Publication Information

{'id': 'https://openalex.org/W2149143432', 'doi': 'https://doi.org/10.1128/iai.01392-07', 'title': 'Cathelicidin LL-37 in Severe <i>Streptococcus pyogenes</i> Soft Tissue Infections in Humans', 'display_name': 'Cathelicidin LL-37 in Severe <i>Streptococcus pyogenes</i> Soft Tissue Infections in Humans', 'publication_year': 2008, 'publication_date': '2008-05-20', 'ids': {'openalex': 'https://openalex.org/W2149143432', 'doi': 'https://doi.org/10.1128/iai.01392-07', 'mag': '2149143432', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18490458', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2493236'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/iai.01392-07', 'pdf_url': 'https://iai.asm.org/content/iai/76/8/3399.full.pdf', 'source': {'id': 'https://openalex.org/S128227336', 'display_name': 'Infection and Immunity', 'issn_l': '0019-9567', 'issn': ['0019-9567', '1070-6313', '1098-5522'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://iai.asm.org/content/iai/76/8/3399.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005179796', 'display_name': 'Linda Johansson', 'orcid': 'https://orcid.org/0000-0001-7071-4699'}, 'institutions': [{'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Linda Johansson', 'raw_affiliation_strings': ['Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm'], 'affiliations': [{'raw_affiliation_string': 'Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm', 'institution_ids': ['https://openalex.org/I1335113835', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047850258', 'display_name': 'Pontus Thulin', 'orcid': 'https://orcid.org/0009-0002-5041-8790'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Pontus Thulin', 'raw_affiliation_strings': ['Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm'], 'affiliations': [{'raw_affiliation_string': 'Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm', 'institution_ids': ['https://openalex.org/I28166907', 'https://openalex.org/I1335113835']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077875571', 'display_name': 'Parham Sendi', 'orcid': 'https://orcid.org/0000-0002-7347-6312'}, 'institutions': [{'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Parham Sendi', 'raw_affiliation_strings': ['Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm'], 'affiliations': [{'raw_affiliation_string': 'Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm', 'institution_ids': ['https://openalex.org/I1335113835', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016278318', 'display_name': 'Erika Hertzén', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Erika Hertzén', 'raw_affiliation_strings': ['Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm'], 'affiliations': [{'raw_affiliation_string': 'Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm', 'institution_ids': ['https://openalex.org/I1335113835', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061549353', 'display_name': 'Adam Linder', 'orcid': 'https://orcid.org/0000-0002-8187-7239'}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Adam Linder', 'raw_affiliation_strings': ['Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031563377', 'display_name': 'Per Åkesson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Per Åkesson', 'raw_affiliation_strings': ['Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Clinical and Experimental Infection Medicine, Lund University, Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107830215', 'display_name': 'Donald E. Low', 'orcid': 'https://orcid.org/0000-0001-8962-946X'}, 'institutions': [{'id': 'https://openalex.org/I1291836623', 'display_name': 'Mount Sinai Hospital', 'ror': 'https://ror.org/05deks119', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1291836623', 'https://openalex.org/I4210130843']}, {'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Donald E. Low', 'raw_affiliation_strings': ['Department of Microbiology, Mount Sinai Hospital, and the University of Toronto, Toronto, Ontario, M5G 1x5, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Mount Sinai Hospital, and the University of Toronto, Toronto, Ontario, M5G 1x5, Canada', 'institution_ids': ['https://openalex.org/I1291836623', 'https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108515902', 'display_name': 'Birgitta Agerberth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Birgitta Agerberth', 'raw_affiliation_strings': ['Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080532498', 'display_name': 'Anna Norrby‐Teglund', 'orcid': 'https://orcid.org/0000-0001-9372-1795'}, 'institutions': [{'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': True, 'raw_author_name': 'Anna Norrby-Teglund', 'raw_affiliation_strings': ['Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm'], 'affiliations': [{'raw_affiliation_string': 'Center for Infectious Medicine, Karolinska Institutet, Department of