The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease

Name: Work Video:
Duration: 3 min 30 s
Veronica Hirsch‐Reinshagen; Luı́s F. Maia; Braydon L. Burgess; Jean‐François Blain; Kathryn E. Naus; Sean A. McIsaac; Pamela F. Parkinson; Jennifer Y. Chan; Gavin Tansley; Michael R. Hayden; Judes Poirier; William Van Nostrand; Cheryl L. Wellington
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3993, 4155, 4228, 4368, 4489, 4543, 4618], 'levels': [19, 72, 93, 159, 185, 238, 259, 325, 2220, 2425, 3132, 3351, 3830, 3881, 4156, 4490, 4507, 4526], 'and': [20, 115, 124, 160, 186, 281, 290, 326, 362, 383, 397, 432, 446, 455, 506, 536, 550, 992, 1003, 1177, 1235, 1237, 1377, 1435, 1439, 1441, 1451, 1622, 1724, 2200, 2226, 2309, 2363, 2400, 2517, 2671, 2826, 2828, 2836, 3021, 3032, 3040, 3126, 3140, 3255, 3267, 3318, 3522, 3537, 3539, 3771, 3879, 3945, 4139, 4157, 4358, 4412, 4430, 4444, 4455, 4488, 4519], 'lipidation': [21, 161, 187, 327, 3319, 4158], 'central': [24, 190, 1429, 2679, 3322, 4078], 'nervous': [25, 191, 1430, 2680, 2847, 3323, 4079], 'system.': [26, 192], 'In': [27, 193, 1127, 1223, 1427, 1596, 1704, 2296, 2664, 3696], 'addition,': [28, 194], 'ABCA1': [29, 46, 64, 195, 212, 230, 2212, 2304, 2408, 2496, 2673, 2820, 2843, 2992, 3004, 3026, 3112, 3310, 3329, 3704, 3778, 3827, 3899, 3911, 4084, 4094, 4107, 4131, 4150, 4361, 4373, 4387, 4404, 4420, 4440, 4482, 4499, 4534], 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'S.S.': [406], 'Annu.': [407, 1399], 'Rev.': [408, 526, 588, 1400, 1586], 'Genet.': [409, 777, 1214, 1341, 1403, 1839, 2015, 2482, 2580, 2611, 2655, 4261], '1998;': [410, 1499, 3446, 3631], '32:': [411, 1199], '461-493Crossref': [412], 'PubMed': [413, 479, 530, 592, 611, 631, 764, 781, 871, 928, 980, 1042, 1072, 1092, 1124, 1155, 1206, 1218, 1280, 1307, 1345, 1407, 1422, 1477, 1502, 1532, 1572, 1591, 1640, 1655, 1674, 1699, 1744, 1773, 1843, 1882, 1909, 1931, 1954, 2019, 2058, 2085, 2107, 2130, 2184, 2259, 2291, 2347, 2486, 2584, 2615, 2659, 2713, 2763, 2783, 2815, 2881, 2931, 2951, 2983, 3073, 3105, 3173, 3205, 3250, 3302, 3396, 3421, 3449, 3485, 3506, 3581, 3606, 3634, 3670, 3691, 3742, 3766, 3807, 3871, 3979, 4028, 4058, 4190, 4222, 4265, 4304, 4331, 4353, 4580, 4612], 'Scopus': [414, 466, 519, 531, 581, 593, 612, 632, 765, 782, 872, 929, 981, 1043, 1073, 1093, 1156, 1207, 1219, 1281, 1308, 1346, 1408, 1423, 1478, 1503, 1592, 1641, 1656, 1675, 1700, 1745, 1774, 1844, 1883, 1910, 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1349, 1426, 1595, 1703, 1777, 1958, 2134, 2188, 2295, 2351, 2490, 2663, 2819, 2987, 3109, 3209, 3306, 3510, 3695, 3811, 4062, 4226, 4616], 'Characteristic': [418], 'neuropathological': [419], 'hallmarks': [420], 'include': [423], 'intraneuronal': [424, 4115, 4137], 'fibrillary': [425], 'tangles': [426], 'composed': [427, 437], 'hyperphosphorylated': [429], 'tau': [430], 'protein': [431, 502, 643, 660], 'deposits': [434, 1970], 'are': [436, 484, 496, 538, 1804, 2388, 2395, 2996, 4463], 'largely': [438], 'peptides,': [441], 'apolipoprotein': [442, 639], 'E': [443, 640], '(apoE),': [444], 'lipids,': [445], 'other': [447, 3923, 3985, 4066, 4147], 'proteins': [448], 'accumulate': [450], 'neural': [453], 'parenchyma': [454, 1018], 'cerebrovasculature': [457], '(2Morris': [458], 'J.C.': [459, 619, 915, 1545, 3853, 4010], 'Acta': [460], 'Neurol.': [461, 602, 1088, 2180], 'Scand.': [462], '1996;': [463, 3461, 3646], '165:': [464], '41-50Crossref': [465], '(25)': [467], 'Scholar,': [469, 522, 584, 596, 615, 768, 875, 957, 1046, 1076, 1096, 1210, 1284, 1311, 1411, 1481, 1506, 1534, 1574, 1644, 1659, 1678, 1748, 1847, 1886, 1913, 1935, 2023, 2062, 2089, 2111, 2263, 2588, 2619, 2717, 2767, 2787, 2885, 2935, 2955, 3077, 3177, 3400, 3425, 3453, 3472, 3489, 3585, 3610, 3638, 3657, 3674, 3746, 4032, 4194, 4269, 4308, 4335, 4584], '3Geldmacher': [470], 'D.S.': [471], 'Whitehouse': [472], 'Jr.,': [473, 1397, 2335, 2477, 2575, 2602], 'P.J.': [474, 1663, 1682], 'Neurology.': [475], '1997;': [476, 1840, 2016, 4262], '48:': [477], 'S2-S9Crossref': [478], 'peptides': [483, 489, 1723, 1791, 3710], 'heterogeneous': [486], 'group': [487], '39–43': [490], 'amino': [491], 'acids': [492, 2399], 'length': [494], 'proteolytically': [497], 'cleaved': [498], 'from': [499, 792, 948, 1618, 1792, 2311, 2356, 2385, 2402, 3038, 3712], '(APP)': [503], 'γ-': [505], 'β-secretases': [507], '(4Haass': [508, 570], 'C.': [509, 571, 707, 814, 963, 971, 1049, 1457, 1518, 1540, 1543, 1560, 1580, 2442, 2540, 2637, 2649, 2745, 2913, 3364, 3495, 3497, 3549, 3680, 3682], 'Selkoe': [510, 572, 974], 'D.J.': [511, 524, 573, 586, 975, 