Title: Expression of multidrug resistance (P‐glycoprotein) gene in liver cancers
Abstract: Abstract Hepatocellular carcinomas have been known to exhibit a poor response to chemotherapeutic agents. However, the mechanism for drug resistance is unknown. Recent studies have demonstrated that expression of a group of membrane proteins known as P‐glycoproteins (P‐gp) or multidrug transporters encoded by multidrug‐resistance ( MDR ) or P‐glycoprotein gene family is correlated with a poor clinical prognosis for particular non‐responsive neoplasms. The possible involvement of MDR gene expression with the intrinsic poor response to chemotherapeutic agents is discussed.
Publication Year: 1993
Publication Date: 1993-01-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot