The structural requirements for ceramide activation of serine-threonine protein phosphatases

Name: Work Video:
Duration: 3 min 30 s
Charles E. Chalfant; Zdzisław M. Szulc; Patrick Roddy; Alicja Bielawska; Yusuf A. Hannun
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1730], '(CAPP).': [12, 239], 'In': [13, 42, 240, 269, 1733], 'this': [14, 241, 1734], 'study,': [15, 242, 1735], 'the': [16, 30, 46, 78, 83, 93, 96, 99, 104, 109, 117, 164, 168, 182, 185, 243, 257, 273, 305, 310, 320, 323, 326, 331, 336, 344, 391, 395, 409, 412, 628, 670, 700, 1027, 1331, 1422, 1577, 1634, 1710, 1720, 1723, 1726, 1738, 1742, 1748, 1762, 1767, 1770, 1779, 1800, 1803, 1836, 1840, 1877, 2051, 2064, 2067, 2350, 2461, 2470, 2507, 2607, 2613, 2687, 2696, 2744, 2750, 2939, 3255, 3575, 3810, 4054, 4063, 4067], 'structural': [17, 194, 244, 422, 1739, 1831, 2345, 2502, 2934], 'requirements': [18, 195, 245, 423, 1740, 2306, 2348, 2503, 2906, 2937, 3174, 3417, 3649, 3883, 4138], 'for': [19, 95, 112, 196, 246, 322, 339, 424, 779, 816, 1354, 1470, 1564, 1746, 1788, 1799, 1998, 2506, 3084, 3327, 3559, 3794, 4043, 4066], 'interaction': [20, 197, 247, 425, 1727, 1804], 'between': [21, 248], 'ceramide': [22, 28, 69, 86, 171, 199, 204, 221, 249, 255, 296, 313, 398, 427, 432, 449, 461, 556, 649, 688, 694, 1129, 1325, 1427, 1639, 1718, 1743, 1789, 1806, 1828, 1999, 2308, 2394, 2439, 2505, 2615, 2665, 2752, 2908, 2982, 3176, 3419, 3651, 3885, 4140], 'CAPP': [24, 175, 251, 402, 1020, 1702, 1715], 'were': [25, 154, 252, 381, 1816, 1833, 1848, 1887, 1905, 1942, 2058, 2253, 2330, 2379, 2449, 2601, 2675, 2738], 'determined.': [26, 253], 'd-erythro-C6': [27, 254], 'activated': [29, 256, 1323], 'catalytic': [31, 258, 1272, 1332], 'subunit': [32, 259, 1273, 1281, 2584, 2721], 'of': [33, 45, 77, 85, 108, 114, 121, 143, 149, 159, 170, 184, 198, 210, 225, 260, 272, 304, 312, 335, 341, 348, 370, 376, 386, 397, 411, 426, 438, 453, 457, 467, 555, 561, 584, 632, 648, 687, 693, 702, 746, 808, 850, 880, 1007, 1026, 1030, 1071, 1094, 1218, 1241, 1301, 1307, 1318, 1334, 1417, 1426, 1430, 1531, 1537, 1579, 1629, 1638, 1642, 1714, 1722, 1725, 1728, 1769, 1786, 1802, 1805, 1843, 1914, 1921, 1925, 1940, 1962, 1966, 1968, 2026, 2029, 2042, 2066, 2097, 2123, 2141, 2173, 2199, 2217, 2275, 2307, 2313, 2344, 2352, 2367, 2393, 2463, 2469, 2472, 2487, 2504, 2509, 2585, 2609, 2612, 2626, 2645, 2689, 2695, 2698, 2713, 2722, 2746, 2749, 2763, 2782, 2819, 2823, 2825, 2845, 2848, 2875, 2907, 2913, 2933, 2941, 3113, 3116, 3143, 3175, 3181, 3245, 3252, 3356, 3359, 3386, 3418, 3424, 3588, 3591, 3618, 3650, 3656, 3822, 3825, 3852, 3884, 3890, 4057, 4077, 4080, 4107, 4139, 4145], 'PP2A': [34, 261, 1260, 1321], '(PP2Ac)': [35, 262], 'approximately': [36, 263], '3-fold': [37, 264], 'in': [38, 265, 502, 528, 532, 590, 650, 1098, 1131, 1134, 1245, 1268, 1284, 1295, 1347, 1474, 1541, 1576, 1605, 1703, 1708, 1868, 1882, 1889, 