Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2147166694', 'doi': 'https://doi.org/10.1158/0008-5472.can-11-0532', 'title': 'Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors', 'display_name': 'Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors', 'publication_year': 2011, 'publication_date': '2011-08-26', 'ids': {'openalex': 'https://openalex.org/W2147166694', 'doi': 'https://doi.org/10.1158/0008-5472.can-11-0532', 'mag': '2147166694', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21868758', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3209585'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-11-0532', 'pdf_url': 'https://aacrjournals.org/cancerres/article-pdf/71/20/6503/2656658/6503.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://aacrjournals.org/cancerres/article-pdf/71/20/6503/2656658/6503.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5050848129', 'display_name': 'Changmeng Cai', 'orcid': 'https://orcid.org/0000-0002-8701-2586'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Changmeng Cai', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1316535847', 'https://openalex.org/I136199984', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100658278', 'display_name': 'Sen Chen', 'orcid': 'https://orcid.org/0000-0002-5872-2597'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sen Chen', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1316535847', 'https://openalex.org/I136199984', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085472051', 'display_name': 'Patrick Kwok‐Shing Ng', 'orcid': 'https://orcid.org/0000-0003-0364-7443'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrick Ng', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1316535847', 'https://openalex.org/I136199984', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043769628', 'display_name': 'Glenn J. Bubley', 'orcid': 'https://orcid.org/0000-0002-3062-643X'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Glenn J. Bubley', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1316535847', 'https://openalex.org/I136199984', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067800417', 'display_name': 'Peter S. Nelson', 'orcid': 'https://orcid.org/0000-0002-5451-5726'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter S. Nelson', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1316535847', 'https://openalex.org/I136199984', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071509387', 'display_name': 'Elahe A. Mostaghel', 'orcid': 'https://orcid.org/0000-0001-8169-8743'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elahe A. Mostaghel', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1316535847', 'https://openalex.org/I136199984', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028428149', 'display_name': 'Brett T. Marck', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brett Marck', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1316535847', 'https://openalex.org/I136199984', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052592209', 'display_name': 'Alvin M. Matsumoto', 'orcid': 'https://orcid.org/0000-0002-6506-8650'}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}, {'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alvin M. Matsumoto', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I4210089486', 'https://openalex.org/I136199984', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033450748', 'display_name': 'Nicholas I. Simon', 'orcid': 'https://orcid.org/0000-0003-1259-9201'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicholas I. Simon', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1316535847', 'https://openalex.org/I201448701', 'https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101635645', 'display_name': 'Hongyun Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}, {'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hongyun Wang', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I201448701', 'https://openalex.org/I4210089486', 'https://openalex.org/I136199984']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066896225', 'display_name': 'Shaoyong Chen', 'orcid': 'https://orcid.org/0000-0003-0809-8383'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}, {'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shaoyong Chen', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I201448701', 'https://openalex.org/I4210089486', 'https://openalex.org/I1316535847']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087350413', 'display_name': 'Steven P. Balk', 'orcid': 'https://orcid.org/0000-0002-4546-7371'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven P. Balk', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 2Fred Hutchinson Cancer Research Center, University of