Publication Information

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2192, 2200, 2205, 2256, 2277, 2401, 2541, 2568, 2649, 2664, 2736, 2747, 2764, 2814, 2938, 2989, 2993, 3035, 3064, 3080, 3100, 3142, 3323, 3365], 'favoritesDownload': [19], 'citationsTrack': [20], 'citationsPermissions': [21], 'ShareShare': [22], 'onFacebookTwitterLinked': [23], 'InMendeleyReddit': [24], 'Jump': [25], 'toFree': [26], 'ArticlePDF/EPUBRole': [28], 'Eiki': [37, 43], 'Takimoto': [38, 45], 'David': [40, 61, 3143], 'A.': [41, 62, 64, 3144, 3296], 'Kass': [42, 65, 3563, 3612], 'TakimotoEiki': [44], 'From': [46, 66], 'the': [47, 67, 91, 146, 267, 352, 357, 382, 509, 657, 688, 765, 896, 934, 1003, 1047, 1067, 1226, 1258, 1315, 1342, 1345, 1364, 1436, 1443, 1464, 1486, 1504, 1577, 1616, 1639, 1725, 1735, 1739, 1792, 1797, 1827, 1857, 1865, 1907, 1919, 1939, 1953, 1958, 1983, 1988, 2016, 2044, 2169, 2321, 2346, 2420, 2430, 2503, 2513, 2618, 2635, 2666, 2681, 2820, 2906, 2966, 2969, 3012, 3044, 3085, 3121, 3169, 3171, 3174, 3248, 3434, 3469, 3519, 3538, 3691, 3741, 3792], 'Division': [48, 68], 'Cardiology,': [50, 70], 'Department': [51, 71], 'Medicine,': [53, 73], 'Johns': [54, 74, 3151], 'Hopkins': [55, 75, 3152], 'Medical': [56, 76, 3153], 'Institutions,': [57, 77, 3154], 'Baltimore,': [58, 78, 3155], 'Md.': [59, 79], 'KassDavid': [63], 'Originally': [80], 'published26': [81], 'Dec': [82], '2006https://doi.org/10.1161/01.HYP.0000254415.31362.a7Hypertension.': [83], '2007;49:241–248Other': [84], 'version(s)': [85], 'this': [87, 96, 139, 177, 259, 562, 1096, 1171, 1195, 1305, 1337, 2115, 2304, 2449, 2884, 3032, 3102], 'articleYou': [88], 'are': [89, 188, 388, 722, 864, 914, 922, 1308, 1913, 1963, 1982, 2537, 2972, 3073, 3077], 'viewing': [90], 'most': [92, 1631], 'recent': [93, 263, 1093, 1872, 2893], 'version': [94], 'article.': [97], 'Previous': [98, 103], 'versions:': [99], 'December': [100], '26,': [101], '2006:': [102], 'Version': [104], '1': [105, 1764, 3162], 'adaptation': [107], 'response': [109, 128, 702, 978, 2068, 2255], 'intrinsic': [111, 196, 426, 2659, 2863, 3056], 'or': [112, 256, 334, 982, 1081, 1267, 1390, 1393, 1398, 1684, 1825, 2371, 2417, 2671, 2708, 2960, 3054], 'external': [113], 'stress': [114, 132, 180, 271, 849, 1182, 1392, 1665, 2315, 2592, 2788, 2813, 2904, 3196, 3226, 3317, 3395, 3473, 3658], 'involves': [115], 'a': [116, 219, 227, 392, 406, 495, 581, 672, 780, 1089, 1311, 1348, 1371, 1411, 1460, 1558, 1647, 1700, 1837, 1890, 1923, 1970, 2083, 2202, 2318, 2393, 2583, 2694, 2766, 2774, 2850, 2899, 3310, 3491, 3752, 3788], 'complex': [117], 'process': [118, 563], 'chamber': [120, 136, 413, 612, 1156, 1479], 'remodeling': [121, 613, 961, 976, 1101, 1466, 2266, 2464, 2631, 2911], 'myocyte': [123, 533, 1158], 'molecular': [124, 1418, 1950], 'modifications.': [125], 'A': [126, 1077, 2722, 2845, 2890], 'fundamental': [127], 'increased': [130, 573, 1582, 1589, 2182, 2439, 2478, 2810], 'biomechanical': [131], 'is': [133, 218, 321, 466, 499, 554, 564, 585, 713, 955, 992, 1223, 1229, 1325, 1355, 1375, 1557, 1564, 1608, 1625, 1661, 1712, 1852, 1900, 2219, 2773, 2829], 'cardiomyocyte': [134, 2740], 'hypertrophy.': [137, 2096, 3476, 3921], 'Although': [138, 1854, 2921], 'may': [140, 1550, 1703, 1789, 2047, 2109, 2299, 2976, 3033, 3058], 'provide': [141, 1232, 3060], 'initial': [142, 1663, 2595], 'salutary': [143], 'compensation': [144], 'stress,': [147, 1262, 2240, 3048, 3413], 'sustained': [148, 1138], 'hypertrophic': [149, 757, 960, 1167, 1239, 2275, 2770, 2910, 2957, 3810], 'stimulation': [150, 758], 'becomes': [151, 1401], 'maladaptive,': [152], 'worsening': [153, 1603], 'morbidity': [154], 'mortality': [156], 'risks': [157], 'because': [158, 1584, 1893], 'congestive': [160, 2995, 3230], 'heart': [161, 2026, 2128, 2143, 2325, 2342, 2350, 2490, 2559, 2669, 2691, 2958, 2961, 2996, 3199, 3231, 3250, 3308, 3324, 3366, 3416, 3470, 3663], 'failure': [162, 2129, 2144, 2326, 2351, 2543, 2560, 2670, 2692, 2997, 3200, 3367], 'sudden': [164], 'death.1': [165], 'Growing': [166], 'evidence': [167, 265, 1094], 'highlights': [168], 'oxidative': [169, 223, 349, 768, 1062, 1389, 1491, 1545, 2239, 2591, 2787, 2812, 2825, 2842, 3047, 3195, 3225, 3394, 3412, 3472], 'nitrosative': [171, 1064, 1181, 1391], 'stresses': [172], 'as': [173, 211, 291, 300, 437, 448, 494, 620, 1130, 1351, 1353, 1370, 1410, 1833, 1978, 1997, 2049, 2280, 2729, 2945, 3050], 'important': [174, 501, 752, 957, 2868], 'mechanisms': [175, 658, 1457, 1641, 1788], 'for': [176, 266, 376, 649, 715, 1327, 1357, 2052, 2585, 2869, 3104, 3313, 3578, 3754], 'maladaptation.2–9': [178], 'occurs': [181, 1005, 1946], 'when': [182, 1394], 'excess': [183], 'reactive': [184, 208, 359, 502, 582, 3816], 'oxygen': [185, 1419, 1951, 3430, 3817, 3915], 'species': [186, 583, 3818, 3916], '(ROS)': [187], 'generated': [189, 1515, 1634, 1748, 2195], 'that': [190, 304, 429, 584, 640, 1455, 1511, 1549, 1573, 1606, 1662, 1830, 1849, 1875, 1916, 2218, 2310, 2413, 2458, 2502], 'cannot': [191], 'be': [192, 306, 647, 1870, 2300, 2582], 'adequately': [193], 'countered': [194], 'by': [195, 326, 469, 514, 556, 659, 759, 810, 925, 1026, 1146, 1173, 1497, 1499, 1516, 1566, 1635, 1657, 1743, 1757, 1816, 1826, 1842, 1903, 2168, 2196, 2452, 2789, 2794, 2831, 3125, 3720, 3748, 3759, 3815, 3847], 'antioxidant': [197, 379, 427, 489, 2683, 2731, 2758, 2864], 'systems.': [198], 'Superoxide': [199, 459], 'anion': [200, 3785], '(O2−)': [201, 293, 1666], 'can': [202, 250, 305, 355, 618, 1198, 1271, 1716, 1814, 2033, 2149, 2179, 2581, 2605, 2727, 3019], 'further': [203, 467, 2653], 'combine': [204], 'with': [205, 541, 576, 724, 930, 1066, 1175, 1481, 1503, 1535, 1581, 1615, 1682, 1845, 2236, 2284, 2355, 2373, 2403, 2572, 2680, 2716, 2796, 2809, 3229, 3307], 'NO,': [206], 'forming': [207], 'compounds': [209, 298], 'such': [210, 290, 299, 436, 447, 1129, 1996, 2944, 3049], 'peroxynitrite,': [212, 580, 1179], 'generating': [213, 2422], 'nitroso-redox': [214], 'imbalance.4': [215], 'ROS': [216, 239, 377, 387, 431, 650, 661, 670, 748, 773, 824, 926, 938, 1000, 1021, 1079, 1169, 1280, 1512, 1583, 1633, 1694, 1727, 2028, 2055, 2476, 2514, 2533, 2611, 2639, 2791], 'generation': [217, 240, 374, 1695], 'normal': [220, 230, 315, 395, 632, 641, 1219, 1290], 'component': [221], 'phosphorylation': [224, 350, 3846], 'plays': [226, 2593], 'role': [228, 268, 393, 407, 753, 1462, 1785, 1863, 2084, 2204, 2319, 2596, 2637, 2768, 2851, 2901, 3312, 3577], 'redox': [231, 3271, 3688], 'control': [232], 'physiological': [234, 559], 'signaling': [235, 677, 778, 790, 805, 821, 878, 970, 1019, 2248, 2508, 2798, 3813], 'pathways.5,8,9': [236], 'However,': [237, 2269, 2634, 2951, 3008], 'excessive': [238], 'triggers': [241], 'cell': [242, 254, 963, 1628, 3687, 3695, 3779], 'dysfunction,': [243, 2913], 'lipid': [244, 595, 2874], 'peroxidation,': [245, 596], 'DNA': [247, 1011, 2600, 2624], 'mutagenesis': [248], 'lead': [251], 'irreversible': [253], 'damage': [255, 1014, 2625], 'death.5,8,9': [257], 'In': [258, 682, 1134, 1194, 1257, 1304, 1677, 2225], 'review,': [260], 'we': [261], 'discuss': [262], 'experimental': [264, 2307, 2554, 2674, 2895, 3092], 'oxidant': [270, 1261, 1664, 2314, 3316], 'on': [272, 276, 895, 1046, 1236, 1791, 1856, 2099, 3005, 3690, 3791], 'cardiac': [273, 396, 826, 900, 1116, 1214, 1244, 1288, 1604, 2067, 2208, 2216, 2289, 2384, 2434, 2446, 2466, 2542, 2687, 2712, 2807, 2858, 2909, 2979, 3066, 3274, 3475, 3820, 3851, 3884, 3920], 'remodeling,': [274, 410, 666], 'focusing': [275], 'pressure-': [277], 'overload–induced': [278], 'hypertrophy': [279, 676, 808, 827, 1117, 1159, 1215, 1237, 2020, 2217, 2644, 2672, 2713, 2745, 2808, 2823, 3398], 'dilation.ROS,': [281], 'Antioxidant': [282], 'Enzymes,': [283], 'Nitroso-Redox': [285], 'BalanceROS': [286], 'include': [287, 434, 831, 1010], 'free': [288], 'radicals': [289], 'superoxide': [292, 417, 442, 2399, 2421, 2442, 3784], 'hydroxyl': [295, 360], 'radical': [296, 361, 3356], 'hydrogen': [301], 'peroxide': [302, 3873], '(H2O2)': [303], 'converted': [307, 468], 'radicals,': [309], 'they': [311, 2484], 'participate': [312], 'both': [314, 973, 1567], 'pathologic': [317, 1100, 1287], 'biochemical': [318], 'reactions.9': [319], 'O2−': [320, 462, 557, 574, 1200, 1426, 1719, 2185], 'formed': [322], 'intracellularly': [323], '(Figure': [324, 1102, 1911, 2327, 2860], '1)': [325], 'activation': [327, 605, 624, 728, 1016, 1153, 1882, 2245, 3842], 'nicotinamide-adenine': [329], 'dinucleotide': [330], 'phosphate': [331], '(NADPH)': [332], 'oxidase': [333, 336, 1365, 1669, 1689, 1991, 2009, 2198, 2233, 2756, 3719, 3758], 'xanthine': [335, 2423, 2440, 3696, 3718], '(XO),': [337], 'uncoupling': [338, 1212, 1553, 1645, 1709, 2036], 'NO': [340, 507, 538, 577, 617, 642, 1107, 1176, 1185, 1282, 1297, 2404, 2487, 2507], 'synthase': [341], '(NOS),': [342], 'electron': [344, 1330, 2569, 2576], 'transport': [345, 2577], '"leakage"': [347], 'during': [348, 2015], 'mitochondria.5,8,9': [353], 'H2O2': [354, 686, 721, 2871], 'generate': [356, 1199, 1275], 'highly': [358], 'via': [362, 543, 1120, 3787], 'Fenton': [363], 'chemistry': [364], 'under': [365], 'pathological': [366], 'conditions.9Download': [367], 'figureDownload': [368, 817, 1204, 2058], 'PowerPointFigure': [369, 818, 1205, 2059], '1.': [370], 'General': [371], 'schematic': [372], 'pathways': [375, 822, 2293, 2759, 3814], 'systems': [380, 428], 'heart.': [383], 'Low': [384, 718], 'levels': [385, 404, 568, 638, 719, 734, 998, 1651, 1756, 2477, 2488, 3298, 3358], 'thought': [389, 1230], 'play': [391, 405, 750, 1459, 2082, 2201, 2317, 2849], 'signaling,': [397, 1128, 1240], 'growth': [398], 'adaptations,': [399], 'matrix': [401, 607, 665, 911], 'changes.': [402], 'Higher': [403], 'pathophysiologic': [409], 'apoptosis,': [411], 'dysfunction.': [414, 669, 1245], 'SOD': [415], 'indicates': [416, 869, 1247], 'dismutase;': [418], 'GPX,': [419], 'glutathione': [420, 439, 472, 2866], 'peroxidase;': [421], 'TRX,': [422], 'thioredoxin.Cells': [423], 'also': [424, 539, 749, 774, 891, 939, 1458, 2263, 2316, 2377, 2538, 2550, 2726, 2877], 'have': [425, 892, 1588, 1867, 2105, 2230, 2336, 2549, 2661, 2760, 2927, 2936, 2954], 'counter': [430], 'accumulation.': [432], 'These': [433], 'enzymes': [435, 1915], 'catalase,': [438], 'peroxidases,': [440], 'dismutase,': [443], 'nonenzymatic': [445], 'antioxidants,': [446, 3432], 'vitamins': [449], 'E,': [450, 3334, 3455], 'C,': [451, 697, 2155, 3451], 'beta': [452], 'carotene,': [453], 'ubiquinone,': [454], 'lipotic': [455], 'acid,': [456], 'urate.9,10': [458], 'dismutase': [460], 'converts': [461], 'H2O2,': [464, 2587], 'which': [465, 492, 660, 1113, 1627, 2971], 'catalase': [470], 'peroxidase': [473], 'water.': [475], 'The': [476, 1218, 1321, 1493, 1705, 1783, 2454, 2719, 3091], 'thioredoxin': [477, 481, 2781, 2828, 3436, 3467], 'system,': [478, 491], 'including': [479, 594], 'thioredoxin,': [480, 2780], 'reductase,': [482, 2782], 'NADPH,': [484], 'forms': [485, 3083], 'an': [486, 589, 621, 751, 918, 1233, 1329, 1718, 1834, 2594, 2700, 2730, 3777], 'additional': [487], 'integrated': [488], 'defense': [490], 'operates': [493], 'powerful': [496], 'protein–disulfide': [497], 'oxidoreductase.10–12NO': [498], 'another': [500, 956], 'molecule': [503], 'controlling': [504], 'cardiovascular': [505, 1099, 3252, 3495, 3520, 3539, 3641], 'homeostasis.': [506, 634, 3496], 'stimulates': [508, 687, 1286], 'synthesis': [510, 1841], 'intracellular': [512, 3717], 'cGMP': [513, 520, 1110, 1144], 'activating': [515, 904], 'soluble': [516, 1188], 'guanylyl': [517], 'cyclase,': [518], 'its': [522, 1052, 1379, 1862, 2089, 2147, 3070], 'target': [523], 'kinase': [524, 527, 690, 696, 703, 727, 782, 786, 882, 1151, 1253, 2833, 2854, 3841], 'cGK-1': [525], '(protein': [526], 'G': [528, 755, 1152, 2834], '1),': [529], 'turn,': [531, 1594, 1730], 'modulate': [532], 'function,': [534, 2103], 'growth,': [535, 664], 'remodeling.13': [537], 'interacts': [540, 575], 'proteins': [542, 1028], 'S-nitrosylation': [544], 'at': [545, 558, 566, 996, 1006, 1952], 'specific': [546, 2636, 3041], 'cysteine': [547, 2710], 'residues': [548], 'alter': [550], 'their': [551, 1678, 1772, 3038, 3118], 'function.14,15': [552], 'S-nitosylation': [553], 'facilitated': [555], 'levels;': [560], 'however,': [561, 2104, 2473], 'inhibited': [565, 993], 'high': [567], 'O2−.9': [570], 'As': [571, 1692], 'noted,': [572], 'form': [579, 920, 1178], 'capable': [586], 'triggering': [588], 'array': [590], 'cytotoxic': [592], 'processes,': [593], 'protein': [597, 693, 695, 699, 730, 871, 881, 1150, 1252, 1405, 1753, 1942, 2380, 2821, 3516, 3746, 3876], 'oxidation,': [598], 'nitration': [600, 3639], '(altering': [601], 'excitation–contraction': [602, 1031], 'coupling),16': [603], 'metalloproteinases': [608], '(MMPs)': [609], 'contributing': [610], '(reviewed': [614, 1033, 2544], 'References17,18).': [616], 'act': [619, 2728], 'antioxidant,': [622, 2620], 'inhibiting': [623, 2187], 'XO19,20': [626], 'NADPH': [628, 1294, 1668, 1688, 1948, 1990, 2008, 2031, 2045, 2064, 2197, 2232, 2755, 2784, 3021, 3029, 3269, 3757, 3793], 'oxidase21,22': [629], 'maintaining': [631], 'O2−/NO': [633], 'Thus,': [635, 2291], 'increasing': [636], 'peroxynitrite': [637, 3574], 'means': [639], 'bioavailability': [643], 'physiology': [645], 'would': [646], 'compromised.Mechanisms': [648], 'Stimulation': [651], 'Hypertrophy/RemodelingFigure': [654], '2': [655], 'summarizes': [656], 'stimulate': [662, 735, 775, 798, 940, 951, 1109], 'myocardial': [663, 984, 1501, 1622, 2075, 2238, 2396, 2407, 2471, 2811, 3370, 3397, 3618], 'cellular': [668, 776, 989, 1115, 2614], 'activate': [671, 2041], 'broad': [673], 'variety': [674], 'kinases': [678, 700, 744, 3517, 3877], 'transcription': [680, 861, 941], 'factors.23': [681], 'rat': [683, 3850, 3883], 'neonatal': [684, 3882], 'cardiomyocytes,': [685], 'tyrosine': [689], 'Src,': [691], 'GTP-binding': [692, 1941], 'Ras,': [694], 'mitogen-activated': [698, 870, 3875], '(extracellular': [701], 'extracellular': [705, 725, 736, 897, 1596], 'signal–regulated': [706, 726, 737], 'kinase),': [707], 'Jun-nuclear': [709, 739, 785], 'kinase.24–26': [710], 'Phosphoinositol': [711], '3-kinase': [712], 'required': [714, 1356, 1376], 'H2O2-induced': [716], 'hypertrophy.27': [717], 'associated': [723, 2235, 2571], 'synthesis,': [731, 1818], 'whereas': [732, 800, 1002, 2817, 3023], 'higher': [733, 1007], 'kinase,': [738, 740], 'p38,': [741], 'Akt': [743], 'induce': [746, 2034, 2215], 'apoptosis.28': [747], 'protein–coupled': [756], 'angiotensin': [760, 811, 842, 1998, 2072, 2206, 2213, 2257, 3016], 'II': [761, 843, 2214, 2258, 2992], 'α-adrenergic': [763, 2002], 