Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2151902325', 'doi': 'https://doi.org/10.1152/ajprenal.00116.2012', 'title': 'The epithelial sodium channel δ-subunit: new notes for an old song', 'display_name': 'The epithelial sodium channel δ-subunit: new notes for an old song', 'publication_year': 2012, 'publication_date': '2012-05-10', 'ids': {'openalex': 'https://openalex.org/W2151902325', 'doi': 'https://doi.org/10.1152/ajprenal.00116.2012', 'mag': '2151902325', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22573384'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajprenal.00116.2012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200780590', 'display_name': 'AJP Renal Physiology', 'issn_l': '1522-1466', 'issn': ['1522-1466', '1931-857X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035488933', 'display_name': 'Teresa Giráldez', 'orcid': 'https://orcid.org/0000-0002-4096-810X'}, 'institutions': [], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Teresa Giraldez', 'raw_affiliation_strings': ['Research Division, University Hospital N.S. Candelaria, Santa Cruz de Tenerife, Tenerife, Spain;'], 'affiliations': [{'raw_affiliation_string': 'Research Division, University Hospital N.S. Candelaria, Santa Cruz de Tenerife, Tenerife, Spain;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056623129', 'display_name': 'Patricio Rojas', 'orcid': 'https://orcid.org/0000-0002-7221-6738'}, 'institutions': [{'id': 'https://openalex.org/I10457146', 'display_name': 'Universidad de Santiago de Chile', 'ror': 'https://ror.org/02ma57s91', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I10457146']}], 'countries': ['CL'], 'is_corresponding': False, 'raw_author_name': 'Patricio Rojas', 'raw_affiliation_strings': ['Department of Biology, Universidad de Santiago de Chile, Santiago, Chile;'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Universidad de Santiago de Chile, Santiago, Chile;', 'institution_ids': ['https://openalex.org/I10457146']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011039716', 'display_name': 'Jonathan Jou', 'orcid': 'https://orcid.org/0000-0001-7172-9032'}, 'institutions': [{'id': 'https://openalex.org/I107639228', 'display_name': 'University of Notre Dame', 'ror': 'https://ror.org/00mkhxb43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I107639228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan Jou', 'raw_affiliation_strings': ['University of Notre Dame, South Bend, Indiana;'], 'affiliations': [{'raw_affiliation_string': 'University of Notre Dame, South Bend, Indiana;', 'institution_ids': ['https://openalex.org/I107639228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056138948', 'display_name': 'Carlos Flores', 'orcid': 'https://orcid.org/0000-0001-5352-069X'}, 'institutions': [{'id': 'https://openalex.org/I2801357902', 'display_name': 'Instituto de Salud Carlos III', 'ror': 'https://ror.org/00ca2c886', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4387152914']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Carlos Flores', 'raw_affiliation_strings': ['CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; and', 'Research Division, University Hospital N.S. Candelaria, Santa Cruz de Tenerife, Tenerife, Spain;'], 'affiliations': [{'raw_affiliation_string': 'Research Division, University Hospital N.S. Candelaria, Santa Cruz de Tenerife, Tenerife, Spain;', 'institution_ids': []}, {'raw_affiliation_string': 'CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; and', 'institution_ids': ['https://openalex.org/I2801357902']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010231452', 'display_name': 'Diego Álvarez de la Rosa', 'orcid': 'https://orcid.org/0000-0002-4324-2793'}, 'institutions': [{'id': 'https://openalex.org/I158438070', 'display_name': 'Universidad de La Laguna', 'ror': 'https://ror.org/01r9z8p25', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I158438070']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Diego Alvarez de la Rosa', 'raw_affiliation_strings': ['Department of Physiology, Instituto de Tecnologías Biomédicas, Universidad de La Laguna, Tenerife, Spain'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, Instituto de Tecnologías