1144, 1831, 1853, 2007, 2029, 4253, 4275], 'Cell.': [512, 574], '1993;': [513, 575, 1277, 1304], '75:': [514, 576], '154-159Abstract': [515, 577], 'Full': [516, 578, 606, 608, 1119, 1121, 1201, 1203, 1527, 1529, 1567, 1569, 1652, 2254, 2256, 2286, 2288, 2758, 2760, 2810, 2812, 2926, 2928, 2978, 2980, 3068, 3070, 3100, 3102, 3168, 3170, 3200, 3202, 3245, 3247, 3297, 3299, 3464, 3466, 3649, 3651, 3737, 3739, 3761, 3763, 3802, 3804, 3866, 3868, 4023, 4025, 4185, 4187, 4217, 4219, 4575, 4577, 4607, 4609], 'Text': [517, 579, 607, 609, 1120, 1122, 1202, 1204, 1528, 1530, 1568, 1570, 1653, 2255, 2257, 2287, 2289, 2759, 2761, 2811, 2813, 2927, 2929, 2979, 2981, 3069, 3071, 3101, 3103, 3169, 3171, 3201, 3203, 3246, 3248, 3298, 3300, 3465, 3467, 3650, 3652, 3738, 3740, 3762, 3764, 3803, 3805, 3867, 3869, 4024, 4026, 4186, 4188, 4218, 4220, 4576, 4578, 4608, 4610], 'PDF': [518, 580, 610, 1123, 1205, 1531, 1571, 1654, 2258, 2290, 2762, 2814, 2930, 2982, 3072, 3104, 3172, 3204, 3249, 3301, 3468, 3653, 3741, 3765, 3806, 3870, 4027, 4189, 4221, 4579, 4611], '(742)': [520, 582], '5Selkoe': [523, 585], 'Physiol.': [525, 587], '2001;': [527, 589, 1089, 1152, 1198, 1524, 2755, 2780, 2923, 2948, 3393, 3418, 3482, 3578, 3603, 3667], '81:': [528, 590], '741-766Crossref': [529, 591], '(5196)': [532, 594], 'Aβ40': [535, 560, 3878], 'Aβ42': [537, 546, 3880], 'main': [540], 'species': [542, 564], 'less': [548, 1161, 2143], 'present': [552], 'all': [554], 'types': [555, 3016, 4090], 'plaques,': [558], 'whereas': [559, 1253, 3528], 'major': [563, 1231, 1445, 1713, 1784, 2379, 4401], 'deposited': [565, 1962], 'cerebral': [567, 1011], 'blood': [568, 1012], 'vessels': [569, 1013], '6Blennow': [597], 'K.': [598, 711, 818, 1512, 1756, 1764, 1894, 2070, 2172, 2435, 2452, 2469, 2533, 2550, 2567, 2645, 3360, 3379, 3383, 3434, 3438, 3499, 3545, 3564, 3568, 3619, 3623, 3684, 4316], 'Hampel': [599], 'H.': [600, 705, 812, 2267, 2594, 3081, 3181, 3278, 3372, 3557, 3787, 4198, 4588], 'Lancet': [601], '2003;': [603, 1770, 2807, 2975, 3503, 3688, 3734, 3758], '2:': [604, 629], '605-613Abstract': [605], '(1048)': [613], '7Bales': [616], 'K.R.': [617, 1813, 1849, 1921, 1989, 2025, 2097, 3959, 4235, 4271, 4343], 'Dodart': [618], 'DeMattos': [620, 3960], 'R.B.': [621, 3961], 'Holtzman': [622, 1495, 1924, 2100, 2278, 3092, 3192, 3289, 4209, 4346, 4599], 'D.M.': [623, 1925, 2101, 2160, 2279, 3093, 3193, 3290, 4210, 4347, 4600], 'Paul': [624, 1836, 1870, 1895, 1922, 2012, 2046, 2071, 2098, 2169, 3972, 4258, 4292, 4317, 4344], 'S.M.': [625, 1086, 1485, 1837, 1871, 1896, 1923, 2013, 2047, 2072, 2099, 2170, 2331, 2431, 2529, 2725, 2893, 3973, 4259, 4293, 4318, 4345], 'Mol.': [626, 1767, 4053], 'Interv.': [627], '2002;': [628, 1741, 1928, 2104, 2710, 2878, 3799, 4055, 4350], '363-375Crossref': [630], '(109)': [633, 2349], 'presenilin': [644], 'enzyme-linked': [646], 'assay': [648], 'glyceraldehyde-3-phosphate': [649], 'dehydrogenase': [650], 'analysis': [651], 'variance': [653], 'phosphate-buffered': [654], 'saline': [655], 'high': [656, 2667, 3529], 'lipoprotein': [658, 1370, 1376], 'receptor-related': [659], 'female': [661], 'male.': [662], 'Most': [663], 'affected': [664], 'individuals': [665], 'have': [666, 1137, 3023, 3346, 3987], 'late': [667], 'onset': [668, 1261, 2203, 3333], 'typically': [671], 'manifests': [672], 'after': [673], '70': [674], 'However,': [678, 1160], 'number': [680], 'families': [682], 'develop': [683], 'their': [687, 1389], '4th': [688], '5th': [690], 'decades': [691], '(8Sherrington': [692, 799], 'R.': [693, 750, 800, 857, 877, 895, 1102, 1817, 1993, 2693, 2861, 3491, 3676, 4239], 'Rogaev': [694, 801], 'E.': [695, 699, 802, 806, 911, 1020, 1053, 1549, 1758, 2623, 2699, 2867, 3402, 3587], 'Liang': [696, 803], 'Y.': [697, 804, 897, 1471, 1634, 1819, 1855, 1903, 1995, 2031, 2079, 3748, 3949, 3955, 4241, 4277, 4325], 'Rogaeva': [698, 805], 'Levesque': [700, 807], 'G.': [701, 709, 772, 808, 816, 921, 1104, 1464, 1538, 1737, 2609, 2647, 2653, 2741, 2909, 3404, 3589, 3971], 'Ikeda': [702, 809], 'M.': [703, 748, 770, 810, 855, 923, 959, 1065, 1514, 1558, 1576, 1823, 1917, 1919, 1999, 2093, 2095, 2269, 2429, 2438, 2463, 2527, 2536, 2561, 2592, 2621, 2639, 3083, 3183, 3280, 3362, 3366, 3381, 3427, 3547, 3551, 3566, 3612, 3847, 3855, 4004, 4012, 4200, 4245, 4339, 4341, 4590], 'Chi': [704, 811], 'Lin': [706, 813, 3950], 'Li': [708, 815, 3964], 'Holman': [710, 817], 'Tsuda': [712, 819], 'T.': [713, 820, 913, 961, 1100, 1815, 1851, 1991, 2027, 2166, 2277, 2627, 3091, 3191, 3288, 3376, 3385, 3561, 3570, 4208, 4237, 4273, 4598], 'Mar': [714, 821], 'L.': [715, 727, 729, 822, 834, 