1907, 2000, 2063, 2374, 2381, 2443, 2496, 2606, 2624, 2656, 2669, 2743, 2761], 'a': [39, 206, 266, 434, 558, 690, 813, 851, 1024, 1265, 1271, 1279, 1292, 1299, 1381, 1467, 1783, 1851, 1897, 1918, 2072, 2125, 2201, 2256, 2497, 2657, 2802, 2978, 2984, 3100, 3215, 3219, 3343, 3452, 3685, 3918, 4171], 'stereospecific': [40, 267, 948, 1159, 2347, 2936], 'manner.': [41, 268], 'contrast,': [43, 270], 'saturation': [44, 271], '4-5': [47, 274], 'double': [48, 275], 'bond,': [49, 276], 'producing': [50, 277], 'd-erythro-dihydro': [51, 278], 'C6': [52, 62, 65, 123, 126, 129, 132, 135, 140, 161, 279, 289, 292, 350, 353, 356, 359, 362, 367, 388, 2521, 2526, 2531, 2536, 2541, 2579, 2981], 'ceramide,': [53, 63, 66, 124, 127, 130, 133, 136, 162, 280, 290, 293, 351, 354, 357, 360, 363, 389], 'inhibited': [54, 281], 'PP2Ac': [55, 74, 115, 282, 301, 342, 2473, 2660, 2699], '(IC50': [56, 283], '=': [57, 284, 2481, 2634, 2707, 2771, 3006, 3015, 3026, 3052, 3469, 3475, 3483, 3491, 3498, 3509, 3516, 3535, 3702, 3708, 3716, 3761, 3936, 3942, 3949, 3965, 3981, 3987, 4006], '8.5': [58, 285], 'μM).': [59, 286], 'Furthermore,': [60, 287], 'phyto': [61, 288], 'd-erythro-dehydro': [64, 291, 2980], 'd-erythro-cis-C6': [68, 295], 'had': [70, 297, 2159], 'no': [71, 298], 'effect': [72, 299], 'on': [73, 300, 1421, 1633, 1896, 2491, 2649, 2717, 2786], 'activity.': [75, 302], 'Modification': [76, 303], 'sphingoid': [79, 110, 306, 337, 1763], 'chain': [80, 307, 938, 1149], 'also': [81, 155, 214, 308, 382, 442, 1598], 'abolished': [82, 309], 'ability': [84, 169, 183, 311, 396, 410, 1768], 'to': [87, 173, 187, 189, 216, 314, 400, 414, 416, 444, 654, 699, 1127, 1298, 1327, 1607, 1761, 1772, 2161, 2396, 2451, 2677, 2976, 3213], 'activate': [88, 315, 940, 1151, 1776], 'PP2Ac.': [89, 150, 316, 377], 'Further': [90, 317], 'studies': [91, 153, 213, 318, 380, 441, 1597], 'demonstrated': [92, 319], 'requirement': [94, 321], 'amide': [97, 324], 'group,': [98, 102, 325, 329], 'primary': [100, 327], 'hydroxyl': [101, 106, 328, 333, 4060], 'secondary': [105, 332, 4059], 'group': [107, 334, 4061], 'backbone': [111, 338, 1764], 'activation': [113, 148, 340, 375, 783, 1414, 1429, 1536, 1626, 1641, 1749, 2508], 'through': [116, 343, 2349, 2938], 'synthesis': [118, 345, 1585, 2065, 2096, 2122, 2172, 2198], 'evaluation': [120, 347], 'd-erythro-urea': [122, 349], 'l-erythro-urea': [125, 352], 'd-erythro-N-methyl': [128, 355], 'd-erythro-1-O-methyl': [131, 358], 'd-erythro-3-O-methyl': [134, 361], '(2S)': [138, 365], '3-keto': [139, 366], 'ceramide.': [141, 368, 1732], 'None': [142, 369], 'these': [144, 371, 1335, 1601, 1696, 1729, 1791], 'compounds': [145, 372], 'induced': [146, 373, 485, 524], 'significant': [147, 374], 'Liposome': [151, 378], 'binding': [152, 379, 2391, 2471, 2697, 3243], 'conducted': [156, 383], 'using': [157, 384, 1850], 'analogs': [158, 172, 186, 222, 385, 399, 413, 450, 1832, 2249, 2395, 