Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2151233592', 'doi': 'https://doi.org/10.1073/pnas.0502521102', 'title': 'Conservation and evolvability in regulatory networks: The evolution of ribosomal regulation in yeast', 'display_name': 'Conservation and evolvability in regulatory networks: The evolution of ribosomal regulation in yeast', 'publication_year': 2005, 'publication_date': '2005-05-09', 'ids': {'openalex': 'https://openalex.org/W2151233592', 'doi': 'https://doi.org/10.1073/pnas.0502521102', 'mag': '2151233592', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15883364', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1091753'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0502521102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.0502521102', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083312685', 'display_name': 'Amos Tanay', 'orcid': 'https://orcid.org/0000-0001-9419-3824'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['IL', 'US'], 'is_corresponding': False, 'raw_author_name': 'Amos Tanay', 'raw_affiliation_strings': ['School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel; Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138; and The Broad Institute of Harvard and Massachusetts Institute of Technology, 320 Charles Street, Cambridge, MA 02141'], 'affiliations': [{'raw_affiliation_string': 'School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel; Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138; and The Broad Institute of Harvard and Massachusetts Institute of Technology, 320 Charles Street, Cambridge, MA 02141', 'institution_ids': ['https://openalex.org/I107606265', 'https://openalex.org/I16391192', 'https://openalex.org/I136199984', 'https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004067604', 'display_name': 'Aviv Regev', 'orcid': 'https://orcid.org/0000-0003-3293-3158'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}], 'countries': ['IL', 'US'], 'is_corresponding': False, 'raw_author_name': 'Aviv Regev', 'raw_affiliation_strings': ['School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel; Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138; and The Broad Institute of Harvard and Massachusetts Institute of Technology, 320 Charles Street, Cambridge, MA 02141', 'The Broad Institute of Harvard and Massachusetts Institute of Technology, 320 Charles Street, Cambridge, MA 02141'], 'affiliations': [{'raw_affiliation_string': 'School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel; Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138; and The Broad Institute of Harvard and Massachusetts Institute of Technology, 320 Charles Street, Cambridge, MA 02141', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I107606265', 'https://openalex.org/I16391192', 'https://openalex.org/I63966007']}, {'raw_affiliation_string': 'The Broad Institute of Harvard and Massachusetts Institute of Technology, 320 Charles Street, Cambridge, MA 02141', 'institution_ids': ['https://openalex.org/I107606265', 'https://openalex.org/I63966007']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038806020', 'display_name': 'Ron Shamir', 'orcid': 'https://orcid.org/0000-0003-1889-9870'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}, {'id': 'https://openalex.org/I16391192', 'display_name': 'Tel Aviv University', 'ror': 'https://ror.org/04mhzgx49', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I16391192']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['IL', 'US'], 'is_corresponding': False, 'raw_author_name': 'Ron Shamir', 'raw_affiliation_strings': ['School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel; Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138; and The Broad Institute of Harvard and Massachusetts Institute of Technology, 320 Charles Street, Cambridge, MA 02141'], 'affiliations': [{'raw_affiliation_string': 'School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel; Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138; and The Broad Institute of Harvard and Massachusetts Institute of Technology, 320 Charles Street, Cambridge, MA 02141', 'institution_ids': ['https://openalex.org/I107606265', 'https://openalex.org/I16391192', 'https://openalex.org/I136199984', 'https://openalex.org/I63966007']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.827, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 