Gas6 Induces Mesangial Cell Proliferation via Latent Transcription Factor STAT3

Name: Work Video:
Duration: 3 min 30 s
Motoko Yanagita; Hidenori Arai; Toru Nakano; Kazumasa Ohashi; Kensaku Mizuno; Atsushi Fukatsu; Toshio Doi; Toru Kita
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25, 49, 161, 184, 207, 231, 343, 386, 458, 480, 711, 1038, 1167, 2930, 2976, 2984, 2999, 3125, 3500, 3614, 3655, 3671, 3899, 3970, 4066, 4170, 4204], 'is': [3, 107, 185, 289, 387, 398, 462, 589, 594, 598, 660, 895, 965, 1022, 1158, 2600, 2654, 2672, 2745, 2971, 3491, 3520, 3638, 3744, 3891, 4019, 4030, 4051, 4098, 4133, 4171, 4248], 'essential': [4, 186, 463, 1146], 'for': [5, 175, 187, 357, 464, 585, 665, 706, 780, 1006, 1147, 1302, 1352, 1542, 1555, 1566, 1580, 1625, 1679, 1694, 1812, 1825, 1904, 1912, 1923, 1930, 2197, 2536, 3314, 3561, 3740, 4234, 4305, 4493, 4597, 4602, 4620, 4634], 'the': [6, 32, 44, 72, 120, 131, 188, 214, 226, 254, 302, 313, 406, 457, 465, 583, 601, 699, 716, 764, 791, 798, 817, 849, 901, 933, 971, 990, 1012, 1143, 1176, 1183, 1208, 1316, 1459, 1479, 1567, 1634, 1636, 1683, 1707, 1764, 1843, 2063, 2069, 2114, 2168, 2174, 2191, 2214, 2224, 2232, 2270, 2276, 2384, 2461, 2485, 2495, 2518, 2531, 2617, 2624, 2639, 2650, 2656, 2661, 2675, 2699, 2705, 2729, 2741, 2776, 2855, 2861, 2916, 2933, 2961, 2982, 3004, 3012, 3140, 3184, 3223, 3256, 3289, 3297, 3355, 3364, 3379, 3433, 3443, 3455, 3516, 3523, 3539, 3600, 3642, 3650, 3662, 3675, 3688, 3692, 3700, 3709, 3725, 3737, 3751, 3759, 3878, 3882, 3903, 3910, 3923, 3948, 3953, 3958, 3966, 4010, 4035, 4046, 4054, 4059, 4063, 4081, 4087, 4136, 4146, 4159, 4175, 4187, 4203, 4209, 4220, 4235, 4254, 4263, 4414, 4430, 4450, 4458, 4468, 4515, 4531, 4590], 'pathogenesis': [7, 189, 466, 1184], 'and': [8, 28, 52, 64, 74, 93, 112, 130, 148, 190, 210, 234, 246, 256, 275, 294, 312, 330, 369, 397, 467, 488, 597, 695, 698, 937, 995, 1027, 1170, 1189, 1207, 1221, 1311, 1315, 1356, 1478, 1498, 1551, 1623, 1655, 1674, 1700, 1786, 1807, 1902, 1926, 1933, 2057, 2131, 2199, 2329, 2448, 2515, 2543, 2556, 2584, 2864, 3134, 3201, 3207, 3288, 3306, 3316, 3369, 3503, 3515, 3541, 3549, 3559, 3656, 3729, 3773, 3887, 3900, 3927, 3952, 3971, 4040, 4077, 4127, 4130, 4138, 4269, 4432, 4437, 4452, 4472, 4543, 4599, 4631], 'progression': [9, 191, 468, 792, 4545], 'of': [10, 39, 66, 91, 102, 122, 126, 134, 140, 192, 221, 248, 273, 284, 304, 308, 316, 322, 371, 391, 394, 408, 459, 469, 702, 715, 760, 766, 793, 800, 812, 816, 848, 903, 923, 928, 932, 939, 954, 1009, 1019, 1039, 1078, 1130, 1142, 1179, 1185, 1307, 1462, 1466, 1482, 1621, 1633, 1646, 1770, 1831, 1856, 1988, 2066, 2113, 2151, 2167, 2180, 2193, 2231, 2272, 2278, 2331, 2368, 2386, 2457, 2497, 2526, 2534, 2550, 2573, 2578, 2598, 2616, 2620, 2627, 2634, 2641, 2652, 2658, 2714, 2732, 2740, 2780, 2811, 2836, 2843, 2857, 2872, 2918, 2935, 3006, 3016, 3028, 3142, 3186, 3211, 3225, 3240, 3249, 3259, 3266, 3275, 3299, 3320, 3361, 3367, 3371, 3381, 3394, 3410, 3424, 3435, 3446, 3460, 3474, 3518, 3536, 3547, 3552, 3602, 3618, 3632, 3644, 3664, 3674, 3687, 3694, 3702, 3727, 3736, 3750, 3761, 3862, 3877, 3884, 3896, 3905, 3912, 3925, 3933, 3950, 3955, 3968, 4022, 4028, 4037, 4048, 4065, 4072, 4075, 4083, 4089, 4102, 4115, 4140, 4161, 4164, 4177, 4189, 4205, 4222, 4228, 4238, 4244, 4256, 4274, 4417, 4429, 4435, 4470, 4508, 4517, 4527, 4533, 4540, 4589, 4623], 'glomerular': [11, 193, 395, 470, 794, 3189, 3192, 3267, 3413, 3645, 3898, 3906], 'disease.': [12, 194, 3742], 'Previously,': [13, 195], 'we': [14, 35, 196, 217, 656, 1135, 1154, 2504, 2593, 2717, 2925, 3010, 3182, 3407, 3486, 3607, 3936, 4013, 4410], 'showed': [15, 197, 657, 2788, 2807, 2827, 3272, 3470, 3937], 'that': [16, 57, 153, 198, 239, 335, 658, 696, 809, 949, 1002, 1156, 2649, 2744, 2835, 2871, 2969, 3378, 3392, 3477, 3489, 3509, 3532, 3597, 3610, 3748, 3870, 3889, 4017, 4045, 4080, 4096, 4506, 4525], 'Gas6': [17, 40, 58, 127, 157, 199, 222, 240, 309, 339, 588, 659, 772, 1357, 1565, 1586, 1678, 1824, 1920, 2507, 2535, 2547, 2579, 2610, 2642, 2659, 2720, 2817, 2937, 2954, 3510, 3533, 3598, 3665, 3926, 3942, 3956], 'plays': [18, 200, 3943], 'a': [19, 100, 171, 201, 282, 353, 388, 778, 787, 814, 930, 1007, 1159, 1571, 1714, 1739, 1886, 1984, 2248, 2378, 2553, 2558, 2567, 2733, 2789, 2808, 2948, 3229, 3492, 3720, 3733, 3892, 3930, 3939, 3944, 3963, 4099, 4595], 'pivotal': [20, 202, 4100], 'role': [21, 45, 203, 227, 789, 1178, 2496, 2917, 3015, 3924, 3946, 4492], 'in': [22, 26, 29, 46, 50, 53, 79, 109, 142, 146, 149, 204, 208, 211, 228, 232, 235, 261, 291, 324, 328, 331, 719, 768, 790, 840, 843, 900, 1037, 1163, 1168, 1171, 1182, 1473, 1535, 1593, 1669, 1909, 2125, 2128, 2261, 2499, 2520, 2552, 2677, 2688, 2698, 2724, 2792, 2830, 2860, 2893, 2921, 2943, 2960, 2973, 3008, 3013, 3019, 3188, 3294, 3363, 3412, 3426, 3496, 3501, 3504, 3624, 3629, 3641, 3652, 3704, 3724, 3754, 3856, 3881, 3929, 3938, 3947, 3957, 4032, 4053, 4058, 4067, 4120, 4240, 4267, 4308, 4373, 4441, 4457, 4495, 4511, 4538, 4546, 4605], 'mesangial': [23, 47, 81, 96, 103, 110, 159, 180, 205, 229, 263, 278, 285, 292, 341, 362, 460, 478, 586, 666, 709, 781, 1132, 1165, 1494, 1574, 1589, 1808, 1819, 1832, 1915, 2501, 2522, 2527, 2607, 2690, 2725, 2800, 2844, 2873, 2894, 2944, 2974, 2997, 3020, 3029, 3123, 3300, 3322, 3401, 3498, 3612, 3653, 3669, 3683, 3710, 3766, 3959, 3969, 4023, 4038, 4084, 4103, 4144, 4168, 4241, 4497, 4518, 4611], 'vitro': [27, 51, 147, 209, 233, 329, 844, 1169, 3502, 3625], 'vivo.': [30, 54, 143, 212, 236, 325, 1172, 3505], 'In': [31, 99, 213, 281, 1151, 2319, 2429, 2566, 2681, 2980, 