2440, 2666], 'd-erythro-C': [160, 387], 'results': [165, 392, 1755], 'showed': [166, 393], 'that': [167, 219, 394, 447, 909, 1600, 1695, 1757], 'influence': [174, 401], '(activation': [176, 403], 'or': [177, 404, 1610], 'inhibition)': [178, 405], 'was': [179, 406, 1021, 1823, 1929, 2435, 2661, 2793, 2958, 3090, 3195, 3333, 3438, 3565, 3670, 3682, 3800, 3904, 4049, 4159], 'associated': [180, 407], 'with': [181, 200, 408, 428, 1731, 1752, 1774, 1807, 1858, 1910, 2437, 2663, 2965, 3202, 3294, 3445, 3677, 3911, 4166], 'bind': [188, 415], 'CAPP.This': [190], 'study': [191, 419, 1721, 1781], 'demonstrates': [192, 420], 'strict': [193, 421], 'CAPP,': [201, 429], 'disclose': [203, 431, 1756], 'very': [207, 435], 'specific': [208, 436, 2043], 'regulator': [209, 437, 466], 'CAPP.': [211, 226, 417, 439, 454, 1777], 'begin': [215, 443], 'define': [217, 445], 'features': [218, 446], 'transform': [220, 448], 'into': [223, 451], 'inhibitors': [224, 452, 2312, 2912, 3180, 3423, 3655, 3889, 4144], 'This': [418, 696, 2791, 3088, 3331, 3563, 3798, 4047], 'Many': [455], 'lines': [456], 'evidence': [458, 1798], 'have': [459, 1124, 1350], 'suggested': [460], 'an': [463, 743, 1275, 1859, 1911], 'important': [464], 'intracellular': [465, 1285], 'various': [468, 1830], 'stress': [469, 672], 'responses': [470, 653], 'growth': [472], 'mechanisms': [473], '(1Obeid': [474], 'L.M.': [475, 497, 667, 1090, 1237, 1497, 1666, 1958, 1994, 2815], 'Linardic': [476, 603, 2337, 2926], 'C.M.': [477, 604, 2338, 2927], 'Karolak': [478], 'L.A.': [479], 'Hannun': [480, 520, 552, 935, 975, 1002, 1039, 1066, 1091, 1146, 1186, 1213, 1238, 1411, 1494, 1623, 1663, 1959, 1995, 2023, 2271, 2301, 2339, 2816, 2842, 2871, 2901, 2928, 3110, 3139, 3169, 3240, 3353, 3382, 3412, 3585, 3614, 3644, 3819, 3848, 3878, 4074, 4103, 4133], 'Y.A.': [481, 521, 553, 580, 602, 623, 646, 665, 936, 976, 1003, 1040, 1067, 1092, 1147, 1187, 1214, 1239, 1412, 1495, 1624, 1664, 1960, 1996, 2024, 2272, 2340, 2817, 2843, 2872, 2929, 3111, 3140, 3241, 3354, 3383, 3586, 3615, 3820, 3849, 4075, 4104], 'Programmed': [482], 'cell': [483, 533, 566, 2001], 'death': [484], 'by': [486, 525, 784, 882, 904, 951, 1162, 1324, 1533, 1586, 1701, 1717, 1790, 1933, 2475, 2701, 2960, 3197, 3248, 3254, 3440, 3672, 3906, 4053, 4161], 'ceramide.Science.': [487], '1993;': [488, 614, 916, 985, 1049, 1196, 1972, 2829], '259:': [489], '1769-1771Crossref': [490], 'PubMed': [491, 511, 543, 576, 596, 617, 642, 659, 679, 755, 794, 831, 864, 889, 922, 964, 991, 1014, 1055, 1078, 1110, 1175, 1202, 1225, 1257, 1396, 1444, 1487, 1515, 1549, 1591, 1656, 1684, 1978, 2014, 2036, 2289, 2319, 2363, 2835, 2855, 2889, 2919, 2952, 3123, 3157, 3187, 3267, 3302, 3366, 3400, 3430, 3598, 3632, 3662, 3832, 3866, 3896, 4087, 4121, 4151], 'Scopus': [492, 512, 597, 618, 660, 680, 832, 890, 965, 1015, 1079, 1176, 1226, 1397, 1445, 1488, 1516, 1550, 1592, 1657, 1685, 2015, 