266, 'citation_normalized_percentile': {'value': 0.99998, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '102', 'issue': '20', 'first_page': '7203', 'last_page': '7208'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10497', 'display_name': 'Genomic Expression and Function in Yeast Organism', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10497', 'display_name': 'Genomic Expression and Function in Yeast Organism', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12668', 'display_name': 'Diversity and Systematics of Yeasts', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10750', 'display_name': 'Microbial Interactions in Wine Production and Flavor', 'score': 0.9805, 'subfield': {'id': 'https://openalex.org/subfields/1106', 'display_name': 'Food Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/evolvability', 'display_name': 'Evolvability', 'score': 0.7467427}, {'id': 'https://openalex.org/keywords/conserved-sequence', 'display_name': 'Conserved sequence', 'score': 0.62452096}, {'id': 'https://openalex.org/keywords/microbial-modulation', 'display_name': 'Microbial Modulation', 'score': 0.509584}, {'id': 'https://openalex.org/keywords/ribosomal-protein', 'display_name': 'Ribosomal protein', 'score': 0.43764466}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7492551}, {'id': 'https://openalex.org/C176147130', 'wikidata': 'https://www.wikidata.org/wiki/Q909622', 'display_name': 'Evolvability', 'level': 2, 'score': 0.7467427}, {'id': 'https://openalex.org/C199216141', 'wikidata': 'https://www.wikidata.org/wiki/Q4995178', 'display_name': 'Conserved sequence', 'level': 4, 'score': 0.62452096}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.5651176}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5617727}, {'id': 'https://openalex.org/C21592294', 'wikidata': 'https://www.wikidata.org/wiki/Q3238407', 'display_name': 'Regulatory sequence', 'level': 4, 'score': 0.5586374}, {'id': 'https://openalex.org/C27153228', 'wikidata': 'https://www.wikidata.org/wiki/Q3787274', 'display_name': 'Transcriptional regulation', 'level': 4, 'score': 0.5385341}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.45392865}, {'id': 'https://openalex.org/C38062823', 'wikidata': 'https://www.wikidata.org/wiki/Q3408228', 'display_name': 'Ribosomal protein', 'level': 5, 'score': 0.43764466}, {'id': 'https://openalex.org/C33498276', 'wikidata': 'https://www.wikidata.org/wiki/Q2138797', 'display_name': 'Regulator gene', 'level': 4, 'score': 0.41191965}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.4071573}, {'id': 'https://openalex.org/C78458016', 'wikidata': 'https://www.wikidata.org/wiki/Q840400', 'display_name': 'Evolutionary biology', 'level': 1, 'score': 0.32135144}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.20979881}, {'id': 'https://openalex.org/C88478588', 'wikidata': 'https://www.wikidata.org/wiki/Q42244', 'display_name': 'Ribosome', 'level': 4, 'score': 0.16258404}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.14769006}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.09710017}], 'mesh': [{'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015966', 'descriptor_name': 'Gene Expression Regulation, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005809', 'descriptor_name': 'Genes, Regulator', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016681', 'descriptor_name': 'Genome, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010802', 'descriptor_name': 'Phylogeny', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012269', 'descriptor_name': 'Ribosomal Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005809', 'descriptor_name': 'Genes, Regulator', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012269', 'descriptor_name': 'Ribosomal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012269', 'descriptor_name': 'Ribosomal Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013045', 'descriptor_name': 'Species Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0502521102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1091753', 'pdf_url': 'https://europepmc.org/articles/pmc1091753?