Title: Phytochemical and antimicrobial studies of Commiphora africana root extracts.
Abstract: The crude ethanolic extract of Commiphora africana root was partitioned with n-hexane, chloroform; water and 10% aqueous methanol and screened for chemical constituents and antimicrobial activity. The n-hexane fraction, which was the most bioactive was chromatographed on a column silica gel to give a number of purified components. The components from the nhexane were found to be active against Staphylococcus aureus, E. coli and C. albicans. S. aureus (ATCC 13709) was susceptible to fractions C1 - C11 giving zonal inhibition of between 1-3 mm. Ethanolic crude root extract (2000 µg mL -1 ) proved highly active against C. albicans, while 10% aqueous methanol was the most active against E. coli. Though C. africana root crude extracts, fractions and components showed promising in-vitro antimicrobial activity, it was not as high as that of the standard antibiotics used for comparison.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 9
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