2037, 2108, 2134, 2184, 2210, 2320, 2856, 2920, 3124, 3188, 3268, 3303, 3367, 3431, 3599, 3663, 3833, 3897, 4088, 4152], '(1573)': [493], 'Google': [494, 514, 544, 577, 599, 620, 643, 662, 682, 756, 795, 834, 865, 892, 923, 967, 992, 1017, 1056, 1081, 1111, 1178, 1203, 1228, 1258, 1399, 1447, 1490, 1518, 1552, 1594, 1659, 1687, 1979, 2017, 2039, 2110, 2136, 2186, 2212, 2290, 2322, 2364, 2836, 2858, 2890, 2922, 2953, 3126, 3158, 3190, 3270, 3305, 3369, 3401, 3433, 3601, 3633, 3665, 3835, 3867, 3899, 4090, 4122, 4154], 'Scholar,': [495, 515, 545, 578, 600, 621, 644, 663, 757, 796, 835, 866, 893, 924, 968, 993, 1057, 1082, 1179, 1204, 1229, 1400, 1448, 1491, 1519, 1553, 1660, 1980, 2018, 2111, 2137, 2187, 2213, 2291, 2837, 2859, 2891, 2923, 3127, 3159, 3271, 3370, 3402, 3602, 3634, 3836, 3868, 4091, 4123], '2Obeid': [496], 'Venable': [498], 'M.E.': [499], 'Signal': [500], 'transduction': [501], 'cellular': [503, 591, 652, 1500, 1669], 'senescence.J.': [504], 'Am.': [505], 'Geriatr.': [506], 'Soc.': [507, 674], '1997;': [508, 676], '45:': [509], '361-366Crossref': [510], '(21)': [513], '3Okazaki': [516], 'T.': [517, 547, 730, 1371], 'Bell': [518, 550, 581], 'R.M.': [519, 551, 582], 'Sphingomyelin': [522], 'turnover': [523], 'vitamin': [526], 'D3': [527], 'HL-60': [529, 565], 'cells.': [530], 'Role': [531, 554, 1093, 1240, 1997], 'differentiation.J.': [534, 567], 'Biol.': [535, 568, 634, 751, 786, 821, 856, 914, 954, 983, 1047, 1102, 1165, 1194, 1249, 1386, 1434, 1477, 1505, 1646, 1674, 1970, 2004, 2355, 2827, 2944, 3257], 'Chem.': [536, 569, 635, 787, 822, 857, 915, 955, 984, 1048, 1103, 1166, 1195, 1250, 1387, 1435, 1478, 1506, 1647, 1675, 1971, 2005, 2104, 2150, 2180, 2226, 2356, 2828, 2945, 3258], '1989;': [537, 593], '264:': [538], '19076-19080Abstract': [539], 'Full': [540, 573, 639, 791, 826, 828, 861, 919, 959, 961, 988, 1052, 1107, 1170, 1172, 1199, 1254, 1391, 1393, 1439, 1441, 1482, 1484, 1510, 1512, 1651, 1653, 1679, 1681, 1975, 2009, 2011, 2284, 2286, 2360, 2832, 2884, 2886, 2949, 3152, 3154, 3262, 3264, 3395, 3397, 3627, 3629, 3861, 3863, 4116, 4118], 'Text': [541, 574, 640, 792, 827, 829, 862, 920, 960, 962, 989, 1053, 1108, 1171, 1173, 1200, 1255, 1392, 1394, 1440, 1442, 1483, 1485, 1511, 1513, 1652, 1654, 1680, 1682, 1976, 2010, 2012, 2285, 2287, 2361, 2833, 2885, 2887, 2950, 3153, 3155, 3263, 3265, 3396, 3398, 3628, 3630, 3862, 3864, 4117, 4119], 'PDF': [542, 575, 641, 793, 830, 863, 921, 963, 990, 1054, 1109, 1174, 1201, 1256, 1395, 1443, 1486, 1514, 1655, 1683, 1977, 2013, 2288, 2362, 2834, 2888, 2951, 3156, 3266, 3399, 3631, 3865, 4120], '4Okazaki': [546], 'Bielawska': [548, 933, 1087, 1144, 1234, 1985, 2269, 2303, 2869, 2903, 3137, 3171, 3380, 3414, 3612, 3646, 3846, 3880, 4101, 4135], 'A.': [549, 934, 1088, 1145, 1235, 1527, 1529, 1952, 2020, 2270, 2304, 2336, 2809, 2839, 2870, 2904, 2925, 3107, 3138, 3172, 3350, 3381, 3415, 3582, 