Biomédicas, Universidad de La Laguna, Tenerife, Spain', 'institution_ids': ['https://openalex.org/I158438070']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5010231452'], 'corresponding_institution_ids': ['https://openalex.org/I158438070'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.737, 'has_fulltext': False, 'cited_by_count': 69, 'citation_normalized_percentile': {'value': 0.999716, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '303', 'issue': '3', 'first_page': 'F328', 'last_page': 'F338'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12280', 'display_name': 'Magnesium in Health and Disease', 'score': 0.9818, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9704, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/epithelial-sodium-channel', 'display_name': 'Epithelial sodium channel', 'score': 0.99034643}, {'id': 'https://openalex.org/keywords/amiloride', 'display_name': 'Amiloride', 'score': 0.840612}, {'id': 'https://openalex.org/keywords/renal-sodium-reabsorption', 'display_name': 'Renal sodium reabsorption', 'score': 0.62954867}, {'id': 'https://openalex.org/keywords/distal-convoluted-tubule', 'display_name': 'Distal convoluted tubule', 'score': 0.5136356}, {'id': 'https://openalex.org/keywords/hek-293-cells', 'display_name': 'HEK 293 cells', 'score': 0.4286685}, {'id': 'https://openalex.org/keywords/apical-membrane', 'display_name': 'Apical membrane', 'score': 0.42677718}], 'concepts': [{'id': 'https://openalex.org/C6507245', 'wikidata': 'https://www.wikidata.org/wiki/Q424948', 'display_name': 'Epithelial sodium channel', 'level': 3, 'score': 0.99034643}, {'id': 'https://openalex.org/C2779608910', 'wikidata': 'https://www.wikidata.org/wiki/Q419995', 'display_name': 'Amiloride', 'level': 3, 'score': 0.840612}, {'id': 'https://openalex.org/C56906281', 'wikidata': 'https://www.wikidata.org/wiki/Q4391435', 'display_name': 'Reabsorption', 'level': 3, 'score': 0.75702214}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.65186274}, {'id': 'https://openalex.org/C57476199', 'wikidata': 'https://www.wikidata.org/wiki/Q7312501', 'display_name': 'Renal sodium reabsorption', 'level': 4, 'score': 0.62954867}, {'id': 'https://openalex.org/C2776777027', 'wikidata': 'https://www.wikidata.org/wiki/Q2914731', 'display_name': 'Distal convoluted tubule', 'level': 4, 'score': 0.5136356}, {'id': 'https://openalex.org/C50254741', 'wikidata': 'https://www.wikidata.org/wiki/Q62536', 'display_name': 'Ion channel', 'level': 3, 'score': 0.5062303}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45996884}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.4531971}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45254254}, {'id': 'https://openalex.org/C174510640', 'wikidata': 'https://www.wikidata.org/wiki/Q489618', 'display_name': 'HEK 293 cells', 'level': 3, 'score': 0.4286685}, {'id': 'https://openalex.org/C3018436504', 'wikidata': 'https://www.wikidata.org/wiki/Q29548', 'display_name': 'Apical membrane', 'level': 3, 'score': 0.42677718}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.402766}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37999403}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3646775}, {'id': 'https://openalex.org/C529295009', 'wikidata': 'https://www.wikidata.org/wiki/Q41301', 'display_name': 'Epithelium', 'level': 2, 'score': 0.31942153}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.25020492}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2363117}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23283201}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.21974242}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19394615}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15847516}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D053503', 'descriptor_name': 'Epithelial Sodium Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002918', 'descriptor_name': 'Chymotrypsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002918', 'descriptor_name': 'Chymotrypsin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D053503', 'descriptor_name': 'Epithelial Sodium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053503', 'descriptor_name': 