836, 965, 1098, 1196, 1460, 1762, 1821, 1997, 2168, 2235, 2433, 2440, 2531, 2538, 3049, 3149, 3226, 4166, 4243, 4556], 'Foncin': [716, 823], 'J.F.': [717, 824], 'Bruni': [718, 825], 'A.C.': [719, 826], 'Montesi': [720, 827], 'M.P.': [721, 828, 1750, 1939, 2115], 'Sorbi': [722, 829], 'S.': [723, 830, 881, 883, 891, 899, 903, 951, 1150, 1271, 1275, 1508, 1551, 1694, 1877, 2053, 2231, 2459, 2461, 2557, 2559, 2590, 2635, 3045, 3145, 3222, 3374, 3391, 3406, 3416, 3444, 3455, 3559, 3576, 3591, 3601, 3629, 3640, 3851, 3951, 4008, 4162, 4299, 4552], 'Rainero': [724, 831], 'I.': [725, 731, 832, 838, 973, 1028], 'Pinessi': [726, 833], 'Nee': [728, 835], 'Chumakov': [730, 837], 'Pollen': [732, 839], 'D.': [733, 840, 1269, 1466, 1578, 1898, 2074, 2465, 2563, 3368, 3553, 3849, 4006, 4320], 'Brookes': [734, 841], 'A.': [735, 842, 1060, 1151, 1695, 1878, 2054, 2333, 2338, 2427, 2525, 2629, 2687, 2689, 2733, 2735, 2855, 2857, 2901, 2903, 3392, 3417, 3445, 3577, 3602, 3630, 3789, 4300], 'Sansosu': [736, 843], 'P.': [737, 759, 844, 866, 887, 893, 969, 1273, 1547, 1825, 1833, 1865, 2001, 2009, 2041, 2607, 3370, 3429, 3493, 3555, 3614, 3678, 4247, 4255, 4287], 'Polinsky': [738, 845], 'R.J.': [739, 846], 'Wasco': [740, 847], 'W.': [741, 848, 1035, 1058, 2631, 2633, 3408, 3593], 'Da': [742, 849], 'Silva': [743, 850], 'H.A.R': [744, 851], 'Haines': [745, 852, 1299, 1336], 'J.L.': [746, 853, 1300, 1337, 4038], 'Pericak-Vance': [747, 854, 1301, 1338], 'Roses': [751, 858, 1297, 1334], 'A.D.': [752, 859, 1298, 1335], 'Fraser': [753, 860], 'P.E.': [754, 861], 'Rommens': [755, 862], 'J.M.': [756, 863], 'St.': [757, 773, 864], 'George-Hyslop': [758, 774, 865], 'Nature.': [760, 867, 976], '1995;': [761, 868], '375:': [762, 869], '754-760Crossref': [763, 870], '(3599)': [766, 873], '9Nishimura': [769], 'Yu': [771, 2439, 2537], 'P.H.': [775], 'Clin.': [776, 1213], '1999;': [778, 925, 1588, 1879, 2055, 2483, 2581, 2612, 2656, 4301], '55:': [779], '219-225Crossref': [780], '(31)': [783], 'The': [786, 2208, 2352, 3307, 3812], 'cases': [787], 'familial': [789, 2411], 'result': [791, 1004, 4390, 4536], 'mutations': [793, 1130, 1136, 1174], 'within': [794, 1727, 3017], 'APP': [795, 949, 986, 1176, 3356, 3519, 3533, 3714], 'secretase': [797], 'components': [798], '10Vassar': [876], 'Bennett': [878], 'B.D.': [879], 'Babu-Khan': [880], 'Kahn': [882], 'Mendiaz': [884], 'E.A.': [885], 'Denis': [886, 2462, 2560], 'Teplow': [888], 'D.B.': [889], 'Ross': [890], 'Amarante': [892], 'Loeloff': [894], 'Luo': [896], 'Fisher': [898], 'Fuller': [900], 'J.': [901, 905, 919, 1051, 1112, 1113, 1265, 1267, 1497, 1521, 1556, 1561, 1584, 1631, 1646, 1760, 1859, 1937, 1945, 1949, 2035, 2113, 2121, 2125, 2248, 2271, 2280, 2336, 2467, 2478, 2565, 2576, 2625, 2752, 2795, 2804, 2920, 2963, 2972, 3062, 3085, 3094, 3162, 3185, 3194, 3239, 3282, 3291, 3458, 3479, 3500, 3643, 3664, 3685, 3722, 3731, 3750, 3755, 3796, 3860, 3974, 4017, 4179, 4202, 4211, 4281, 4569, 4592, 4601], 'Edenson': [902], 'Lile': [904], 'Jarosinski': [906], 'M.A.': [907, 1302, 1339, 1735, 4036], 'Biere': [908], 'A.L.': [909], 'Curran': [910], 'Burgess': [912, 2232, 3046, 3146, 3223, 4163, 4553], 'Louis': [914], 'Collins': [916, 2443, 2541, 4037], 'F.': [917, 1108, 1941, 2117, 3410, 3595], 'Treanor': [918], 'Rogers': [920], 'Citron': [922], 'Science.': [924, 1038, 1068, 1303], '286:': [926], '735-741Crossref': [927], '(3327)': [930], 'For': [933, 3929, 4104], 'example,': [934, 3930, 4105], 'Swedish': [936], 'mutation': [937], '(K670M/N671L)': [938], 'increases': [939, 1243, 3541, 3991], 'amount': [941], 'peptide': [944, 1002], 'generated': [947, 2355], '(11Lake': [950], 'Lakartidningen.': [952], '1991;': [953], '88:': [954, 3977], '1271-1272PubMed': [955], '12Citron': [958], 'Oltersdorf': [960], 'Haass': [962, 3494, 3679], 'McConlogue': [964], 'Hung': [966], 'A.Y.': [967], 'Seubert': [968], 'Vigo-Pelfrey': [970], 'Lieberburg': [972], '1992;': [977], '360:': [978], '672-674Crossref': [979], '(1537)': [982], 'Other': [985], 'mutations,': [987, 995], 'including': [988, 1372], 'Dutch': [990], '(E693D)': [991], 'Iowa': [993], '(Q694N)': [994], 'alter': [996], 'charge': [998], 'deposition': [1007, 2137, 2199, 2512, 4233, 4380, 4396, 4413, 4446, 4462], 'predominantly': [1008], 'than': [1015, 1162], '(13Levy': [1019], 'Carman': [1021], 'M.D.': [1022, 1026, 2793, 2961, 3720], 'Fernandez-Madrid': [1023], 'I.J.': [1024], 'Power': [1025], 'Leiberbrug': [1027], 'van': [1029, 1062, 2436, 2534], 'Duinen': [1030], 'S.G.': [1031], 'Bots': [1032], 'G.T.': [1033], 'Luyendijk': [1034], 'Frangione': [1036, 1109], 'B.': [1037, 1110, 1835, 1869, 1892, 2011, 