's": [1481, 1889], 'modified': [1482, 1890], "Eagle's": [1483, 1891], 'medium,': [1484, 1487], 'α-minimal': [1485, 1950], 'essential': [1486, 1951], 'fetal': [1489], 'bovine': [1490], 'serum': [1491], 'Invitrogen.': [1494], 'Superscript™': [1496], 'first-strand': [1497], 'synthesis': [1498], 'system': [1499, 1528], 'LipofectAMINE': [1504, 2353], 'Plus': [1505, 2354], 'Invitrogen': [1508], '(Carlsbad,': [1509], 'CA)': [1510], 'Taq': [1512], 'polymerase,': [1513], 'dNTP': [1515], 'mixture,': [1516], 'G418': [1518], 'Promega': [1521], '(Madison,': [1522], 'WI).': [1523, 2210], 'Megaprime': [1525], 'DNA': [1526, 1561, 1858, 2181, 2222], 'labeling': [1527], 'kit': [1529, 1557, 2410], 'Amersham': [1532], 'Biosciences': [1533], 'Express': [1536], 'hybridization': [1537], 'solution': [1538], 'Clontech': [1541], '(Palo': [1542], 'Alto,': [1543], 'CA).': [1544], 'Zeta': [1546], 'probe': [1547, 3047, 3067, 3105, 3150, 4054, 4081, 4099], 'membrane': [1548], 'Bio-Rad,': [1551], 'whereas': [1552, 2571, 3288, 4091], 'cytochemical': [1554, 3711], 'staining': [1556, 2158], 'Sigma.': [1560], 'Construction—The': [1562], 'construction': [1563], 'vector': [1568, 1573, 1624, 1692, 1813, 2368, 2432, 2925], 'mouse': [1615, 2095], '(–1838': [1618], 'bp)': [1619], 'pGL3': [1622, 1690], 'basic': [1623, 1691], 'kindly': [1626], 'provided': [1627], 'Dr.': [1629], 'Hideyuki': [1630], 'Harada': [1631], 'deletion': [1666, 1672, 1728, 2804, 2837], 'constructs': [1667, 2805], 'serial': [1671], '5′': [1675], 'end': [1676], 'using': [1681, 2155, 2187, 2203, 2406], 'restriction': [1682, 1736], 'sites.': [1683], 'ALP-1838': [1686, 3394, 3843, 3897], 'digested': [1694, 1788], 'NheI,': [1696], 'SacI,': [1697], 'SmaI,': [1698], 'PvuII,': [1700], 'HindIII': [1702, 1862], 'produce': [1704, 1747, 1850], 'ALP-1488': [1705], '(–1488': [1706], '+81': [1708, 1713, 1718, 1724], 'bp),': [1709, 1714, 1719, 1725], 'ALP-1050': [1710], '(–1050': [1711], 'ALP-553': [1715, 2914, 2932, 3173, 3224, 3396, 3934], '(–553': [1716], 'ALP-229': [1721, 2916, 2937, 3800], '(–229': [1722], 'respectively.': [1726], 'Each': [1727, 2356, 3698], 'construct': [1729, 1749, 1803, 2919, 3175, 3226], 'then': [1731, 2313, 2398, 3404], 'ligated': [1732], 'corresponding': [1735, 1845], 'sites': [1737, 1742, 1846], 'multiple': [1740], 'cloning': [1741], 'vector.': [1745, 2376, 2441], 'To': [1746, 1849, 2037, 2412, 3017, 3114, 3535, 3669, 3866], 'bears': [1751, 2841], 'mutation': [1753, 3165, 3218], 'putative': [1756, 2795, 2973, 3001, 3015], 'homeodomain-binding': [1757, 3169], 'site,': [1758], 'mutagenic': [1761], 'PCR': [1762, 1780], 'performed': [1764, 2053, 2360, 3127], 'Mt1': [1767], 'forward': [1768], 'oligonucleotides': [1769, 2172], '(see': [1770], 'Fig.': [1771, 2177, 3093], '3A': [1772], 'sequence)': [1775], 'universal': [1777], 'primer.': [1778], 'mutant': [1784, 2171], 'PstI': [1790], 'PvuII': [1792], 'substituted': [1794], 'counterpart': [1797, 4070], 'wild': [1799, 2168, 3103, 3144], 'type': [1800, 2169, 3104, 3145], 'ALP-553.': [1801], 'denoted': [1805], 'Mt': [1806, 3180], '(Mt).': [1808], 'FLAG-tagged': [1810], 'constructed': [1815, 2807, 3078], 'subcloning': [1817], 'BamHI-XhoI': [1819], 'fragment': [1820], 'pDS56-Msx2': [1822], '(15Catron': [1823], 'K.M.': [1824], 'Hu': [1827], 'G.': [1828], 'Shen': [1829], 'M.M.': [1830], 'Abate-Shen': [1831], 'Mech.': [1833], 'Dev.': [1834], '1996;': [1835], '55:': [1836], '185-199Crossref': [1837], '(115)': [1840], 'pcDNA3.1-Flag.': [1848], 'vector,': [1855, 2596, 2648, 3782], 'subcloned': [1860], 'BamHI': [1864], 'pcDNA3.1.': [1866], 'Culture': [1868], 'Determination': [1870], 'Levels': [1873], 'Activity—': [1876], 'Myogenic': [1877], 'fibroblastic': [1882], 'cultured': [1887, 2389], 'medium.': [1892, 1952], 'primordium': [1897], 'calvarial': [1899], 'mice': [1903], '(9Lee': [1904], 'Scholar),': [1936], 'osteoblast-like': [1937, 2894], 'MC3T3-E1': [1938], 'ROS': [1941], '17/2.8': [1942], 'rat': [1945, 2766, 2818], 'osteosarcoma': [1946], 'maintained': [1948, 3570], 'maintenance': [1955], 'protocol': [1956], 'culture': [1959], 'conditions': [1960], 'Total': [2002], 'cellular': [2003], 'RNA': [2004, 2017, 2028], 'extracted': [2006], 'concentration': [2012], 'measured': [2014], 'spectrophotometry.': [2016], 'integrity': [2018], 'assessed': [2020], '28/18': [2025], 'S': [2026], 'ribosomal': [2027], 'electrophoresis': [2030], '1%': [2032], 'agarose,': [2033], '5.5%': [2034], 'formaldehyde': [2035], 'gels.': [2036], 'determine': [2038], 'Dlx5,': [2040, 2423, 2712, 2993, 3121, 3541, 3591, 3809], 'levels,': [2045], 'Northern': [2046], 'blot': [2047], 'analysis': [2048, 2967], 'transcriptase-PCR': [2051], 'GAPDH-specific': [2096], 'primers': [2097, 2139], 'ALP-specific': [2138], 'follows:': [2142], 'forward,': [2144], '5′-CTTGACTGTGGTTACTGCTG-3′;': [2145], 'reverse,': [2147], '5′-GAGCGTAATCTACCATGGAG-3′.': [2148], 'cytochemically': [2152], 'kit.': [2159], 'Electrophoretic': [2160], 'Mobility': [2161], 'Shift': [2162], 'Assay': [2163, 2409], '(EMSA)—The': [2164], 'sequences': [2165, 2771], 'listed': [2175], '3A.': [2178], 'double-stranded': [2180, 2221], 'probes': [2182, 2223, 3075, 3097], 'end-labeled': [2184], '[α-32P]dCTP': [2186], 'Klenow': [2188], 'enzyme.': [2189], 'proteins': [2194, 2215], 'produced': [2196], 'translation': [2202], 'TnT': [2204], 'Coupled': [2205], 'Reticulocyte': [2206], 'Lysate': [2207], '(Promega,': [2208], 'Madison,': [2209], 'incubated': [2217, 2304, 4056], 'labeled,': [2220, 3033], 'presence': [2226], '100-fold': [2231], 'molar': [2232, 3062], 'excess': [2233, 3063], 'unlabeled': [2236, 3066], 'competitor': [2237, 4131], '20': [2239, 2296], 'min': [2240, 2297], 'room': [2242, 2299], 'temperature.': [2243], 'For': [2244], 'supershift': [2246, 3124], 'assay,': [2247], 'preincubated': [2252], 'anti-Dlx5': [2255, 3135], 'rabbit': [2256, 3136], 'polyclonal': [2257, 3137], 'antibody': [2258, 3138, 3156, 4189], 'temperature': [2300], 'before': [2301, 2557, 3139, 3562, 3597], 'labeled': [2307, 3046, 4053], 'probe.': [2308, 3147], 'protein-DNA': [2310, 3149], 'complexes': [2311, 4153, 4167], 'separated': [2314], '4': [2316], '°C': [2317], '6%': [2320], 'polyacrylamide': [2321], 'gel': [2322], 'containing': [2323], '0.5×': [2324], 'TBE': [2325], 'buffer.': [2326], 'Transfection': [2327], 'Luciferase': [2329, 2408], 'Assay—Cells': [2330], 'plated': [2332], '6-well': [2334], 'plates': [2335], 'density': [2338], '1.5': [2340], '×': [2341], '105': [2342], 'cells/well.': [2343], 'After': [2344], 'overnight': [2345], 'culture,': [2346, 3581], 'transfected': [2350, 2421, 2427, 2443, 3389, 3684, 3840], 'reagent.': [2355], 'transfection': [2357, 2643, 3742], 'assay': [2358, 3125], '0.5': [2362, 2372], 'μg': [2363], 'Dlx5,Msx2': [2366], 'pcDNA3': [2370], 'μgofthe': [2373], 'ALP-luciferase': [2374], 'reporter': [2375, 2675, 2918, 3845, 3899, 3913, 3936], 'Three': [2377], 'hours': [2378], 'transfection,': [2380], 'medium': [2382], 'changed': [2384], 'additional': [2392], '24': [2393, 3409], 'h.': [2394], 'harvested': [2399], 'luciferase': [2401, 3407], '(Promega).': [2411], 'establish': [2413], 'overexpressing': [2415, 2482, 3890], 'stably': [2420, 2615, 3683], 'had': [2434, 2693, 3907], 'cloned': [2436], 'pcDNA3.1/Zeo': [2439], 'Stably': [2442], 'clones': [2445], 'selected': [2447], '800': [2449], 'μg/ml': [2450], 'Zeocin': [2451], '(Invitrogen,': [2452], 'Groningen,': [2453], 'Netherlands).': [2455], 'Overexpression': [2457, 3713], 'Stimulates': [2458, 4539], 'Expression': [2460, 4361, 4541], 'Runx2-independent': [2463], 'Manner—It': [2464], 'shown': [2467], 'pathway': [2476], 'BMP-stimulated': [2488], 'R-Smads': [2489], 'them': [2540, 3400], 'express': [2542], '(Fig.': [2549, 2581, 2608, 2632, 2658, 2697, 2820, 2827, 2871, 2897, 2938, 3029, 3068, 3110, 3157, 3199, 3422, 3550, 3607, 3667, 3734, 3759, 3802, 3864, 3920, 3948, 4072, 4132, 4156, 4178, 4209], '1A).': [2550, 2582], 'treating': [2552], 'cycloheximide': [2556], 'introducing': [2558], 'indicated': [2560, 4552], 'requires': [2566], 'de': [2567], 'novo': [2568], 'synthesis,': [2570], 'when': [2584, 2612, 2635, 2661, 3387, 3656, 3763, 3836, 4170], 'overexpressed': [2587, 2638, 2666], 'transfecting': [2589], '1B).': [2609], 'antisense,': [2618], 'no': [2621], 'longer': [2622], 'very': [2630, 3559], 'weakly': [2631], '1C).': [2633], 'Furthermore,': [2634], 'their': [2642, 3406], 'despite': [2653], 'lack': [2655], '1D).': [2659], 'along': [2670, 2920], 'construct,': [2676, 2838], 'factors': [2679, 2692, 4324], 'coexpression': [2686], 'effect': [2696, 3828, 3856, 3888, 3910], '1E).': [2698], 'together': [2701, 3777, 3846, 3894, 4464], '(i)': [2705], 'downstream': [2709], '(ii)': [2713], '(iii)': [2723], 'involves': [2731], 'positive': [2733], 'regulation': [2734, 3678], 'two': [2737, 2774, 4102, 4106, 4379], 'factors.': [2739], 'Characterization': [2740], 'Murine': [2743], 'Promoter': [2745], 'Identification': [2747], 'Element—To': [2751], 'identify': [2752], 'element(s)': [2755, 2887], 'promoter,': [2760], 'compared': [2762], 'promoters.': [2768], 'nucleotide': [2770, 2792], 'promoters': [2775], 'highly': [2777], 'conserved': [2778], 'contain': [2781], 'factor-response': [2784], 'elements': [2785, 2863], 'region': [2788, 2876], 'between': [2789, 2849, 2880, 2956, 2977, 3816], '–900': [2791], 'start': [2797], 'site.': [2798], 'A': [2799, 2822], 'series': [2800], 'introduction': [2809], 'types': [2814], 'non-osteogenic': [2819, 2867, 2906], '2,': [2821, 2828, 