Publication Information

{'id': 'https://openalex.org/W2166121531', 'doi': 'https://doi.org/10.1152/ajprenal.00652.2012', 'title': 'WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination', 'display_name': 'WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination', 'publication_year': 2013, 'publication_date': '2013-04-18', 'ids': {'openalex': 'https://openalex.org/W2166121531', 'doi': 'https://doi.org/10.1152/ajprenal.00652.2012', 'mag': '2166121531', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23594824', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3725674'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajprenal.00652.2012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200780590', 'display_name': 'AJP Renal Physiology', 'issn_l': '1522-1466', 'issn': ['1522-1466', '1931-857X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3725674', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5015064187', 'display_name': 'Ling Yu', 'orcid': 'https://orcid.org/0000-0001-6241-2228'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I119454577', 'display_name': 'Nanjing Agricultural University', 'ror': 'https://ror.org/05td3s095', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I119454577']}], 'countries': ['CN', 'US'], 'is_corresponding': True, 'raw_author_name': 'Ling Yu', 'raw_affiliation_strings': ['Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;', 'College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, China', 'Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; and'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;', 'institution_ids': ['https://openalex.org/I150468666']}, {'raw_affiliation_string': 'Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; and', 'institution_ids': ['https://openalex.org/I150468666']}, {'raw_affiliation_string': 'College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, China', 'institution_ids': ['https://openalex.org/I119454577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053967516', 'display_name': 'Hui Cai', 'orcid': 'https://orcid.org/0000-0002-6207-0456'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hui Cai', 'raw_affiliation_strings': ['Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;', 'Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; and'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;', 'institution_ids': ['https://openalex.org/I150468666']}, {'raw_affiliation_string': 'Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; and', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025531603', 'display_name': 'Yue Qian', 'orcid': 'https://orcid.org/0000-0001-9224-8721'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qian Yue', 'raw_affiliation_strings': ['Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026771942', 'display_name': 'Abdel A. Alli', 'orcid': 'https://orcid.org/0000-0003-4381-1172'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Abdel A. Alli', 'raw_affiliation_strings': ['Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039443241', 'display_name': 'DeXuan Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'DeXuan Wang', 'raw_affiliation_strings': ['Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; and', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111678856', 'display_name': 'Otor Al‐Khalili', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Otor Al-Khalili', 'raw_affiliation_strings': ['Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109289334', 'display_name': 'Hui‐Fang Bao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hui-Fang Bao', 'raw_affiliation_strings': ['Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048901627', 'display_name': 'Douglas C. Eaton', 'orcid': 'https://orcid.org/0000-0002-2686-6692'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Douglas C. Eaton', 'raw_affiliation_strings': ['Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;'], 'affiliations': [{'raw_affiliation_string': 'Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;', 'institution_ids': ['https://openalex.org/I150468666']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5015064187'], 'corresponding_institution_ids': ['https://openalex.org/I150468666', 'https://openalex.org/I119454577'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.934, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.884369, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '305', 'issue': '1', 'first_page': 'F31', 'last_page': 'F41'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9625, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12280', 'display_name': 'Magnesium in Health and Disease', 'score': 0.9509, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/epithelial-sodium-channel', 'display_name': 'Epithelial sodium channel', 'score': 0.97655827}, {'id': 'https://openalex.org/keywords/apical-membrane', 'display_name': 'Apical membrane', 'score': 0.6431833}, {'id': 'https://openalex.org/keywords/distal-convoluted-tubule', 'display_name': 'Distal convoluted tubule', 'score': 