Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2139629484', 'doi': 'https://doi.org/10.1093/humrep/deh408', 'title': 'Inhibiting MMP activity prevents the development of endometriosis in the chicken chorioallantoic membrane model', 'display_name': 'Inhibiting MMP activity prevents the development of endometriosis in the chicken chorioallantoic membrane model', 'publication_year': 2004, 'publication_date': '2004-07-09', 'ids': {'openalex': 'https://openalex.org/W2139629484', 'doi': 'https://doi.org/10.1093/humrep/deh408', 'mag': '2139629484', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15242997'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/humrep/deh408', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S127900037', 'display_name': 'Human Reproduction', 'issn_l': '0268-1161', 'issn': ['0268-1161', '1460-2350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043699827', 'display_name': 'Annemiek W. Nap', 'orcid': 'https://orcid.org/0000-0002-2716-8351'}, 'institutions': [{'id': 'https://openalex.org/I2800191616', 'display_name': 'Maastricht University Medical Centre', 'ror': 'https://ror.org/02d9ce178', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800191616']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Annemiek W. Nap', 'raw_affiliation_strings': ['Research Institute Growth and Development (GROW), Department of Obstetrics and Gynaecology, University Maastricht and University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'Research Institute Growth and Development (GROW), Department of Obstetrics and Gynaecology, University Maastricht and University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands.', 'institution_ids': ['https://openalex.org/I2800191616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113635573', 'display_name': 'Gerard A.J. Dunselman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gerard A.J. Dunselman', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113529926', 'display_name': 'Anton F.P.M. de Goeij', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Anton F.P.M. de Goeij', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103145466', 'display_name': 'J.L.H. Evers', 'orcid': 'https://orcid.org/0000-0001-8079-1436'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Johannes L.H. Evers', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083069711', 'display_name': 'Patrick G. Groothuis', 'orcid': 'https://orcid.org/0000-0003-1615-1930'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Patrick G. Groothuis', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3752, 'currency': 'EUR', 'value_usd': 4046, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.197, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 76, 'citation_normalized_percentile': {'value': 0.960866, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '19', 'issue': '10', 'first_page': '2180', 'last_page': '2187'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10935', 'display_name': 'Endometriosis Research and Treatment', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10935', 'display_name': 'Endometriosis Research and Treatment', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11561', 'display_name': 'Protein Hydrolysis and Bioactive Peptides', 'score': 0.9713, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11510', 'display_name': 'Reproductive System and Pregnancy', 'score': 0.9673, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chorioallantoic-membrane', 'display_name': 'Chorioallantoic membrane', 'score': 0.89113307}], 'concepts': [{'id': 'https://openalex.org/C97230052', 'wikidata': 'https://www.wikidata.org/wiki/Q3854334', 'display_name': 'Chorioallantoic membrane', 'level': 3, 'score': 0.89113307}, {'id': 'https://openalex.org/C2779522080', 'wikidata': 'https://www.wikidata.org/wiki/Q205764', 'display_name': 'Endometriosis', 'level': 2, 'score': 0.7330743}, {'id': 'https://openalex.org/C109523444', 'wikidata': 'https://www.wikidata.org/wiki/Q424216', 'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.57913405}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.46854746}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.4647908}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.450455}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43549448}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.41776943}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36147943}, {'id': 'https://openalex.org/C29456083', 'wikidata': 'https://www.wikidata.org/wiki/Q1221899', 'display_name': 'Gynecology', 'level': 1, 'score': 0.30087316}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.27975547}], 'mesh': [{'descriptor_ui': 'D049033', 'descriptor_name': 'Chorioallantoic Membrane', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D049033', 'descriptor_name': 'Chorioallantoic Membrane', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D004715', 'descriptor_name': 'Endometriosis', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D061965', 'descriptor_name': 'Matrix Metalloproteinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049033', 'descriptor_name': 'Chorioallantoic Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004715', 'descriptor_name': 'Endometriosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004715', 'descriptor_name': 'Endometriosis', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D004715', 'descriptor_name': 'Endometriosis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004717', 'descriptor_name': 'Endometrium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004717', 'descriptor_name': 'Endometrium', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020782', 