3613, 3647, 3816, 3847, 3881, 4071, 4102, 4136], 'lipid': [559, 745, 1771], 'mediator': [560], '1': [562, 2376], 'alpha,25-dihydroxyvitamin': [563], 'D3-induced': [564], '1990;': [570], '265:': [571], '15823-15831Abstract': [572], '5Hannun': [579], 'Functions': [583, 647], 'sphingolipids': [585], 'sphingolipid': [587], 'breakdown': [588, 606], 'products': [589], 'regulation.Science.': [592], '243:': [594], '500-507Crossref': [595], '(1094)': [598], '6Hannun': [601], 'Sphingolipid': [605], 'products:': [607], 'anti-proliferative': [608], 'tumor-suppressor': [610], 'lipids.Biochim.': [611], 'Biophys.': [612], 'Acta.': [613], '1154:': [615], '223-236Crossref': [616], '(279)': [619], '7Hannun': [622], 'sphingomyelin': [625], 'cycle': [626, 2002], 'second': [629], 'messenger': [630], 'function': [631], 'ceramide.J.': [633], '1994;': [636, 788, 858, 1104, 1251], '269:': [637, 789, 859, 1105, 1252], '3125-3128Abstract': [638], '8Hannun': [645], 'coordinating': [651], 'stress.Science.': [655], '1996;': [656, 1479, 1507, 1676], '274:': [657, 957, 1168, 1389], '1855-1859Crossref': [658], '(1475)': [661], '9Hannun': [664], 'Obeid': [666, 1089, 1236, 1496, 1665, 1957, 1993, 2814], 'Ceramide': [668, 741, 977, 1041, 1188, 1376, 1498, 1667], 'eukaryotic': [671], 'response.Biochem.': [673], 'Trans.': [675], '25:': [677], '1171-1175Crossref': [678], '(58)': [681], 'Scholar).': [683, 1018, 1112, 1259, 1595, 1688, 2040, 2154, 2230, 2323, 2365, 2954, 3191, 3306, 3434, 3666, 3900, 4155], 'These': [684], 'emerging': [685], 'roles': [686], 'necessitate': [689], 'mechanistic': [691], 'understanding': [692], 'action.': [695], 'has': [697], 'led': [698], 'identification': [701], 'several': [703], 'candidate': [704], 'ceramide-regulated': [705], 'enzymes,': [706], 'including': [707, 1356], 'kinase,': [710], 'kinase': [712, 773, 818, 910, 1359, 1502, 1573, 1581, 1671, 2127, 2203], 'Cζ,': [713], 'cathepsin': [714, 747], 'D,': [715], 'phosphatase': [719, 981, 1045, 1097, 1192, 1244, 1432, 1473, 1540, 1566, 1644, 2622, 2759], '(CAPP)': [720], '(10Heinrich': [721], 'M.': [722, 724, 738, 1521, 1992], 'Wickel': [723], 'Winoto-Morbach': [725], 'S.': [726, 740, 839, 872, 874, 876, 995, 1059, 1206, 1406, 1618, 1982, 2113, 2189, 2262, 2296, 2862, 2896, 3130, 3164, 3373, 3407, 3605, 3639, 3839, 3873, 4094, 4128], 'Schneider-Brachert': [727], 'W.': [728], 'Weber': [729], 'Brunner': [731], 'J.': [732, 759, 771, 800, 804, 837, 2264, 2293, 2864, 2893, 3132, 3161, 3375, 3404, 3607, 3636, 3841, 3870, 4096, 4125], 'Saftig': [733], 'P.': [734, 802, 2090, 2166, 2266, 2298, 2866, 2898, 3134, 3166, 3377, 3409, 3609, 3641, 3843, 3875, 4098, 4130], 'Peters': [735], 'C.': [736, 932, 972, 999, 1036, 1063, 1143, 1183, 1210, 1561], 'Kronke': [737], 'Schutze': [739], 'activator': [744], 'D.Adv.': [748], 'Exp.': [749], 'Med.': [750], '2000;': [752, 1546, 2033, 2852, 3120, 3363, 3595, 3829, 