'stimulation,29–33': [764], 'latter': [766, 1494, 1617, 1740], 'involving': [767], 'modulation': [769, 3661], 'Ras': [771], 'thiols.34': [772], 'apoptosis': [777, 804, 877, 954, 969, 2247], 'kinase-1,': [779], 'redox-sensitive': [781], 'upstream': [783], 'p38.': [788], 'Apoptosis': [789, 991], 'kinase-1': [791, 806, 971, 2249], 'overexpression': [792, 1760, 2818], 'activates': [793, 3874], 'nuclear': [794, 860, 885, 943, 2251], 'factor': [795, 886, 944, 1548, 2252], 'κB': [796, 2253], 'hypertrophy,': [799, 1534, 1847, 2087, 2113, 2242, 3275], 'genetic': [801, 1685, 2090, 3086], 'silencing': [802], 'inhibits': [807, 2627, 3782], 'induced': [809, 1149], 'II,': [812], 'norepinephrine,': [813], 'endothelin': [815], 'I.35Download': [816], '2.': [819], 'Molecular': [820], 'linking': [823], 'remodeling.': [829, 912, 1217, 2771, 3067], 'Pathways': [830], 'calcium': [832, 1058, 2166, 2188], 'channels': [833], '(ICa),': [834], 'α': [835], 'β': [837], 'adrenergic': [838], '(αAR': [839], 'βAR),': [841], '(AT1)': [844], 'receptor': [845, 1049, 2171, 3017], 'agonism,': [846], 'modification': [847, 1039], 'kinases,': [850], 'collagen': [851], 'metalloproteinases,': [853], 'sarcomeric': [854], 'excitation-contraction': [856], 'coupling': [857, 1032], 'proteins,': [858], 'factors.': [862], 'Details': [863], 'provided': [865], 'text.': [867], 'MAPK': [868], 'kinases;': [872], 'PI3K,': [873], 'phosphoinositol': [874], '3-kinase;': [875], 'Ask-1,': [876], 'kinase-1;': [879], 'PKC,': [880], 'C;': [883], 'NFκB,': [884], 'κB;': [887], 'AP-1,': [888], 'activator': [889, 948, 1879, 1897], 'protein-1.ROS': [890], 'potent': [893, 3111], 'effects': [894, 906, 3569], 'matrix,': [898, 1597], 'stimulating': [899, 1180], 'fibroblast': [901], 'proliferation36': [902], 'MMPs,37–39': [905], 'central': [907, 1029], 'fibrosis': [909, 1119, 1161, 2100, 2286], 'MMPs': [913], 'generally': [915], 'secreted': [916], 'inactive': [919], 'activated': [923, 1902], 'posttranslationally': [924], 'from': [927, 1131, 1300, 1310, 1468, 1667, 1947, 1994, 2030, 2535, 2640, 2841, 2942, 2973, 3523], 'targeted': [928, 1127], 'interactions': [929], 'critical': [931, 1041], 'cysteines': [932], 'propeptide': [935], 'autoinhibitory': [936], 'domain.40': [937], 'factors': [942], 'κB,': [945], 'Ets,': [946], 'protein-1': [949], 'MMP': [952, 1241, 1590], 'expression.38Cardiomyocyte': [953], 'contributor': [958], 'dysfunction.41': [964], 'For': [965, 1799, 2676], 'example,': [966, 1800, 2677], 'mice': [967, 1135, 2229, 2270, 2368, 2388, 2715], 'lacking': [968, 1522, 2223, 2271], 'display': [972, 2264], 'reduced': [974, 1496, 1817, 2231, 2358, 2573, 2999], 'ventricular': [975, 1600, 2361, 2530, 2630, 3319], 'pressure': [980, 1139, 1470, 1526, 1904, 2070, 2132, 2278, 2717, 2815], 'load': [981], 'after': [983, 2267, 2369, 2470, 2632, 3368], 'infarction': [985], '(MI)': [986], 'less': [988, 1539, 1544, 2244, 2265, 2285], 'apoptosis.42': [990], 'cells': [995, 1885, 2840], 'low': [997], 'stimulation,': [1001, 2073], 'opposite': [1004], 'levels.28': [1008], 'Mechanisms': [1009], 'mitochondrial': [1013, 2599, 2619, 2623], 'proapoptotic': [1018], 'kinases.Lastly,': [1020], 'directly': [1022], 'influence': [1023, 1235], 'contractile': [1024, 2102, 2173, 2193], 'function': [1025, 1097, 2385, 2467, 2603, 2688], 'modifying': [1027, 2165], 'Reference': [1035, 2546], '43).': [1036], 'This': [1037, 1278, 1430, 1563, 2564, 2590], 'includes': [1038], 'thiol': [1042, 2776], 'groups': [1043, 1045], '(-SH)': [1044], 'ryanodine': [1048, 2170], 'enhance': [1051], 'open': [1053], 'probability,44': [1054], 'suppression': [1055, 1125], 'L-type': [1057], 'channel': [1059], 'current,45': [1060], 'interaction': [1065, 1706, 2157, 2795], 'sarcoplasmic': [1068, 2431], 'reticular': [1069], 'Ca2+': [1070, 1074], 'ATPase': [1071], 'inhibit': [1073, 3025], 'uptake.46,47NOS3': [1075], 'Uncoupling:': [1076], 'Pathophysiologic': [1078], 'GeneratorNOS3,': [1080], 'endothelial': [1082, 1444, 1884, 3694, 3778], 'NOS,': [1083], 'has': [1084, 1439, 2078, 2116, 2137, 2523, 2565, 2645, 2733, 2876], 'not': [1085, 2093, 2117, 2496, 2646, 2704, 2955, 2977], 'been': [1086, 1440, 2079, 2106, 2118, 2138, 2337, 2524, 2551, 2566, 2647, 2662, 2734, 2761, 2878, 2928], 'traditionally': [1087], 'considered': [1088], 'major': [1090, 1547], 'oxidase,': [1091, 3022, 3030], 'yet': [1092, 1868, 3002], 'suggests': [1095], '3).48–51': [1103], 'NOS3': [1104, 1197, 1209, 1211, 1292, 1400, 1483, 1523, 1552, 1587, 1607, 1636, 1644, 1675, 1708, 1715, 1752, 1778, 1781, 1801, 2035], 'normally': [1105, 1369], 'generates': [1106, 1296], 'cGK-1,': [1112], 'blunt': [1114], 'transcriptional': [1121], 'regulation,': [1122], 'phosphorylation,': [1123], 'Gαq': [1132], 'stimulation.52–58': [1133], 'exposed': [1136, 1387, 1473, 1524], 'overload,': [1140, 2071, 2816], 'chronic': [1141, 1469, 2324, 2678, 3198], 'inhibition': [1142, 1164, 2148, 