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449, 465], '<20%,': [267], 'it': [268], 'found': [270, 430, 551, 595, 744], '37%': [272], 'patients;': [275], '32%': [276], 'did': [277, 283, 1176], 'not': [278, 364, 660, 1177, 1206, 1305, 1343, 1598], 'have': [279, 284, 974, 1370, 1471], 'anemia,': [280, 365, 1512, 1557, 1997], '57%': [282], 'anemia': [285, 417, 474, 845, 960, 1184, 1288, 1369, 1449, 1566, 1746, 1818], '(anemia': [286], 'hemoglobin': [290], '[Hb]': [291], 'level': [292], '<12': [294], 'g/dL': [295, 300], 'women': [297], '<13': [299], 'men).1': [302], 'Iron': [303, 1657, 2079], 'more': [306, 313, 336, 1426], 'prevalent': [307], 'women,': [309], 'those': [311, 324, 340, 1600], 'advanced': [314, 1750], 'measured': [317, 630], 'New': [319, 1037, 1139, 1200], 'York': [320, 1038, 1140, 1201], 'Association': [322, 1040, 1142, 1203], 'class,': [323, 1041, 1144], 'higher': [326, 342], 'N-terminal': [327, 1066], 'pro': [328, 1067], 'β-type': [329, 1068], 'natriuretic': [330, 1069, 2006], 'peptide': [331, 2007], 'levels': [332, 345, 394, 837, 902], '(a': [333, 346, 407], 'sign': [334, 347, 1661], 'severe': [337, 419], 'CHF),': [338], 'C-reactive': [343, 1063], 'protein': [344, 1863], 'increased': [349, 369, 863], 'inflammation).': [350], 'After': [351], 'mean': [353], 'duration': [354], '731': [356], 'days,': [357], 'multivariable': [359], 'models,': [360], 'deficiency,': [362, 1462], 'but': [363, 662, 977, 1401], 'risk': [370], 'death': [372], 'transplantation,': [375], 'adjusted': [377], 'hazard': [378], 'ratio': [379], 'being': [380], '1.58': [381], '(P<0.01).In': [382], 'anemic': [386, 1240, 1298, 1910], 'patients,': [388], 'approximately': [389], 'half': [390], 'had': [391, 402], 'serum': [392, 442, 458, 1225], 'below': [395], 'normal,': [396], 'great': [399], 'majority': [400], 'also': [401, 742, 756, 799, 1205], 'elevated': [403], 'soluble': [404], 'receptor': [406], 'dependable': [408], 'measure': [409], 'deficiency).2': [412], 'another': [414, 674, 1284], 'CHF,': [420, 563, 813, 956, 1221], 'markedly': [421], 'reduced': [422, 716, 769, 827, 853, 900, 908], 'stores': [424, 889, 935], 'bone': [427, 848, 858, 913], 'marrow': [428, 849, 859, 914], 'were': [429, 980, 1094, 1122, 1204, 1434], '73%': [432], 'cases.2,3Thus,': [435], 'absolute': [436], '(defined': [439, 455, 1185], '%': [447], '<20%)': [450, 466], 'functional': [452, 1143], '≥100': [460], 'percentage': [463], 'commonly': [468], 'seen': [469], 'even': [476, 1214], 'anemia.Iron': [478], 'indispensable': [480], 'life,': [482], 'serving': [483], 'metal': [486], 'cofactor': [487], 'many': [489, 501, 708, 1273], 'enzymes,': [490], 'either': [491, 997], 'nonheme': [492, 520], 'iron-containing': [493, 521, 535], 'proteins': [494, 522, 536], 'hemoproteins.': [496], 'Hemoproteins': [497], 'involved': [499, 526], 'crucial': [502], 'biological': [503], 'functions,': [504], 'including': [505, 715], 'oxygen': [506, 509], 'binding': [507], '(hemoglobins),': [508], 'metabolism': [510, 529, 541, 806], '(oxidases,': [511], 'peroxidase,': [512], 'catalases,': [513], 'etc),': [514], 'electron': [516], 'transfer': [517], '(cytochromes).': [518], 'Many': [519], 'catalyze': [523], 'key': [524], 'reactions': [525], 'energy': [528], 'DNA': [531], 