Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2148876129', 'doi': 'https://doi.org/10.2174/187231210792928251', 'title': 'P-Glycoprotein, but not Multidrug Resistance Protein 4, Plays a Role in the Systemic Clearance of Irinotecan and SN-38 in Mice', 'display_name': 'P-Glycoprotein, but not Multidrug Resistance Protein 4, Plays a Role in the Systemic Clearance of Irinotecan and SN-38 in Mice', 'publication_year': 2010, 'publication_date': '2010-09-30', 'ids': {'openalex': 'https://openalex.org/W2148876129', 'doi': 'https://doi.org/10.2174/187231210792928251', 'mag': '2148876129', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20583968', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4486004'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/187231210792928251', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S51092485', 'display_name': 'Drug Metabolism Letters', 'issn_l': '1872-3128', 'issn': ['1872-3128', '1874-0758'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://ri.conicet.gov.ar/bitstream/11336/189193/2/CONICET_Digital_Nro.54d5484c-91a6-4cb8-92eb-ea9aa77251a9_B.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026099902', 'display_name': 'Michael Tagen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Tagen', 'raw_affiliation_strings': ["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037777681', 'display_name': 'Yanli Zhuang', 'orcid': 'https://orcid.org/0000-0003-4700-5207'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yanli Zhuang', 'raw_affiliation_strings': ["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100403486', 'display_name': 'Fan Zhang', 'orcid': 'https://orcid.org/0000-0002-6257-8911'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fan Zhang', 'raw_affiliation_strings': ["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078084633', 'display_name': 'K. Elaine Harstead', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K. Elaine Harstead', 'raw_affiliation_strings': ["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062351846', 'display_name': 'Jun Shen', 'orcid': 'https://orcid.org/0000-0002-8319-8213'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jun Shen', 'raw_affiliation_strings': ["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053462540', 'display_name': 'Paula Schaiquevich', 'orcid': 'https://orcid.org/0000-0002-2568-4731'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paula Schaiquevich', 'raw_affiliation_strings': ["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031725346', 'display_name': 'Charles H. Fraga', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles H. Fraga', 'raw_affiliation_strings': ["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039997334', 'display_name': 'John C. Panetta', 'orcid': 'https://orcid.org/0000-0003-1308-7208'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John C. Panetta', 'raw_affiliation_strings': ["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077126677', 'display_name': 'Christopher M. Waters', 'orcid': 'https://orcid.org/0000-0002-6706-1284'}, 'institutions': [{'id': 'https://openalex.org/I160606119', 'display_name': 'University of Tennessee Health Science Center', 'ror': 'https://ror.org/0011qv509', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I160606119']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher M. Waters', 'raw_affiliation_strings': ['Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA', 'institution_ids': ['https://openalex.org/I160606119']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043293908', 'display_name': 'Clinton F. Stewart', 'orcid': 'https://orcid.org/0000-0002-1546-9720'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Clinton F. Stewart', 'raw_affiliation_strings': ["Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;"], 'affiliations': [{'raw_affiliation_string': "Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA;", 'institution_ids': ['https://openalex.org/I1313298211']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5043293908'], 'corresponding_institution_ids': ['https://openalex.org/I1313298211'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.813, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 31, 'citation_normalized_percentile': {'value': 0.886364, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '4', 'issue': '4', 'first_page': '195', 'last_page': '201'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Antibiotics Pharmacokinetics and Efficacy', 'score': 0.9891, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/p-glycoprotein', 'display_name': 'P-glycoprotein', 'score': 0.8009454}], 'concepts': [{'id': 'https://openalex.org/C2778707650', 'wikidata': 'https://www.wikidata.org/wiki/Q412902', 'display_name': 'P-glycoprotein', 'level': 4, 'score': 0.8009454}, {'id': 'https://openalex.org/C133936738', 'wikidata': 'https://www.wikidata.org/wiki/Q643839', 'display_name': 'Multiple drug resistance', 'level': 3, 'score': 0.769521}, {'id': 'https://openalex.org/C2780259306', 'wikidata': 'https://www.wikidata.org/wiki/Q412197', 'display_name': 'Irinotecan', 'level': 4, 'score': 0.7660852}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.49408773}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43392128}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.38325286}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3422559}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32228744}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24397194}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.11716437}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.10779187}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018435', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D027425', 'descriptor_name': 'Multidrug Resistance-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018435', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018435', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D018435', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000097202', 'descriptor_name': 'ATP-Binding Cassette Sub-Family