Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1502203491', 'doi': 'https://doi.org/10.1111/j.1740-0929.2012.01032.x', 'title': 'Bone morphogenetic protein 4 (BMP‐4) and BMP‐7 induce vascular endothelial growth factor expression in bovine granulosa cells', 'display_name': 'Bone morphogenetic protein 4 (BMP‐4) and BMP‐7 induce vascular endothelial growth factor expression in bovine granulosa cells', 'publication_year': 2012, 'publication_date': '2012-06-27', 'ids': {'openalex': 'https://openalex.org/W1502203491', 'doi': 'https://doi.org/10.1111/j.1740-0929.2012.01032.x', 'mag': '1502203491', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22943534'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1740-0929.2012.01032.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S21531271', 'display_name': 'Animal Science Journal', 'issn_l': '1344-3941', 'issn': ['1344-3941', '1740-0929'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059138509', 'display_name': 'Takashi Shimizu', 'orcid': 'https://orcid.org/0000-0003-1294-0799'}, 'institutions': [{'id': 'https://openalex.org/I6446798', 'display_name': 'Obihiro University of Agriculture and Veterinary Medicine', 'ror': 'https://ror.org/02t9fsj94', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I6446798']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takashi SHIMIZU', 'raw_affiliation_strings': ['Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Inada‐machi, Obihiro, Hokkaido'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Inada‐machi, Obihiro, Hokkaido', 'institution_ids': ['https://openalex.org/I6446798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048010975', 'display_name': 'Fumie Magata', 'orcid': 'https://orcid.org/0000-0001-8204-2332'}, 'institutions': [{'id': 'https://openalex.org/I6446798', 'display_name': 'Obihiro University of Agriculture and Veterinary Medicine', 'ror': 'https://ror.org/02t9fsj94', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I6446798']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumie MAGATA', 'raw_affiliation_strings': ['Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Inada‐machi, Obihiro, Hokkaido'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Inada‐machi, Obihiro, Hokkaido', 'institution_ids': ['https://openalex.org/I6446798']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109949574', 'display_name': 'Yasuyuki Abe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I112524849', 'display_name': 'Yamagata University', 'ror': 'https://ror.org/00xy44n04', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I112524849']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuyuki ABE', 'raw_affiliation_strings': ['Graduate School of Science and Engineering, Yamagata University , Yamagata, Japan'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Science and Engineering, Yamagata University , Yamagata, Japan', 'institution_ids': ['https://openalex.org/I112524849']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061027903', 'display_name': 'Akio Miyamoto', 'orcid': 'https://orcid.org/0000-0003-0401-7304'}, 'institutions': [{'id': 'https://openalex.org/I6446798', 'display_name': 'Obihiro University of Agriculture and Veterinary Medicine', 'ror': 'https://ror.org/02t9fsj94', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I6446798']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akio MIYAMOTO', 'raw_affiliation_strings': ['Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Inada‐machi, Obihiro, Hokkaido'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Inada‐machi, Obihiro, Hokkaido', 'institution_ids': ['https://openalex.org/I6446798']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4000, 'currency': 'USD', 'value_usd': 4000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.127, 'has_fulltext': False, 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.649019, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '83', 'issue': '9', 'first_page': '663', 'last_page': '667'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10364', 'display_name': 'Reproductive Biology and Fertility', 'score': 0.9565, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C54537546', 'wikidata': 'https://www.wikidata.org/wiki/Q14903582', 'display_name': 'Bone morphogenetic protein 15', 'level': 5, 'score': 0.8451164}, {'id': 'https://openalex.org/C30352789', 'wikidata': 'https://www.wikidata.org/wiki/Q14903153', 'display_name': 'Bone morphogenetic protein 2', 'level': 3, 'score': 0.83092403}, {'id': 'https://openalex.org/C31507581', 'wikidata': 'https://www.wikidata.org/wiki/Q425383', 'display_name': 'Bone morphogenetic protein', 'level': 3, 'score': 0.75905573}, {'id': 'https://openalex.org/C144746171', 'wikidata': 'https://www.wikidata.org/wiki/Q14903759', 'display_name': 'Bone morphogenetic protein 5', 'level': 5, 'score': 0.65057737}, {'id': 'https://openalex.org/C172105316', 'wikidata': 'https://www.wikidata.org/wiki/Q14903592', 'display_name': 'Bone morphogenetic protein 10', 'level': 5, 'score': 0.5940573}, {'id': 'https://openalex.org/C125349252', 'wikidata': 'https://www.wikidata.org/wiki/Q14903102', 'display_name': 'Bone morphogenetic protein 7', 'level': 4, 'score': 0.5882598}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.56126904}, {'id': 'https://openalex.org/C181628713', 'wikidata': 'https://www.wikidata.org/wiki/Q14903748', 'display_name': 'Bone morphogenetic protein 6', 'level': 5, 'score': 