Washington; and 3Department of Medicine, University of Washington School of Medicine, Seattle, Washington", 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1316535847', 'https://openalex.org/I136199984', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Department of Medicine, University of Washington School of Medicine, Seattle, Washington', 'institution_ids': ['https://openalex.org/I201448701']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 38.173, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 413, 'citation_normalized_percentile': {'value': 0.999969, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '71', 'issue': '20', 'first_page': '6503', 'last_page': '6513'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyp17a1', 'display_name': 'CYP17A1', 'score': 0.988058}], 'concepts': [{'id': 'https://openalex.org/C142716871', 'wikidata': 'https://www.wikidata.org/wiki/Q408305', 'display_name': 'CYP17A1', 'level': 3, 'score': 0.988058}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.81161565}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.64129204}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.5899655}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.56575567}, {'id': 'https://openalex.org/C2779279991', 'wikidata': 'https://www.wikidata.org/wiki/Q6058681', 'display_name': 'Testosterone (patch)', 'level': 2, 'score': 0.54238683}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.51269615}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.50003195}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48057508}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.47389546}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.38548243}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32869798}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.15197605}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.056398153}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.046553046}], 'mesh': [{'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011284', 'descriptor_name': 'Pregnenolone', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D011374', 'descriptor_name': 'Progesterone', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000735', 'descriptor_name': 'Androstenedione', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000735', 'descriptor_name': 'Androstenedione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000736', 'descriptor_name': 'Androstenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000737', 'descriptor_name': 'Androstenols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000737', 'descriptor_name': 'Androstenols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002277', 'descriptor_name': 'Carcinoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003687', 'descriptor_name': 'Dehydroepiandrosterone', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D003687', 'descriptor_name': 'Dehydroepiandrosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007213', 'descriptor_name': 'Indomethacin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007213', 'descriptor_name': 'Indomethacin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009919', 'descriptor_name': 'Orchiectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011284', 'descriptor_name': 'Pregnenolone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011374', 'descriptor_name': 'Progesterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-11-0532', 'pdf_url': 'https://aacrjournals.org/cancerres/article-pdf/71/20/6503/2656658/6503.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3209585', 'pdf_url': 'https://europepmc.org/articles/pmc3209585?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209585', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22388436', 'pdf_url': 'https://aacr.figshare.com/ndownloader/files/39833919', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21868758', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-11-0532', 'pdf_url': 'https://aacrjournals.org/cancerres/article-pdf/71/20/6503/2656658/6503.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.71, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1816722347', 'https://openalex.org/W1973165542', 'https://openalex.org/W1975609403', 'https://openalex.org/W1992166168', 'https://openalex.org/W2008145170', 'https://openalex.org/W2011974240', 'https://openalex.org/W2014476883', 'https://openalex.org/W2021181403', 'https://openalex.org/W2023007598', 'https://openalex.org/W2024304133', 'https://openalex.org/W2041880296', 'https://openalex.org/W2066570340', 'https://openalex.org/W2067890225', 'https://openalex.org/W2075379080', 'https://openalex.org/W2077301757', 'https://openalex.org/W2081365151', 'https://openalex.org/W2083926838', 'https://openalex.org/W2085847636', 