Publication Information

{'id': 'https://openalex.org/W2153600354', 'doi': 'https://doi.org/10.1177/1087057110381783', 'title': 'An Effective Method for Controlling False Discovery and False Nondiscovery Rates in Genome-Scale RNAi Screens', 'display_name': 'An Effective Method for Controlling False Discovery and False Nondiscovery Rates in Genome-Scale RNAi Screens', 'publication_year': 2010, 'publication_date': '2010-09-21', 'ids': {'openalex': 'https://openalex.org/W2153600354', 'doi': 'https://doi.org/10.1177/1087057110381783', 'mag': '2153600354', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20855561'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1177/1087057110381783', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1177/1087057110381783', 'source': {'id': 'https://openalex.org/S4387277810', 'display_name': 'SLAS DISCOVERY', 'issn_l': '2472-5552', 'issn': ['2472-5552', '2472-5560'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://journals.sagepub.com/doi/pdf/10.1177/1087057110381783', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013542379', 'display_name': 'Xiaohua Douglas Zhang', 'orcid': 'https://orcid.org/0000-0002-2486-7931'}, 'institutions': [{'id': 'https://openalex.org/I192545095', 'display_name': 'United States Military Academy', 'ror': 'https://ror.org/01jepya76', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1304082316', 'https://openalex.org/I1330347796', 'https://openalex.org/I192545095', 'https://openalex.org/I4210088792']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Xiaohua Douglas Zhang', 'raw_affiliation_strings': ['Biometrics Research, Merck Research Laboratories, West Point, PA, USA.'], 'affiliations': [{'raw_affiliation_string': 'Biometrics Research, Merck Research Laboratories, West Point, PA, USA.', 'institution_ids': ['https://openalex.org/I192545095']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5013542379'], 'corresponding_institution_ids': ['https://openalex.org/I192545095'], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'fwci': 2.569, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.829803, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '15', 'issue': '9', 'first_page': '1116', 'last_page': '1122'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T14117', 'display_name': 'Integrated Circuits and Semiconductor Failure Analysis', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2208', 'display_name': 'Electrical and Electronic Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T14117', 'display_name': 'Integrated Circuits and Semiconductor Failure Analysis', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2208', 'display_name': 'Electrical and Electronic Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11970', 'display_name': 'Molecular Biology Techniques and Applications', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'Advanced biosensing and bioanalysis techniques', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/false-discovery-rate', 'display_name': 'False Discovery Rate', 'score': 0.75036395}, {'id': 'https://openalex.org/keywords/false-positive-rate', 'display_name': 'False positive rate', 'score': 0.61227095}, {'id': 'https://openalex.org/keywords/false-negative-reactions', 'display_name': 'False Negative Reactions', 'score': 0.4752457}, {'id': 'https://openalex.org/keywords/true-positive-rate', 'display_name': 'True positive rate', 'score': 0.46500668}, {'id': 'https://openalex.org/keywords/multiple-comparisons-problem', 'display_name': 'Multiple comparisons problem', 'score': 0.43703005}], 'concepts': [{'id': 'https://openalex.org/C112789634', 'wikidata': 'https://www.wikidata.org/wiki/Q18207010', 'display_name': 'False positives and false negatives', 'level': 3, 'score': 0.9145591}, {'id': 'https://openalex.org/C64869954', 'wikidata': 'https://www.wikidata.org/wiki/Q1859747', 'display_name': 'False positive paradox', 'level': 2, 'score': 0.9119421}, {'id': 'https://openalex.org/C193244246', 'wikidata': 'https://www.wikidata.org/wiki/Q5432696', 'display_name': 'False discovery rate', 'level': 3, 'score': 0.75036395}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.6346607}, {'id': 'https://openalex.org/C95922358', 'wikidata': 'https://www.wikidata.org/wiki/Q5432725', 'display_name': 'False positive rate', 'level': 2, 'score': 0.61227095}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.50773466}, {'id': 'https://openalex.org/C32022120', 'wikidata': 'https://www.wikidata.org/wiki/Q797225', 'display_name': 'Interference (communication)', 'level': 3, 'score': 0.50653994}, {'id': 'https://openalex.org/C2909814700', 'wikidata': 'https://www.wikidata.org/wiki/Q18207010', 'display_name': 'False Negative Reactions', 'level': 2, 'score': 0.4752457}, {'id': 'https://openalex.org/C2989486834', 'wikidata': 'https://www.wikidata.org/wiki/Q3808900', 'display_name': 'True positive rate', 'level': 2, 'score': 0.46500668}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.46373263}, {'id': 'https://openalex.org/C22615655', 'wikidata': 'https://www.wikidata.org/wiki/Q203221', 'display_name': 'Small interfering RNA', 'level': 4, 'score': 0.45160684}, {'id': 'https://openalex.org/C183905921', 'wikidata': 'https://www.wikidata.org/wiki/Q1038757', 'display_name': 'Multiple comparisons problem', 'level': 2, 'score': 0.43703005}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3440792}, {'id': 'https://openalex.org/C154945302', 'wikidata': 'https://www.wikidata.org/wiki/Q11660', 'display_name': 'Artificial intelligence', 'level': 1, 'score': 0.24486166}, {'id': 'https://openalex.org/C105795698', 'wikidata': 'https://www.wikidata.org/wiki/Q12483', 'display_name': 'Statistics', 'level': 1, 'score': 0.22134677}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.21101135}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.21036336}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.16395581}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.15581304}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.1437912}, {'id': 'https://openalex.org/C76155785', 'wikidata': 'https://www.wikidata.org/wiki/Q418', 'display_name': 'Telecommunications', 'level': 1, 'score': 0.0700908}, {'id': 'https://openalex.org/C127162648', 'wikidata': 'https://www.wikidata.org/wiki/Q16858953', 'display_name': 'Channel (broadcasting)', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C126838900', 'wikidata': 'https://www.wikidata.org/wiki/Q77604', 'display_name': 'Radiology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016678', 'descriptor_name': 'Genome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D023281', 'descriptor_name': 'Genomics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005188', 'descriptor_name': 'False Negative Reactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005189', 'descriptor_name': 'False Positive Reactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016678', 'descriptor_name': 'Genome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023281', 'descriptor_name': 'Genomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1177/1087057110381783', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1177/1087057110381783', 'source': {'id': 'https://openalex.org/S4387277810', 'display_name': 'SLAS DISCOVERY', 'issn_l': '2472-5552', 'issn': ['2472-5552', '2472-5560'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20855561', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1177/1087057110381783', 'pdf_url': 'https://journals.sagepub.com/doi/pdf/10.1177/1087057110381783', 'source': {'id': 'https://openalex.org/S4387277810', 'display_name': 'SLAS DISCOVERY', 'issn_l': '2472-5552', 'issn': ['2472-5552', '2472-5560'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/16', 'display_name': 'Peace, justice, and strong institutions', 'score': 0.52}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 14, 'referenced_works': ['https://openalex.org/W1824047490', 'https://openalex.org/W1964685229', 'https://openalex.org/W1964895626', 'https://openalex.org/W2046084252', 'https://openalex.org/W2049131636', 'https://openalex.org/W2102634733', 'https://openalex.org/W2105381419', 'https://openalex.org/W2110065044', 'https://openalex.org/W2134696273', 'https://openalex.org/W2134810580', 'https://openalex.org/W2136434805', 'https://openalex.org/W2143947607', 'https://openalex.org/W2150091347', 'https://openalex.org/W2157630430'], 'related_works': ['https://openalex.org/W4388328864', 'https://openalex.org/W4301749514', 'https://openalex.org/W4212966421', 'https://openalex.org/W2317297514', 'https://openalex.org/W2102122784', 'https://openalex.org/W2093463665', 'https://openalex.org/W2079592427', 'https://openalex.org/W2072794497', 'https://openalex.org/W2020413892', 'https://openalex.org/W1991225657'], 'abstract_inverted_index': {'In': [0], 'most': [1], 'genome-scale': [2, 194], 'RNA': [3], 'interference': [4], '(RNAi)': [5], 'screens,': [6], 'the': [7, 51, 71, 92, 100, 135, 147], 'ultimate': [8], 'goal': [9], 'is': [10, 134, 146], 'to': [11, 79, 164, 184], 'select': [12], 'siRNAs': [13, 142], 'with': [14], 'a': [15, 103, 124, 198], 'large': [16], 'inhibition': [17], 'or': [18, 128], 'activation': [19], 'effect.': [20], 'The': [21, 117, 155, 170], 'selection': [22, 179], 'of': [23, 29, 39, 94, 137, 149], 'hits': [24], 'typically': [25], 'requires': [26], 'statistical': [27], 'control': [28, 81, 165, 185], '2': [30], 'errors:': [31], 'false': [32, 35, 41, 44, 82, 85, 108, 111, 118, 129, 138, 150, 187, 190], 'positives': [33, 42, 83, 109], 'and': [34, 43, 74, 84, 110, 162, 167, 189], 'negatives.': [36, 86], 'Traditional': [37], 'methods': [38], 'controlling': [40, 107], 'negatives': [45, 112, 119, 139, 151], 'do': [46], 'not': [47], 'take': [48], 'into': [49], 'account': [50], 'important': [52], 'feature': [53], 'in': [54, 91, 97, 113, 180, 193, 197], 'RNAi': [55, 98, 114, 195], 'screens:': [56], 'many': [57], 'small-interfering': [58], 'RNAs': [59], '(siRNAs)': [60], 'may': [61], 'have': [62, 174], 'very': [63], 'small': [64], 'but': [65], 'real': [66], 'nonzero': [67], 'average': [68], 'effects': [69], 'on': [70], 'measured': [72], 'response': [73], 'thus': [75], 'cannot': [76], 'allow': [77], 'us': [78], 'effectively': [80], 'To': [87], 'address': [88], 'for': [89, 106, 177], 'deficiencies': [90], 'application': [93], 'traditional': [95], 'approaches': [96], 'screening,': [99], 'author': [101, 156], 'proposes': [102, 158], 'new': [104, 159], 'method': [105, 172], 'high-throughput': [115], 'screens.': [116], 'are': [120], 'statistically': [121], 'controlled': [122], 'through': [123], 'false-negative': [125], 'rate': [126, 131], '(FNR)': [127], 'nondiscovery': [130, 191], '(FNDR).': [132], 'FNR': [133, 166], 'proportion': [136, 148], 'among': [140, 152], 'all': [141], 'examined,': [143], 'whereas': [144], 'FNDR': [145], 'declared': [153], 'nonhits.': [154], 'also': [157], 'concepts,': [160], 'q*-value': [161], 'p*-value,': [163], 'FNDR,': [168], 'respectively.': [169], 'proposed': [171], 'should': [173], 'broad': [175], 'utility': [176], 'hit': [178], 'which': [181], 'one': [182], 'needs': [183], 'both': [186], 'discovery': [188], 'rates': [192], 'screens': [196], 'robust': [199], 'manner.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2153600354', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-17T01:53:33.086648', 'created_date': '2016-06-24'}