Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells

Name: Work Video:
Duration: 3 min 30 s
Catia Attanasio; Alexandre Reymond; Richard Humbert; Robert Lyle; Michael S. Kuehn; Shane Neph; Peter J. Sabo; Jeff Goldy; Molly Weaver; Andrew Haydock; Kristin Lee; Michael O. Dorschner; Emmanouil T. Dermitzakis; Stylianos E. Antonarakis; J Stamatoyannopoulos
{'id': 'https://openalex.org/W2162630564', 'doi': 'https://doi.org/10.1186/gb-2008-9-12-r168', 'title': 'Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells', 'display_name': 'Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells', 'publication_year': 2008, 'publication_date': '2008-01-01', 'ids': {'openalex': 'https://openalex.org/W2162630564', 'doi': 'https://doi.org/10.1186/gb-2008-9-12-r168', 'mag': '2162630564', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19055709', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2646272'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/gb-2008-9-12-r168', 'pdf_url': 'https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2008-9-12-r168', 'source': {'id': 'https://openalex.org/S81160022', 'display_name': 'Genome biology', 'issn_l': '1474-7596', 'issn': ['1474-7596', '1474-760X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2008-9-12-r168', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025343701', 'display_name': 'Catia Attanasio', 'orcid': 'https://orcid.org/0000-0001-8077-5719'}, 'institutions': [{'id': 'https://openalex.org/I148283060', 'display_name': 'Lawrence Berkeley National Laboratory', 'ror': 'https://ror.org/02jbv0t02', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1330989302', 'https://openalex.org/I148283060', 'https://openalex.org/I39565521']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Catia Attanasio', 'raw_affiliation_strings': ['Genomics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, 94720, USA'], 'affiliations': [{'raw_affiliation_string': 'Genomics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, 94720, USA', 'institution_ids': ['https://openalex.org/I148283060']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014464174', 'display_name': 'Alexandre Reymond', 'orcid': 'https://orcid.org/0000-0003-1030-8327'}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Alexandre Reymond', 'raw_affiliation_strings': ['Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211, Geneva 4, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211, Geneva 4, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109212670', 'display_name': 'Richard Humbert', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Humbert', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027866836', 'display_name': 'Robert Lyle', 'orcid': 'https://orcid.org/0000-0001-6317-732X'}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Robert Lyle', 'raw_affiliation_strings': ['Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211, Geneva 4, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211, Geneva 4, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103551801', 'display_name': 'Michael S. Kuehn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael S Kuehn', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077099192', 'display_name': 'Shane Neph', 'orcid': 'https://orcid.org/0000-0003-2962-8777'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shane Neph', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103237021', 'display_name': 'Peter J. Sabo', 'orcid': 'https://orcid.org/0000-0003-2290-1718'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter J Sabo', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036232013', 'display_name': 'Jeff Goldy', 'orcid': 'https://orcid.org/0000-0001-5140-6922'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeff Goldy', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108561325', 'display_name': 'Molly Weaver', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Molly Weaver', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053458465', 'display_name': 'Andrew Haydock', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew Haydock', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076600194', 'display_name': 'Kristin Lee', 'orcid': 'https://orcid.org/0000-0003-4906-1800'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kristin Lee', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108419547', 'display_name': 'Michael O. Dorschner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Dorschner', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084258150', 'display_name': 'Emmanouil T. Dermitzakis', 'orcid': 'https://orcid.org/0000-0002-9302-6490'}, 'institutions': [{'id': 'https://openalex.org/I2802476451', 'display_name': 'Wellcome Sanger Institute', 'ror': 'https://ror.org/05cy4wa09', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802476451', 'https://openalex.org/I87048295']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Emmanouil T Dermitzakis', 'raw_affiliation_strings': ['The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK'], 'affiliations': [{'raw_affiliation_string': 'The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK', 'institution_ids': ['https://openalex.org/I2802476451']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085581810', 'display_name': 'Stylianos E. Antonarakis', 'orcid': 'https://orcid.org/0000-0001-8907-5823'}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Stylianos E Antonarakis', 'raw_affiliation_strings': ['Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211, Geneva 4, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211, Geneva 4, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006847496', 'display_name': 'J Stamatoyannopoulos', 'orcid': 'https://orcid.org/0000-0002-2664-5769'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John A Stamatoyannopoulos', 'raw_affiliation_strings': ['Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington, 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.445, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.66386, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '9', 'issue': '12', 'first_page': 'R168', 'last_page': 'R168'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10434', 'display_name': 'Chromosomal and Genetic Variations', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/conserved-sequence', 'display_name': 'Conserved sequence', 'score': 0.73760414}, {'id': 'https://openalex.org/keywords/coding-region', 'display_name': 'Coding region', 'score': 0.41668817}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7516966}, {'id': 'https://openalex.org/C199216141', 'wikidata': 'https://www.wikidata.org/wiki/Q4995178', 'display_name': 'Conserved sequence', 'level': 4, 'score': 0.73760414}, {'id': 'https://openalex.org/C111936080', 'wikidata': 'https://www.wikidata.org/wiki/Q913367', 'display_name': 'Enhancer', 'level': 4, 'score': 0.7072665}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.6833355}, {'id': 'https://openalex.org/C21592294', 'wikidata': 'https://www.wikidata.org/wiki/Q3238407', 'display_name': 'Regulatory sequence', 'level': 4, 'score': 0.6740142}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.5823867}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.5683351}, {'id': 'https://openalex.org/C197077220', 'wikidata': 'https://www.wikidata.org/wiki/Q720988', 'display_name': 'Human genome', 'level': 4, 'score': 0.5518924}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.43207347}, {'id': 'https://openalex.org/C158448853', 'wikidata': 'https://www.wikidata.org/wiki/Q425218', 'display_name': 'Repressor', 'level': 4, 'score': 0.4188304}, {'id': 'https://openalex.org/C91779695', 'wikidata': 'https://www.wikidata.org/wiki/Q3780824', 'display_name': 'Coding region', 'level': 3, 'score': 0.41668817}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.41071314}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.38702044}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.27971494}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.11080146}], 'mesh': [{'descriptor_ui': 'D017124', 'descriptor_name': 'Conserved Sequence', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015894', 'descriptor_name': 'Genome, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012045', 'descriptor_name': 'Regulatory Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017124', 'descriptor_name': 'Conserved Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016678', 'descriptor_name': 'Genome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 8, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/gb-2008-9-12-r168', 'pdf_url': 'https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2008-9-12-r168', 'source': {'id': 'https://openalex.org/S81160022', 'display_name': 'Genome biology', 'issn_l': '1474-7596', 'issn': ['1474-7596', '1474-760X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.osti.gov/biblio/1626725', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402487', 'display_name': 'OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I139351228', 'host_organization_name': 'Office of Scientific and Technical Information', 'host_organization_lineage': ['https://openalex.org/I139351228'], 'host_organization_lineage_names': ['Office of Scientific and Technical Information'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2646272', 'pdf_url': 'https://europepmc.org/articles/pmc2646272?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://lirias.kuleuven.be/handle/123456789/685541', 'pdf_url': 'https://lirias.kuleuven.be/bitstream/123456789/685541/2/Assaying%20the%20regulatory%20potential%20of%20mammalian%20conserved%20non-coding%20sequences%20in%20human%20cells.pdf', 'source': {'id': 'https://openalex.org/S4306401954', 'display_name': 'Lirias (KU Leuven)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I99464096', 'host_organization_name': 'KU Leuven', 'host_organization_lineage': ['https://openalex.org/I99464096'], 'host_organization_lineage_names': ['KU Leuven'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://serval.unil.ch/notice/serval:BIB_6836FD75BA2C', 'pdf_url': 'https://serval.unil.ch/resource/serval:BIB_6836FD75BA2C.P001/REF.pdf', 'source': {'id': 'https://openalex.org/S4306401797', 'display_name': 'SERVAL (Université de Lausanne)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210093590', 'host_organization_name': 'Swiss School of Archaeology in Greece', 'host_organization_lineage': ['https://openalex.org/I4210093590'], 'host_organization_lineage_names': ['Swiss School of Archaeology in Greece'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10852/46669', 'pdf_url': 'https://www.duo.uio.no/bitstream/10852/46669/1/13059_2008_Article_2030.pdf', 'source': {'id': 'https://openalex.org/S4306401716', 'display_name': 'Duo Research Archive (University of Oslo)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I184942183', 'host_organization_name': 'University of Oslo', 'host_organization_lineage': ['https://openalex.org/I184942183'], 'host_organization_lineage_names': ['University of Oslo'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646272', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19055709', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/gb-2008-9-12-r168', 