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1091753', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15883364', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0502521102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land', 'score': 0.71}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1530113860', 'https://openalex.org/W1847805250', 'https://openalex.org/W1910853983', 'https://openalex.org/W1975931018', 'https://openalex.org/W1978684735', 'https://openalex.org/W2000495354', 'https://openalex.org/W2015660450', 'https://openalex.org/W2016690997', 'https://openalex.org/W2020726089', 'https://openalex.org/W2034719432', 'https://openalex.org/W2037652809', 'https://openalex.org/W2038661569', 'https://openalex.org/W2041096569', 'https://openalex.org/W2047138284', 'https://openalex.org/W2049992533', 'https://openalex.org/W2054624670', 'https://openalex.org/W2058682865', 'https://openalex.org/W2071294032', 'https://openalex.org/W2078143516', 'https://openalex.org/W2084833542', 'https://openalex.org/W2087430129', 'https://openalex.org/W2100295605', 'https://openalex.org/W2118852675', 'https://openalex.org/W2126449841', 'https://openalex.org/W2132789530', 'https://openalex.org/W2133147430', 'https://openalex.org/W2140538490', 'https://openalex.org/W2155940790', 'https://openalex.org/W2158128075', 'https://openalex.org/W2162142896', 'https://openalex.org/W2167190345', 'https://openalex.org/W2168157737', 'https://openalex.org/W2169101569', 'https://openalex.org/W3214669750', 'https://openalex.org/W4241088457'], 'related_works': ['https://openalex.org/W2287312813', 'https://openalex.org/W2167300924', 'https://openalex.org/W2163667623', 'https://openalex.org/W2162630564', 'https://openalex.org/W2153492159', 'https://openalex.org/W2128504545', 'https://openalex.org/W2072226307', 'https://openalex.org/W1970337814', 'https://openalex.org/W1968200681', 'https://openalex.org/W1966781601'], 'abstract_inverted_index': {'Transcriptional': [0], 'modules': [1, 16, 48, 76, 84, 140, 174], 'of': [2, 17, 34, 42, 63, 81, 95, 111, 113, 121, 131, 163, 166, 172, 185], 'coregulated': [3], 'genes': [4, 19], 'play': [5], 'a': [6, 61, 105, 122, 157], 'key': [7], 'role': [8], 'in': [9, 109, 178, 188], 'regulatory': [10, 97, 135, 146], 'networks.': [11], 'Comparative': [12], 'studies': [13], 'show': [14, 68, 103], 'that': [15, 69, 128], 'coexpressed': [18], 'are': [20, 77, 85], 'conserved': [21, 47, 75, 83, 138], 'across': [22], 'taxa.': [23], 'However,': [24], 'little': [25], 'is': [26], 'known': [27], 'about': [28], 'the': [29, 32, 40, 71, 92, 96, 119, 161, 164, 170, 180], 'mechanisms': [30], 'underlying': [31], 'evolution': [33, 41, 168], 'module': [35], 'regulation.': [36], 'Here,': [37], 'we': [38, 90], 'explore': [39], 'cis-regulatory': [43], 'programs': [44], 'associated': [45], 'with': [46], 'by': [49, 118], 'integrating': [50], 'expression': [51], 'profiles': [52], 'for': [53, 60, 160], 'two': [54], 'yeast': [55], 'species': [56], 'and': [57, 175, 182], 'sequence': [58], 'data': [59], 'total': [62], '17': [64], 'fungal': [65], 'genomes.': [66], 'We': [67, 102, 126], 'although': [70], 'cis-elements': [72], 'accompanying': [73], 'certain': [74], 'strictly': [78], 'conserved,': [79], 'those': [80], 'other': [82], 'remarkably': [86], 'diverged.': [87], 'In': [88], 'particular,': [89], 'infer': [91], 'evolutionary': [93], 'history': [94], 'program': [98, 136], 'governing': [99], 'ribosomal': [100, 114], 'modules.': [101], 'how': [104], 'cis-element': [106], 'emerged': [107], 'concurrently': [108], 'dozens': [110], 'promoters': [112], 'protein': [115], 'genes,': [116], 'followed': [117], 'loss': [120], 'more': [123], 'ancient': [124], 'cis-element.': [125], 'suggest': [127], 'this': [129], 'formation': [130], 'an': [132], 'intermediate': [133], 'redundant': [134], 'allows': [137], 'transcriptional': [139, 173, 186], 'to': [141, 148], 'gradually': [142], 'switch': [143], 'from': [144], 'one': [145], 'mechanism': [147], 'another': [149], 'while': [150], 'maintaining': [151], 'their': [152], 'functionality.': [153], 'Our': [154], 'work': [155], 'provides': [156], 'general': [158], 'framework': [159], 'study': [162], 'dynamics': [165], 'promoter': [167], 'at': [169], 'level': [171], 'may': [176], 'help': [177], 'understanding': [179], 'evolvability': [181], 'increased': [183], 'redundancy': [184], 'regulation': [187], 'higher': [189], 'organisms.': [190]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2151233592', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-09-10T17:55:57.809344', 'created_date': '2016-06-24'}