3120, 3483, 3634, 4009, 4142, 4485], 'present': [33, 215, 3855, 4011, 4266, 4372], 'study,': [34, 216, 1153, 3485, 4012], 'identified': [36, 218, 3717], 'downstream': [37, 219, 1139], 'targets': [38, 220, 4601], 'signaling': [41, 223, 1140, 1161, 3494, 3721, 3894], 'to': [42, 71, 224, 253, 405, 476, 774, 785, 961, 970, 997, 1137, 1435, 1489, 1548, 1651, 1706, 1763, 1775, 1794, 1804, 1838, 1842, 1899, 2275, 2374, 2390, 2517, 2660, 2674, 2679, 2747, 2834, 3001, 3285, 3353, 3538, 3556, 3627, 3681, 3746, 3921, 4062, 4111, 4135, 4186, 4214, 4250, 4262, 4302, 4419, 4449, 4504], 'examine': [43, 225, 4112], 'We': [55, 237, 2605, 2665, 3023, 3452, 3506, 3528, 3620, 4614, 4626], 'found': [56, 238], 'tyrosine': [59, 241, 2513, 2571, 2632, 3514, 3545, 4272], 'phosphorylates': [60, 242, 3511], 'STAT3': [61, 86, 92, 106, 141, 168, 243, 268, 274, 288, 323, 350, 1032, 1157, 1180, 1303, 1310, 1735, 1863, 2498, 2509, 2551, 2574, 2599, 2635, 2653, 2670, 2748, 2806, 2826, 2850, 2882, 2919, 2970, 3007, 3017, 3187, 3212, 3241, 3250, 3411, 3425, 3447, 3490, 3512, 3519, 3548, 3603, 3637, 3703, 3718, 3762, 3863, 3872, 3890, 3928, 4018, 4029, 4049, 4090, 4097, 4116, 4201, 4229, 4245, 4257, 4275, 4306, 4418, 4436, 4494, 4509, 4528, 4536], '(signal': [62, 244, 935], 'transducers': [63, 245, 368, 936], 'activators': [65, 247, 370, 938], 'transcription)': [67, 249, 940], 'with': [68, 250, 401, 1025, 1075, 1251, 1475, 1564, 1578, 1585, 1677, 1688, 1702, 1713, 1718, 1728, 1823, 1853, 1919, 1928, 2142, 2159, 2177, 2216, 2235, 2247, 2252, 2259, 2530, 2541, 2609, 2612, 2623, 2643, 2707, 2785, 2797, 2803, 2823, 2847, 2870, 2876, 2947, 2964, 3205, 3228, 3296, 3358, 3419, 3466, 3677, 4034, 4152, 4198, 4610], 'concomitant': [69, 251], 'translocation': [70, 252, 969, 2516, 2713, 3535, 3551], 'nucleus': [73, 255, 972, 2519, 2676, 3540, 4451], 'induces': [75, 158, 257, 340], 'STAT3-dependent': [76, 258], 'transcriptional': [77, 89, 259, 271, 2730], 'activation': [78, 90, 260, 272, 593, 811, 1033, 1073, 1181, 2731, 2749, 3601, 3617, 3873, 4227, 4307, 4510, 4529], 'cultured': [80, 262], 'cells.': [82, 264, 2523, 3646, 3684, 4207, 4242], 'Expressing': [83, 265], 'dominant': [84, 266, 1312, 1733, 1861, 2804, 2848, 2965, 2992, 4178, 4199, 4223, 4534], 'negative': [85, 267, 1313, 1734, 1862, 2225, 2805, 2849, 2966, 2993, 4179, 4200, 4224, 4535], 'inhibited': [87, 269, 599, 3431, 3699, 3758, 4173], 'Gas6-mediated': [88, 270, 717, 1131, 1164, 2500, 2922, 2928, 2996, 3497, 3611, 3752, 3871, 3897, 4167, 4496], 'abolished': [94, 138, 276, 320, 2637], 'Gas6-induced': [95, 277, 2596, 2631], 'proliferation.': [98, 181, 280, 363, 3022, 3712, 4105, 4499, 4520, 4613], 'model': [101, 283, 3027, 3631, 3932], 'proliferative': [104, 286, 3030, 4212], 'glomerulonephritis,': [105, 287, 3951, 4122, 4129], 'phosphorylated': [108, 290, 2669, 3640], 'cells,': [111, 293, 782, 4145, 4166], 'its': [113, 135, 295, 317, 592, 1148, 2512, 3562, 4259, 4374], 'phosphorylation': [114, 139, 296, 321, 927, 953, 2514, 2549, 2572, 2597, 2633, 2651, 2920, 2934, 3005, 3018, 3185, 3239, 3290, 3409, 3517, 3546, 3648, 3701, 3760, 3861, 4027, 4050, 4114, 4132, 4273], 'peaks': [115, 297, 3130, 3657], 'at': [116, 298, 1458, 1628, 1661, 1697, 2209, 2560, 2586, 3127, 3131, 3658, 4464], 'day': [117, 299, 2326, 2379, 2391, 2436, 3128, 3132, 3137, 3217, 3233, 3244, 3270, 3281, 3304, 3309, 3375, 3659], '8': [118, 300, 1826, 3234, 3376, 3660], 'after': [119, 301, 2383, 2704, 3139, 4253, 4467], 'injection': [121, 303, 1987, 2385, 3141], 'anti-Thy1.1': [123, 305, 1990, 3143], 'antibody.': [124, 306], 'Inhibition': [125, 307], 'by': [128, 179, 310, 361, 481, 600, 712, 796, 897, 952, 968, 1323, 1758, 1974, 1983, 2155, 2172, 2213, 2223, 2442, 2453, 2460, 2481, 2510, 2575, 2581, 2603, 2638, 2727, 2775, 2816, 2853, 2891, 2941, 2978, 2985, 2990, 3136, 3263, 3387, 3432, 3457, 3691, 3908, 4174, 4219, 4246, 4270, 4530], 'warfarin': [129, 311, 603, 697, 2260, 3420, 3436, 3467, 3695], 'extracellular': [132, 314, 700, 2618], 'domain': [133, 315, 701, 2619, 4261, 4376], 'receptor,': [136, 318, 3526], 'Axl,': [137, 319], 'Thus,': [144, 326, 771, 3713, 4092], 'our': [145, 327, 3594, 3714, 3867, 4041, 4093, 4487, 4624], 'vivo': [150, 332, 3014, 3630, 4512, 4547], 'findings': [151, 333, 3868], 'indicate': [152, 334, 3869, 4079, 4095], 'autocrine': [154, 336, 662], 'growth': [155, 337, 365, 491, 663, 802, 1015, 1028, 1076, 1776, 1900, 3771, 3914], 'factor': [156, 165, 338, 347, 366, 492, 664], 'via': [162, 344, 4258], 'latent': [163, 345, 946], 'transcription': [164, 346, 372, 947, 2723, 2814, 2890], 'STAT3.': [166, 348, 2936, 2994, 3619, 4180, 4225], 'Therefore,': [167, 349, 3866, 4106, 4226], 'might': [169, 351, 3901, 4183, 4230], 'be': [170, 352, 775, 3286, 3400, 3557, 3682, 3875, 3918, 3962, 4109, 4118, 4184, 4232, 4303, 4427, 4455, 4476], 'new': [172, 354, 4598], 'therapeutic': [173, 355, 3738, 4603], 'target': [174, 356, 3735], 'kidney': [176, 358, 411, 1493, 3372, 3461, 3741, 4607], 'disease': [177, 359, 412], 'induced': [178, 360, 1982, 2711, 2815, 2977], 'platelet-derived': [364], 'signal': [367], 'fluorescein': [373], 'isothiocyanate': [374], 'smooth': [375, 1246], 'muscle': [376, 1247], 'actin': [377, 1248], "Dulbecco's": [378], 'modified': [379], "Eagle's": [380], 'medium': [381, 1537, 1545, 1772, 1777, 1790, 1800, 1896, 1901, 1911], '5-bromo-4-chloro-3-indolyl-β-d-galactopyranoside': [382], 'glomerulonephritis': [383, 721, 3031, 3035, 3728, 3972], 'characteristic': [389], 'feature': [390], 'many': [392, 898], 'types': [393, 3357], 'diseases': [396, 795, 3907, 4608], 'usually': [399, 