Medicine—F59, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm', 'institution_ids': ['https://openalex.org/I1335113835', 'https://openalex.org/I28166907']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5080532498'], 'corresponding_institution_ids': ['https://openalex.org/I1335113835', 'https://openalex.org/I28166907'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.847, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 86, 'citation_normalized_percentile': {'value': 0.943575, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '76', 'issue': '8', 'first_page': '3399', 'last_page': '3404'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides and Activities', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides and Activities', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11153', 'display_name': 'Streptococcal Infections and Treatments', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11961', 'display_name': 'Neonatal and Maternal Infections', 'score': 0.9886, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/streptococcus-pyogenes', 'display_name': 'Streptococcus Pyogenes', 'score': 0.9124758}, {'id': 'https://openalex.org/keywords/cathelicidin', 'display_name': 'Cathelicidin', 'score': 0.8429574}, {'id': 'https://openalex.org/keywords/colocalization', 'display_name': 'Colocalization', 'score': 0.45418775}], 'concepts': [{'id': 'https://openalex.org/C2779306812', 'wikidata': 'https://www.wikidata.org/wiki/Q131271', 'display_name': 'Streptococcus pyogenes', 'level': 4, 'score': 0.9124758}, {'id': 'https://openalex.org/C2777379352', 'wikidata': 'https://www.wikidata.org/wiki/Q24739493', 'display_name': 'Cathelicidin', 'level': 4, 'score': 0.8429574}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.6809223}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.67586136}, {'id': 'https://openalex.org/C2777217379', 'wikidata': 'https://www.wikidata.org/wiki/Q1870975', 'display_name': 'Fasciitis', 'level': 2, 'score': 0.54056174}, {'id': 'https://openalex.org/C2777238321', 'wikidata': 'https://www.wikidata.org/wiki/Q876887', 'display_name': 'Cellulitis', 'level': 2, 'score': 0.51440126}, {'id': 'https://openalex.org/C2778276568', 'wikidata': 'https://www.wikidata.org/wiki/Q190161', 'display_name': 'Streptococcus', 'level': 3, 'score': 0.50139666}, {'id': 'https://openalex.org/C40209533', 'wikidata': 'https://www.wikidata.org/wiki/Q5147828', 'display_name': 'Colocalization', 'level': 2, 'score': 0.45418775}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.36130512}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3440118}, {'id': 'https://openalex.org/C540938839', 'wikidata': 'https://www.wikidata.org/wiki/Q1201508', 'display_name': 'Antimicrobial peptides', 'level': 3, 'score': 0.30041155}, {'id': 'https://openalex.org/C4937899', 'wikidata': 'https://www.wikidata.org/wiki/Q68541106', 'display_name': 'Antimicrobial', 'level': 2, 'score': 0.2360177}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.15719146}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.10399318}, {'id': 'https://openalex.org/C2779489039', 'wikidata': 'https://www.wikidata.org/wiki/Q188121', 'display_name': 'Staphylococcus aureus', 'level': 3, 'score': 0.08867732}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D023181', 'descriptor_name': 'Antimicrobial Cationic Peptides', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D018461', 'descriptor_name': 'Soft Tissue Infections', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018461', 'descriptor_name': 'Soft Tissue Infections', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D013290', 'descriptor_name': 'Streptococcal Infections', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D013290', 'descriptor_name': 'Streptococcal Infections', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D013297', 'descriptor_name': 'Streptococcus pyogenes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D023181', 'descriptor_name': 'Antimicrobial Cationic Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D001706', 'descriptor_name': 'Biopsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005098', 'descriptor_name': 'Exotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005098', 'descriptor_name': 'Exotoxins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D018461', 'descriptor_name': 'Soft Tissue Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013290', 'descriptor_name': 'Streptococcal Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013297', 'descriptor_name': 'Streptococcus pyogenes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013297', 'descriptor_name': 'Streptococcus pyogenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/iai.01392-07', 'pdf_url': 'https://iai.asm.org/content/iai/76/8/3399.full.pdf', 'source': {'id': 'https://openalex.org/S128227336', 'display_name': 'Infection and Immunity', 'issn_l': '0019-9567', 'issn': ['0019-9567', '1070-6313', '1098-5522'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2493236', 'pdf_url': 'https://europepmc.org/articles/pmc2493236?