2045, 2068, 2164, 2471, 2569, 2731, 2749, 2899, 2917, 3432, 3617, 4257, 4291, 4314], '1990;': [1039, 1069], '248:': [1040, 1070], '1124-1126Crossref': [1041], '(1166)': [1044], '14Van': [1047], 'Broeckhoven': [1048], 'Haan': [1050], 'Bakker': [1052], 'Hardy': [1054], 'J.A.': [1055, 2444, 2542], 'Van': [1056, 1458, 1492, 1946, 2122], 'Hul': [1057], 'Wehnert': [1059], 'Vegter': [1061], 'der': [1063], 'Vlis': [1064], 'Roos': [1066], 'R.A.': [1067], '1120-1122Crossref': [1071], '(362)': [1074], '15Grabowski': [1077], 'T.J.': [1078], 'Cho': [1079], 'H.S.': [1080], 'Vonsattel': [1081], 'J.P.': [1082], 'Rebeck': [1083, 1889, 2065, 3794, 4311], 'G.W.': [1084, 1296, 1333, 1890, 2066, 3795, 4312], 'Greenberg': [1085], 'Ann.': [1087, 1469, 1632, 1901, 2077, 2179, 4323], '49:': [1090], '697-705Crossref': [1091], '(435)': [1094], '16Miravalle': [1097], 'Tokuda': [1099], 'Chiarle': [1101], 'Giaccone': [1103], 'Bugiani': [1105], 'O.': [1106, 2448, 2546, 2703, 2871], 'Tagliavini': [1107], 'Ghiso': [1111], 'Biol.': [1114, 2249, 2281, 2753, 2779, 2805, 2921, 2947, 2973, 3063, 3095, 3163, 3195, 3240, 3292, 3459, 3502, 3644, 3687, 3732, 3756, 3797, 3861, 4018, 4180, 4212, 4570, 4602], 'Chem.': [1115, 2250, 2282, 2754, 2806, 2922, 2974, 3064, 3096, 3164, 3196, 3241, 3293, 3460, 3645, 3733, 3757, 3798, 3862, 4019, 4181, 4213, 4571, 4603], '2000;': [1116, 1404, 1419, 1474, 1564, 1637, 1906, 2082, 2181, 2344, 4328], '275:': [1117], '27110-27116Abstract': [1118], 'addition': [1128, 1705, 2665, 3926], 'APP,': [1132], '100': [1134], 'different': [1135], 'identified': [1139], 'presenilin-1': [1141], 'alone': [1142], '(17Selkoe': [1143], 'Proc.': [1145, 1689, 1872, 2048, 3386, 3411, 3439, 3571, 3596, 3624, 4294], 'Natl.': [1146, 1690, 1873, 2049, 3387, 3412, 3440, 3572, 3597, 3625, 4295], 'Acad.': [1147, 1472, 1635, 1691, 1874, 1904, 2050, 2080, 3388, 3413, 3441, 3573, 3598, 3626, 4296, 4326], 'Sci.': [1148, 1473, 1636, 1692, 1875, 1905, 2051, 2081, 3389, 3414, 3442, 3574, 3599, 3627, 4297, 4327], 'U.': [1149, 1520, 1582, 1693, 1876, 2052, 3390, 3415, 3443, 3575, 3600, 3628, 4298], '98:': [1153, 3394, 3419, 3579, 3604], '11039-11041Crossref': [1154], '(198)': [1157], '5%': [1163], 'overall': [1166], 'clinical': [1167], 'caused': [1172], 'presenilins': [1178], 'combined.': [1179], 'To': [1180], 'date,': [1181], 'only': [1183], 'established': [1185], 'risk': [1186, 1245, 2520], 'factor': [1187], 'for': [1188, 3909, 4153, 4231, 4621], 'late-onset': [1189], '(18Tanzi': [1193], 'Bertram': [1195], 'Neuron.': [1197], '181-184Abstract': [1200], '(423)': [1208], '19Wellington': [1211], 'C.L.': [1212, 2247, 2683, 2747, 2851, 2915, 3061, 3161, 3238, 4178, 4568], '2004;': [1215, 2251, 2283, 3065, 3097, 3165, 3197, 3242, 3294, 3976, 4182, 4214, 4572, 4604], '66:': [1216], '1-16Crossref': [1217], '(51)': [1220], 'human': [1225, 3713, 4512], 'population,': [1226], 'exists': [1228], 'three': [1230], 'alleles': [1232, 2494], '(apoE2,': [1233], 'apoE3,': [1234], 'apoE4),': [1236], 'inheritance': [1238, 1254], 'apoE4': [1241], 'allele': [1242, 2409], 'developing': [1247], 'at': [1249], 'earlier': [1251], 'age,': [1252], 'apoE2': [1256], 'delays': [1257], 'age': [1259], '(20Poirier': [1264], 'Davignon': [1266], 'Bouthillier': [1268], 'Kogan': [1270], 'Bertrand': [1272], 'Gauthier': [1274], 'Lancet.': [1276], '342:': [1278], '697-699Abstract': [1279], '(1171)': [1282], '21Corder': [1285], 'E.H.': [1286, 1313], 'Saunders': [1287, 1314], 'A.M.': [1288, 1315, 1462, 1915, 2091, 2162, 4337], 'Strittmatter': [1289, 1318], 'W.J.': [1290, 1319, 1752], 'Schmechel': [1291, 1320], 'D.E.': [1292, 1321], 'Gaskell': [1293, 1322], 'P.C.': [1294, 1323, 3963], 'Small': [1295, 1332], '261:': [1305], '921-923Crossref': [1306], '(7342)': [1309], '22Corder': [1312], 'Risch': [1316], 'N.J.': [1317], 'Rimmler': [1324], 'J.B.': [1325], 'Locke': [1326], 'P.A.': [1327], 'Conneally': [1328], 'P.M.': [1329], 'Schmader': [1330], 'K.E.': [1331], 'Nat.': [1340, 1838, 2014, 2481, 2579, 2610, 2654, 4260], '1994;': [1342, 1649], '7:': [1343], '180-184Crossref': [1344], '(1552)': [1347], 'How': [1350], 'subject': [1360], 'intense': [1362], 'investigation.': [1363], 'ApoE': [1364, 1718, 1778], 'component': [1367], 'several': [1369, 3922, 4088], 'subclasses,': [1371], 'very': [1373], 'low': [1374, 3257], 'HDL': [1378, 2326, 2370, 2424], 'particles': [1379, 2354], 'peripheral': [1382, 2297, 2386, 2417], 'circulation,': [1383], 'where': [1384, 1611, 2393, 4449], 'acts': [1386], 'mediate': [1388], 'uptake': [1390], 'receptors': [1393], '(23Mahley': [1394], 'R.W.': [1395], 'Rall': [1396], 'S.C.': [1398], 'Genom.': [1401], 