2748, 3755], 'hydrolysis': [1145], 'phosphodiesterase': [1147], '5A': [1148], 'attenuated': [1155], 'coupled': [1162], 'multiple': [1166], 'cascades.59': [1168], 'impede': [1170], 'regulation': [1172, 1858, 2405, 3692], 'reacting': [1174], 'reducing': [1184], 'bioactivity,': [1186], 'limiting': [1187], 'guanylate': [1189, 1249], 'cyclase': [1190], 'activity': [1191, 1992, 2010, 2136, 2335, 2522, 2574], 'expression.60': [1193], 'setting,': [1196], 'instead': [1201], 'NO.61Download': [1203], '3.': [1206], 'Involvement': [1207], '(coupled)': [1220], 'eNOS': [1221], 'pathway': [1222, 1829], 'shown': [1224, 1742, 2663, 2735], 'right': [1227, 2529], 'inhibitory': [1234], 'activation,': [1242, 1591], 'sGC': [1246], 'soluable': [1248], 'cyclase;': [1250], 'PKG,': [1251], 'G;': [1254], 'Trx,': [1255], 'thioredoxin.': [1256], 'presence': [1259], 'depletion': [1263, 1686, 1813], 'substrate': [1265], '(arginine),': [1266], 'cofactors': [1268], '(BH4),': [1269], 'NOS': [1270, 1358, 1367, 1505, 1517, 2162, 2415, 3053], 'become': [1272, 1415, 1717], 'uncoupled': [1273, 1586], 'more': [1276, 1409, 1529, 2301, 2518, 3061, 3110], 'ROS.': [1277], 'enhanced': [1279, 2806], 'diverts': [1281], '(forming': [1283], 'peroxynitirite)': [1284], 'remodeling.Under': [1289], 'conditions,': [1291], 'consumes': [1293], 'l-citrulline': [1299], 'l-arginine': [1301], 'O2.': [1303], 'process,': [1306], 'electrons': [1307, 1414], 'passed': [1309], 'reductase': [1312, 2723, 3744], 'domain': [1313, 1318], 'heme-containing': [1316], 'oxygenase': [1317], '(catalytic': [1319], 'core).': [1320], 'cofactor': [1322], 'tetrahydrobiopterin': [1323], '(BH4)': [1324], 'essential': [1326], 'donating': [1328], 'proton': [1332], 'versatile': [1334], 'intermediates': [1335], 'reaction': [1338], 'cycle.': [1339], 'Calmodulin': [1340], 'controls': [1341, 2282], 'shuttling': [1343], 'electrons,': [1346], 'zinc-thiolate': [1349], 'complex,': [1350], 'well': [1352, 3074], 'BH4,': [1354], 'dimer': [1359, 1484], 'formation': [1360, 1427, 1959], 'stability': [1362], 'domain.62,63': [1366], 'functions': [1368], 'homodimer,': [1372], 'BH4': [1374, 1397, 1561, 1569, 1574, 1650, 1671, 1683, 1711, 1722, 1732, 1755, 1767, 1776, 1812, 1840, 1850, 3068], 'maintain': [1378], '"coupled"': [1380], 'state': [1381], 'and,': [1382, 2130, 2751, 3027], 'thus,': [1383, 2043, 2752, 3028], 'synthesize': [1385], 'NO.When': [1386], 'deprived': [1395], 'l-arginine,': [1399, 1423], 'structurally': [1402], 'unstable.': [1403], 'On': [1404], 'gels,': [1406], 'it': [1407, 1624, 3097], 'appears': [1408], 'monomer,': [1412], 'diverted': [1416], 'rather': [1420, 2511], 'than': [1421, 2468, 2512], 'resulting': [1424, 1467, 1673, 1956], '(uncoupled': [1428], 'state).64–66': [1429], 'change': [1431], 'was': [1432, 1495, 1741, 2450, 2517, 2703], 'first': [1433], 'reported': [1434, 1453, 1656, 2412, 2457, 2525, 2552, 2648], 'vasculature': [1437], 'linked': [1441, 2746], 'pathophysiology': [1445, 2907], 'hypertension,': [1447], 'diabetes,': [1448], 'smoking,': [1449], 'atherosclerosis.48,50,51,67–70': [1451], 'We': [1452], 'recently': [1454], 'similar': [1456, 1701, 2274, 2846], 'key': [1461, 2203, 2900, 3492], 'adverse': [1465, 2359, 2628], 'overload.49': [1471], 'Hearts': [1472, 1580], 'trans-aortic': [1475], 'constriction': [1476], 'developed': [1477, 1528], 'marked': [1478], 'dilation': [1480], 'decreased': [1482], 'myocardium': [1487, 1866], 'elevation': [1489], 'stress.': [1492], 'half': [1498], 'preincubating': [1500], 'extract': [1502], 'inhibitor,': [1506], 'NG-nitro-l-arginine': [1507], 'methyl': [1508], 'ester,': [1509], 'suggesting': [1510, 1848, 2501], 'were': [1513], 'being': [1514], 'itself.': [1518], 'Similarly,': [1519], 'animals': [1520], 'genetically': [1521, 2762, 3524], 'overload': [1527, 1905, 2279], 'modest': [1530], 'compensated': [1532], 'concentric': [1533], 'little': [1536], 'cavity': [1537], 'dilation,': [1538], 'interstitial': [1540], 'fibrosis,': [1541], 'far': [1543], 'stress.A': [1546], 'mediate': [1551], 'pressure-overloaded': [1555], 'hearts': [1556, 2222, 2262, 2461], 'decline': [1559], 'levels.': [1562], 'supported': [1565], 'direct': [1568, 2790, 3789], 'measurements': [1570], 'findings': [1572, 2918], 'supplementation': [1575, 1681], 'offsets': [1576], 'hypertrophic/dilative': [1578], 'phenotype.49': [1579], 'which,': [1592], 'degraded': [1595], 'facilitating': [1598], 'left': [1599, 2360, 2629], 'dilatation49,71,72': [1601], 'function.Given': [1605], 'expressed': [1609, 1968, 1986], 'vascular': [1611], 'endothelium': [1612], 'myocytes,': [1614], 'representing': [1618], '<20': [1619], 'total': [1621], 'NOS3,': [1623, 1770], 'unclear': [1626], 'type': [1629], 'contributes': [1630], 'uncoupling.': [1637, 1676, 1691, 1782], 'Furthermore,': [1638], 'exact': [1640], 'leading': [1642, 2191], 'reduction': [1648, 2753], 'remain': [1652, 2919], 'unknown.': [1653], 