966], 'associated': [400, 1024, 4609], 'matrix': [402], 'expansion,': [403], 'leading': [404], 'development': [407, 3726, 3883, 3904, 3949], 'end': [409], 'stage': [410], '(1Fogo': [413], 'A.': [414, 500, 737, 879, 1096, 1403, 2078, 2298, 2408, 3053, 3160, 3988, 4384], 'Ichikawa': [415], 'I.': [416], 'Semin.': [417, 432], 'Nephrol.': [418, 433, 689, 1382, 1524, 1962, 2041, 2086, 2359, 3113, 3823], '1989;': [419, 434], '9:': [420, 435, 2088], '329-342PubMed': [421], 'Google': [422, 437, 454, 516, 550, 580, 621, 653, 693, 756, 837, 872, 892, 918, 987, 1069, 1103, 1124, 1348, 1386, 1422, 1528, 1883, 1966, 2024, 2046, 2090, 2109, 2317, 2363, 2427, 2769, 2912, 3072, 3097, 3118, 3179, 3349, 3592, 3794, 3810, 3828, 3853, 4007, 4293, 4331, 4358, 4407, 4569, 4584], 'Scholar,': [423, 438, 517, 551, 622, 873, 1104, 1387, 2025, 2091, 3073, 3795, 3811, 3829, 4570], '2Striker': [424], 'L.J.': [425, 440], 'Doi': [426, 445, 684, 738, 1377, 1404, 1519, 1957, 2299, 2354, 2409, 3054, 3161, 3989], 'T.': [427, 446, 521, 624, 677, 683, 685, 729, 739, 741, 974, 1042, 1052, 1056, 1370, 1376, 1378, 1395, 1405, 1407, 1512, 1518, 1520, 1950, 1956, 1958, 2029, 2290, 2300, 2302, 2347, 2353, 2355, 2400, 2410, 2412, 3045, 3055, 3057, 3101, 3152, 3162, 3164, 3980, 3990, 3992], 'Elliot': [428, 443], 'S.': [429, 1095], 'Striker': [430, 447], 'G.E.': [431, 448], '318-328PubMed': [436], '3Striker': [439], 'Peten': [441], 'E.P.': [442], 'S.J.': [444, 2099], 'Lab.': [449], 'Invest.': [450, 2102, 3342, 3846], '1991;': [451, 3343, 3785, 4401], '64:': [452, 2907], '446-456PubMed': [453], 'Scholar).': [455, 581, 654, 757, 919, 988, 1125, 1349, 1423, 1529, 1967, 2047, 2110, 2318, 2364, 2428, 2770, 2913, 3119, 3180, 4008, 4294, 4359, 4408, 4585], 'Since': [456, 2995], 'cells': [461, 587, 667, 1040, 1079, 1495, 1531, 1552, 1560, 1575, 1590, 1666, 1685, 1722, 1809, 1820, 1833, 1847, 1916, 2528, 2608, 2691, 2726, 2783, 2801, 2821, 2845, 2874, 2895, 2945, 2962, 3268, 3398, 3402, 3676, 4085, 4196], 'diseases,': [471], 'several': [472, 4309], 'studies': [473], 'have': [474, 3487, 3507, 3529, 3608, 3621, 4014], 'attempted': [475], 'suppress': [477], 'inhibiting': [482], 'specific': [483, 713, 1455, 4600], 'mitogens,': [484], 'such': [485, 4123], 'as': [486, 1500, 1640, 1938, 1998, 2280, 2335, 2474, 2896, 3033, 3666, 3668, 3706, 3708, 3719, 3732, 3763, 3765, 3864, 4124], 'PDGF1': [487], 'basic': [489], 'fibroblast': [490], '(4Johnson': [493], 'R.J.': [494, 573, 907, 3325, 3803, 3813, 3843], 'Raines': [495], 'E.W.': [496], 'Floege': [497, 2036, 3108, 3814], 'J.': [498, 507, 519, 537, 565, 575, 630, 639, 686, 743, 885, 908, 1379, 1409, 1521, 1959, 2037, 2038, 2083, 2100, 2304, 2356, 2414, 3059, 3109, 3110, 3166, 3340, 3578, 3776, 3782, 3797, 3815, 3820, 3831, 3844, 3994, 4344], 'Yoshimura': [499], 'Pritzl': [501], 'P.': [502, 976, 3335], 'Alpers': [503, 566, 3328, 3818, 3836], 'C.': [504, 529, 557, 607, 611, 875, 2080, 2900, 4388], 'Ross': [505], 'R.': [506, 877, 2074, 4390, 4551, 4553, 4561], 'Exp.': [508], 'Med.': [509], '1992;': [510], '175:': [511], '1413-1416Crossref': [512], 'PubMed': [513, 547, 618, 650, 753, 834, 869, 889, 917, 984, 1066, 1100, 1121, 1345, 1419, 1880, 2021, 2045, 2106, 2314, 2424, 2766, 2909, 3069, 3094, 3117, 3176, 3346, 3589, 3791, 3827, 3850, 4004, 4290, 4328, 4355, 4404], 'Scopus': [514, 548, 619, 651, 754, 835, 870, 890, 985, 1067, 1101, 1122, 1346, 1420, 1881, 2022, 2107, 2315, 2425, 2767, 2910, 3070, 3095, 3177, 3347, 3590, 3792, 3851, 4005, 4291, 4329, 4356, 4405], '(354)': [515], '5Floege': [518], 'Ostendorf': [520, 2028, 3100], 'Janssen': [522], 'U.': [523, 1094, 2031, 3103], 'Burg': [524], 'M.': [525, 669, 723, 1044, 1048, 1108, 1362, 1389, 1504, 1942, 2004, 2010, 2033, 2284, 2339, 2394, 3039, 3077, 3083, 3105, 3146, 3565, 3974, 4557], 'Radeke': [526], 'H.H.': [527], 'Vargeese': [528], 'Gill': [530], 'S.C.': [531], 'Green': [532], 'L.S.': [533], 'Janjic': [534], 'N.': [535, 628, 3778, 4313], 'Am.': [536, 574, 687, 742, 1380, 1408, 1522, 1960, 2039, 2084, 2303, 2357, 2413, 3058, 3111, 3165, 3781, 3821, 3993], 'Pathol.': [538, 576, 744, 1410, 2305, 2415, 3060, 3167, 3995], '1999;': [539, 690, 831, 866, 981, 1383, 1525, 1963, 2360, 4287, 4566], '154:': [540], '169-179Abstract': [541], 'Full': [542, 544, 645, 647, 748, 750, 914, 1061, 1063, 1414, 1416, 2016, 2018, 2309, 2311, 2419, 2421, 3064, 3066, 3089, 3091, 3171, 3173, 3584, 3586, 3788, 3999, 4001, 4350, 4352], 'Text': [543, 545, 646, 648, 749, 751, 915, 1062, 1064, 1415, 1417, 2017, 2019, 2310, 2312, 2420, 2422, 3065, 3067, 3090, 3092, 3172, 3174, 3585, 3587, 3789, 4000, 4002, 4351, 4353], 'PDF': [546, 649, 752, 916, 1065, 1418, 2020, 2313, 2423, 3068, 3093, 3175, 3588, 3790, 4003, 4354], '(223)': [549], '6Pichler': [552], 'R.H.': [553], 'Bassuk': [554], 'J.A.': [555], 'Hugo': [556], 'Reed': [558], 'M.J.': [559], 'Eng': [560, 3798, 3832], 'E.': [561, 2008, 3081, 3799, 3833], 'Gordon': [562, 3336], 'K.L.': [563], 'Pippin': [564], 'C.E.': [567, 3329, 3819, 3837], 'Couser': [568, 3816], 'W.G.': [569, 3817], 'Sage': [570], 'E.H.': [571], 'Johnson': [572, 3802, 3842], '1996;': [577, 886, 1058, 1097, 1118, 4347], '148:': [578], '1153-1167PubMed': [579], 'Among': [582], 'mitogens': [584], 'unique': [590], 'because': [591, 4026, 4428], 'vitamin': [595], 'K-dependent': [596], 'anticoagulant': [602], '(7Manfioletti': [604], 'G.': [605, 609, 4549], 'Brancolini': [606], 'Avanzi': [608], 'Schneider': [610], 'Mol.': [612, 828, 863, 978, 1339, 1874, 2760, 4284, 4398], 'Cell.': [613, 829, 864, 977, 1340, 1875, 2761, 4285, 4399], 'Biol.': [614, 640, 830, 865, 909, 1341, 