Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2144937592', 'doi': 'https://doi.org/10.1016/j.vetimm.2004.09.018', 'title': 'Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination', 'display_name': 'Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination', 'publication_year': 2004, 'publication_date': '2004-10-27', 'ids': {'openalex': 'https://openalex.org/W2144937592', 'doi': 'https://doi.org/10.1016/j.vetimm.2004.09.018', 'mag': '2144937592', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15507306', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7112652'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.vetimm.2004.09.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S194416120', 'display_name': 'Veterinary Immunology and Immunopathology', 'issn_l': '0165-2427', 'issn': ['0165-2427', '1873-2534'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1016/j.vetimm.2004.09.018', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090633563', 'display_name': 'Atabak R. Royaee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210088410', 'display_name': 'Beltsville Human Nutrition Research Center', 'ror': 'https://ror.org/004zpe866', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1312222531', 'https://openalex.org/I1336096307', 'https://openalex.org/I4210088410', 'https://openalex.org/I4210138094']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Atabak R. Royaee', 'raw_affiliation_strings': ['Animal Parasitic Disease Laboratory, Animal and Natural Resources Institute, Beltsville Human Nutrition Research Center, ARS, BARC, USDA, Beltsville, MD 20705, USA'], 'affiliations': [{'raw_affiliation_string': 'Animal Parasitic Disease Laboratory, Animal and Natural Resources Institute, Beltsville Human Nutrition Research Center, ARS, BARC, USDA, Beltsville, MD 20705, USA', 'institution_ids': ['https://openalex.org/I4210088410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051080238', 'display_name': 'Robert J. Husmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183874917', 'display_name': 'Urbana University', 'ror': 'https://ror.org/04kp3hw27', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I183874917']}, {'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert J. Husmann', 'raw_affiliation_strings': ['Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA', 'institution_ids': ['https://openalex.org/I183874917', 'https://openalex.org/I157725225']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030498708', 'display_name': 'Harry Dawson', 'orcid': 'https://orcid.org/0000-0002-7648-9952'}, 'institutions': [{'id': 'https://openalex.org/I4210088410', 'display_name': 'Beltsville Human Nutrition Research Center', 'ror': 'https://ror.org/004zpe866', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1312222531', 'https://openalex.org/I1336096307', 'https://openalex.org/I4210088410', 'https://openalex.org/I4210138094']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Harry D. Dawson', 'raw_affiliation_strings': ['Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, ARS, BARC, USDA, Beltsville, MD 20705, USA'], 'affiliations': [{'raw_affiliation_string': 'Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, ARS, BARC, USDA, Beltsville, MD 20705, USA', 'institution_ids': ['https://openalex.org/I4210088410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071491713', 'display_name': 'Gabriela Calzada-Nova', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183874917', 'display_name': 'Urbana University', 'ror': 'https://ror.org/04kp3hw27', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I183874917']}, {'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gabriela Calzada-Nova', 'raw_affiliation_strings': ['Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA', 'institution_ids': ['https://openalex.org/I183874917', 'https://openalex.org/I157725225']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018248999', 'display_name': 'William M. Schnitzlein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183874917', 'display_name': 'Urbana University', 'ror': 'https://ror.org/04kp3hw27', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I183874917']}, {'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William M. Schnitzlein', 'raw_affiliation_strings': ['Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA', 'institution_ids': ['https://openalex.org/I183874917', 'https://openalex.org/I157725225']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013943720', 'display_name': 'Federico A. Zuckermann', 'orcid': 'https://orcid.org/0000-0002-8408-5659'}, 'institutions': [{'id': 'https://openalex.org/I183874917', 'display_name': 'Urbana University', 'ror': 'https://ror.org/04kp3hw27', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I183874917']}, {'id': 'https://openalex.org/I157725225', 'display_name': 'University of Illinois Urbana-Champaign', 'ror': 'https://ror.org/047426m28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I157725225']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Federico A. Zuckermann', 'raw_affiliation_strings': ['Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA', 'institution_ids': ['https://openalex.org/I183874917', 'https://openalex.org/I157725225']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083684557', 'display_name': 'Joan K. Lunney', 'orcid': 'https://orcid.org/0000-0002-1147-8662'}, 'institutions': [{'id': 'https://openalex.org/I1312222531', 'display_name': 'Agricultural Research Service', 'ror': 'https://ror.org/02d2m2044', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1312222531', 'https://openalex.org/I1336096307']}, {'id': 'https://openalex.org/I4210088410', 'display_name': 'Beltsville Human Nutrition Research Center', 'ror': 'https://ror.org/004zpe866', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1312222531', 'https://openalex.org/I1336096307', 'https://openalex.org/I4210088410', 'https://openalex.org/I4210138094']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Joan K. Lunney', 'raw_affiliation_strings': ['APDL, ANRI, ARS, USDA, Building 1040, Room 103, BARC-East, Beltsville, MD 20705, USA', 'Animal Parasitic Disease Laboratory, Animal and Natural Resources Institute, Beltsville Human Nutrition Research Center, ARS, BARC, USDA, Beltsville, MD 20705, USA'], 'affiliations': [{'raw_affiliation_string': 'APDL, ANRI, ARS, USDA, Building 1040, Room 103, BARC-East, Beltsville, MD 20705, USA', 'institution_ids': ['https://openalex.org/I1312222531']}, {'raw_affiliation_string': 'Animal Parasitic Disease Laboratory, Animal and Natural Resources Institute, Beltsville Human Nutrition Research Center, ARS, BARC, USDA, Beltsville, MD 20705, USA', 'institution_ids': ['https://openalex.org/I4210088410']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5013943720', 'https://openalex.org/A5083684557'], 'corresponding_institution_ids': ['https://openalex.org/I183874917', 'https://openalex.org/I157725225', 'https://openalex.org/I1312222531', 'https://openalex.org/I4210088410'], 'apc_list': {'value': 3040, 'currency': 'USD', 'value_usd': 3040, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 10.352, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 152, 'citation_normalized_percentile': {'value': 0.999722, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '102', 'issue': '3', 'first_page': '199', 'last_page': '216'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11495', 'display_name': 'Viral Diseases in Livestock and Poultry', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1103', 'display_name': 'Animal Science and Zoology'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11495', 'display_name': 'Viral Diseases in Livestock and Poultry', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1103', 'display_name': 'Animal Science and Zoology'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Gene Therapy Techniques and Applications', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11560', 'display_name': 'Dynamics of Livestock Disease Transmission and Control', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1102', 'display_name': 'Agronomy and Crop Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/elispot', 'display_name': 'ELISPOT', 'score': 0.64084065}, {'id': 'https://openalex.org/keywords/porcine-reproductive-and-respiratory-syndrome-virus', 'display_name': 'Porcine Reproductive and Respiratory Syndrome Virus', 'score': 0.492776}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8023077}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.6814043}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.67811215}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.67586255}, {'id': 'https://openalex.org/C2779053233', 'wikidata': 'https://www.wikidata.org/wiki/Q731235', 'display_name': 'ELISPOT', 'level': 4, 'score': 0.64084065}, {'id': 'https://openalex.org/C22070199', 'wikidata': 'https://www.wikidata.org/wiki/Q192995', 'display_name': 'Vaccination', 'level': 2, 'score': 0.6023428}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.572495}, {'id': 'https://openalex.org/C2779819720', 'wikidata': 'https://www.wikidata.org/wiki/Q1760147', 'display_name': 'Porcine reproductive and respiratory syndrome virus', 'level': 3, 'score': 0.53206474}, {'id': 'https://openalex.org/C2779341262', 'wikidata': 