CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial

Name: Work Video:
Duration: 3 min 30 s
Description: BackgroundAdjuvant tamoxifen therapy is effective for postmenopausal women with endocrine-responsive breast cancer. Cytochrome P450 2D6 (CYP2D6) enzyme metabolizes tamoxifen to clinically active metabolites, and CYP2D6 polymorphisms may adversely affect tamoxifen efficacy. In this study, we investigated the clinical relevance of CYP2D6 polymorphisms.
Meredith M. Regan; Brian Leyland‐Jones; Mark Bouzyk; Olivia Pagani; Weining Tang; Roswitha Kammler; Patrizia Dell’Orto; Maria Olivia Biasi; Beat Thürlimann; Maria Lyng; Henrik J. Ditzel; Patrick Neven; Marc Debled; Rudolf Maibach; Karen N. Price; Richard D. Gelber; Alan S. Coates; Aron Goldhirsch; James M. Rae; Giuseppe Viale
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