2898, 2939], 'B)': [2824], 'C': [2829, 2899, 3201], 'D)': [2831], 'smallest': [2836], 'ALP-229,': [2839], 'minimal': [2842], 'basal': [2843, 3230], 'activity.': [2845, 3233, 3721], 'segment': [2848], 'nucleotides': [2850, 2881, 2957, 2978, 3028, 3817], '–1838': [2851], '–1050': [2853], 'seems': [2858], 'bear': [2860], 'common': [2861], 'enhancer': [2862], '2).': [2872], 'contrast,': [2874, 4161], '–553': [2882, 2958, 3820], '–229': [2884, 3818], 'D).': [2901, 3203], 'Significantly,': [2902], 'cotransfection': [2903], 'line': [2911], 'showed': [2926, 4369, 4516], 'significantly': [2930, 3716, 3785], 'E': [2940], 'F).': [2942], '–229.': [2960], 'Supporting': [2961, 3825], 'data': [2965], 'base': [2966], '(HDRE)': [2976], '–486': [2979], '–483': [2981], 'sequence': [2985, 3025, 3083, 3170], 'ATTA.': [2986], 'As': [2987], 'HDRE': [3002, 3209, 3221, 3931, 4004, 4080, 4098, 4224], 'responded': [3003], 'overexpression,': [3006, 3879], 'checked': [3008], 'whether': [3009, 4570, 4577], 'bind': [3012, 3247], 'HDRE.': [3016], 'do': [3018], 'this,': [3019, 3537], 'oligonucleotide': [3021, 3146], 'bearing': [3022], 'ATTA': [3024, 3082, 3168], 'plus': [3026], 'surrounding': [3027], '3A)': [3030], 'synthesized,': [3032], 'EMSA': [3038, 3123, 4048], 'experiment': [3039], 'vitro-translated': [3042], 'protein.': [3044], 'bound': [3049, 3214, 3993], 'diminished': [3058], '×100': [3061], '3B,': [3069, 3111, 3158], 'lanes': [3070, 3112, 4134, 4158, 4180, 4211], '3': [3071, 3578, 3604, 3620, 3631, 4137], '4).': [3073], 'Mutant': [3074], 'wholly': [3085], 'partly': [3087], 'mutated': [3088], '(Mt1,': [3089], 'Mt2,': [3090], 'Mt3,': [3092], '3A).': [3094], '5–7).': [3113], 'confirm': [3115, 3670], 'complex': [3119, 3151, 4190], 'includes': [3120], 'preincubating': [3129], 'adding': [3140], 'supershifted': [3153, 4187], 'lane': [3159], '8).': [3160, 4141], 'CGAC': [3177], '(which': [3178], 'ALP)': [3181], '3,': [3200], 'recognized': [3212], 'Notably,': [3217], 'strong': [3241, 3434], 'negative': [3242, 3435, 3672], 'basally': [3254], 'down-regulates': [3255], 'Antagonizes': [3259], 'Stimulatory': [3261], 'Effect': [3262], 'Expression—We': [3267], 'noted': [3269], 'repeatedly': [3270], 'previous': [3272], 'reports': [3273], 'while': [3275], 'immediate,': [3287], 'takes': [3291], 'place': [3292], 'later': [3296, 3606], '(5Skillington': [3297], '12Lee': [3347, 4265], 'Here': [3383], 'constructs,': [3398], 'treated': [3399, 3702], 'BMP-2,': [3402], 'analyzed': [3405, 4337], 'activities': [3408], 'h': [3410, 3605, 3632], 'later,': [3411], 'activated': [3417], '4A).': [3423], 'support': [3427], 'notion': [3429, 4486], 'early': [3441], 'BMP2': [3443], 'antagonist': [3461], '16Barnes': [3497], 'G.L.': [3498], 'Waller': [3501], 'S.M.': [3502], 'Kamal': [3503], 'Hebert': [3505], 'K.E.': [3506], 'Hassan': [3507], 'M.Q.': [3508], 'Bellahcene': [3509], 'Van': [3511], 'Young': [3514], 'M.F.': [3515], 'Gerstenfeld': [3520], 'L.C.': [3521], 'Cancer': [3522], '63:': [3525], '2631-2637PubMed': [3526], 'whose': [3529], 'BMP-2.': [3534], 'assess': [3536], '4B).': [3551, 3608, 3668], 'up': [3571], '1': [3573, 3959], 'day': [3574, 3960], 