0.55220205}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.54557157}, {'id': 'https://openalex.org/C202450454', 'wikidata': 'https://www.wikidata.org/wiki/Q14903775', 'display_name': 'Bone morphogenetic protein 8A', 'level': 5, 'score': 0.5269231}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.4367175}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38913524}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.38158926}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2884123}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14670447}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.13771799}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.12900835}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.050777614}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.05019951}], 'mesh': [{'descriptor_ui': 'D055415', 'descriptor_name': 'Bone Morphogenetic Protein 4', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D055419', 'descriptor_name': 'Bone Morphogenetic Protein 7', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D006107', 'descriptor_name': 'Granulosa Cells', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055415', 'descriptor_name': 'Bone Morphogenetic Protein 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055419', 'descriptor_name': 'Bone Morphogenetic Protein 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006107', 'descriptor_name': 'Granulosa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048348', 'descriptor_name': 'Reverse Transcription', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1740-0929.2012.01032.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S21531271', 'display_name': 'Animal Science Journal', 'issn_l': '1344-3941', 'issn': ['1344-3941', '1740-0929'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22943534', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W148216960', 'https://openalex.org/W1534163224', 'https://openalex.org/W1972926354', 'https://openalex.org/W1980755389', 'https://openalex.org/W1985712533', 'https://openalex.org/W1986586226', 'https://openalex.org/W2007004659', 'https://openalex.org/W2014907034', 'https://openalex.org/W2026831351', 'https://openalex.org/W2048459905', 'https://openalex.org/W2049434910', 'https://openalex.org/W2056754736', 'https://openalex.org/W2062331471', 'https://openalex.org/W2066565504', 'https://openalex.org/W2091228862', 'https://openalex.org/W2093417867', 'https://openalex.org/W2094614243', 'https://openalex.org/W2107859844', 'https://openalex.org/W2126516708', 'https://openalex.org/W2148353329', 'https://openalex.org/W2150073419', 'https://openalex.org/W2162233013', 'https://openalex.org/W2163213568', 'https://openalex.org/W4242376174'], 'related_works': ['https://openalex.org/W565014269', 'https://openalex.org/W2418202487', 'https://openalex.org/W2385422439', 'https://openalex.org/W2344478911', 'https://openalex.org/W2156139917', 'https://openalex.org/W2079294621', 'https://openalex.org/W2042505270', 'https://openalex.org/W2015164004', 'https://openalex.org/W1963879934', 'https://openalex.org/W1791850325'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Bone': [1], 'morphogenetic': [2], 'protein‐4': [3], '(BMP‐4)': [4], 'and': [5, 51, 81, 113, 123, 142, 161, 170, 177], 'BMP‐7,': [6], 'theca': [7, 167], 'cell‐derived': [8, 168], 'growth': [9, 34], 'factors,': [10], 'directly': [11], 'affect': [12], 'the': [13, 25, 84, 94, 98, 107, 110, 119, 132], 'granulosa': [14, 40, 127, 156, 184], 'cell': [15], 'function.': [16], 'The': [17, 75], 'aim': [18], 'of': [19, 27, 56, 77, 89, 103, 109, 121, 134], 'this': [20], 'study': [21], 'was': [22, 83, 91], 'to': [23, 93, 174], 'examine': [24], 'involvement': [26], 'BMP‐4': [28, 72, 90, 117, 141, 158, 169], 'or': [29, 73], 'BMP‐7': [30, 104, 130, 143, 162, 171], 'in': [31, 38, 64, 126, 154, 183], 'vascular': [32], 'endothelial': [33], 'factor': [35], '(VEGF)': [36], 'expression': [37, 76, 108, 120, 133, 149, 182], 'bovine': [39, 155], 'cells.': [41, 185], 'Granulosa': [42], 'cells': [43, 61], 'were': [44], 'collected': [45], 'from': [46], 'small': [47], 'follicles': [48], '(4–6': [49], 'mm)': [50], 'seeded': [52], 'at': [53], 'a': [54], 'density': [55], '2–5': [57], '×': [58], '10': [59, 101], '5': [60], 'per': [62], 'well': [63], "Dulbecco's": [65], 'modified': [66], "Eagle's": [67], 'medium': [68, 70], '(DMEM)/F12': [69], 'with': [71, 147], 'BMP‐7.': [74], 'VEGF': [78, 111, 148, 181], 'messenger': [79], 'RNA': [80], 'protein': [82], 'maximum': [85], 'when': [86], '1.0': [87], 'ng/mL': [88, 102], 'added': [92], 'culture': [95], 'medium.': [96], 'On': [97], 'other': [99], 'hand,': [100], 'significantly': [105], 'increased': [106], 'gene': [112], 'protein.': [114], 'In': [115, 165], 'addition,': [116], 'stimulated': [118, 131], 'Smad1': [122], 'Smad5': [124, 135], 'genes': [125], 'cells,': [128], 'whereas': [129], 'gene.': [136], 'These': [137], 'results': [138], 'suggested': [139], 'that': [140], 'may': [144], 'be': [145], 'associated': [146], 'via': [150, 159, 163], 'several': [151], 'specific': [152], 'Smads': [153], 'cells:': [157], 'Smad1/Smad5': [160], 'Smad5.': [164], 'conclusion,': [166], 'might': [172], 'contribute': [173], 'follicular': [175], 'vasculature': [176], 'development': [178], 'by': [179], 'inducing': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1502203491', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-14T14:50:47.658702', 'created_date': '2016-06-24'}