4084], '477:': [753], '305-315Crossref': [754], '11Lozano': [758], 'Berra': [760], 'E.': [761, 2094, 2170], 'Municio': [762], 'M.M.': [763, 798], 'Diaz-Meco': [764, 805], 'M.T.': [765, 806], 'Dominguez': [766], 'I.': [767], 'Sanz': [768], 'L.': [769, 1557], 'Moscat': [770, 803], 'Protein': [772], 'C': [774, 819, 1503, 1574, 1672, 2128, 2204], 'zeta': [775], 'isoform': [776], 'is': [777, 912, 947, 1158, 1261, 1288, 1466, 1691, 1719], 'critical': [778], 'kappa': [780], 'B-dependent': [781], 'promoter': [782], 'sphingomyelinase.J.': [785], '19200-19202Abstract': [790], '12Municio': [797], 'Lozano': [799], 'Sanchez': [801], 'Identification': [807], 'heterogeneous': [809], 'ribonucleoprotein': [810], 'A1': [811], 'novel': [814], 'substrate': [815], 'zeta.J.': [820], '1995;': [823, 886, 2006], '270:': [824, 2007], '15884-15891Abstract': [825], '(79)': [833, 3269], '13Liu': [836], 'Mathias': [838, 873], 'Yang': [840], 'Z.': [841, 2022, 2841, 3109, 3352, 3584, 3818, 4073], 'Kolesnick': [842, 877, 900], 'R.N.': [843, 901], 'Renaturation': [844], 'tumor': [846], 'necrosis': [847], 'factor-alpha': [848], 'stimulation': [849], '97-kDa': [852], 'kinase.J.': [855], '3047-3052Abstract': [860], '14Yao': [867], 'B.': [868, 1404, 1616, 1984], 'Zhang': [869], 'Y.': [870, 2302, 2902, 3170, 3277, 3413, 3645, 3879, 4134], 'Delikat': [871], 'Basu': [875], 'R.': [878, 899, 1523, 1555], 'Phosphorylation': [879], 'Raf': [881], 'kinase.Nature.': [885], '378:': [887], '307-310Crossref': [888], '(302)': [891], '15Joseph': [894], 'C.K.': [895], 'Byun': [896], 'H.S.': [897], 'Bittman': [898], 'Substrate': [902, 2273, 2873, 3141, 3384, 3616, 3850, 4105], 'recognition': [903], 'kinase.': [907], 'Evidence': [908], 'activity': [911, 1967, 2623, 2760, 2824], 'proline-directed.J.': [913], '268:': [917, 986, 1050, 1197, 1973, 2830], '20002-20006Abstract': [918], '16Chalfant': [925], 'C.E.': [926, 1137, 1402, 1614], 'Kishikawa': [927, 996, 1060, 1138, 1207], 'K.': [928, 997, 1061, 1139, 1208], 'Mumby': [929, 973, 1000, 1037, 1064, 1140, 1184, 1211], 'M.C.': [930, 974, 1001, 1038, 1065, 1141, 1185, 1212], 'Kamibayashi': [931, 971, 998, 1035, 1062, 1142, 1182, 1209], 'Long': [937, 1148], 'ceramides': [939, 1150, 1609], 'phosphatase-1': [942, 1118, 1153, 3247], 'phosphatase-2A.': [945, 1156], 'Activation': [946, 1157], 'regulated': [950, 1161], 'phosphatidic': [952, 1163, 3249], 'acid.J.': [953, 1164], '1999;': [956, 1167, 1388], '20313-20317Abstract': [958, 1169], '(263)': [966, 1177], '17Dobrowsky': [969, 1180], 'R.T.': [970, 1034, 1086, 1181, 1233], 'activates': [978, 1042, 1189], 'heterotrimeric': [979, 1043, 1190, 1266], '2A.J.': [982, 1046, 1193], '15523-15530Abstract': [987, 1051, 1198], '18Galadari': [994, 1058, 1205], 'Purification': [1004, 1068, 1215], 'characterization': [1006, 1070, 1217], 'phosphatases.Biochemistry.': [1010, 1074, 1221], '1998;': [1011, 1075, 1222], '37:': [1012, 1076, 