'Epithelial Sodium Channels', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D053503', 'descriptor_name': 'Epithelial Sodium Channels', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004848', 'descriptor_name': 'Epithelium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004848', 'descriptor_name': 'Epithelium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007685', 'descriptor_name': 'Kidney Tubules, Collecting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007685', 'descriptor_name': 'Kidney Tubules, Collecting', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007685', 'descriptor_name': 'Kidney Tubules, Collecting', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007686', 'descriptor_name': 'Kidney Tubules, Distal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007686', 'descriptor_name': 'Kidney Tubules, Distal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007686', 'descriptor_name': 'Kidney Tubules, Distal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajprenal.00116.2012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200780590', 'display_name': 'AJP Renal Physiology', 'issn_l': '1522-1466', 'issn': ['1522-1466', '1931-857X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22573384', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.62, 'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 103, 'referenced_works': ['https://openalex.org/W1501106827', 'https://openalex.org/W1582195464', 'https://openalex.org/W1590409568', 'https://openalex.org/W1633681515', 'https://openalex.org/W1820962178', 'https://openalex.org/W1850052335', 'https://openalex.org/W1964151355', 'https://openalex.org/W1967249092', 'https://openalex.org/W1968921354', 'https://openalex.org/W1971488179', 'https://openalex.org/W1971536987', 'https://openalex.org/W1972659631', 'https://openalex.org/W1974642350', 'https://openalex.org/W1974805514', 'https://openalex.org/W1980097406', 'https://openalex.org/W1980383200', 'https://openalex.org/W1982363657', 'https://openalex.org/W1983430950', 'https://openalex.org/W1986109085', 'https://openalex.org/W1988825593', 'https://openalex.org/W1989295134', 'https://openalex.org/W1990681783', 'https://openalex.org/W1992733303', 'https://openalex.org/W1992983911', 'https://openalex.org/W1993270050', 'https://openalex.org/W1995294810', 'https://openalex.org/W2004404685', 'https://openalex.org/W2005579207', 'https://openalex.org/W2006312715', 'https://openalex.org/W2008174645', 'https://openalex.org/W2009665317', 'https://openalex.org/W2009697157', 'https://openalex.org/W2013711061', 'https://openalex.org/W2016106273', 'https://openalex.org/W2017945956', 'https://openalex.org/W2021407435', 'https://openalex.org/W2022689385', 'https://openalex.org/W2027862991', 'https://openalex.org/W2030065382', 'https://openalex.org/W2034093166', 'https://openalex.org/W2040616883', 'https://openalex.org/W2051103595', 'https://openalex.org/W2051271691', 'https://openalex.org/W2052083434', 'https://openalex.org/W2052096747', 'https://openalex.org/W2057618310', 'https://openalex.org/W2058717038', 'https://openalex.org/W2059727905', 'https://openalex.org/W2062624996', 'https://openalex.org/W2063100923', 'https://openalex.org/W2064280886', 'https://openalex.org/W2065877675', 'https://openalex.org/W2068761963', 'https://openalex.org/W2074459538', 'https://openalex.org/W2075971181', 'https://openalex.org/W2076598988', 'https://openalex.org/W2077004303', 'https://openalex.org/W2077426649', 'https://openalex.org/W2080970091', 'https://openalex.org/W2081317765', 'https://openalex.org/W2082341144', 'https://openalex.org/W2085957678', 'https://openalex.org/W2086035859', 'https://openalex.org/W2087034411', 'https://openalex.org/W2087499467', 'https://openalex.org/W2088459490', 'https://openalex.org/W2089147915', 'https://openalex.org/W2089612795', 'https://openalex.org/W2090117730', 'https://openalex.org/W2107827966', 'https://openalex.org/W2108521165', 'https://openalex.org/W2116064075', 'https://openalex.org/W2118748839', 'https://openalex.org/W2119338395', 'https://openalex.org/W2120245762', 'https://openalex.org/W2120557074', 'https://openalex.org/W2120883755', 'https://openalex.org/W2123221350', 