'https://www.wikidata.org/wiki/Q182581', 'display_name': 'Immunity', 'level': 3, 'score': 0.52799344}, {'id': 'https://openalex.org/C193419808', 'wikidata': 'https://www.wikidata.org/wiki/Q1645075', 'display_name': 'Acquired immune system', 'level': 3, 'score': 0.4889373}, {'id': 'https://openalex.org/C2777863537', 'wikidata': 'https://www.wikidata.org/wiki/Q357896', 'display_name': 'Adjuvant', 'level': 2, 'score': 0.4566483}, {'id': 'https://openalex.org/C137061746', 'wikidata': 'https://www.wikidata.org/wiki/Q736033', 'display_name': 'Peripheral blood mononuclear cell', 'level': 3, 'score': 0.4545665}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.44288123}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.41367632}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.3800154}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.18795165}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06168112}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.057548672}], 'mesh': [{'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D019316', 'descriptor_name': 'Porcine respiratory and reproductive syndrome virus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D013552', 'descriptor_name': 'Swine', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D014765', 'descriptor_name': 'Viral Vaccines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000276', 'descriptor_name': 'Adjuvants, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007111', 'descriptor_name': 'Immunity, Cellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D019318', 'descriptor_name': 'Porcine Reproductive and Respiratory Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019318', 'descriptor_name': 'Porcine Reproductive and Respiratory Syndrome', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D019318', 'descriptor_name': 'Porcine Reproductive and Respiratory Syndrome', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D019316', 'descriptor_name': 'Porcine respiratory and reproductive syndrome virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012044', 'descriptor_name': 'Regression Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013552', 'descriptor_name': 'Swine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014613', 'descriptor_name': 'Vaccines, Attenuated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014613', 'descriptor_name': 'Vaccines, Attenuated', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014765', 'descriptor_name': 'Viral Vaccines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.vetimm.2004.09.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S194416120', 'display_name': 'Veterinary Immunology and Immunopathology', 'issn_l': '0165-2427', 'issn': ['0165-2427', '1873-2534'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7112652', 'pdf_url': 'https://europepmc.org/articles/pmc7112652?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112652', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15507306', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.vetimm.2004.09.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S194416120', 'display_name': 'Veterinary Immunology and Immunopathology', 'issn_l': '0165-2427', 'issn': ['0165-2427', '1873-2534'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W1502386716', 'https://openalex.org/W1526789785', 'https://openalex.org/W1578854334', 'https://openalex.org/W174132141', 'https://openalex.org/W1963978160', 'https://openalex.org/W1967679039', 'https://openalex.org/W1981579957', 'https://openalex.org/W1981969796', 'https://openalex.org/W1987429299', 'https://openalex.org/W1987786107', 'https://openalex.org/W1990350083', 'https://openalex.org/W2001114840', 'https://openalex.org/W2007802775', 'https://openalex.org/W2012121871', 'https://openalex.org/W2013435693', 'https://openalex.org/W2014212115', 'https://openalex.org/W2015721404', 'https://openalex.org/W2018745726', 'https://openalex.org/W2021596106', 'https://openalex.org/W2022897278', 'https://openalex.org/W2023262974', 'https://openalex.org/W2027005967', 'https://openalex.org/W2029571878', 'https://openalex.org/W2030190658', 'https://openalex.org/W2030912283', 'https://openalex.org/W2033351973', 'https://openalex.org/W2034292919', 'https://openalex.org/W2037653553', 'https://openalex.org/W2039130722', 'https://openalex.org/W2040024010', 'https://openalex.org/W2045509929', 'https://openalex.org/W2045792492', 'https://openalex.org/W2047850703', 'https://openalex.org/W2064677985', 'https://openalex.org/W2065180218', 'https://openalex.org/W206556109', 'https://openalex.org/W2070542693', 'https://openalex.org/W2071033603', 'https://openalex.org/W2085646411', 