'synthesis.': [532], 'addition,': [534, 761], 'required': [538], 'collagen,': [543], 'tyrosine,': [544], 'catecholamines.4': [546], 'However,': [547], 'Naito': [548, 1771, 1798], 'et': [549, 2168], 'al5': [550], 'Dahl': [556, 1791], 'salt-sensitive': [557, 1792], 'rats': [558, 590, 671], 'improved': [559, 1278], 'survival,': [560], 'prevented': [561], 'hypertension,': [562], 'vascular': [564, 1468], 'hypertrophy,': [565, 568], 'left': [566, 612, 1042, 1118], 'ventricular': [567, 613, 1043, 1119, 1848], 'proteinuria,': [570], 'inhibited': [571], 'oxidative': [572], 'stress,': [573], 'fibrosis,': [574, 618], 'inflammation,': [576], 'maintained': [578], 'molecular': [580, 626], 'signaling': [581, 627], 'pathway.': [582], 'contrast,': [584], 'previous': [586, 1457], 'Sprague-Dawley': [589], 'same': [593], 'group': [594, 1033, 1237], 'just': [596], 'opposite,': [598], 'actually': [602], 'caused': [603, 683, 726], 'diastolic': [604], 'dysfunction': [605, 767, 1121], 'pulmonary': [610, 2117], 'congestion,': [611], 'hypertrophy': [614], 'dilation,': [616, 1849], 'cardiac': [617, 632], 'reduction': [619], 'erythropoietin': [621, 1698], 'levels,': [622, 1036], 'pathways': [628], '(as': [629], 'STAT3': [633], 'phosphorylation),': [634], 'an': [636, 1492, 1533, 1550, 1659], 'increase': [637, 1309, 1428, 1437], 'inflammatory': [640], 'cytokine': [641], 'tumor': [642, 815], 'necrosis': [643, 816], 'factor-α': [644, 817], 'proteinuria.6': [646], 'The': [647, 895, 1127, 1191, 1228, 1382, 1408, 2107], 'reason': [648], 'discrepancy': [651], 'results': [654, 1398], '2': [657, 897, 979, 988], 'studies': [658, 951, 964, 1266, 1507, 1525], 'clear': [661], 'probably': [664], 'different': [668, 702, 2045], 'types': [669], 'used.': [672], 'animal': [676, 703], 'study,': [677, 1086], 'rat': [681], 'hearts': [682], 'mitochondrial': [684, 1850], 'ultrastructural': [685, 1851], 'aberrations,': [686], 'irregular': [687], 'sarcomere': [688], 'organization,': [689], 'release': [691, 930], 'cytochrome': [693], 'C.7': [694], 'Thus,': [695], 'effects': [697, 1193, 1329], 'models': [704], 'contradictory.There': [706], 'causes': [709, 1367, 1708], 'CHF,8': [714], 'intake': [718], 'due': [719], 'anorexia,': [721], 'gastrointestinal': [723, 728, 925], 'blood': [724, 840], 'loss': [725], 'bleeding': [729], 'from': [730, 866, 876, 933, 1585, 2085], 'diaphragmatic': [731], 'hernias,': [732], 'ulcers,': [733], 'gastritis,': [734], 'tumors,': [735], 'platelet': [736], 'inhibitors,': [737], 'anticoagulants.': [739], 'It': [740], 'has': [741, 1395, 1582], 'been': [743, 975, 1371, 1472], 'proton': [746], 'pump': [747], 'inhibitors': [748], 'such': [749], 'omeprazole,': [751], 'which': [752, 869], 'widely': [754], 'used,': [755, 1423], 'reduce': [757, 1445], 'absorption.': [759], 'can': [763, 792, 798, 821, 870, 1276, 1567], 'cause': [764, 793, 800, 822, 871, 1424, 1569], 'intestinal': [765], 'cell': [766], 'absorption': [771, 875, 926], 'because': [772, 1255], 'bowel': [774], 'edema': [775], 'other': [777, 1083, 1366, 1573], 'factors.': [778], 'Erythropoietin': [779, 1995], '(EPO)': [780], 'its': [782, 1257, 1377, 1387], 'derivatives': [783, 1378, 1388], 'use': [784, 1128, 1293, 1383, 1453], 'up': [785], 'form': [788], 'Hb,': [789, 1138, 1444], 