'Hum.': [1402], '1:': [1405], '507-537Crossref': [1406], '(1344)': [1409], '24Curtiss': [1412], 'L.K.': [1413], 'Boisvert': [1414], 'W.A.': [1415], 'Curr.': [1416, 2341], 'Opin.': [1417, 2342], 'Lipidol.': [1418, 2343], '11:': [1420, 2345], '243-251Crossref': [1421], '(196)': [1424], 'system,': [1431], 'synthesized': [1434], 'secreted': [1436], 'astrocytes': [1438, 3039], 'microglia': [1440, 2827, 3041], 'serves': [1442], 'carrier': [1447], 'brain': [1450, 2995], 'cerebrospinal': [1452, 2224, 3265], 'fluid': [1453, 3266], '(25Ladu': [1454], 'M.J.': [1455, 1483, 1661, 1680, 4044], 'Reardon': [1456, 1490], 'Eldik': [1459, 1493], 'Fagan': [1461, 2161], 'Bu': [1463], 'Holtzmann': [1465], 'Getz': [1467], 'G.S.': [1468], 'N.': [1470, 1510, 1536, 1633, 1902, 2078, 2605, 2691, 2737, 2859, 2905, 4324], '903:': [1475], '167-175Crossref': [1476], '(170)': [1479], '26Ladu': [1482], 'Gilligan': [1484], 'Lukens': [1486], 'J.R.': [1487], 'Cabana': [1488], 'V.G.': [1489], 'C.A.': [1491, 1863, 2039, 4285], 'L.J.': [1494], 'D.A.': [1496, 4050], 'Neurochem.': [1498, 3975], '70:': [1500], '2070-2081Crossref': [1501], '(244)': [1504, 2715, 2883], '27Koch': [1507], 'Donarski': [1509], 'Goetze': [1511], 'Kreckel': [1513], 'Sturernburg': [1515], 'H.J.': [1516], 'Buhmann': [1517], 'Beisiegel': [1519], 'Lipid': [1522, 1562], 'Res.': [1523, 1563, 1670, 1766, 1769], '42:': [1525], '1143-1151Abstract': [1526], '28Demeester': [1535], 'Castro': [1537], 'Desrumaux': [1539], 'De': [1541, 1552, 3430, 3615], 'Geitere': [1542], 'Fruchart': [1544], 'Santens': [1546], 'Mulleners': [1548], 'Engelborghs': [1550], 'Deyn': [1553], 'P.P.': [1554], 'Vandekerckhove': [1555], 'Rosseneu': [1557], 'Labeur': [1559], '41:': [1565], '963-974Abstract': [1566], '29Danik': [1575], 'Champagne': [1577], 'Petit-Turcotte': [1579], 'Beffert': [1581], 'Poirer': [1583], 'Crit.': [1585], 'Neurobiol.': [1587, 1926, 2102, 4348], '13:': [1589], '357-407Crossref': [1590], '(70)': [1593], 'expression': [1600, 2668, 3900, 3920, 3938, 3994], 'under': [1603], 'conditions': [1604], 'chronic': [1606], 'acute': [1608], 'neuronal': [1609, 1620, 3910, 4106], 'damage,': [1610], 'it': [1612, 3000], 'believed': [1614, 1780], 'acquire': [1616, 2364], 'lipids': [1617, 1625, 2366, 3117, 4138], 'damaged': [1619], 'processes': [1621], 'rede-liver': [1623], 'these': [1624, 3817, 3904], 'neurons': [1627, 4454], 'during': [1628, 4457], 'reinnervation': [1629], '(30Poirier': [1630], '924:': [1638], '81-90Crossref': [1639], '(139)': [1642], '31Poirier': [1645], 'Trends': [1647], 'Neurosci.': [1648, 1950, 2126], '17:': [1650, 1841, 2017, 4263], '525-530Abstract': [1651], '(610)': [1657], '32Ignatius': [1660], 'Gebicke-Harter': [1662, 1681], 'Pitas': [1664], 'Shooter': [1666], 'E.M.': [1667, 1827, 2003, 4249], 'Prog.': [1668], 'Brain': [1669, 1765, 1768], '1987;': [1671], '71:': [1672], '177-184Crossref': [1673], '(39)': [1676], '33Ignatius': [1679], 'Skene': [1683], 'J.H.': [1684], 'Schilling': [1685], 'J.W.': [1686], 'Weisgraber': [1687], 'K.H.': [1688, 2174], '1986;': [1696], '83:': [1697], '1125-1129Crossref': [1698], '(496)': [1701], 'lipid': [1707, 2373, 2418, 3010, 4081], 'trafficking,': [1708], 'also': [1710, 2196, 2675, 4064, 4075], 'plays': [1711], 'metabolism.': [1717], 'binds': [1719], 'avidly': [1720], 'found': [1726, 3775], 'plaques': [1729], '(34Atwood': [1730], 'C.S.': [1731], 'Martins': [1732], 'R.N.': [1733], 'Smith': [1734], 'Perry': [1736], 'Peptides': [1738], '(N.': [1739], 'Y.).': [1740], '23:': [1742], '1343-1350Crossref': [1743], '(115)': [1746], '35Burns': [1749], 'Noble': [1751], 'Olm': [1753], 'V.': [1754, 1867, 2043, 2229, 2721, 2889, 3043, 3143, 3220, 4160, 4289, 4550], 'Gaynor': [1755], 'Casey': [1757], 'LaFrancois': [1759], 'Wang': [1761], 'Duff': [1763], '110:': [1771], '119-125Crossref': [1772], '(110)': [1775], 'conversion': [1788], 'fibrillar': [1795], 'form,': [1796], 'based': [1797], 'observation': [1800, 3308], 'apoE-deficient': [1802, 1967], 'unable': [1805], 'form': [1807, 2368], 'mature': [1808, 2369], 'vivo': [1811, 3836, 4448], '(36Bales': [1812, 1988, 4234], 'Verina': [1814, 1850, 1990, 2026, 4236, 4272], 'Dodel': [1816, 1856, 1992, 2032, 4238, 4278], 'Du': [1818, 1854, 1994, 2030, 4240, 4276], 'Alsteil': [1820, 1996, 4242], 'Bender': [1822, 1998, 4244], 'Hyslop': [1824, 2000, 4246], 'Johnstone': [1826, 2002, 4248], 'Little': [1828, 2004, 4250], 'S.P.': [1829, 2005, 4251], 'Cummins': [1830, 1852, 2006, 2028, 4252, 4274], 'Piccardo': [1832, 1864, 2008, 2040, 4254, 4286], 'Ghetti': [1834, 1868, 2010, 2044, 4256, 4290], '263-264Crossref': [1842, 2018, 4264], '(709)': [1845, 2021, 