'pdf_url': 'https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2008-9-12-r168', 'source': {'id': 'https://openalex.org/S81160022', 'display_name': 'Genome biology', 'issn_l': '1474-7596', 'issn': ['1474-7596', '1474-760X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.69, 'display_name': 'Life below water', 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 64, 'referenced_works': ['https://openalex.org/W1600524753', 'https://openalex.org/W1701439323', 'https://openalex.org/W1964441911', 'https://openalex.org/W1970774008', 'https://openalex.org/W1971846931', 'https://openalex.org/W1973904936', 'https://openalex.org/W1974736226', 'https://openalex.org/W1980121867', 'https://openalex.org/W1983658501', 'https://openalex.org/W1986085728', 'https://openalex.org/W1994954155', 'https://openalex.org/W1996760543', 'https://openalex.org/W1998745514', 'https://openalex.org/W2001912720', 'https://openalex.org/W2007364430', 'https://openalex.org/W2008269261', 'https://openalex.org/W2017535650', 'https://openalex.org/W2021062976', 'https://openalex.org/W2023096878', 'https://openalex.org/W2026315272', 'https://openalex.org/W2026404162', 'https://openalex.org/W2030975965', 'https://openalex.org/W2038684779', 'https://openalex.org/W2039376144', 'https://openalex.org/W2039923266', 'https://openalex.org/W2053833990', 'https://openalex.org/W2054244366', 'https://openalex.org/W2055643269', 'https://openalex.org/W2057587811', 'https://openalex.org/W2057829817', 'https://openalex.org/W2061057966', 'https://openalex.org/W2071238021', 'https://openalex.org/W2077132193', 'https://openalex.org/W2082032892', 'https://openalex.org/W2085270765', 'https://openalex.org/W2092445607', 'https://openalex.org/W2095825597', 'https://openalex.org/W2100990361', 'https://openalex.org/W2102304447', 'https://openalex.org/W2102326832', 'https://openalex.org/W2102365433', 'https://openalex.org/W2107448064', 'https://openalex.org/W2110320405', 'https://openalex.org/W2112555386', 'https://openalex.org/W2113810173', 'https://openalex.org/W2115836056', 'https://openalex.org/W2116251070', 'https://openalex.org/W2122818453', 'https://openalex.org/W2125827936', 'https://openalex.org/W2125985596', 'https://openalex.org/W2127935186', 'https://openalex.org/W2135218715', 'https://openalex.org/W2143696091', 'https://openalex.org/W2144857133', 'https://openalex.org/W2145673003', 'https://openalex.org/W2151464048', 'https://openalex.org/W2153145187', 'https://openalex.org/W2158826174', 'https://openalex.org/W2165503425', 'https://openalex.org/W2168783124', 'https://openalex.org/W2170120590', 'https://openalex.org/W2170465332', 'https://openalex.org/W2177510297', 'https://openalex.org/W2740984310'], 'related_works': ['https://openalex.org/W2163667623', 'https://openalex.org/W2162630564', 'https://openalex.org/W2137491265', 'https://openalex.org/W2128504545', 'https://openalex.org/W2122609286', 'https://openalex.org/W2109672343', 'https://openalex.org/W2072226307', 'https://openalex.org/W2057750912', 'https://openalex.org/W1986060922', 'https://openalex.org/W1970337814'], 'abstract_inverted_index': {'Conserved': [0], 'non-coding': [1, 32, 78, 101, 134, 181], 'sequences': [2, 33, 79, 102, 135, 182], 'in': [3, 80, 183], 'the': [4, 21, 27, 35, 76, 81, 90, 128, 171, 175, 184], 'human': [5, 39, 82, 121, 185], 'genome': [6], 'are': [7, 60, 85, 167], 'approximately': [8], 'tenfold': [9], 'more': [10], 'abundant': [11], 'than': [12], 'known': [13], 'genes,': [14], 'and': [15, 50, 59, 112, 114, 145], 'have': [16], 'been': [17], 'hypothesized': [18], 'to': [19, 34, 169], 'mark': [20], 'locations': [22], 'of': [23, 30, 38, 75, 93, 97, 106, 130, 164, 174, 178], 'cis-regulatory': [24, 165], 'elements.': [25, 66], 'However,': [26, 67], 'global': [28], 'contribution': [29], 'conserved': [31, 45, 70, 77, 100, 133, 180], 'transcriptional': [36, 64], 'regulation': [37], 'genes': [40, 55], 'is': [41, 141], 'currently': [42], 'unknown.': [43], 'Deeply': [44], 'elements': [46, 71], 'shared': [47], 'between': [48], 'humans': [49], 'teleost': [51], 'fish': [52], 'predominantly': [53, 86], 'flank': [54], 'active': [56, 132], 'during': [57], 'morphogenesis': [58], 'enriched': [61], 'for': [62, 73], 'positive': [63], 'regulatory': [65, 91], 'such': [68], 'deeply': [69], 'account': [72], '<1%': [74], 'genome,': [83], 'which': [84], 'mammalian.': [87], 'We': [88], 'explored': [89], 'potential': [92, 166, 173], 'a': [94, 104], 'large': [95], 'sample': [96], 'these': [98], "'common'": [99], 'using': [103], 'variety': [105], 'classic': [107, 162], 'assays,': [108], 'including': [109], 'chromatin': [110], 'remodeling,': [111], 'enhancer/repressor': [113], 'promoter': [115], 'activity.': [116], 'When': [117], 'tested': [118], 'across': [119, 155], 'diverse': [120], 'model': [122], 'cell': [123, 139, 156], 'types,': [124], 'we': [125], 'find': [126], 'that': [127, 146, 161], 'fraction': [129], 'experimentally': [131], 'within': [136], 'any': [137], 'given': [138], 'type': [140], 'low': [142], '(approximately': [143], '5%),': [144], 'this': [147], 'proportion': [148], 'increases': [149], 'only': [150], 'modestly': [151], 'when': [152], 'considered': [153], 'collectively': [154], 'types.': [157], 'The': [158], 'results': [159], 'suggest': [160], 'assays': [163], 'unlikely': [168], 'expose': [170], 'functional': [172], 'substantial': [176], 'majority': [177], 'mammalian': [179], 'genome.': [186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2162630564', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-20T02:30:40.158870', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