'https://openalex.org/W2086935843', 'https://openalex.org/W2087335546', 'https://openalex.org/W2089568026', 'https://openalex.org/W2097722577', 'https://openalex.org/W2103906844', 'https://openalex.org/W2106389211', 'https://openalex.org/W2107800288', 'https://openalex.org/W2109450812', 'https://openalex.org/W2112982595', 'https://openalex.org/W2114357202', 'https://openalex.org/W2122129870', 'https://openalex.org/W2129569261', 'https://openalex.org/W2131322510', 'https://openalex.org/W2139133939', 'https://openalex.org/W2151075263', 'https://openalex.org/W2156672979', 'https://openalex.org/W2160581420', 'https://openalex.org/W2170829223', 'https://openalex.org/W2317410864'], 'related_works': ['https://openalex.org/W4396978436', 'https://openalex.org/W3214021846', 'https://openalex.org/W3037401902', 'https://openalex.org/W2416010474', 'https://openalex.org/W2414222088', 'https://openalex.org/W2347275099', 'https://openalex.org/W2100609764', 'https://openalex.org/W2008184737', 'https://openalex.org/W1972821856', 'https://openalex.org/W1794808949'], 'abstract_inverted_index': {'The': [0], 'natural': [1], 'response': [2, 58, 98], 'of': [3, 55, 59, 85, 95, 124, 142, 179, 191, 204, 231, 242, 255], 'pigs': [4, 60, 112], 'to': [5, 17, 51, 114, 155, 224], 'porcine': [6, 165], 'reproductive': [7], 'and': [8, 14, 29, 48, 101, 133, 136, 147, 152], 'respiratory': [9], 'syndrome': [10], 'virus': [11, 65], '(PRRSV)': [12], 'infections': [13], 'vaccinations': [15], 'needs': [16], 'be': [18, 250], 'altered': [19], 'so': [20], 'that': [21], 'better': [22], 'protection': [23], 'is': [24], 'afforded': [25], 'against': [26], 'both': [27], 'homologous': [28], 'heterologous': [30], 'challenges': [31], 'by': [32, 82, 159, 200, 213], 'this': [33, 37], 'pathogen.': [34], 'To': [35], 'address': [36], 'problem,': [38], 'real-time': [39], 'gene': [40], 'expression': [41, 123, 162, 190], 'assays': [42], 'were': [43], 'coupled': [44], 'with': [45, 62, 117, 209], 'cytokine': [46, 194], 'Elispot': [47], 'protein': [49], 'analyses': [50], 'assess': [52], 'the': [53, 56, 83, 92, 96, 125, 140, 145, 177, 189, 240], 'nature': [54], 'anti-PRRSV': [57], 'immunized': [61], 'modified': [63], 'live': [64], '(MLV)': [66], 'vaccine.': [67], 'Although': [68], 'T': [69], 'helper': [70], '1': [71], '(Th1)': [72], 'immunity': [73], 'was': [74, 99], 'elicited': [75], 'in': [76, 121, 139, 172, 176, 188], 'all': [77], 'vaccinated': [78], 'animals,': [79], 'as': [80, 168], 'evidenced': [81], 'genesis': [84], 'PRRSV-specific': [86, 180], 'interferon-gamma': [87], 'secreting': [88], 'cells': [89, 107], '(IFNG': [90], 'SC),': [91], 'overall': [93, 187], 'extent': [94], 'memory': [97], 'variable': [100], 'generally': [102], 'weak.': [103], 'Peripheral': [104], 'blood': [105], 'mononuclear': [106], '(PBMC)': [108], 'isolated': [109], 'from': [110], 'these': [111], 'responded': [113], 'PRRSV': [115, 234], 'exposure': [116], 'a': [118, 137, 173, 243], 'limited': [119], 'increase': [120, 175], 'their': [122, 222], 'Th1': [126, 157, 192, 244], 'immune': [127, 197, 245], 'markers,': [128], 'IFNG,': [129], 'tumor': [130], 'necrosis': [131], 'factor-alpha': [132], 'interleukin-15': [134], '(IL15),': [135], 'reduction': [138], 'quantity': [141], 'mRNAs': [143], 'encoding': [144, 164], 'innate': [146, 196], 'inflammatory': [148], 'proteins,': [149], 'IL1B,': [150], 'IL8': [151], 'IFNA.': [153], 'Efforts': [154], 'enhance': [156], 'immunity,': [158], 'utilizing': [160], 'an': [161, 169, 237], 'plasmid': [163], 'IFNA': [166, 232], '(pINA)': [167], 'adjuvant,': [170], 'resulted': [171], 'temporary': [174], 'frequency': [178], 'IFNG': [181], 'SC': [182], 'but': [183, 217], 'only': [184], 'minor': [185], 'changes': [186], 'associated': [193], 'or': [195], 'marker': [198], 'mRNA': [199], 'virus-stimulated': [201], 'PBMC.': [202], 'Administration': [203], 'pINA,': [205], 'however,': [206], 'did': [207], 'correlate': [208], 'decreased': [210], 'IL1B': [211], 'secretion': [212], 'cultured,': [214], 'unstimulated': [215], 'PBMC': [216], 'had': [218], 'no': [219], 'effect': [220], 'on': [221, 239], 'ability': [223], 'release': [225], 'IFNG.': [226], 'Thus,': [227], 'while': [228], 'exogenous': [229], 'addition': [230], 'during': [233], 'vaccination': [235], 'has': [236], 'impact': [238], 'development': [241], 'response,': [246], 'other': [247], 'alterations': [248], 'will': [249], 'required': [251], 'for': [252], 'substantial': [253], 'boosting': [254], 'virus-specific': [256], 'protection.': [257]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2144937592', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-09-24T02:42:37.348859', 'created_date': '2016-06-24'}