4267], '37Bales': [1848, 2024, 4270], 'R.C.': [1857, 2033, 4279], 'Saura': [1858, 2034, 4280], 'Fishman': [1860, 2036, 4282], 'C.E.': [1861, 2037, 4283], 'DeLong': [1862, 2038, 4284], 'Petegnief': [1866, 2042, 4288], '96:': [1880, 2056, 4302], '15233-15238Crossref': [1881, 2057, 4303], '(416)': [1884, 2060, 4306], '38Irizarry': [1887, 2063, 4309], 'M.C.': [1888, 2064, 2176, 3791, 4310], 'Cheung': [1891, 2067, 4313], 'Bales': [1893, 1920, 2069, 2096, 2171, 3958, 4315, 4342], 'Holzman': [1897, 2073, 4319], 'Hyman': [1899, 2075, 2177, 4321], 'B.T.': [1900, 2076, 2178, 4322], '920:': [1907, 2083, 4329], '171-178Crossref': [1908, 2084, 4330], '(53)': [1911, 2087, 4333], '39Fagan': [1914, 2090, 4336], 'Watson': [1916, 2092, 4035, 4338], 'Parsadanian': [1918, 2094, 2268, 3082, 3182, 3279, 4199, 4340, 4589], 'Dis.': [1927, 2103, 3481, 3666, 4349], '9:': [1929, 2105, 4351], '305-318Crossref': [1930, 2106, 4352], '(222)': [1933, 2109, 4355], '40Miao': [1936, 2112], 'Vitek': [1938, 2114], 'Xu': [1940, 2116], 'Previti': [1942, 2118], 'M.L.': [1943, 2119, 3793], 'Davis': [1944, 2120], 'Nostrand': [1947, 2123], 'W.E.': [1948, 2124, 2641], '2005;': [1951, 2127, 3863, 4020], '25:': [1952, 2128], '6271-6277Crossref': [1953, 2129], '(56)': [1956, 2132], 'brains': [1965, 3268], 'do': [1971], 'contain': [1973], 'structural': [1974], 'defined': [1977], 'ability': [1980], 'bind': [1982], 'thioflavine': [1983], 'Congo': [1985], 'Red': [1986], 'dyes': [1987], 'similar': [2139, 2841], 'distribution': [2141], 'extensive': [2144], 'heterozygous': [2147], 'suggesting': [2149], 'dose-dependent': [2151], 'effect': [2152, 4427, 4438, 4521], 'level': [2155, 3258], 'formation': [2158], '(41Holtzman': [2159], 'Mackey': [2163], 'Tenkova': [2165], 'Sartorius': [2167], 'Ashe': [2173], 'Irizarry': [2175, 3790], '47:': [2182], '739-747Crossref': [2183], '(268)': [2186], 'Therefore,': [2189, 4383], 'factors': [2190], 'abundance': [2194, 3317], 'influence': [2201, 3331], 'progression': [2205, 3335], 'AD.': [2207, 4103], 'ATP-binding': [2209], 'cassette': [2210], 'fluid,': [2225], 'plasma': [2227, 2313, 2423, 2510], '(42Hirsch-Reinshagen': [2228, 3042, 3142, 3219, 4159, 4549], 'Zhou': [2230, 3044, 3144, 3221, 4161, 4551], 'B.L.': [2233, 3047, 3147, 3224, 4164, 4554], 'Bernier': [2234, 3048, 3148, 3225, 4165, 4555], 'McIsaac': [2236, 3050, 3150, 3227, 4167, 4557], 'S.A.': [2237, 3051, 3151, 3228, 4052, 4168, 4558], 'Chan': [2238, 3052, 3152, 3229, 4169, 4559], 'J.Y.': [2239, 3053, 3153, 3230, 4170, 4560], 'Tansley': [2240, 3054, 3154, 3231, 4171, 4561], 'G.H.': [2241, 3055, 3155, 3232, 4172, 4562], 'Cohn': [2242, 3056, 3156, 3233, 4173, 4563], 'J.S.': [2243, 2803, 2971, 3057, 3157, 3234, 3730, 3859, 4016, 4174, 4564], 'Hayden': [2244, 2479, 2577, 2706, 2750, 2874, 2918, 3058, 3158, 3235, 4175, 4565], 'M.R.': [2245, 2329, 2480, 2578, 2707, 2751, 2875, 2919, 3059, 3159, 3236, 4176, 4566], 'Wellington': [2246, 2746, 2914, 3060, 3160, 3237, 4177, 4567], '279:': [2252, 2284, 3066, 3098, 3166, 3198, 3243, 3295, 4183, 4215, 4573, 4605], '41197-41207Abstract': [2253, 3067, 3167, 3244, 4184, 4574], '(300)': [2261, 3075, 3175, 3252, 4192, 4582], '43Wahrle': [2264, 3078, 3178, 4195, 4585], 'S.E.': [2265, 3079, 3179, 3276, 4196, 4586], 'Jiang': [2266, 3080, 3180, 3277, 3966, 4197, 4587], 'Legleiter': [2270, 3084, 3184, 3281, 4201, 4591], 'Han': [2272, 3086, 3186, 3283, 4203, 4593], 'X.': [2273, 3087, 3187, 3284, 3957, 4204, 4594], 'Fryer': [2274, 3088, 3188, 3285, 4205, 4595], 'J.D.': [2275, 3089, 3189, 3286, 3474, 3659, 4206, 4596], 'Kowalewski': [2276, 3090, 3190, 3287, 4207, 4597], '40987-40993Abstract': [2285, 3099, 3199, 3296, 4216, 4606], '(342)': [2293, 3107, 3207, 3304, 4224, 4614], 'tissues,': [2298], 'primary': [2300], 'biochemical': [2301], 'function': [2302], 'transport': [2307, 2374], 'phospholipids': [2310], 'membrane': [2314], 'lipid-free': [2316], 'apoAI,': [2317], 'reaction': [2319, 2358], 'constitutes': [2321], 'first': [2323], 'step': [2324], 'biogenesis': [2327], '(44Hayden': [2328], 'Clee': [2330, 2430, 2528, 2724, 2892], 'Brooks-Wilson': [2332, 2732, 2900], 'Genest': [2334, 2476, 2574], 'Attie': [2337], 'Kastelein': [2339, 2474, 2572], 'J.J.P': [2340, 2475, 2573], '117-122Crossref': [2346], 'pre-β-HDL': [2353], 'circulate': [2359], 'bloodstream': [2362], 'additional': [2365], 'particles.': [2371], 'ABCA1-dependent': [2372], 'apoAI': [2376], 'pathway': [2380], 'which': [2382, 2501], 'excess': [2383, 3777], 'sterols': [2384], 'tissues': [2387], 'transported': [2389], 'liver': [2392, 2670, 2833, 3891], 'they': [2394], 'converted': [2396], 'into': [2397], 'bile': [2398], 