'One': [1654], 'possibility': [1655], 'Landmesser': [1658], 'et': [1659, 1745, 2410], 'al51': [1660], 'enhances': [1670], 'oxidization': [1672, 2381], 'study,': [1679], 'oral': [1680], 'prevented': [1690, 2378], 'NADPH-dependent': [1693], 'increases': [1696, 1803, 1993, 3471], 'pressure-overload': [1698, 2019, 2697], 'hypertrophy,73': [1699], 'scenario': [1702], 'apply.': [1704], 'between': [1707, 1751, 1775, 2158, 2505], 'somewhat': [1713], 'circular;': [1714], 'generator': [1720], 'without': [1721], 'depletion,48': [1723], 'consequent': [1726], 'can,': [1728], 'oxidize': [1731], 'worsen': [1734], 'process.': [1736], 'Evidence': [1737, 3193], 'Bendall': [1744], 'al,74': [1746], 'who': [1747], 'stoichiometric': [1749], 'discordance': [1750], 'comparing': [1758], 'endothelial-targeted': [1759], 'GTP': [1762], 'cyclohydrolase': [1763], '([GTPCH-1]': [1765], 'rate-limiting': [1766], 'synthetic': [1768], 'enzyme),': [1769], 'combination.': [1773], 'Imbalance': [1774], 'resulted': [1779], 'relative': [1784], 'these': [1787, 2917, 2952], 'depend': [1790], 'nature': [1793], 'and/or': [1794, 2294], 'stage': [1795], 'pathology.': [1798], 'expression': [1802, 2013, 2333], 'cardiomyopathic': [1805], 'hamsters75': [1806], 'decreases': [1808], 'ischemic': [1810], 'cardiomyopathy.76': [1811], 'occur': [1815], 'particularly': [1819], 'related': [1820], 'changes': [1822], 'GTPCH-1,': [1824, 1843], 'salvage': [1828], 'uses': [1831], 'sepiapterin': [1832, 3072], 'intermediate.77': [1835], 'Neopterin,': [1836], 'byproduct': [1838], 'declines': [1844], 'pressure-load': [1846, 2112], 'biosynthesis': [1851], 'diminished.49': [1853], 'studies': [1855, 2896, 2926, 2953, 3108], 'GTPCH-1': [1860, 1887], 'reported,': [1871], 'data': [1873, 2308, 2915, 3093], 'showing': [1874], 'signal': [1876, 1894], 'transducer': [1877, 1895], 'transcription-3': [1881, 1899], 'lowers': [1886], 'expression78': [1888], 'suggest': [1889, 2309], 'potential': [1891, 2609, 3311, 3576], 'mechanism,': [1892], 'potently': [1901], 'heart.79NADPH': [1908], 'OxidasesNADPH': [1909], 'oxidases': [1910, 2032, 2046, 2065], '4A)': [1912], 'multimeric': [1914], 'consist': [1917], 'membrane-bound': [1920], 'flavocytochrome': [1921], 'composing': [1922], 'catalytic': [1924, 1954], 'Nox': [1925, 1965, 2295], 'subunit': [1926, 2012], 'p22phox': [1928], 'subunit,': [1929], '4': [1931], 'cytosolic': [1932], 'regulatory': [1933], 'subunits,': [1934], 'p40phox,': [1935], 'p47phox,': [1936], 'p67phox,': [1937], 'small': [1940], 'Rac.80': [1943], 'Electron': [1944], 'transfer': [1945], 'site,': [1955], 'superoxide.': [1961], 'There': [1962], '5': [1964], 'isoforms': [1966, 1985, 2296], '(Nox1–5),': [1967], 'tissue-specific': [1971], 'manner.': [1972], 'Among': [1973], 'these,': [1974], 'Nox2': [1975, 2077, 2260, 2272], '(known': [1976], 'previously': [1977], 'gp91phox)': [1979], 'Nox4': [1981, 2108], 'main': [1984], 'myocardium.5': [1989], 'stimuli': [1995], 'II,81,82': [1999], 'cyclic': [2000], 'load,83,84': [2001], 'agonists,85': [2003], 'tumor': [2005, 3360], 'necrosis': [2006, 3361], 'factor-α.86': [2007], 'increase': [2014], 'development': [2017], 'guinea': [2022, 2695], 'pigs73': [2023], 'human': [2025, 2341, 2836], 'failure.87,88': [2027], 'derived': [2029, 2534], '(as': [2037], 'discussed': [2038], 'above)': [2039], 'XO,89': [2042], 'serve': [2048], 'priming': [2050], 'sources': [2051], 'amplification': [2053], 'generation.': [2056], 'Download': [2057], '4.': [2060], 'A,': [2061, 3213, 3219, 3342, 3803, 3863], 'Role': [2062, 2123, 3392], 'infarction.': [2076, 3371], 'found': [2080, 2485, 2998], 'angiotensin-stimulated': [2086], 'but': [2088, 2114, 2283, 2495], 'absence': [2091], 'does': [2092], 'prevent': [2094, 2737], 'pressure-load–induced': [2095], 'Other': [2097], 'influences': [2098], 'observed.': [2107, 2705], 'contribute': [2110, 3034], 'clarified': [2119], 'date.': [2121], 'B,': [2122], 'XO': [2125, 2135, 2159, 2183, 2311, 2332, 2521], 'system': [2126], 'potentially,': [2131], 'overload.': [2133], 'Increased': [2134, 2520, 3224], 'observed': [2139], 'various': [2141], 'animal': [2142], 'models,': [2145], 'improve': [2150], 'contraction': [2151], 'energetic': [2153], 'efficiency.': [2154], 'Proposed': [2156], 'neuronal': [2161, 2414], '(nNOS)': [2163], 'handling': [2167, 2189], 'function.': [2174], 'Genetic': [2175], 'loss': [2176], 'NOS1': [2178, 2438, 2459, 2498], 'result': [2180, 2606], 'generation,': [2186, 3357], 'dysfunction.ROS': [2194], 'seem': [2199, 3094], 'II–induced': [2207], 'hypertrophy/remodeling.': [2209], 'Subpressor': [2210], 'doses': [2211], 'blunted': [2220, 2241, 2690, 2711], 'Nox2.90': [2224], 'addition,': [2226], 'Rac1': [2227, 2750, 3026], 'null': [2228, 2261, 2460, 2499], 'activity,': [2234], 'lower': [2237], 'infusion.91': [2259], 'MI.92': [2268], 'develop': [2273], 'responses': [2276], 'better': [2288], 'contraction.93–95': [2290], 