1876, 2762, 3579, 4286, 4345, 4400], '1993;': [615, 911, 3807, 3824, 3847], '13:': [616], '4976-4985Crossref': [617], '(539)': [620], '8Nakano': [623], 'Higashino': [625], 'K.': [626, 632, 671, 679, 681, 727, 731, 733, 1054, 1364, 1372, 1374, 1393, 1397, 1399, 1506, 1514, 1516, 1944, 1952, 1954, 2076, 2288, 2292, 2294, 2341, 2349, 2351, 2398, 2402, 2404, 3043, 3047, 3049, 3150, 3154, 3156, 3337, 3780, 3978, 3982, 3984], 'Kikuchi': [627], 'Kishino': [629], 'Nomura': [631], 'Fujita': [633], 'H.': [634, 638, 673, 675, 725, 827, 862, 883, 1366, 1368, 1391, 1508, 1510, 1946, 1948, 2286, 2343, 2345, 2396, 3041, 3148, 3327, 3976, 4283, 4563], 'Ohara': [635], 'O.': [636], 'Arita': [637], 'Chem.': [641, 910, 3580, 4346], '1995;': [642, 2906, 4325], '270:': [643], '5702-5705Abstract': [644], '(165)': [652], 'Recently': [655], 'an': [661, 1486, 1729, 1857, 2828, 3025, 3628, 4490], '(9Yanagita': [668, 1361, 1503, 1941, 2338], 'Ishii': [670, 726, 1363, 1392, 1505, 1943, 2287, 2340, 2397, 3042, 3149, 3977], 'Ozaki': [672, 1365, 1507, 1945, 2342], 'Arai': [674, 724, 1367, 1390, 1509, 1947, 2285, 2344, 2395, 3040, 3147, 3975], 'Nakano': [676, 728, 1369, 1394, 1511, 1949, 2289, 2346, 2399, 3044, 3151, 3979], 'Ohashi': [678, 730, 1371, 1396, 1513, 1951, 2291, 2348, 2401, 3046, 3153, 3981], 'Mizuno': [680, 732, 1373, 1398, 1515, 1953, 2293, 2350, 2403, 3048, 3155, 3983], 'Kita': [682, 740, 1375, 1406, 1517, 1955, 2301, 2352, 2411, 3056, 3163, 3991], 'Soc.': [688, 1381, 1523, 1961, 2040, 2085, 2358, 3112, 3822], '10:': [691, 1384, 1526, 1964, 2361], '2503-2509PubMed': [692, 1385, 1527, 1965, 2362], 'Scholar)': [694, 1884, 3350, 3854], 'Axl': [703, 818, 2621, 4360, 4420], '(a': [704, 3318], 'receptor': [705], 'Gas6)': [707], 'abolish': [708], 'inhibition': [714, 2810, 4507, 4526], 'pathway': [718, 854, 1145, 3690, 3753, 4592], 'experimental': [720, 1186], '(10Yanagita': [722, 2283, 2393, 3038, 3145, 3973], 'Varnum': [734, 1400, 2295, 2405, 3050, 3157, 3985], 'B.': [735, 1401, 2296, 2406, 3051, 3158, 3986, 4386], 'Fukatsu': [736, 1402, 2297, 2407, 3052, 3159, 3987], '2001;': [745, 1411, 2306, 2416, 3061, 3168, 3996], '158:': [746, 1412, 2307, 2417, 3062, 3169, 3997], '1423-1432Abstract': [747, 1413, 2308, 2418, 3063, 3170, 3998], '(93)': [755, 986, 1421, 2316, 2426, 3071, 3178, 4006], 'Moreover,': [758], 'administration': [759, 3434, 3693, 4532], 'these': [761, 3395, 3623], 'agents': [762], 'abolishes': [763], 'induction': [765], 'PDGF-B': [767], 'Thy1': [769, 1979, 2273, 3034, 3121, 3226, 3416, 3427, 3635, 3755, 3857, 3885, 4068], 'GN.': [770, 4069], 'seems': [773], 'not': [776, 2840, 2866, 2884, 2956, 2988, 3253, 3450, 4156, 4217, 4231, 4362, 4412, 4422, 4454, 4475, 4483], 'only': [777], 'mitogen': [779], 'but': [783, 2695, 3219, 4365], 'also': [784, 2666, 2710, 3453, 3530, 4300, 4627], 'play': [786], 'crucial': [788, 1177, 3945], 'modulating': [797, 3909], 'expression': [799, 1305, 1730, 1858, 3247, 3444, 3663, 3911, 3954], 'other': [801, 3770, 3913, 4210], 'factors.': [803, 3915], 'It': [804, 3743, 3916], 'has': [805, 1034, 3716], 'been': [806, 1035], 'previously': [807, 1359, 1501, 1939, 2281, 2336, 2897], 'reported': [808], 'constitutive': [810], 'Eyk,': [813], 'member': [815, 931], 'superfamily': [819], '(11Besser': [820, 855, 4276], 'D.': [821, 856, 1334, 1869, 2027, 2755, 3099, 4277, 4555], 'Bromberg': [822, 857, 1325, 4278], 'J.F.': [823, 858, 1081, 1330, 1865, 2751, 4279], 'Darnell': [824, 859, 880, 1088, 1337, 1872, 2758, 2901, 4280, 4320, 4340], 'J.E.': [825, 860, 881, 1089, 1338, 1873, 2759, 2902, 4281, 4321, 4341], 'Hanafusa': [826, 861, 882, 4282], '19:': [832, 867, 4288], '1401-1409Crossref': [833, 868, 4289], '(108)': [836, 871, 4292], 'Scholar),': [838, 893, 1070, 3593], 'results': [839, 2226, 4071, 4537], 'transformation': [842, 905, 4542], 'without': [845, 3478], 'significant': [846], 'stimulation': [847, 1584, 2706], 'Ras/ERK': [850], '(extracellular': [851], 'signal-regulated': [852], 'kinase)': [853], '12Zong': [874], 'Yan': [876], 'August': [878], 'EMBO': [884], '15:': [887], '4515-4525Crossref': [888], '(74)': [891], 'which': [894, 957], 'activated': [896, 951, 3321], 'oncogenes': [899], 'process': [902], '(13Davis': [906], '268:': [912], '14553-14556Abstract': [913], 'The': [920, 1350, 1968, 2111, 3191, 3246, 4460], 'transforming': [921], 'activities': [922, 2450, 2779, 2794, 2832, 3563, 3967, 4237], 'Eyk': [924, 4247], 'depend': [925, 3002], 'on': [926, 2051, 2325, 2435, 2932, 3003, 3195, 3216, 3232, 3243, 3269, 3303, 3308, 3374, 3513, 3616, 4202], 'STAT3,': [929, 1314, 2967], 'STAT': [934, 943, 959, 963, 992, 1020], 'protein': [941, 1258, 3251, 3448], 'family.': [942], 'proteins': [944, 960, 993, 1021, 3193, 3414], 'are': [945, 2472, 3554, 4086, 4299, 4371], 'factors': [948, 3772, 4192], 'become': [950], 'single': [955, 1985], 'tyrosine,': [956], 'causes': [958], 'dimerize.': [962], 'dimerization': [964], 'followed': [967, 2212, 2459], '(14Decker': [973], 'Kovarik': [975], 'Life': [979, 1287], 'Sci.': [980, 1093], '55:': [982], '1535-1546Crossref': [983], 'Within': [989], 'nucleus,': [991], 'recognize': [994], 'bind': [996], 'consensus': [998], 'DNA': [999], 'binding': [1000, 2657, 4255, 4416, 4434], 'sites': [1001, 4088], 'represent': [1003], 'enhancer': [1004], 'sequences': [1005, 4296, 4368], 'variety': [1008], 'genes,': [1010], 'including': [1011], 'immediate': [1013], 'early': [1014], 'response': [1016, 2678, 4213], 'genes.': [1017], 'Activation': [1018, 4243], 'often': [1023], 'differentiation': [1026], 'regulation.': [1029], 'For': [1030], 'example,': [1031], 'implicated': [1036, 