0.6286532}, {'id': 'https://openalex.org/keywords/nedd4', 'display_name': 'NEDD4', 'score': 0.5602745}, {'id': 'https://openalex.org/keywords/sgk1', 'display_name': 'SGK1', 'score': 0.50601286}, {'id': 'https://openalex.org/keywords/pseudohypoaldosteronism', 'display_name': 'Pseudohypoaldosteronism', 'score': 0.48717278}, {'id': 'https://openalex.org/keywords/renal-sodium-reabsorption', 'display_name': 'Renal sodium reabsorption', 'score': 0.43000782}], 'concepts': [{'id': 'https://openalex.org/C6507245', 'wikidata': 'https://www.wikidata.org/wiki/Q424948', 'display_name': 'Epithelial sodium channel', 'level': 3, 'score': 0.97655827}, {'id': 'https://openalex.org/C56906281', 'wikidata': 'https://www.wikidata.org/wiki/Q4391435', 'display_name': 'Reabsorption', 'level': 3, 'score': 0.80798775}, {'id': 'https://openalex.org/C3018436504', 'wikidata': 'https://www.wikidata.org/wiki/Q29548', 'display_name': 'Apical membrane', 'level': 3, 'score': 0.6431833}, {'id': 'https://openalex.org/C2776777027', 'wikidata': 'https://www.wikidata.org/wiki/Q2914731', 'display_name': 'Distal convoluted tubule', 'level': 4, 'score': 0.6286532}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5897413}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5687368}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5653442}, {'id': 'https://openalex.org/C2777265272', 'wikidata': 'https://www.wikidata.org/wiki/Q18030005', 'display_name': 'NEDD4', 'level': 5, 'score': 0.5602745}, {'id': 'https://openalex.org/C2779276759', 'wikidata': 'https://www.wikidata.org/wiki/Q412747', 'display_name': 'Forskolin', 'level': 3, 'score': 0.55364835}, {'id': 'https://openalex.org/C184150571', 'wikidata': 'https://www.wikidata.org/wiki/Q18031469', 'display_name': 'SGK1', 'level': 3, 'score': 0.50601286}, {'id': 'https://openalex.org/C2776273561', 'wikidata': 'https://www.wikidata.org/wiki/Q200745', 'display_name': 'Pseudohypoaldosteronism', 'level': 3, 'score': 0.48717278}, {'id': 'https://openalex.org/C57476199', 'wikidata': 'https://www.wikidata.org/wiki/Q7312501', 'display_name': 'Renal sodium reabsorption', 'level': 4, 'score': 0.43000782}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37270856}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.34568077}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.33449304}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.21561965}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21055809}, {'id': 'https://openalex.org/C2778525890', 'wikidata': 'https://www.wikidata.org/wiki/Q184564', 'display_name': 'Aldosterone', 'level': 2, 'score': 0.19423047}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.18199366}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16831383}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1429098}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.122546464}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.11377454}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D056827', 'descriptor_name': 'Endosomal Sorting Complexes Required for Transport', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053503', 'descriptor_name': 'Epithelial Sodium Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009399', 'descriptor_name': 'Nephrons', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005576', 'descriptor_name': 'Colforsin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005576', 'descriptor_name': 'Colforsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056827', 'descriptor_name': 'Endosomal Sorting Complexes Required for Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056827', 'descriptor_name': 'Endosomal Sorting Complexes Required for Transport', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053503', 'descriptor_name': 'Epithelial Sodium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053503', 'descriptor_name': 'Epithelial Sodium Channels', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D053503', 'descriptor_name': 'Epithelial Sodium Channels', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000075702', 'descriptor_name': 'Nedd4 Ubiquitin Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009399', 'descriptor_name': 'Nephrons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009399', 'descriptor_name': 'Nephrons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054875', 'descriptor_name': 'Ubiquitination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029867', 'descriptor_name': 'Xenopus Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D029867', 'descriptor_name': 'Xenopus Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajprenal.00652.2012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200780590', 'display_name': 'AJP Renal Physiology', 'issn_l': '1522-1466', 'issn': ['1522-1466', '1931-857X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3725674', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725674', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23594824', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3725674', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1590547533', 