'alternative': [2292], '(eg,': [2297, 2561], 'Nox4)': [2298], 'relevant': [2302], 'setting.Xanthine': [2305], 'OxidaseRecent': [2306], 'XO-related': [2313], 'pathogenesis': [2322], '4B': [2328], '4C).': [2330], 'Elevated': [2331, 3297], 'demonstrated': [2338], 'end-stage': [2340], 'failure96': [2343], 'canine': [2347], 'rapid': [2348], 'pacing-induced': [2349], 'model.97,98': [2352], 'Chronic': [2353], 'treatment': [2354, 2679], 'allopurinol': [2356, 2986], 'significantly': [2357], 'remodeling99': [2362], 'modestly': [2364], 'improved': [2365, 2686], 'survival100': [2366], 'MI': [2370, 2557], 'rats': [2372], 'dilated': [2374], 'cardiomyopathy.101': [2375], 'Allopurinol': [2376], 'myofibrillar': [2379], 'preserved': [2383], 'transgenic': [2387], 'harboring': [2389], 'truncated': [2390], 'troponin': [2391], 'I,': [2392, 3188, 3288], 'model': [2394, 3753], 'stunning.102Interestingly,': [2397], 'XO-derived': [2398], 'seems': [2400, 3098], 'interfere': [2402], 'energetics.103': [2408], 'Khan': [2409], 'al104': [2411], '(NOS1': [2416], 'nNOS)': [2418], 'oxidoreductase': [2424, 2777], 'lie': [2425], 'physical': [2427], 'proximity': [2428], 'reticulum': [2432], 'myocytes.': [2435, 3821, 3852, 3885], 'Deficiency': [2436], 'oxidoreductase–mediated': [2441], 'production,': [2443], 'negatively': [2444], 'regulating': [2445], 'contractility,': [2447], 'reversible': [2451], 'allopurinol.': [2453], 'same': [2455], 'group': [2456], 'had': [2462], 'worse': [2463], 'wild-type': [2469, 2494], 'infarct;': [2472], 'surprisingly,': [2474], 'tissue': [2475], 'similarly': [2479], 'either': [2481], 'genotype.105': [2482], 'Importantly,': [2483], 'different': [2486], 'tissues': [2491], '(increase': [2492], 'hearts),': [2500], 'imbalance': [2504], 'NOS1-mediated': [2506], 'ROS,': [2510], 'level': [2515], 'itself,': [2516], 'important.': [2519], 'late-stage': [2527], 'pressure-overload–induced': [2528, 2643, 2744], 'hypertrophy.106Mitochondrial': [2531], 'ROSExcessive': [2532], 'mitochondria': [2536, 2641], 'likely': [2539], 'contributors': [2540], '107)': [2547], 'models': [2555], 'tachypacing-induced': [2562], 'failure108,109).': [2563], 'attributed': [2567], 'leakage': [2570], 'chain': [2578], 'complexes': [2579], 'source': [2584, 3045], 'O2−,': [2586], 'OH−.': [2589], 'damaging': [2598], 'organelle': [2602], 'membrane': [2608], 'abnormalities,': [2610], 'leakage,': [2612], 'damage.': [2615], 'Overexpression': [2616], 'peroxiredoxin-3,': [2621], 'ameliorates': [2622], 'MI.110': [2633], 'date': [2650], 'awaits': [2652], 'elucidation.Antioxidant': [2654], 'Systems': [2655], 'Pressure': [2657], 'OverloadSeveral': [2658], 'antioxidants': [2660, 2943], 'ameliorate': [2665], 'evolution': [2667], 'models.': [2675], 'nonspecific': [2682], 'vitamin': [2684, 2946, 2949], 'E': [2685], 'pig': [2696], 'model,111': [2698], 'although': [2699], 'antihypertrophic': [2701], 'effect': [2702], '2N-merocaptoproninyl': [2706], 'glycine': [2707], 'N-acetyl': [2709], 'overload.93,112': [2718], '3-hydroxy-3-methylglutaryl': [2720], 'coenzyme': [2721], 'inhibitor': [2724], 'simvastatin': [2725], 'vitro': [2739, 3624], 'vivo': [2743, 3315, 3621], 'activity.113Enzyme': [2757], 'manipulated': [2763], 'reveal': [2765], 'prominent': [2767], 'Thioredoxin': [2772], 'ubiquitous': [2775], 'composed': [2778], 'limits': [2786], 'scavenging': [2792], 'other': [2797], 'kinases.12': [2799], 'Inhibition': [2800, 3464, 3739], 'endogenous': [2802, 3466], 'thioredoxin-1': [2803], 'results': [2804], 'reduces': [2822], 'stress.11': [2826], 'Interestingly,': [2827], 'upregulated': [2830], 'cGMP/protein': [2832], 'neuroblastoma': [2837], 'cells,': [2838], 'protecting': [2839], 'stress–induced': [2843], 'apoptosis.114': [2844], 'mechanism': [2847], 'might': [2848], 'NO/cGMP/protein': [2853], 'G–mediated': [2855], 'amelioration': [2856], 'hypertrophy/remodeling': [2859], '3).': [2861], 'Another': [2862], 'enzyme,': [2865], 'peroxidase,': [2867], 'removing': [2870], 'detoxifying': [2873], 'hydroperoxides,': [2875], 'overexpressed': [2879], 'mouse': [2881], 'heart,': [2882], 'ameliorated': [2885], 'post-MI': [2886], 'remodeling.115Targeting': [2887], 'Oxidative/Nitrosative': [2888], 'Stress:': [2889], 'Clinical': [2891], 'StrategyAlthough': [2892], 'basic': [2894], 'strongly': [2897], 'support': [2898], 'oxidative/nitrosative': [2903], 'clinical': [2914, 2925, 2940, 2983, 3006, 3105], 'testing': [2916], 'scant.': [2920], 'small,': [2922], 'often': [2923], 'uncontrolled': [2924], 'supportive,': [2929], 'larger': [2930], 'prospective': [2931], 'randomized,': [2933], 'controlled': [2934], 'trials': [2935, 2984], 'failed': [2937], 'show': [2939], 'benefit': [2941], 'C': [2947], 'E.116–118': [2950], 'examined': [2956], 'disease': [2959, 2980, 3087], 'failure,': [2962], 'per': [2963], 'se,': [2964], 'bulk': [2967], 'data,': [2970], 'cancer': [2974], 'trials,': [2975], 