3730], '(15Fukada': [1041], 'Hibi': [1043], 'Yamanaka': [1045], 'Y.': [1046, 1050, 1114, 2002, 2006, 3075, 3079], 'Takahashi-Tezuka': [1047], 'Fujitani': [1049], 'Yamaguchi': [1051], 'Nakajima': [1053], 'Hirano': [1055], 'Immunity.': [1057], '5:': [1059], '449-460Abstract': [1060], '(586)': [1068], 'while': [1071, 2799], 'STAT1': [1072], 'correlates': [1074], 'arrest': [1077], '(16Bromberg': [1080], 'Horvath': [1082, 1331, 1866, 2752], 'C.M.': [1083, 1332, 1867, 2753], 'Wen': [1084], 'Z.': [1085, 4319, 4572], 'Schreiber': [1086, 4342], 'R.D.': [1087, 4343], 'Proc.': [1090], 'Natl.': [1091], 'Acad.': [1092], '93:': [1098], '7673-7678Crossref': [1099], '(447)': [1102], '17Chin': [1105], 'Y.E.': [1106], 'Kitagawa': [1107], 'Su': [1109], 'W.C.': [1110], 'You': [1111], 'Z.H.': [1112], 'Iwamoto': [1113], 'Fu': [1115], 'X.Y.': [1116], 'Science.': [1117, 4324], '272:': [1119], '719-722Crossref': [1120], '(743)': [1123], 'To': [1126, 2189, 2493, 2914], 'elucidate': [1127, 2494, 2915], 'molecular': [1128], 'mechanisms': [1129], 'proliferation,': [1134, 2503, 2924, 3301, 3768, 4025, 4039], 'sought': [1136], 'identify': [1138, 3354], 'components': [1141], 'Gas6/Axl': [1144], 'various': [1149, 4606], 'activities.': [1150], 'this': [1152, 1490, 2320, 2430, 3484], 'report': [1155], 'key': [1160, 3493], 'molecule': [1162, 3495, 3722, 3895], 'This': [1173, 3647, 4181], 'study': [1174, 3715, 3922, 4043, 4488], 'reveals': [1175], 'glomerulonephritis.': [1187, 3633, 3934, 4141], 'Anti-STAT3': [1188], 'anti-phospho-STAT3': [1190, 1703, 2542, 3208], '(Y705,': [1191], '9131)': [1192], 'polyclonal': [1193, 2144, 2545], 'antibodies': [1194, 2145, 2184, 2205, 2234, 2389], 'were': [1195, 1212, 1226, 1266, 1276, 1320, 1358, 1442, 1452, 1471, 1496, 1533, 1553, 1561, 1576, 1591, 1638, 1659, 1672, 1675, 1686, 1711, 1726, 1810, 1821, 1836, 1851, 1917, 2049, 2060, 2122, 2136, 2206, 2245, 2257, 2323, 2433, 2440, 2451, 2468, 2539, 2773, 2865, 3203, 3385, 3679], 'from': [1196, 1213, 1227, 1238, 1254, 1260, 1267, 1277, 1286, 1293, 1430, 1444, 2062, 2266, 2380, 3415, 3463, 4194], 'New': [1197], 'England': [1198], 'Biolabs': [1199], '(Beverly,': [1200], 'MA).': [1201], 'Horseradish': [1202], 'peroxidase-conjugated': [1203], 'goat': [1204, 1223], 'anti-rabbit': [1205, 1224, 2218], 'IgG': [1206, 1225], 'enhanced': [1209], 'chemiluminescent': [1210], 'system': [1211], 'Amersham': [1214], 'Pharmacia': [1215], 'Biotech': [1216], '(Buckinghamshire,': [1217], 'United': [1218], 'Kingdom).': [1219], 'FITC-': [1220], 'rhodamine-labeled': [1222], 'Chemicon': [1228], 'International': [1229, 1280], 'Inc.': [1230, 1289, 1295], '(Temecula,': [1231], 'CA).': [1232, 2492], 'Anti-Thy1.1': [1233], 'monoclonal': [1234, 1991, 2161, 2183, 2238], 'antibody': [1235, 1243, 1704, 1992, 2162, 2176, 2239, 3144], 'OX-7': [1236, 1993], 'was': [1237, 1253, 1259, 1285, 1292, 1429, 1546, 1649, 1773, 1791, 1801, 1897, 1936, 1971, 1981, 2116, 2153, 2170, 2201, 2221, 2333, 2371, 2479, 2636, 2685, 2851, 2987, 3213, 3252, 3261, 3351, 3429, 3449, 4149, 4216, 4446, 4462, 4523], 'Cedarlane': [1239], '(Hornby,': [1240], 'Canada).': [1241], 'Monoclonal': [1242], 'against': [1244, 2146, 2163], 'α': [1245], '(αSMA)': [1249], 'conjugated': [1250, 2622], 'FITC': [1252], 'Sigma.': [1255], 'Recombinant': [1256], 'PDGF-BB': [1257, 1579, 2709, 2886, 2986, 4215, 4239], 'Roche': [1261], 'Molecular': [1262], 'Biochemicals.': [1263], 'Nitrocellulose': [1264], 'filters': [1265], 'Schleiecher': [1268], '&': [1269], 'Schuell': [1270], '(Keene,': [1271], 'NH).': [1272], 'LAB-TEK': [1273], 'chamber': [1274, 1670], 'slides': [1275, 1671], 'Nalgen': [1278], 'Nunc': [1279], '(Naperville,': [1281], 'IL).': [1282], 'LipofectAMINE': [1283, 1760, 1891, 4153], 'Plus': [1284, 1761], 'Technologies,': [1288], 'OCT': [1290, 2129], 'compound': [1291, 2130], 'Miles': [1294], '(Elkhart,': [1296], 'IN).': [1297], 'A': [1298, 4586], 'luciferase': [1299, 1425, 1745, 1752, 1839, 2449, 2778, 2793, 2831], 'reporter': [1300, 1426, 1746, 1753, 2734], 'construct': [1301, 1747, 2736], '(p4xM67-tk-Luc),': [1304], 'vectors': [1306], 'wild': [1308, 2824, 2880], 'type': [1309, 2825, 2881], 'control': [1317, 1740, 1887, 2786, 2837, 2877, 2949], 'vector': [1318, 1731, 1859, 2787, 2838, 2878, 2950], 'ReCMV': [1319, 1742, 1889], 'kindly': [1321], 'provided': [1322, 4015], 'Jackie': [1324], '(The': [1326], 'Rockefeller': [1327], 'Univ.)': [1328], '(18Bromberg': [1329, 1864, 2750], 'Besser': [1333, 1868, 2754], 'Lathem': [1335, 1870, 2756], 'W.W.': [1336, 1871, 2757], '1998;': [1342, 1877, 2087, 2763], '18:': [1343, 1878, 2764], '2553-2558Crossref': [1344, 1879, 2765], '(572)': [1347, 1882, 2768], 'constructs': [1351], 'recombinant': [1353, 2369], 'Axl-Fc,': [1354], 'Fc,': [1355], 'described': [1360, 1502, 1940, 1999, 2282, 2337, 2898], '10Yanagita': [1388], 'Renilla': [1424], 'construct,': [1427, 1754], 'pRLCMV': [1428, 1755], 'Promega': [1431], '(Madison,': [1432], 'WI).': [1433], 'Eight-': [1434], '12': [1436], 'week-old': [1437], 'Wistar': [1438], 'rats': [1439, 2067, 2256, 2322, 2376, 2432, 3417, 3464], '(180–200': [1440], 'g)': [1441], 'purchased': [1443], 'Shimizu': [1445], 'Laboratory': [1446], 'Animal': [1447, 1460], 'Center': [1448], '(Hamamatsu,': [1449], 'Japan).': [1450], 'Rats': [1451, 2048], 'housed': [1453], 'under': [1454], 'pathogen-free': [1456], 'conditions': [1457], 'Facilities': [1461], 'Kyoto': [1463, 1483], 'University,': [1464], 'Faculty': [1465], 'Medicine.': [1467], 'All': [1468, 1657], 'animal': [1469], 'experiments': [1470, 1658], 'performed': [1472, 2334, 2480], 'accordance': [1474], 