'disappeared': [3585], 'almost': [3586], 'completely.': [3587], 'With': [3588], 'regard': [3589], 'however,': [3592], 'gradually': [3612, 4192], 'increased': [3613, 3753, 4155, 4208], '(at': [3636], 'low).': [3649], 'Rather,': [3650], 'decreasing': [3661], 'increasing': [3666, 3968, 4066, 4171], 'action': [3673], 'sense': [3686], 'vectors': [3690], 'established': [3695], 'clones.': [3697], 'clone': [3700], 'staining.': [3712], 'On': [3722], 'contrary,': [3724], 'slightly': [3729], '4C).': [3735], 'Consistent': [3736], 'results,': [3739], 'stable': [3741], '4D).': [3760], 'cotransfected': [3767], 'ALP-1838,': [3770, 3791], '-1488,': [3771, 3792], '-553,': [3772], '-229': [3774], 'reporters': [3776], 'suppress': [3786, 3799], 'baseline': [3788], '-553': [3794], '4E).': [3803], 'recognize': [3812, 3983], 'lying': [3815], 'repressive': [3827], 'vectors,': [3853], '4F).': [3865], 'rule': [3867], 'out': [3868], 'secondarily': [3875], 'indirect': [3883], 'effect,': [3884], 'cells.': [3902], 'observed': [3916], '4,': [3921], 'F': [3922], 'G).': [3924], 'mutating': [3929], '4H).': [3949], 'appears': [3978], 'Competes': [3997], 'Binding': [4001, 4363], 'Promoter—Because': [4008], 'our': [4009, 4548], 'date': [4012], 'activate': [4022], 'transcription,': [4024], 'next': [4026], 'question': [4027], 'addressed': [4030], 'was,': [4031], 'what': [4032], 'molecular': [4035, 4303], 'mechanism': [4036, 4304], 'antagonizes': [4040], 'activity?': [4042], 'performing': [4047], 'HDRE-containing': [4052], 'constant': [4059], 'amount': [4060, 4196], '5A).': [4073], 'resulted': [4082, 4100], 'single': [4085], 'band': [4086], '(indicated': [4087, 4104], 'arrowhead),': [4090], 'bands': [4103, 4123], 'arrows),': [4107], 'upper': [4109], 'located': [4113, 4489], 'Dlx5-probe': [4120], 'complex.': [4121], 'All': [4122], 'eliminated': [4125], 'competition': [4127], 'cold': [4130], '5A,': [4133, 4157, 4179], '2': [4135, 4613], '7': [4139], 'When': [4142], 'more': [4143], 'present,': [4147], 'Msx2-HDRE': [4152, 4165], '4–6).': [4159], 'decreased': [4169, 4193], 'amounts': [4172], 'added': [4177, 4203], '9-11).': [4181], 'Dlx5-HDRE-anti-Dlx5': [4188], '(asterisk)': [4191], 'mixture': [4206], '5B,': [4210], '3–6).': [4212], 'each': [4220], 'faithful': [4237], 'understood,': [4315], 'although': [4316], 'such': [4325], 'Here,': [4335], 'Regulates': [4359], 'Directly': [4364], 'Promoter—We': [4368], 'mediates': [4373], 'key': [4380], 'master': [4381], 'genes,': [4382], 'Osx': [4386], '17Lee': [4423], 'Kwon': [4425], 'T.G.': [4426], 'H.S.': [4428], '309:': [4438], '689-694Crossref': [4439], '(341)': [4442], 'demonstrated': [4448], 'sufficient': [4456], 'led': [4465], 'us': [4466], 'propose': [4468], 'present': [4480], 'supports': [4484], 'responsible': [4508], 'activating': [4510], 'critical': [4533, 4557], 'mediator': [4534], 'Absence': [4544], 'Runx2—': [4546], 'Whereas': [4547], 'published': [4550], 'clear': [4566], 'up-regulates': [4573], 'does': [4579], 'so': [4580]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2154094043', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2025-01-05T15:57:46.003713', 'created_date': '2016-06-24'}