'predict': [2978], 'responses.': [2981], 'Recent': [2982], 'oxypurinol': [2988], 'treat': [2990, 3081], 'class': [2991], 'III': [2994], 'plasma': [3000], 'urate': [3001], 'no': [3003], 'impact': [3004], 'outcome.119': [3007], 'angiotensin-converting': [3009], 'enzyme': [3010], 'inhibitors,': [3011], 'β-blocker': [3013], 'carvedilol,': [3014], 'blockers': [3018], 'block': [3020], 'statins': [3024], 'part': [3036], 'efficacy.': [3039], 'More': [3040], 'targeting': [3042], 'recoupling': [3051], 'enhancing': [3055], 'antioxidants,120': [3057], 'ultimately': [3059], 'effective': [3062], 'approaches': [3063], 'reversing': [3065], 'precursor': [3071], 'tolerated': [3075], 'currently': [3078], 'used': [3079], 'some': [3082], 'phenylketonuria': [3088], 'humans.121': [3090], 'compelling,': [3095], 'premature': [3099], 'abandon': [3101], 'tactic': [3103], 'treatment.': [3106], 'Further': [3107], 'using': [3109], 'better-targeted': [3113], 'agents': [3114], 'will': [3115], 'hopefully': [3116], 'establish': [3117], 'use': [3119], 'future.Sources': [3122], 'FundingSupported': [3124], 'Peter': [3126], 'Belfer': [3127], 'Laboratory': [3128], 'Endowment': [3129], 'PO1H077180,': [3130], 'AG18324,': [3131], 'PO1HL59408': [3133], '(D.A.K.)': [3134], 'American': [3136], 'Heart': [3137, 3204, 3583], 'Association': [3138], 'SDG': [3139], 'Award': [3140], '(E.T.).DisclosuresNone.FootnotesCorrespondence': [3141], 'Kass,': [3145], 'Ross': [3146], '835,': [3147], '720': [3148], 'Rutland': [3149], 'Ave,': [3150], 'MD': [3156], '21205.': [3157], 'E-mail': [3158], '[email': [3159], 'protected]': [3160], 'References': [3161], 'Frey': [3163], 'N,': [3164, 3550], 'Olson': [3165], 'EN.': [3166], 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3543, 3581, 3699, 3725, 3795, 3854], 'Am': [3234, 3373, 3580, 3698, 3724, 3853], 'Coll': [3235, 3374], 'Cardiol.': [3236, 3375, 3404], '1998;': [3237, 3327, 3888], '31:': [3238, 3443], '1352–1356.CrossrefMedlineGoogle': [3239], 'Scholar4': [3240], 'Hare': [3241, 3533, 3565], 'JM,': [3242], 'Stamler': [3243], 'JS.': [3244], 'NO/redox': [3245], 'disequilibrium': [3246], 'failing': [3249], 'system.': [3253, 3437, 3540], 'Clin': [3255, 3419, 3478, 3796], 'Invest.': [3256, 3420, 3479, 3797], '2005;': [3257, 3421, 3668], '115:': [3258, 3422], '509–517.CrossrefMedlineGoogle': [3259], 'Scholar5': [3260], 'Murdoch': [3261], 'CE,': [3262], 'Zhang': [3263], 'Cave': [3265], 'AC,': [3266, 3679], 'Shah': [3267], 'AM.': [3268], 'oxidase-dependent': [3270], 'signalling': [3272], 'remodelling': [3276], 'Cardiovasc': [3279], 'Res.': [3280, 3498, 3528, 3887], '2006;': [3281, 3630], '71:': [3282], '208–215.CrossrefMedlineGoogle': [3283], 'Scholar6': [3284], 'Mallat': [3285], 'Z,': [3286], 'Philip': 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'inotropic': [3568], 'nitric': [3571, 3684, 3722, 3749], 'oxide': [3572, 3685, 3750], 'donors:': [3575], 'nitrosylation.': [3579], 'Physiol': [3582, 3855], '2000;': [3586], '279:': [3587], 'H1982–H1988.CrossrefMedlineGoogle': [3588], 'Scholar16': [3589], 'Katori': [3590], 'Donzelli': [3592], 'S,': [3593, 3830], 'Tocchetti': [3594], 'CG,': [3595, 3706], 'Miranda': [3596], 'KM,': [3597], 'Belardi': [3598], 'DF,': [3599], 'Cormaci': [3600], 'Thomas': [3602], 'DD,': [3603], 'Ketner': [3604], 'EA,': [3605], 'Lee': [3606], 'Mancardi': [3608], 'Wink': [3610], 'N.': [3615], 'Peroxnitrite': [3616], 'contractility:': [3619], 'versus': [3622], 'effects.': [3625], '41:': [3631], '1606–1618.CrossrefMedlineGoogle': [3632], 'Scholar17': [3633], 'Turko': [3634], 'IV,': [3635], 'Murad': [3636], 'Protein': [3638], 'diseases.': [3642], 'Pharmacol': [3643, 3666], 'Rev.': [3644], '54:': [3646], '619–634.CrossrefMedlineGoogle': [3647], 'Scholar18': [3648], 'Pacher': [3649], 'Schulz': [3651], 'Liaudet': 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[3767], 'Scholar22': [3768], 'Clancy': [3769], 'RM,': [3770], 'Leszczynska-Piziak': [3771], 'Abramson': [3773], 'SB.': [3774], 'Nitric': [3775], 'oxide,': [3776], 'relaxation': [3780], 'factor,': [3781], 'neutrophil': [3783], 'production': [3786], 'action': [3790], 'oxidase.': [3794], '1992;': [3798], '90:': [3799], '1116–1121.CrossrefMedlineGoogle': [3800], 'Scholar23': [3801], 'Sabri': [3802, 3862], 'Hughie': [3804], 'HH,': [3805], 'Lucchesi': [3806, 3837, 3870], 'PA.': [3807, 3838, 3871], 'apoptotic': [3812], 'Antioxid': [3822], 'Redox': [3823], 'Signal.': [3824], '5:': [3826], '731–740.CrossrefMedlineGoogle': [3827], 'Scholar24': [3828], 'Wei': [3829], 'Rothstein': [3831], 'EC,': [3832], 'Fliegel': [3833], "Dell'Italia": [3835], 'LJ,': [3836], 'Differential': [3839], 'MAP': [3840], 'Na(+)/H(+)': [3844], 'exchanger': [3845], 'H(2)O(2)': [3848], '281:': [3859], 'C1542–C1550.CrossrefMedlineGoogle': [3860], 'Scholar25': [3861], 'Byron': [3864], 'KL,': [3865], 'Samarel': [3866], 'AM,': 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