'excreted': [2401], 'body.': [2404], 'Mutation': [2405, 2491], 'one': [2407], 'causes': [2410], 'hypoalphalipoproteinemia,': [2412], 'mild': [2414], 'disorder': [2415], 'metabolism': [2419], 'reduced': [2422, 3705, 3884], '(45Brooks-Wilson': [2426, 2524], 'Marcil': [2428, 2526], 'Zhang': [2432, 2530, 2696, 2726, 2864, 2894, 3954], 'Roomp': [2434, 2532], 'Dam': [2437, 2535], 'Brewer': [2441, 2539, 2601], 'Molhuizen': [2445, 2543], 'H.O.F': [2446, 2544], 'Loubser': [2447, 2545], 'Ouellette': [2449, 2547], 'B.F.F': [2450, 2548], 'Fichter': [2451, 2549], 'Ashbourne': [2453, 2551], 'Excoffon': [2454, 2552], 'K.J.D': [2455, 2553], 'Sensen': [2456, 2554], 'C.W.': [2457, 2555], 'Scherer': [2458, 2556], 'Mott': [2460, 2558], 'Martindale': [2464, 2562], 'Frohlich': [2466, 2564], 'Morgan': [2468, 2566], 'Koop': [2470, 2568], 'Pimstone': [2472, 2570], 'S.N.': [2473, 2571], '22:': [2484, 2582, 2613, 2657], '336-345Crossref': [2485, 2583], '(1509)': [2488, 2586], 'both': [2493], 'results': [2497, 3113, 3905, 4362, 4548], 'Tangier': [2499], 'disease,': [2500], 'nearly': [2506], 'complete': [2507], 'absence': [2508, 4371], 'HDL,': [2511], 'intracellular': [2514, 3349, 3512, 3530], 'esters,': [2516], 'cardiovascular': [2522], '46Rust': [2589], 'Rosier': [2591], 'Funke': [2593], 'Amoura': [2595], 'Z.': [2596], 'Piette': [2597], 'J.-C.': [2598], 'Deleuze': [2599], 'J.-F.': [2600], 'H.B.': [2603], 'Duverger': [2604], 'Denèfle': [2606], 'Assmann': [2608], '352-355Crossref': [2614], '(1269)': [2617], '47Bodzioch': [2620], 'Orsó': [2622], 'Klucken': [2624], 'Langmann': [2626], 'Böttcher': [2628], 'Diederich': [2630], 'Drobnik': [2632], 'Barlage': [2634], 'Büchler': [2636], 'Porsch-Özcürümez': [2638], 'Kaminski': [2640], 'Hahmann': [2642], 'H.W.': [2643], 'Oette': [2644], 'Rothe': [2646], 'Aslanidis': [2648], 'Lackner': [2650], 'K.J.': [2651], 'Schmitz': [2652], '347-351Crossref': [2658], '(1349)': [2661], 'macrophages,': [2672], 'abundant': [2676], 'system': [2681, 2848, 3324, 4080], '(48Wellington': [2682, 2850], 'Walker': [2684, 2852], 'E.K.': [2685, 2853], 'Suarez': [2686, 2854], 'Kwok': [2688, 2734, 2856, 2902], 'Bissada': [2690, 2736, 2858, 2904], 'Singaraja': [2692, 2860], 'Yang': [2694, 2738, 2862, 2906], 'Y.-Z.': [2695, 2739, 2863, 2907], 'L.H.': [2697, 2865], 'James': [2698, 2722, 2866, 2890], 'Wilson': [2700, 2868, 4047], 'J.E.': [2701, 2869], 'Francone': [2702, 2870], 'McManus': [2704, 2872], 'B.M.': [2705, 2873], 'Lab.': [2708, 2876], 'Investig.': [2709, 2877], '82:': [2711, 2879], '273-283Crossref': [2712, 2880], '49Singaraja': [2718, 2886], 'R.R.': [2719, 2887], 'Bocher': [2720, 2888], 'E.R.': [2723, 2891], 'L.-H.': [2727, 2895], 'Leavitt': [2728, 2896], 'B.R.': [2729, 2897], 'Tan': [2730, 2898], 'Liu': [2740, 2908], 'Tafuri': [2742, 2910], 'S.R.': [2743, 2911], 'Fievet': [2744, 2912], 'Staels': [2748, 2916], '276:': [2756, 2924], '33969-33979Abstract': [2757, 2925], '(173)': [2765, 2933], '50Lawn': [2768, 2936], 'R.M.': [2769, 2937], 'Wade': [2770, 2938], 'D.P.': [2771, 2939], 'Couse': [2772, 2940], 'T.L.': [2773, 2941], 'Wilcox': [2774, 2942], 'J.N.': [2775, 2943], 'Arterioscler.': [2776, 2944], 'Thromb.': [2777, 2945], 'Vasc.': [2778, 2946], '21:': [2781, 2949], '378-385Crossref': [2782, 2950], '(104)': [2785, 2953], '51Koldamova': [2788, 2956], 'R.P.': [2789, 2957, 3716, 3843, 4000], 'Lefterov': [2790, 2796, 2958, 2964, 3717, 3723, 3844, 4001], 'I.M.': [2791, 2959, 3718, 3845, 4002], 'Ikonomovic': [2792, 2960, 3719], 'Skoko': [2794, 2962, 3721], 'P.I.': [2797, 2965, 3724, 3969], 'Isanski': [2798, 2966, 3725], 'B.A.': [2799, 2967, 3726], 'DeKosky': [2800, 2968, 3727], 'S.T.': [2801, 2969, 3728], 'Lazo': [2802, 2970, 3729, 3858, 4015], '278:': [2808, 2976, 3735, 3759], '13244-13256Abstract': [2809, 2977, 3736], '(217)': [2817, 2985, 3744], 'neurons,': [2824], 'astrocytes,': [2825], 'transcriptionally': [2830], 'induced': [2831], 'X': [2834, 2838, 3892], 'receptor': [2835, 2839, 3893], 'retinoic': [2837], 'agonists,': [2840], 'regulation': [2844, 3008], 'noncentral': [2846], 'cells': [2849], 'completely': [2998], 'understood,': [2999], 'likely': [3002], 'participates': [3005], 'trafficking': [3011], 'among': [3012, 3816, 4453], 'various': [3014], 'cell': [3015, 3943, 4089], 'We': [3020, 4465], 'others': [3022], 'mediates': [3027], 'efflux': [3029, 3216], 'regulates': [3033], 'secretion': [3035, 3122], 'Lack': [3110, 4532], 'accumulation': [3115], 'cultured': [3119], 'glia,': [3120], 'impaired': [3121, 3214], 'glia-derived': [3124], 'apoE,': [3125], 'drastic': [3128], 'hippocampus': [3139], 'striatum': [3141], 'ABCA1-deficient': [3211, 3270, 4468, 4530], 