'institutional': [1476], 'guidelines,': [1477], 'Review': [1480], 'Board': [1481], 'University': [1484], 'granted': [1485], 'ethical': [1487], 'permission': [1488], 'study.': [1491], 'Mouse': [1492], 'characterized': [1497], 'maintained': [1499], '(106)': [1532], 'serum-starved': [1534, 1673], 'starving': [1536, 1795, 1910], '(0.5%': [1538], 'bovine': [1539], 'serum': [1540, 1817], 'albumin/DMEM)': [1541], '48': [1543, 1798], 'h,': [1544, 1799, 1895, 1914, 1932], 'changed': [1547, 1774, 1792, 1802, 1898, 3254], 'serum-free': [1549, 1805], 'DMEM,': [1550, 1779, 1806], 'incubated': [1554, 1811, 1903, 2207], 'another': [1556, 1813, 4020], '2': [1557, 1612, 1814, 1931], 'h.': [1558, 1815, 1827, 1906], 'then': [1562], 'stimulated': [1563, 1577, 1676, 1822, 1918], 'indicated': [1568, 2532], 'times.': [1569, 1664], 'As': [1570, 3935, 4439], 'positive': [1572, 3397], 'control,': [1573], '10': [1581, 1619, 1680, 1695, 2537, 2587, 2702], 'min.': [1582, 1681], 'After': [1583, 1631, 1682, 1767, 1797, 1816, 1893, 1907], 'or': [1587, 1738, 1885, 1921, 2185, 2240, 2879, 3421, 3437, 3468, 3696], 'PDGF-BB,': [1588], 'suspended': [1592], 'RIPA': [1594], 'buffer': [1595], '(50': [1596], 'mm': [1597, 1602, 1610, 1613, 1616], 'Tris,': [1598], 'pH': [1599], '7.5,': [1600], '150': [1601], 'NaCl,': [1603], '1%': [1604], 'Nonidet': [1605], 'P-40,': [1606], '0.25%': [1607], 'SDS,': [1608], '1': [1609, 1615, 1626, 1854, 2564, 2590, 2646, 2693, 4443], 'Na3VO4,': [1611], 'EGTA,': [1614], 'phenylmethylsulfonyl': [1617], 'fluoride,': [1618], 'μg/ml': [1620], 'aprotinin),': [1622], 'rotated': [1624], 'h': [1627, 1769, 1788, 1925, 2382], '4': [1629, 1698, 1905, 2210, 3236, 3278, 3404], '°C.': [1630], 'centrifugation': [1632], 'samples,': [1635], 'supernatants': [1637], 'used': [1639], 'total': [1641], 'lysates.': [1643], 'Sixty': [1644], 'μg': [1645, 1855, 2367], 'each': [1647], 'sample': [1648], 'applied': [1650], 'SDS-polyacrylamide': [1652], 'gel': [1653], 'electrophoresis': [1654], 'immunoblotted.': [1656], 'repeated': [1660, 2455], 'least': [1662], 'three': [1663], '(104/well)': [1667], 'plated': [1668], 'stimulation,': [1684], 'fixed': [1687], 'phosphate-buffered': [1689], 'saline': [1690], 'containing': [1691], '3%': [1692], 'paraformaldehyde': [1693], 'min': [1696, 2538, 2588, 2703, 4466, 4481], '°C': [1699, 2211], 'immunostained': [1701], 'according': [1705, 1762, 1841], "manufacturer's": [1708, 1765, 1844], 'recommendation.': [1709], 'Specimens': [1710, 2244], 'observed': [1712, 2246], 'Zeiss': [1715, 2249], 'microscope': [1716, 2250], 'equipped': [1717, 2251], 'proper': [1719, 2253], 'filters.': [1720, 2254], '(5': [1723], '×': [1724, 1849], '105)': [1725, 1850], 'transfected': [1727, 1852, 2784, 2802, 2822, 2846, 2875, 2946, 2963, 4197], 'encoding': [1732, 1860], '(1': [1736, 1743, 1994], 'μg)': [1737, 1757, 1835], 'vector,': [1741, 1888], 'μg),': [1744, 1750], 'p4xM67-tk-Luc': [1748], '(0.5': [1749, 1848, 2264], 'renilla': [1751, 2777], '(0.1': [1756], 'using': [1759, 1890, 2068, 2138, 2484], 'instructions.': [1766, 1845], '6': [1768, 1894], 'transfection,': [1771], '(60%': [1778], '20%': [1780, 1782], 'F12,': [1781], 'fetal': [1783], 'calf': [1784], 'serum),': [1785], '3': [1787], 'later': [1789], 'again': [1793, 1803], 'medium.': [1796], 'starvation,': [1818], 'Whole': [1828], 'lysates': [1830, 2525], '(10': [1834], 'subjected': [1837], 'assays': [1840], 'Plus.': [1892], 'incubation': [1908, 2215], '24': [1913, 2381], 'PDGF': [1922], '22': [1924], 'pulse-labeled': [1927], '[3H]thymidine': [1929, 1935, 2939, 2958], 'incorporated': [1934], 'measured': [1937], 'transfection': [1969, 4147, 4176, 4221], 'efficiency': [1970, 4148], 'about': [1972, 2582, 4150, 4162], '60%': [1973, 4151], 'X-gal': [1975], 'staining': [1976, 3274, 3360, 3473], '(not': [1977], 'shown).': [1978, 2841, 2885, 4157, 4423, 4484], 'GN': [1980, 2274, 3428, 3756, 3858, 3886], 'intravenous': [1986], 'mouse': [1989, 2237, 2521, 4143], 'mg/kg': [1995], 'body': [1996], 'weight)': [1997], 'elsewhere': [2000], '(19Nagasawa': [2001], 'Takenaka': [2003, 3076], 'Matsuoka': [2005, 3078], 'Imai': [2007, 3080], 'Hori': [2009, 3082, 4630], 'Kidney': [2011, 2120, 3084, 3783, 3804], 'Int.': [2012, 3085, 3805], '2000;': [2013, 2042, 3086, 3114, 3581, 4581], '57:': [2014, 3087], '717-723Abstract': [2015, 3088], '(38)': [2023, 3096], '20Bokemeyer': [2026], 'Kunter': [2030, 3102], 'Lindemann': [2032, 3104], 'Kramer': [2034, 3106], 'H.J.': [2035, 3107], '11:': [2043, 3115, 4402], '232-240Crossref': [2044, 3116], 'sacrificed': [2050, 2324, 2434], 'days': [2052, 2268, 2277, 3196], '0,': [2053, 3197], '3,': [2054, 3198, 3282], '5,': [2055, 3199], '8,': [2056, 3133, 3200, 3305], '15.': [2058, 3245, 3310], 'Glomeruli': [2059], 'isolated': [2061], 'renal': [2064], 'cortex': [2065], 'differential': [2070], 'thieving': [2071], 'method': [2072], '(21Ziswiler': [2073], 'Steinmann-Niggli': [2075], 'Kappeler': [2077], 'Daniel': [2079], 'Marti': [2081], 'H.P.': [2082], '2055-2066PubMed': [2089], '22Pippin': [2092], 'J.W.': [2093], 'Qu': [2094], 'Q.': [2095], 'Meijer': [2096], 'L.': [2097], 'Shankland': [2098], 'Clin.': [2101, 3341, 3845], '1997;': [2103], '100:': [2104], '2512-2520Crossref': [2105], '(132)': [2108], 'purity': [2112], 'glomeruli': [2115, 3705], 'higher': [2117], 'than': [2118, 3476, 4057, 4479], '90%.': [2119], 'tissues': [2121], 'snap': [2123], 'frozen': [2124], 'cold': [2126], 'acetone': [2127], 'cryostat': [2132], 'sections': [2133], '(4': [2134], 'μm)': [2135], 'stained': [2137], 'indirect': [2139], 'immunofluorescence': [2140, 2157], 