'https://openalex.org/W2124097655', 'https://openalex.org/W2124663880', 'https://openalex.org/W2126655566', 'https://openalex.org/W2129180544', 'https://openalex.org/W2129631746', 'https://openalex.org/W2133187939', 'https://openalex.org/W2136335088', 'https://openalex.org/W2136901254', 'https://openalex.org/W2137015675', 'https://openalex.org/W2137742332', 'https://openalex.org/W2155218859', 'https://openalex.org/W2156876013', 'https://openalex.org/W2157073177', 'https://openalex.org/W2158241519', 'https://openalex.org/W2158888624', 'https://openalex.org/W2169494292', 'https://openalex.org/W2170596683', 'https://openalex.org/W2184172377', 'https://openalex.org/W2241461566', 'https://openalex.org/W2276153739', 'https://openalex.org/W2324280667', 'https://openalex.org/W2409568467', 'https://openalex.org/W2414416105', 'https://openalex.org/W4210450218', 'https://openalex.org/W73086792'], 'related_works': ['https://openalex.org/W4389007846', 'https://openalex.org/W4210554114', 'https://openalex.org/W3014676085', 'https://openalex.org/W2331732811', 'https://openalex.org/W2166121531', 'https://openalex.org/W2079127109', 'https://openalex.org/W2004705636', 'https://openalex.org/W1976830450', 'https://openalex.org/W1629156103', 'https://openalex.org/W133291183'], 'abstract_inverted_index': {'Amiloride-sensitive': [0], 'epithelial': [1], 'Na': [2, 32, 76], '+': [3, 33, 77], 'channels': [4, 78], '(ENaCs)': [5], 'can': [6, 194], 'be': [7, 195], 'formed': [8, 93], 'by': [9, 94], 'different': [10, 58, 151], 'combinations': [11, 154], 'of': [12, 63, 134, 144, 150, 164, 174, 210], 'four': [13], 'homologous': [14], 'subunits,': [15], 'named': [16], 'α,': [17, 95], 'β,': [18, 96], 'γ,': [19, 86], 'and': [20, 44, 70, 85, 97, 108, 118, 138, 183, 191], 'δ.': [21], 'In': [22, 167], 'addition': [23], 'to': [24, 73, 158, 189, 197], 'providing': [25], 'an': [26, 127, 156], 'apical': [27], 'entry': [28], 'pathway': [29], 'for': [30, 130], 'transepithelial': [31], 'reabsorption': [34], 'in': [35, 51, 68, 81, 104], 'tight': [36], 'epithelia': [37], 'such': [38], 'as': [39], 'the': [40, 89, 112, 142, 148, 162, 165, 172, 180, 211], 'kidney': [41, 91], 'distal': [42], 'tubule': [43], 'collecting': [45], 'duct,': [46], 'ENaCs': [47], 'are': [48], 'also': [49], 'expressed': [50], 'nonepithelial': [52], 'cells,': [53], 'where': [54], 'they': [55], 'may': [56], 'play': [57], 'functional': [59, 124, 182, 208], 'roles.': [60], 'The': [61], 'δ-subunit': [62], 'ENaC': [64, 92, 136, 152, 175, 212], 'was': [65], 'originally': [66], 'identified': [67], 'humans': [69], 'is': [71], 'able': [72], 'form': [74], 'amiloride-sensitive': [75], 'alone': [79], 'or': [80], 'combination': [82], 'with': [83], 'β': [84], 'generally': [87], 'resembling': [88], 'canonical': [90], 'γ.': [98], 'However,': [99], 'δ': [100, 119, 187], 'differs': [101], 'from': [102], 'α': [103, 117], 'its': [105], 'tissue': [106], 'distribution': [107], 'channel': [109, 177], 'properties.': [110, 140], 'Despite': [111], 'low': [113], 'sequence': [114], 'conservation': [115], 'between': [116], '(37%': [120], 'identity),': [121], 'their': [122], 'similar': [123], 'characteristics': [125], 'provide': [126], 'excellent': [128], 'model': [129], 'exploring': [131], 'structural': [132], 'correlates': [133], 'specific': [135], 'biophysical': [137], 'pharmacological': [139, 184], 'Moreover,': [141], 'study': [143], 'cellular': [145], 'mechanisms': [146], 'modulating': [147], 'activity': [149], 'subunit': [153, 178], 'provides': [155], 'opportunity': [157], 'gain': [159], 'insight': [160], 'into': [161], 'regulation': [163], 'channel.': [166, 202], 'this': [168, 193, 200], 'review,': [169], 'we': [170, 204], 'examine': [171], 'evolution': [173], 'genes,': [176], 'composition,': [179], 'distinct': [181], 'features': [185], 'that': [186], 'confers': [188], 'ENaC,': [190], 'how': [192], 'exploited': [196], 'better': [198], 'understand': [199], 'ion': [201], 'Finally,': [203], 'briefly': [205], 'consider': [206], 'possible': [207], 'roles': [209], 'δ-subunit.': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2151902325', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-11T19:06:36.199688', 'created_date': '2016-06-24'}