'deficiency.': [795, 1560, 1822, 1971], 'Elevated': [796], 'cytokines': [797], 'abnormalities': [801], 'EPO': [803, 828, 1375, 1385, 1420, 1433, 1455, 1476], '(Figure': [807, 1521], '1).': [808], 'These': [809], 'elaborated': [811], 'especially': [814], 'interleukin-6.': [819], 'They': [820], '4': [823], 'hematologic': [824], 'abnormalities:8': [825], '(1)': [826], 'production': [829, 1699], 'kidney,': [832], 'leading': [833, 851], 'inappropriately': [835], 'low': [836], 'degree': [843], 'present;': [846], '(2)': [847], 'damage': [850], 'erythropoietic': [854], 'response': [855, 1811], 'EPO;': [861], '(3)': [862], 'hepcidin': [864], 'secretion': [865], 'liver,': [868], 'gut;': [878], 'well': [880, 1072, 1514], '(4)': [882], 'hepcidin-induced': [883], 'trapping': [884], 'macrophages': [892], 'hepatocytes.': [894], 'latter': [896], 'result': [898], 'blood,': [905], 'therefore': [907], 'supply': [910, 1703], 'rest': [916], 'body.Download': [919], 'figureDownload': [920, 1543], 'PowerPointFigure': [921, 1544], '1.': [922], 'Hepcidin': [923], 'blocks': [924], 'macrophage.Correction': [937], 'men': [943], 'intravenous': [945], '(IV)': [946], 'alone': [948], 'several': [950, 1098, 1506], 'seems': [952, 1547], 'improve': [954, 1510], 'independent': [957], 'whether': [959], 'present.8': [962], 'Six': [963], 'where': [965], 'IV': [966, 998, 1101, 1130, 1252, 1280, 1331, 1361, 1393, 1503], 'used': [969, 1435], 'iron-deficient': [971], 'performed,8': [976], 'only': [978, 1162], 'placebo-controlled,': [981], 'double-blind': [982], 'studies.9,10': [983], 'these': [987], 'studies,': [989], 'small,': [991], 'single-center': [992], 'study,9': [993], '40': [994], 'received': [996, 1583], 'sucrose': [1002], '(Venofer,': [1003], 'Vifor': [1004, 1588], 'Int': [1005, 1105], 'Zurich)': [1006, 1106], 'at': [1007], '200': [1008], 'mg': [1009], 'week': [1011], '5': [1013], 'weeks,': [1014], 'placebo': [1017, 1109], 'infusion.': [1018], 'At': [1019], '6-month': [1020], 'follow-up,': [1021], 'there': [1022], 'significant': [1024, 1135], 'improvement': [1025, 1231, 1313], 'treated': [1028, 1165, 1236], 'compared': [1029, 1451], 'control': [1032], 'Hb': [1035, 1188, 1311, 1347, 1430], 'ejection': [1044], 'fraction,': [1045], '6-minute': [1046, 1145], 'walk': [1047, 1146], 'test,': [1048], 'hospitalization': [1049, 2009], 'rate,': [1050], 'Minnesota': [1051], 'Living': [1052], 'Questionnaire': [1056], 'quality': [1057, 1155], 'life': [1059, 1157], 'score,': [1060], 'creatinine': [1061], 'clearance,': [1062], 'protein,': [1064], 'peptide,': [1070], 'slowing': [1074], 'rate': [1077], 'lower': [1079, 1417], 'diuretic': [1080], 'requirements.In': [1081], 'double-blind,': [1084], 'placebo-controlled': [1085, 1322], 'large,': [1088], 'multicenter': [1089], '(FAIR-HF': [1091], 'study10),': [1092], 'randomly': [1095], 'assigned': [1096], 'doses': [1099, 1418], 'ferric': [1102], 'carboxymaltose': [1103], '(Vifor': [1104], 'versus': [1107], 'matching': [1108], 'control.': [1110], 'total': [1112], '459': [1114], 'subjects': [1115, 1180], 'chronic': [1117, 1713, 1913, 2115], 'studied': [1123], '26': [1125], 'weeks.': [1126], 'associated': [1133, 1306, 1473], 'improvements': [1136], 'distance,': [1147], 'patient': [1149, 1195, 1519], 'global': [1150, 