'glia': [3212, 4456], 'exhibit': [3213], 'Scholar),': [3254, 3770, 3983, 4357], 'remains': [3262], 'mice': [3271, 3887, 3947, 4469], 'poorly': [3273], 'lipidated': [3274], '(43Wahrle': [3275], 'critical': [3313], 'modulator': [3314], 'raises': [3325], 'through': [3338], 'its': [3339], 'apoE.': [3342, 4415], 'Many': [3343], 'previous': [3344, 4547], 'studies': [3345, 3700, 3818], 'modify': [3352], 'cleavage': [3354, 3517, 3534], 'secretases': [3358], '(52Fassbender': [3359, 3544], 'Simons': [3361, 3437, 3498, 3546, 3622, 3683], 'Bergmann': [3363, 3378, 3548, 3563], 'Stroick': [3365, 3550], 'Lütjohann': [3367, 3552], 'Keller': [3369, 3428, 3492, 3554, 3613, 3677], 'Runz': [3371, 3556], 'Kühl': [3373, 3558], 'Bertsch': [3375, 3560], 'von': [3377, 3562], 'Hennerici': [3380, 3565], 'Beyreuther': [3382, 3433, 3567, 3618], 'Hartmann': [3384, 3569], '5856-5861Crossref': [3395, 3580], '(1036)': [3398, 3583], '53Kojro': [3401, 3586], 'Gimple': [3403, 3588], 'Lammich': [3405, 3590], 'März': [3407, 3592], 'Fahrenholz': [3409, 3594], 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'two': [3698, 4471], 'recent': [3699], 'showed': [3701], 'generation': [3707, 3781], 'derived': [3711], '(51Koldamova': [3715], '58Sun': [3747], 'Yao': [3749], 'Kim': [3751], 'T.-W.': [3752], 'Tall': [3753], 'A.R.': [3754], '27688-27694Abstract': [3760], '(165)': [3768], 'third': [3773], 'study': [3774], 'endogenous': [3783, 4523], 'rodent': [3784], '(59Fukumoto': [3786], 'Deng': [3788], 'Fitzgerald': [3792], '277:': [3800], '48508-48513Abstract': [3801], '(141)': [3809], 'lack': [3813, 4385], 'consensus': [3815], 'underscores': [3819], 'need': [3821], 'evaluate': [3823], 'physiologically': [3833], 'relevant': [3834], 'setting.': [3837], 'Recently,': [3838], 'Koldamova': [3839], 'et': [3840], 'al.': [3841], '(60Koldamova': [3842, 3999], 'Staufenbiel': [3846, 4003], 'Wolfe': [3848, 4005], 'Huang': [3850, 4007], 'Glorioso': [3852, 4009], 'Walter': [3854, 4011], 'Roth': [3856, 4013], 'M.G.': [3857, 4014], '280:': [3864, 4021], '4079-4088Abstract': [3865, 4022], '(228)': [3873, 4030], 'Scholar)': [3875], 'demonstrated': [3876], 'were': [3882], 'significantly': [3883], 'APP23': [3886], 'treated': [3888], 'ligand': [3894], 'TO901317,': [3895], 'concomitant': [3896], 'neurons.': [3902], 'support': [3906], 'TO901317': [3917, 3931, 3998, 4063], 'induces': [3918, 4065], 'genes': [3924], 'ABCA1.': [3928], 'stimulate': [3936], 'glial': [3942, 4149], 'lines': [3944], '(61Liang': [3948], 'Beyer': [3952], 'T.P.': [3953], 'Wu': [3956], 'May': [3962], 'S.D.': [3965], 'X.C.': [3967], 'Eacho': [3968], 'Cao': [3970], '623-634Crossref': [3978], '(132)': [3981], 'although': [3984], 'groups': [3986], 'significant': [3990], 'response': [3996], '62Whitney': [4033], 'K.D.': [4034], 'Benson': [4039], 'W.G.': [4040], 'Stone': [4041], 'T.M.': [4042], 'Numerick': [4043], 'Tippin': [4045], 'T.K.': [4046], 'J.G.': [4048], 'Winegar': [4049], 'Kliewer': [4051], 'Endocrinol.': [4054], '16:': [4056], '1378-1385Crossref': [4057], '(151)': [4060], 'members': [4067], 'ABC-cassette': [4070], 'superfamily': [4072], 'participate': [4076], 'homeostasis.': [4082], 'Because': [4083, 4227, 4617], 'multiple': [4097], 'roles': [4098], 'prominent': [4111], 'regulating': [4114], 'content,': [4117], 'influencing': [4119], 'peptides.': [4124], 'From': [4125], 'perspective,': [4127], 'would': [4132, 4374], 'predicted': [4134, 4376], 'lead': [4140], 'elevated': [4142], 'levels.': [4144], 'On': [4145], 'hand,': [4148], 'crucial': [4152], '70%': [4365], 'levels,': [4369, 4487, 4544], 'decrease': [4378], 'could': [4388], 'theoretically': [4389], 'opposite': [4392], 'outcomes': [4393], 'depending': [4397], 'upon': [4398], 'whether': [4399, 4417], 'clearance': [4411], 'via': [4414], 'Determining': [4416], 'increases,': [4421], 'decreases,': [4422], 'no': [4425, 4501, 4520], 'net': [4426], 'will': [4433], 'therefore': [4434, 4466], 'require': [4435], 'investigating': [4436], 'physiological': [4451], 'interactions': [4452], 'process': [4459], 'preserved.': [4464], 'crossed': [4467, 4515], 'independent': [4472], 'murine': [4473, 4524], 'models': [4474], 'determine': [4478], 'impact': [4480, 4503], 'burden,': [4485], 'elimination': [4497], 'measurable': [4502], 'steady-state': [4506], 'when': [4514], 'either': [4517], 'model,': [4518], 'parental': [4529], 'did': [4535], 'consistent': [4545], 'depo': [4623]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2151049459', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-12-10T05:40:33.422583', 'created_date': '2016-06-24'}
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