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.9791', 'pdf_url': 'http://iai.asm.org/content/76/8/3399.full.pdf', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493236', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18490458', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/iai.01392-07', 'pdf_url': 'https://iai.asm.org/content/iai/76/8/3399.full.pdf', 'source': {'id': 'https://openalex.org/S128227336', 'display_name': 'Infection and Immunity', 'issn_l': '0019-9567', 'issn': ['0019-9567', '1070-6313', '1098-5522'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1940255949', 'https://openalex.org/W1943160106', 'https://openalex.org/W1964758221', 'https://openalex.org/W1976499179', 'https://openalex.org/W1978721677', 'https://openalex.org/W1979258089', 'https://openalex.org/W2013334861', 'https://openalex.org/W2025230440', 'https://openalex.org/W2084177740', 'https://openalex.org/W2085793178', 'https://openalex.org/W2086282444', 'https://openalex.org/W2114526613', 'https://openalex.org/W2126306331', 'https://openalex.org/W2131138068', 'https://openalex.org/W2131759804', 'https://openalex.org/W2144017255', 'https://openalex.org/W2145618406', 'https://openalex.org/W2157370631', 'https://openalex.org/W2168856057', 'https://openalex.org/W2169759699', 'https://openalex.org/W2170540001', 'https://openalex.org/W750204356'], 'related_works': ['https://openalex.org/W4389266025', 'https://openalex.org/W4310838850', 'https://openalex.org/W3126164372', 'https://openalex.org/W2401779711', 'https://openalex.org/W2323622067', 'https://openalex.org/W2168905106', 'https://openalex.org/W2079110117', 'https://openalex.org/W2065109108', 'https://openalex.org/W1607188194', 'https://openalex.org/W1535246723'], 'abstract_inverted_index': {'Severe': [0], 'soft': [1, 99], 'tissue': [2, 29, 100, 106, 217, 224], 'infections,': [3], 'such': [4], 'as': [5, 131], 'necrotizing': [6], 'fasciitis': [7], 'and': [8, 47, 89, 94, 120, 144, 149, 180], 'severe': [9, 98, 222], 'cellulitis,': [10], 'caused': [11, 59], 'by': [12, 23, 60, 102], 'group': [13], 'A': [14, 138], 'streptococci': [15], '(GAS)': [16], 'are': [17, 39], 'rapidly': [18], 'progressing': [19], 'life-threatening': [20], 'infections': [21, 58, 101], 'characterized': [22], 'massive': [24], 'bacterial': [25, 150, 184, 211], 'loads': [26, 151], 'in': [27, 79, 124, 194, 219], 'the': [28, 33, 43, 68, 75, 85, 117, 121, 125, 132, 136, 142, 156, 183, 188, 198, 206, 215], 'even': [30], 'late': [31], 'after': [32], 'onset': [34], 'of': [35, 42, 87, 104, 114, 135, 170, 177, 190, 197, 203], 'infection.': [36], 'Antimicrobial': [37], 'peptides': [38], 'important': [40], 'components': [41], 'innate': [44], 'host': [45], 'defense,': [46], 'cathelicidins': [48], 'have': [49, 83], 'been': [50, 65], 'shown': [51], 'to': [52, 155], 'protect': [53], 'against': [54], 'murine': [55], 'necrotic': [56], 'skin': [57], 'GAS.': [61], 'However,': [62], 'it': [63], 'has': [64], 'demonstrated': [66], 'that': [67, 200], 'streptococcal': [69, 207], 'cysteine': [70], 'protease': [71], 'SpeB': [72, 95], 'proteolytically': [73], 'inactivates': [74], 'human': [76], 'cathelicidin': [77], 'LL-37': [78, 88, 145, 157, 162, 181, 204], 'vitro.': [80], 'Here': [81], 'we': [82], 'investigated': [84], 'expression': [86], 'its': [90], 'interaction': [91], 'with': [92, 160, 165, 167, 221], 'GAS': [93, 223], 'during': [96], 'acute': [97], 'analyses': [103], 'patient': [105], 'biopsy': [107], 'specimens.': [108], 'The': [109], 'results': [110], 'showed': [111, 152], 'large': [112, 168], 'amounts': [113, 169], 'LL-37,': [115], 'both': [116], 'proform': [118], '(hCAP18)': [119], 'mature': [122], 'peptide,': [123], 'tissue.': [126], 'Confocal': [127, 172], 'microscopy': [128, 173], 'identified': [129], 'neutrophils': [130], 'main': [133], 'source': [134], 'peptide.': [137], 'distinct': [139], 'colocalization': [140, 176], 'between': [141], 'bacteria': [143], 'could': [146], 'be': [147], 'noted,': [148], 'positive': [153], 'correlation': [154], 'levels.': [158], 'Areas': [159], 'high': [161], 'levels': [163], 'coincided': [164], 'areas': [166], 'SpeB.': [171], 'confirmed': [174], 'strong': [175], 'GAS,': [178], 'SpeB,': [179], 'at': [182, 205, 214], 'surface.': [185], 'Taken': [186], 'together,': [187], 'findings': [189], 'this': [191], 'study': [192], 'provide': [193], 'vivo': [195], 'support': [196], 'hypothesis': [199], 'SpeB-mediated': [201], 'inactivation': [202], 'surface': [208], 'represents': [209], 'a': [210], 'resistance': [212], 'mechanism': [213], 'infected': [216], 'site': [218], 'patients': [220], 'infections.': [225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2149143432', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2025-01-12T19:11:34.079903', 'created_date': '2016-06-24'}