'procedure': [2141, 2158], 'rabbit': [2143, 2186, 2241], 'phospho-STAT3': [2147, 2200, 2684, 3260, 3276, 3315, 3362, 3368, 3396, 3475, 3537, 3553, 3678, 4076, 4445, 4473], '(1:100': [2148], 'dilution).': [2149], 'Detection': [2150], 'αSMA': [2152, 2164, 2198, 3317, 3370, 4078], 'done': [2154, 2441, 3352], 'direct': [2156, 4415], 'FITC-conjugated': [2160], '(1A4).': [2165], 'Specificity': [2166, 2220], 'procedures': [2169], 'confirmed': [2171, 2222, 3262, 3454], 'substituting': [2173], 'primary': [2175, 2204, 2233], 'equivalent': [2178, 2833], 'concentrations': [2179, 2533], 'irrelevant': [2181, 2236], 'murine': [2182], 'preimmune': [2187, 2242], 'IgG.': [2188, 2219, 2243], 'determine': [2190], 'localization': [2192], 'phospho-STAT3,': [2194], 'double': [2195, 3312, 4073], 'immunostaining': [2196, 3313, 4074], 'done.': [2202], 'Both': [2203], 'overnight': [2208], 'rhodamine-conjugated': [2217], 'when': [2227, 2795, 3661], 'replacing': [2228], 'either': [2229], 'one': [2230, 3876], 'Six': [2255], 'treated': [2258, 2529, 2606, 2796, 3418, 3465], 'drinking': [2262], 'water': [2263], 'mg/L)': [2265], '5': [2267, 3440, 3481, 4465, 4480], 'before': [2269], 'initiation': [2271], 'sacrifice': [2279], 'experiment,': [2321, 2431, 2570], '8.': [2327, 2437], 'Expression': [2328], 'purification': [2330], 'Axl-Fc': [2332, 2370, 2644, 3438, 3469, 3697], 'Two': [2365], 'hundred': [2366], 'intravenously': [2372], 'administered': [2373], 'six': [2375], 'once': [2377], 'anti-Thy': [2387], '1.1': [2388], '7': [2392], 'Statistical': [2438], 'analyses': [2439], "Student's": [2443], 't': [2444], 'test.': [2445, 2464], 'Thymidine': [2446], 'incorporation': [2447, 2940, 2959], 'analyzed': [2452], 'two-way': [2454], 'analysis': [2456], 'variance': [2458], "Fisher's": [2462], 'post-hoc': [2463], 'pvalues': [2465], '<': [2466], '0.01': [2467], 'considered': [2469, 4249], 'significant.': [2470], 'Data': [2471], 'expressed': [2473], 'means': [2475], '±': [2476], 'S.D.': [2477], 'Analysis': [2478], 'simple': [2482], 'regression': [2483], 'StatView': [2486], 'program': [2487], '(Abacus': [2488], 'Concepts': [2489], 'Inc.,': [2490], 'Berkeley,': [2491], 'examined': [2505, 2667, 2718, 2852, 2926, 3011, 3183, 3408], 'whether': [2506, 2595, 2668, 2719, 2927, 4113, 4131], 'activates': [2508], 'measuring': [2511, 2728, 2854], 'Cell': [2524], 'immunoblotted': [2540, 3204], 'anti-STAT3': [2544, 3206], 'antibodies.': [2546, 3209], 'increased': [2548, 2580, 2867, 2887, 2938, 3292, 4031], 'dose-dependent': [2554], 'manner': [2555], 'reached': [2557], 'peak': [2559], '500': [2561, 2576], 'ng/ml': [2562, 2577], '(Fig.': [2563, 2589, 2645, 2692, 2818, 2951, 3235, 3277, 3403, 3439, 3480], 'A).': [2565, 3237, 3441], 'time': [2568], 'course': [2569, 3224], '2.6-fold': [2583], 'peaked': [2585, 3302], 'B).': [2591, 3279, 3482], 'Next,': [2592], 'tested': [2594], 'specifically': [2601], 'mediated': [2602, 3521], 'Axl.': [2604, 2664, 3527, 3605, 4438], 'preincubated': [2611], '100': [2613], 'molar': [2614], 'excess': [2615], 'Fc': [2625], 'portion': [2626], 'human': [2628, 4121], 'IgG1': [2629], '(Axl-Fc).': [2630], 'preincubation': [2640], 'C),': [2647], 'indicating': [2648, 2968, 3391], 'through': [2655, 3522, 3604], 'surface': [2663, 3525], '(phospho-STAT3)': [2671], 'translocated': [2673, 4448], 'Gas6.': [2680, 2708, 2979], 'immunofluorescent': [2682, 4042], 'analysis,': [2683], 'almost': [2686, 3214], 'undetectable': [2687, 3215], 'unstimulated': [2689], 'D)': [2694], 'became': [2696, 3220], 'evident': [2697, 3221], 'nuclear': [2700, 2712, 3359, 3550], 'compartment': [2701], 'phospho-STAT3.': [2715], 'Next': [2716], 'stimulates': [2721, 3534, 3599], 'STAT3-specific': [2722, 2812, 2888, 3542], 'gene': [2735, 2813, 2889], 'bearing': [2737], 'four': [2738], 'copies': [2739], 'M67': [2742], 'site': [2743, 4047, 4064], 'responsive': [2746], 'Transfection': [2771], 'efficiencies': [2772], 'normalized': [2774], 'pRLCMV.': [2781], '3.5-fold': [2790], 'increase': [2791, 2829, 2957, 3231, 3651], 'Gas6,': [2798, 4471], 'complete': [2809], '2).': [2819], '(data': [2839, 2883, 4155, 4421, 4482], 'Viability': [2842], 'levels': [2856], 'lactate': [2858], 'dehydrogenase': [2859], 'conditioned': [2862], 'media': [2863], 'significantly': [2868], 'compared': [2869], '2.5-fold': [2892], '(23Schindler': [2899], 'Annu.': [2903], 'Rev.': [2904], 'Biochem.': [2905], '621-651Crossref': [2908], '(1666)': [2911], 'depends': [2931, 3615], '3.2-folds': [2942], '3).': [2952], 'However,': [2953, 3442, 4409], 'did': [2955], 'involved': [2972, 3723], 'contrast,': [2981], 'affected': [2989, 4218], 'overexpressing': [2991], 'appears': [3000], 'vitro,': [3009], 'utilized': [3024], 'acute': [3026], 'known': [3032], '(Thy1': [3036], 'GN)': [3037], '19Nagasawa': [3074], 'Scholar,20Bokemeyer': [3098], 'GN,': [3122, 3227, 3636], 'begins': [3126], '2,': [3129], 'resolves': [3135], '15': [3138, 3202], 'First': [3181], 'proteins.': [3190], 'collected': [3194], 'Phosphorylation': [3210, 3423], '0': [3218, 3271], 'during': [3222, 3255], '5.3-fold': [3230], 'Increased': [3238], 'subsided': [3242], 'level': [3248, 3291, 3445], 'period.': [3257], 'Localization': [3258], 'immunostaining.': [3264, 3458], 'Nuclei': [3265], 'scarce': [3273], 'On': [3280, 4208], 'nuclei': [3283, 3383, 3643, 4082], 'began': [3284], 'phosphorylated,': [3287], 'gradually': [3293], 'parallel': [3295, 4033], 'activity': [3298, 4036, 4137], 'decreased': [3307], 'Simultaneously,': [3311], 'marker': [3319, 3964, 4021], 'cells)': [3323], '(24Johnson': [3324], 'Iida': [3326], 'Majesky': [3330], 'M.W.': [3331], 