'https://openalex.org/W2092172518', 'https://openalex.org/W2097226696', 'https://openalex.org/W2099477169', 'https://openalex.org/W2101605468', 'https://openalex.org/W2109785424', 'https://openalex.org/W2116458141', 'https://openalex.org/W2119409615', 'https://openalex.org/W2133328863', 'https://openalex.org/W2133489902', 'https://openalex.org/W2134256060', 'https://openalex.org/W2137996608', 'https://openalex.org/W2140855177', 'https://openalex.org/W2141569270', 'https://openalex.org/W2144509773', 'https://openalex.org/W2149131962', 'https://openalex.org/W2150609534', 'https://openalex.org/W2155279970', 'https://openalex.org/W2166912270', 'https://openalex.org/W2167749314', 'https://openalex.org/W2340799873', 'https://openalex.org/W2411839432', 'https://openalex.org/W2417873292'], 'related_works': ['https://openalex.org/W3009569511', 'https://openalex.org/W2365928272', 'https://openalex.org/W2327862400', 'https://openalex.org/W2169608764', 'https://openalex.org/W2104364640', 'https://openalex.org/W2095348706', 'https://openalex.org/W2051020921', 'https://openalex.org/W2033566079', 'https://openalex.org/W2012986564', 'https://openalex.org/W1967664125'], 'abstract_inverted_index': {'Relapse': [0], 'of': [1, 12, 21, 36, 63, 86, 133, 143, 151, 160, 168], 'castration-resistant': [2, 116], 'prostate': [3, 14], 'cancer': [4, 15], '(CRPC)': [5], 'that': [6, 72, 112, 130, 165, 186, 201, 223, 238], 'occurs': [7], 'after': [8, 179], 'androgen': [9, 23, 92, 127], 'deprivation': [10], 'therapy': [11], 'primary': [13], 'can': [16, 120, 239], 'be': [17, 108, 121], 'mediated': [18, 212], 'by': [19, 56, 213], 'reactivation': [20, 32], 'the': [22, 37, 45, 57, 60, 64, 84, 99, 157], 'receptor': [24], '(AR).': [25], 'One': [26], 'important': [27], 'mechanism': [28, 148], 'mediating': [29], 'this': [30, 161], 'AR': [31, 46, 113, 195, 202], 'is': [33, 207], 'intratumoral': [34, 87, 141, 166, 244], 'conversion': [35], 'weak': [38], 'adrenal': [39], 'androgens': [40], 'DHEA': [41, 51], 'and': [42, 49, 52, 69, 89, 98, 129, 211, 233], 'androstenedione': [43, 53], 'into': [44], 'ligands': [47], 'testosterone': [48], 'dihydrotestosterone.': [50], 'are': [54, 78, 196], 'synthesized': [55], 'adrenals': [58], 'through': [59, 123], 'sequential': [61], 'actions': [62], 'cytochrome': [65], 'P450': [66], 'enzymes': [67], 'CYP11A1': [68], 'CYP17A1,': [70, 144], 'so': [71], 'CYP17A1': [73, 88, 103, 154, 169, 180, 198, 227], 'inhibitors': [74], 'such': [75], 'as': [76], 'abiraterone': [77, 131], 'effective': [79], 'therapies': [80, 237], 'for': [81, 139, 149], 'CRPC.': [82], 'However,': [83], 'significance': [85], 'de': [90, 125, 242], 'novo': [91, 126, 243], 'synthesis': [93], 'from': [94, 176], 'cholesterol': [95], 'in': [96, 115, 173, 204], 'CRPC,': [97], 'mechanisms': [100], 'contributing': [101], 'to': [102, 107, 153, 226, 236], 'inhibitor': [104, 181], 'resistance/relapse,': [105], 'remain': [106, 230], 'determined.': [109], 'We': [110, 183], 'report': [111], 'activity': [114, 203], 'VCaP': [117], 'tumor': [118, 174], 'xenografts': [119, 135], 'restored': [122], 'CYP17A1-dependent': [124], 'synthesis,': [128], 'treatment': [132], 'these': [134, 205], 'imposes': [136], 'selective': [137], 'pressure': [138], 'increased': [140, 172], 'expression': [142, 167], 'thereby': [145], 'generating': [146], 'a': [147, 190], 'development': [150], 'resistance': [152], 'inhibitors.': [155], 'Supporting': [156], 'clinical': [158], 'relevance': [159], 'mechanism,': [162], 'we': [163], 'found': [164], 'was': [170], 'markedly': [171], 'biopsies': [175], 'CRPC': [177, 187], 'patients': [178], 'therapy.': [182], 'further': [184, 240], 'show': [185], 'cells': [188, 206], 'expressing': [189], 'progesterone': [191], 'responsive': [192, 235], 'T877A': [193], 'mutant': [194], 'not': [197], 'dependent,': [199], 'but': [200], 'still': [208], 'steroid': [209, 231, 245], 'dependent': [210, 232], 'upstream': [214], 'CYP11A1-dependent': [215], 'intraturmoral': [216], 'pregnenolone/progesterone': [217], 'synthesis.': [218, 246], 'Together,': [219], 'our': [220], 'results': [221], 'indicate': [222], 'CRPCs': [224], 'resistant': [225], 'inhibition': [228], 'may': [229], 'therefore': [234], 'suppress': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2147166694', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 18}, {'year': 2022, 'cited_by_count': 28}, {'year': 2021, 'cited_by_count': 33}, {'year': 2020, 'cited_by_count': 23}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 30}, {'year': 2017, 'cited_by_count': 27}, {'year': 2016, 'cited_by_count': 38}, {'year': 2015, 'cited_by_count': 40}, {'year': 2014, 'cited_by_count': 61}, {'year': 2013, 'cited_by_count': 52}, {'year': 2012, 'cited_by_count': 35}], 'updated_date': '2024-12-13T18:04:23.221628', 'created_date': '2016-06-24'}