'descriptor_name': 'Matrix Metalloproteinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020782', 'descriptor_name': 'Matrix Metalloproteinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008597', 'descriptor_name': 'Menstrual Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008597', 'descriptor_name': 'Menstrual Cycle', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010537', 'descriptor_name': 'Peritoneum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010537', 'descriptor_name': 'Peritoneum', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D010537', 'descriptor_name': 'Peritoneum', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019714', 'descriptor_name': 'Tissue Inhibitor of Metalloproteinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019714', 'descriptor_name': 'Tissue Inhibitor of Metalloproteinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/humrep/deh408', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S127900037', 'display_name': 'Human Reproduction', 'issn_l': '0268-1161', 'issn': ['0268-1161', '1460-2350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15242997', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.49, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1568126922', 'https://openalex.org/W1967640121', 'https://openalex.org/W1970637166', 'https://openalex.org/W1975706974', 'https://openalex.org/W1986891553', 'https://openalex.org/W1997184060', 'https://openalex.org/W2002740306', 'https://openalex.org/W2003898114', 'https://openalex.org/W2004307784', 'https://openalex.org/W2012071401', 'https://openalex.org/W2018348630', 'https://openalex.org/W2020723150', 'https://openalex.org/W2030973262', 'https://openalex.org/W2032038471', 'https://openalex.org/W2033100064', 'https://openalex.org/W2053321628', 'https://openalex.org/W2054382813', 'https://openalex.org/W2059671018', 'https://openalex.org/W2062746203', 'https://openalex.org/W2065514821', 'https://openalex.org/W2073595123', 'https://openalex.org/W2077123765', 'https://openalex.org/W2085300593', 'https://openalex.org/W2085585495', 'https://openalex.org/W2088631802', 'https://openalex.org/W2091682191', 'https://openalex.org/W2092166473', 'https://openalex.org/W2105925637', 'https://openalex.org/W2115719370', 'https://openalex.org/W2122365868', 'https://openalex.org/W2135305245', 'https://openalex.org/W2144498589', 'https://openalex.org/W2150365936', 'https://openalex.org/W2152289540', 'https://openalex.org/W2153188915', 'https://openalex.org/W2153717197', 'https://openalex.org/W2161917366', 'https://openalex.org/W2169469417', 'https://openalex.org/W2203749559', 'https://openalex.org/W2346029793', 'https://openalex.org/W2352074286', 'https://openalex.org/W2409160363', 'https://openalex.org/W2413431449', 'https://openalex.org/W2413853648', 'https://openalex.org/W4232416525', 'https://openalex.org/W4256388796'], 'related_works': ['https://openalex.org/W2383211881', 'https://openalex.org/W2382095633', 'https://openalex.org/W2377533390', 'https://openalex.org/W2372001281', 'https://openalex.org/W2360646261', 'https://openalex.org/W2350356125', 'https://openalex.org/W2267440929', 'https://openalex.org/W2129146900', 'https://openalex.org/W2126148372', 'https://openalex.org/W2004691838'], 'abstract_inverted_index': {'Matrix': [0], 'metalloproteinases': [1], '(MMPs)': [2], 'are': [3, 160], 'essential': [4], 'for': [5], 'extracellular': [6], 'matrix': [7], 'remodelling': [8], 'and': [9, 58, 86, 138, 157], 'may': [10], 'contribute': [11], 'to': [12], 'the': [13, 21, 40, 62, 68, 77, 92, 113, 169, 183], 'development': [14, 185], 'of': [15, 18, 42, 46, 70, 80, 115, 118, 133, 151, 164, 186], 'endometriosis.': [16, 131], 'Transplantation': [17], 'endometrium': [19], 'onto': [20], 'chicken': [22], 'chorioallantoic': [23], 'membrane': [24], '(CAM)': [25], 'results': [26], 'in': [27, 48, 53, 55, 59, 61, 72, 76, 91, 105, 112, 122, 125, 146, 155, 168, 182], 'endometriosis-like': [28, 51, 123, 143, 165], 'lesion': [29, 74, 99, 144, 166], 'formation,': [30], 'a': [31, 43, 116, 180], 'process': [32], 'that': [33, 177], 'requires': [34], 'extensive': [35], 'tissue': [36], 'remodelling.': [37], 'We': [38], 'investigated': [39], 'expression': [41, 114, 149], 'wide': [44], 'range': [45], 'MMPs': [47, 71, 81, 102, 119, 178], 'menstrual': [49], 'endometrium,': [50], 'lesions': [52, 124], 'CAMs,': [54], 'peritoneal': [56], 'endometriosis': [57, 60, 154, 159], 'rectovaginal': [63], 'space,': [64], 'as': [65, 67], 'well': [66], 'function': [69, 88, 181], 'early': [73, 184], 'formation': [75, 145, 167], 'CAM': [78, 93, 170], 'model.Expression': [79], 'was': [82, 89], 'evaluated': [83], 'by': [84, 94, 171], 'immunohistochemistry': [85], 'MMP': [87, 96, 148, 173], 'studied': [90], 'inhibiting': [95, 172], 'activity': [97, 174], 'during': [98], 'formation.Nearly': [100], 'all': [101, 106], 'were': [103, 120], 'present': [104], 'tissues': [107], 'studied.': [108], 'No': [109], 'significant': [110], 'differences': [111], 'majority': [117], 'found': [121], 'CAMs': [126, 156], 'when': [127], 'compared': [128], 'with': [129], 'human': [130, 158], 'Inhibition': [132], 'MMP-1,': [134], '-2,': [135], '-3,': [136], '-7': [137], '-13': [139], 'activities': [140], 'significantly': [141], 'impaired': [142], 'CAMs.The': [147], 'profiles': [150], 'experimentally': [152], 'induced': [153], 'similar.': [161], 'The': [162], 'prevention': [163], 'strongly': [175], 'suggests': [176], 'have': [179], 'endometriotic': [187], 'lesions.': [188]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2139629484', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-11T05:27:15.503322', 'created_date': '2016-06-24'}