B Member 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D001711', 'descriptor_name': 'Biotransformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002264', 'descriptor_name': 'Carboxylic Acids', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D002264', 'descriptor_name': 'Carboxylic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007275', 'descriptor_name': 'Injections, Intravenous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077146', 'descriptor_name': 'Irinotecan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007783', 'descriptor_name': 'Lactones', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007783', 'descriptor_name': 'Lactones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057507', 'descriptor_name': 'Mice, 129 Strain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027425', 'descriptor_name': 'Multidrug Resistance-Associated Proteins', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D027425', 'descriptor_name': 'Multidrug Resistance-Associated Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D027425', 'descriptor_name': 'Multidrug Resistance-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/187231210792928251', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S51092485', 'display_name': 'Drug Metabolism Letters', 'issn_l': '1872-3128', 'issn': ['1872-3128', '1874-0758'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11336/189193', 'pdf_url': 'https://ri.conicet.gov.ar/bitstream/11336/189193/2/CONICET_Digital_Nro.54d5484c-91a6-4cb8-92eb-ea9aa77251a9_B.pdf', 'source': {'id': 'https://openalex.org/S4306402455', 'display_name': 'CONICET Digital (CONICET)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210148385', 'host_organization_name': 'Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I4210148385'], 'host_organization_lineage_names': ['Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4486004', 'pdf_url': 'https://europepmc.org/articles/pmc4486004?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20583968', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11336/189193', 'pdf_url': 'https://ri.conicet.gov.ar/bitstream/11336/189193/2/CONICET_Digital_Nro.54d5484c-91a6-4cb8-92eb-ea9aa77251a9_B.pdf', 'source': {'id': 'https://openalex.org/S4306402455', 'display_name': 'CONICET Digital (CONICET)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210148385', 'host_organization_name': 'Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I4210148385'], 'host_organization_lineage_names': ['Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1480944850', 'https://openalex.org/W1502025781', 'https://openalex.org/W1669653647', 'https://openalex.org/W1777256341', 'https://openalex.org/W185482115', 'https://openalex.org/W1985349868', 'https://openalex.org/W1987705191', 'https://openalex.org/W2006587976', 'https://openalex.org/W2068224783', 'https://openalex.org/W2070972281', 'https://openalex.org/W2076260569', 'https://openalex.org/W2079216966', 'https://openalex.org/W2084632548', 'https://openalex.org/W2090632754', 'https://openalex.org/W2091408415', 'https://openalex.org/W2100917151', 'https://openalex.org/W2103238639', 'https://openalex.org/W2106762675', 'https://openalex.org/W2108208897', 'https://openalex.org/W2111700580', 'https://openalex.org/W2118644245', 'https://openalex.org/W2120056936', 'https://openalex.org/W2120082193', 'https://openalex.org/W2120892494', 'https://openalex.org/W2121451528', 'https://openalex.org/W2154035281', 'https://openalex.org/W2156094398', 'https://openalex.org/W2157505013', 'https://openalex.org/W2160320288', 'https://openalex.org/W2166153381', 'https://openalex.org/W4234047354'], 'related_works': ['https://openalex.org/W4226166860', 'https://openalex.org/W3028060764', 'https://openalex.org/W2950442272', 'https://openalex.org/W2497337421', 'https://openalex.org/W2382225335', 'https://openalex.org/W2091807474', 'https://openalex.org/W2074950338', 'https://openalex.org/W2031866272', 'https://openalex.org/W2016114543', 'https://openalex.org/W1999906254'], 'abstract_inverted_index': {'The': [0], 'ATP-binding': [1], 'cassette': [2], 'transporters': [3], 'P-glycoprotein': [4], '(ABCB1,': [5], 'MDR1)': [6], 'and': [7, 15, 22, 34, 44, 53, 56, 60, 81, 88, 113, 136], 'multidrug': [8], 'resistance': [9], 'protein': [10], '4': [11], '(MRP4)': [12], 'efflux': [13], 'irinotecan': [14, 79, 86, 109, 111, 135, 144], 'its': [16], 'active': [17], 'metabolite': [18], 'SN-38': [19, 54, 82, 89, 137, 146], 'in': [20, 99, 117, 134], 'vitro,': [21], 'thus': [23], 'may': [24], 'contribute': [25], 'to': [26, 85, 103, 122], 'system': [27], 'clearance': [28, 76], 'of': [29, 77, 108], 'these': [30], 'compounds.': [31], 'Mdr1a/b-/-,': [32], 'Mrp4-/-,': [33], 'wild-type': [35, 104, 124], 'mice': [36, 101, 119], 'were': [37, 47, 58, 62, 96, 120], 'administered': [38], '20': [39], 'or': [40, 145], '40': [41, 93], 'mg/kg': [42, 94], 'irinotecan,': [43], 'plasma': [45, 147], 'samples': [46], 'collected': [48], 'for': [49, 74], '6': [50], 'hours.': [51], 'Irinotecan': [52], 'lactone': [55, 80, 87, 90, 116], 'carboxylate': [57], 'quantitated': [59], 'data': [61], 'analyzed': [63], 'with': [64], 'nonlinear': [65], 'mixed-effects': [66], 'modeling.': [67], 'Mdr1a/b': [68], 'genotype': [69], 'was': [70], 'a': [71, 92, 132], 'significant': [72], 'covariate': [73], 'the': [75, 123], 'both': [78], 'lactone.': [83], 'Exposures': [84], 'after': [91], 'dose': [95], '1.6-fold': [97], 'higher': [98], 'Mdr1a/b-/-': [100], 'compared': [102], 'mice.': [105], 'Plasma': [106], 'concentrations': [107], 'lactone,': [110], 'carboxylate,': [112], 'SN-': [114], '38': [115], 'Mrp4-/-': [118], 'similar': [121], 'controls.': [125], 'These': [126], 'results': [127], 'suggest': [128], 'that': [129], 'P-gp': [130], 'plays': [131], 'role': [133], 'elimination,': [138], 'but': [139], 'Mrp4': [140], 'does': [141], 'not': [142], 'affect': [143], 'pharmacokinetics.': [148]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2148876129', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-16T00:11:19.615784', 'created_date': '2016-06-24'}