'https://openalex.org/W1820962178', 'https://openalex.org/W1965284733', 'https://openalex.org/W1965762453', 'https://openalex.org/W1969898475', 'https://openalex.org/W1977832158', 'https://openalex.org/W1984344010', 'https://openalex.org/W1996992306', 'https://openalex.org/W1997669162', 'https://openalex.org/W1997987888', 'https://openalex.org/W2001676822', 'https://openalex.org/W2002383227', 'https://openalex.org/W2004049927', 'https://openalex.org/W2006312715', 'https://openalex.org/W2007555006', 'https://openalex.org/W2014839716', 'https://openalex.org/W2015100458', 'https://openalex.org/W2017565760', 'https://openalex.org/W2021549898', 'https://openalex.org/W2034261026', 'https://openalex.org/W2039492547', 'https://openalex.org/W2043134189', 'https://openalex.org/W2049110420', 'https://openalex.org/W2050875396', 'https://openalex.org/W2058058212', 'https://openalex.org/W2058137771', 'https://openalex.org/W2059451064', 'https://openalex.org/W2064226672', 'https://openalex.org/W2069709653', 'https://openalex.org/W2071103368', 'https://openalex.org/W2072079878', 'https://openalex.org/W2073881942', 'https://openalex.org/W2078043014', 'https://openalex.org/W2082341144', 'https://openalex.org/W2082719247', 'https://openalex.org/W2085300356', 'https://openalex.org/W2086376309', 'https://openalex.org/W2087499467', 'https://openalex.org/W2090944524', 'https://openalex.org/W2120245762', 'https://openalex.org/W2123307919', 'https://openalex.org/W2134365507', 'https://openalex.org/W2135095954', 'https://openalex.org/W2136901254', 'https://openalex.org/W2138585774', 'https://openalex.org/W2140853270', 'https://openalex.org/W2142766228', 'https://openalex.org/W2143670888', 'https://openalex.org/W2145443644', 'https://openalex.org/W2149790768', 'https://openalex.org/W2150867522', 'https://openalex.org/W2155234802', 'https://openalex.org/W2157906583', 'https://openalex.org/W2159241220', 'https://openalex.org/W2163610300', 'https://openalex.org/W2315776734', 'https://openalex.org/W2335763281', 'https://openalex.org/W2338181596', 'https://openalex.org/W2418942336', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4297259859', 'https://openalex.org/W4239183226', 'https://openalex.org/W404191146', 'https://openalex.org/W3216735944', 'https://openalex.org/W3014841302', 'https://openalex.org/W2122221794', 'https://openalex.org/W2112275531', 'https://openalex.org/W2104207586', 'https://openalex.org/W2026278264', 'https://openalex.org/W186715032'], 'abstract_inverted_index': {'A': [0], 'serine-threonine': [1], 'protein': [2], 'kinase,': [3], 'WNK4,': [4, 58], 'reduces': [5, 93, 116, 190], 'Na⁺': [6, 51], 'reabsorption': [7, 52], 'and': [8, 25, 53, 72, 108, 188, 193], 'K⁺': [9], 'secretion': [10], 'in': [11, 41, 49, 163, 197], 'the': [12, 20, 34, 42, 60, 84, 136, 148, 164, 170], 'distal': [13, 43, 66], 'convoluted': [14], 'tubule': [15], 'by': [16, 57], 'reducing': [17], 'trafficking': [18], 'of': [19, 83, 86, 106, 129, 138, 150, 172, 174], 'thiazide-sensitive': [21], 'Na-Cl': [22], 'cotransporter': [23], 'to': [24, 154], 'enhancing': [26], 'renal': [27], 'outer': [28], 'medullary': [29], 'potassium': [30], 'channel': [31, 74, 87, 94, 101], 'retrieval': [32], 'from': [33], 'apical': [35, 107, 117], 'membrane.': [36], 'Epithelial': [37], 'sodium': [38], 'channels': [39], '(ENaC)': [40], 'nephron': [44, 67], 'also': [45, 55, 134, 168], 'play': [46], 'a': [47], 'role': [48], 'regulating': [50], 'are': [54], 'regulated': [56], 'but': [59, 96, 143, 167], 'mechanism': [61], 'is': [62], 'unclear.': [63], 'In': [64, 156], 'A6': [65], 'cells,': [68], 'transepithelial': [69, 151], 'current': [70, 152, 175], 'measurement': [71], 'single': [73], 'recording': [75], 'show': [76], 'that': [77, 91, 114], 'WNK4': [78, 92, 115, 124, 133, 178, 189], 'inhibits': [79], 'ENaC': [80, 110, 122, 126, 131, 139, 162, 195], 'activity.': [81], 'Analysis': [82], 'number': [85, 95], 'per': [88], 'patch': [89], 'shows': [90], 'has': [97, 144], 'no': [98, 145], 'effect': [99, 146], 'on': [100, 147], 'open': [102], 'probability.': [103], 'Western': [104], 'blots': [105], 'total': [109, 121], 'provide': [111], 'additional': [112], 'evidence': [113], 'as': [118, 120, 182, 184], 'well': [119, 183], 'expression.': [123], 'enhances': [125], 'internalization': [127], 'independent': [128], 'Nedd4-2-mediated': [130], 'ubiquitination.': [132], 'reduced': [135, 161], 'amount': [137], 'available': [140], 'for': [141], 'recycling': [142, 165], 'rate': [149, 171], 'increase': [153, 173], 'forskolin.': [155, 177], 'contrast,': [157], 'Nedd4-2': [158], 'not': [159], 'only': [160], 'pool': [166], 'decreased': [169], 'after': [176], 'associates': [179], 'with': [180], 'wild-type': [181, 192], "Liddle's": [185], 'mutated': [186, 194], 'ENaC,': [187], 'both': [191], 'expressed': [196], 'HEK293': [198], 'cells.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2166121531', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2025-01-11T12:15:16.356913', 'created_date': '2016-06-24'}