1196], 'assessment': [1151, 1197], 'scale,': [1152, 1158], 'Kansas': [1153], 'City': [1154], 'renal': [1160, 1222, 1555, 1563, 1917, 2001], 'function': [1161, 1520, 2002], 'group.': [1166], 'subgroup': [1168], 'analysis,': [1169], 'magnitude': [1171], 'treatment': [1174, 1192, 1289, 1450, 1530], 'effect': [1175, 1249, 1259], 'differ': [1178], '≤12': [1189], 'g/dL).': [1190], 'on': [1194, 1260], 'scale': [1198], 'age,': [1209], 'presence': [1210], 'diabetes,': [1212], 'initial': [1217], 'severity': [1218], 'function,': [1223], 'levels.': [1227], 'similar': [1233], 'both': [1239], 'nonanemic': [1242], 'groups': [1243], 'suggests': [1244], 'part': [1246], 'direct': [1258], 'body': [1261], 'tissues': [1262], 'irrespective': [1263], 'hemoglobin.These': [1265], 'suggest': [1267], 'be': [1277, 1380, 1422, 1491, 1532, 1549], 'iron.': [1281], 'Conversely,': [1282], 'controlled': [1285, 1406], 'CHF,11': [1291], 'oral': [1295, 1391], 'year': [1303], 'any': [1308, 1315], 'parameters.': [1317], 'Clearly,': [1318], 'large': [1320], 'mortality-driven,': [1321], 'needed': [1325], 'confirm': [1327], 'CHF.In': [1334], 'who': [1341], 'do': [1342], 'reach': [1344], 'target': [1346, 1443], '(usually': [1348], 'about': [1349], '11': [1350], '12': [1352], 'g/dL),8': [1353], 'after': [1354], 'correction': [1355, 1410, 1458, 1501], 'iron,': [1362], 'whom': [1365], 'ruled': [1372], 'out,': [1373, 1528], 'then': [1374], 'should': [1379], 'started.': [1381], 'along': [1389], 'shown': [1396], 'promising': [1397], 'await': [1402], 'confirmation': [1403], 'long-term': [1405], 'studies.': [1407], 'prior': [1409], 'will': [1414, 1464], 'allow': [1415], 'rapid': [1427], 'than': [1431], 'alone,': [1436], 'chances': [1439], 'attaining': [1441], 'price': [1447], 'help': [1465], 'prevent': [1466], 'complications': [1469], 'high-dose': [1475], 'therapy.8ConclusionThere': [1477], 'growing': [1479], 'evidence': [1480], 'may': [1490, 1577], 'important': [1493, 1534], 'contributor': [1494], 'condition.': [1499], 'Its': [1500], 'appeared': [1508], 'cardiac,': [1516], 'renal,': [1517], '2).': [1522], 'If': [1523], 'further': [1524, 1578], 'bear': [1526], 'could': [1531], 'new': [1535], 'addition': [1536], 'therapy': [1539, 2040], 'failure.Download': [1542], '2.': [1545], 'There': [1546], 'interaction': [1551], 'between': [1552], 'each': [1568], 'worsen': [1571, 1579], 'all': [1580], '3.DisclosuresD.Si.': [1581], 'honoraria': [1584], 'Amgen': [1586], 'International': [1589, 2089], 'lectures.FootnotesThe': [1591], 'opinions': [1592], 'expressed': [1593], 'editorial': [1596], 'necessarily': [1599], 'editors': [1603], 'American': [1607, 2186], 'Association.Correspondence': [1609], 'Nephrology,': [1615, 2092], 'Weizman': [1621], 'Street': [1622], '6,': [1623], '64239,': [1626], 'E-mail': [1628], '[email': [1629], 'protected]net.ilReferences1.': [1630], 'Jankowska': [1631], 'EA,': [1632], 'Rozentryt': [1633], 'P,': [1634, 1901, 1959], 'Witkowska': [1635], 'A,': [1636, 1690, 1729, 1874, 1899, 1980, 1990, 2060, 2136], 'Nowak': [1637], 'J,': [1638, 1897, 1930, 1946], 'Hartmann': [1639], 'O,': [1640, 1686], 'Ponikowska': [1641], 'B,': [1642, 1837, 1942, 2064], 'Borodulin-Nadjieja': [1643], 'L,': 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