'Schwartz': [3332], 'S.M.': [3333], 'Pritzi': [3334], 'Gown': [3338], 'A.M.': [3339], '87:': [3344], '847-858Crossref': [3345], '(443)': [3348], 'glomerulus.': [3365], 'Overlay': [3366], 'section': [3373], 'demonstrated': [3377, 3488], 'majority': [3380], 'phospho-STAT3-positive': [3382], '(red)': [3384], 'surrounded': [3386], 'αSMA-expressing': [3388], 'cytoplasm': [3389], '(green),': [3390], 'most': [3393], 'would': [3399, 3874, 3917, 4108], 'C).': [3405], 'Finally,': [3406], 'Axl-Fc.': [3422], 'completely': [3430, 3698, 3757], 'affected.': [3451], 'result': [3456, 4182], 'Immunostaining': [3459], 'specimen': [3462], 'much': [3471], 'less': [3472], 'treatment': [3479], 'shown': [3508, 3531, 3555, 3609, 3680, 4301, 4524], 'transcription.': [3543], 'Because': [3544], 'necessary': [3558, 4233], 'sufficient': [3560], '(25Bartoli': [3564], 'Gu': [3566], 'X.': [3567], 'Tsai': [3568], 'N.T.': [3569], 'Venema': [3570], 'R.C.': [3571], 'Brooks': [3572], 'S.E.': [3573], 'Marrero': [3574], 'M.B.': [3575], 'Caldwell': [3576], 'R.B.': [3577], '275:': [3582], '33189-33192Abstract': [3583], '(124)': [3591], 'data': [3595, 4094, 4501], 'indicates': [3596], 'Further': [3606], 'extended': [3622], 'observations': [3626], 'heavily': [3639], 'parallels': [3649], 'well': [3667, 3707, 3764], 'peaks.': [3672], 'Most': [3673], 'Furthermore,': [3685], 'interference': [3686, 3749], 'Gas6-specific': [3689], 'it': [3731, 4107, 4522], 'novel': [3734], 'strategy': [3739], 'intriguing': [3745, 4110], 'note': [3747], 'although': [3769], 'cytokines': [3774], '(26Floege': [3775], 'Topley': [3777], 'Resch': [3779], 'Dis.': [3784], '17:': [3786], '673-676Abstract': [3787], '(47)': [3793], '27Floege': [3796], 'Young': [3800, 3834], 'B.A.': [3801, 3835], 'Suppl.': [3806], '39:': [3808], 'S47-S54PubMed': [3809], '28Johnson': [3812], '4:': [3825], '119-128Crossref': [3826], '29Floege': [3830], 'Barrett': [3838], 'T.B.': [3839], 'Bowen-Pope': [3840], 'D.F.': [3841], '92:': [3848], '2952-2962Crossref': [3849], '(246)': [3852], 'can': [3859, 4117], 'stimulate': [3860], 'well.': [3865], 'initial': [3879], 'events': [3880], 'suggest': [3888], 'critical': [3893, 4621], 'regulate': [3902], 'more': [3919], 'important': [3920, 4304, 4491], 'chronic': [3931], 'previous': [3940], 'report,': [3941], 'region': [3960], 'could': [3961, 4411, 4453, 4474, 4513, 4593], 'showing': [3965], 'evidence': [4016], 'revealed': [4044], 'mainly': [4052], 'glomerulus': [4055], 'rather': [4056], 'tubulus,': [4060], 'corresponding': [4061], 'Further,': [4070], 'phosphorylation.': [4091], 'mediator': [4101], 'detected': [4119, 4477], 'lupus': [4125], 'nephritis': [4126], 'IgA': [4128], 'related': [4134], 'prognosis': [4139], 'plus': [4154], 'Despite': [4158], 'presence': [4160], '40%': [4163], 'untransfected': [4165, 4206], 'totally': [4172], 'due': [4185], 'effect': [4188], 'some': [4190], 'unknown': [4191], 'secreted': [4193], 'growth-arrested': [4195], 'hand,': [4211], 'mitogenic': [4236], 'occur': [4251], 'directly': [4252], 'SH2': [4260], '933YVPQ': [4264], 'sequence': [4265], 'v-Eyk': [4268], 'subsequent': [4271], 'Similar': [4295], '(Y': [4297], 'XXQ)': [4298], 'cytokine': [4310], 'receptors': [4311], '(30Stahl': [4312], 'Farruggella': [4314], 'T.J.': [4315], 'Boulton': [4316], 'T.G.': [4317], 'Zhong': [4318], 'Yancopoulos': [4322], 'G.D.': [4323], '267:': [4326], '1349-1353Crossref': [4327], '(876)': [4330], 'Scholar,31Weber-Nordt': [4332], 'R.M.': [4333], 'Riley': [4334], 'J.K.': [4335], 'Greenlund': [4336], 'A.C.': [4337, 4578], 'Moore': [4338], 'K.W.': [4339], '271:': [4348], '27954-27961Abstract': [4349], '(180)': [4357], 'dose': [4361], 'contain': [4363], '933YVPQ,': [4364], 'Y': [4366], 'XXQ': [4367], '(YYRQ,': [4369], 'YLRQ)': [4370], 'cytoplasmic': [4375], "(32O'Bryan": [4377], 'J.P.': [4378], 'Frye': [4379], 'R.A.': [4380], 'Cogswell': [4381], 'P.C.': [4382], 'Neubauer': [4383], 'Kitch': [4385], 'Prokop': [4387], 'Espinosa': [4389], 'Le': [4391], 'Beau': [4392], 'M.M.': [4393], 'Earp': [4394], 'H.S.': [4395], 'Liu': [4396], 'E.T.': [4397], '5016-5031Crossref': [4403], '(656)': [4406], 'demonstrate': [4413], 'One': [4424], 'explanation': [4425], 'may': [4426], 'rapid': [4431], 'transient': [4433], 'seen': [4440, 4456], 'Fig.': [4442], 'C,': [4444], 'rapidly': [4447], 'cytoplasm.': [4459], 'phenomenon': [4461], 'similar': [4463], 'addition': [4469], 'earlier': [4478], 'conclusion,': [4486], 'establishes': [4489], 'These': [4500], 'led': [4502], 'us': [4503], 'speculate': [4505], 'limit': [4514], 'extent': [4516], 'Recently,': [4521], 'suppression': [4539], 'tumor': [4544], '(33Niu': [4548], 'Heller': [4550], 'Catlett-Falcone': [4552], 'Coppola': [4554], 'Jaroszeski': [4556], 'Dalton': [4558], 'W.': [4559, 4574], 'Jove': [4560], 'Yu': [4562], 'Cancer': [4564, 4579], 'Res.': [4565, 4580], '59:': [4567], '5059-5063PubMed': [4568], '34Ni': [4571], 'Lou': [4573], 'Leman': [4575], 'E.S.': [4576], 'Gao': [4577], '60:': [4582], '1225-1228PubMed': [4583], 'better': [4587], 'understanding': [4588], 'Gas6-STAT3': [4591], 'provide': [4594], 'basis': [4596], 'interventions': [4604], 'thank': [4615, 4628], 'Dr.': [4616], 'Israel': [4617], 'F.': [4618], 'Charo': [4619], 'reading': [4622], 'manuscript.': [4625], 'Toshiko': [4629], 'Hideo': [4632], 'Uchiyama': [4633], 'their': [4635], 'excellent': [4636], 'technical': [4637], 'assistance.': [4638]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2152252443', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-13T04:17:20.612008', 'created_date': '2016-06-24'}
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