1223], '11232-11238Crossref': [1013, 1077, 1224], '(71)': [1016, 1080, 1227], 'Initially,': [1019], 'identified': [1022], 'member': [1025], 'class': [1029], 'serine-threonine': [1031, 1115, 1336, 1792], '(17Dobrowsky': [1033], '19Wolff': [1083, 1230], 'R.A.': [1084, 1231], 'Dobrowsky': [1085, 1232], 'ceramide-mediated': [1099, 1246, 1963, 2820], 'signal': [1100, 1247], 'transduction.J.': [1101, 1248], '19605-19609Abstract': [1106, 1253], 'Subsequently,': [1113], 'two': [1114, 2492, 2650, 2718, 2787], 'phosphatases,': [1116, 1794], 'phosphatase-2A': [1122, 2512, 2587, 2591, 2724, 2728], '(PP2A),': [1123], 'been': [1125, 1352], 'shown': [1126, 2387], 'be': [1128, 1328], 'responsive': [1130], 'vitro': [1132, 1348], 'vivo': [1135], '(16Chalfant': [1136], 'found': [1262], 'primarily': [1263, 1289], 'enzyme': [1267, 1294], 'cells': [1269, 1296], 'containing': [1270], '(PP2Ac),': [1274, 2588, 2725], 'A': [1276, 1562, 1705, 2120, 2196], 'subunit,': [1277], 'B': [1280], '(possible': [1282], 'role': [1283, 1563], 'targeting).': [1286], 'PP1': [1287, 1319, 1808], 'purified': [1290, 2959, 3196, 3439, 3671, 3905, 4160], 'heterodimeric': [1293], 'bound': [1297], 'number': [1300], 'described': [1302, 1353, 1949, 2258, 2334, 2442, 2604, 2668, 2741, 2806, 3104, 3347, 3579, 4065], 'subunits': [1303, 1333], '(e.g.,': [1304], 'nuclear': [1305], 'inhibitor': [1306], 'phosphatase-1,': [1309], 'pyrimidine': [1310], 'tract-binding': [1311], 'protein-associated': [1312], 'splicing': [1313], 'factor).': [1314], 'Whether': [1315], 'all': [1316, 1813, 1926, 2162, 2247], 'forms': [1317], 'are': [1322, 1339, 1603, 1698, 1866, 1881, 2458, 2485, 2618, 2643, 2684, 2711, 2755, 2780], 'remains': [1326], 'determined,': [1329], 'but': [1330, 1569], 'now': [1340, 1351], 'collectively': [1341], 'termed': [1342], 'phosphatases.': [1345], 'Several': [1346], 'substrates': [1349, 1602, 1697, 2062], 'CAPPs,': [1355], 'Bcl-2,': [1357], 'Cα,': [1360], 'c-jun,': [1361], 'SR': [1362, 1418, 1630], 'proteins,': [1363], 'AKT/PKB': [1365], '(20Ruvolo': [1366], 'P.P.': [1367], 'Deng': [1368], 'X.': [1369], 'Ito': [1370], 'Carr': [1372], 'B.K.': [1373], 'May': [1374], 'W.S.': [1375], 'induces': [1377, 1415, 1627], 'Bcl2': [1378], 'dephosphorylation': [1379, 1416, 1628], 'via': [1380], 'mechanism': [1382], 'involving': [1383], 'mitochondrial': [1384, 2314, 2914, 3182, 3425, 3657, 3891, 4146], 'PP2A.J.': [1385], '20296-20300Abstract': [1390], '(303)': [1398], '21Chalfant': [1401], 'Ogretmen': [1403, 1615], 'Galadari': [1405, 1617], 'Kroesen': [1407, 1619], 'B.J.': [1408, 1410, 1620, 1622], 'Pettus': [1409, 1621], 'FAS': [1413, 1625], 'proteins.': [1419, 1631], 'Dependence': [1420, 1632], 'de': [1423, 1635], 'novo': [1424, 1636], 'generation': [1425, 1637], '1.J.': [1433, 1645], '2001;': [1436, 1588, 1648, 2316, 2916, 3184, 3300, 3427, 3659, 3893, 4148], '276:': [1437, 1649], '44848-44855Abstract': [1438, 1650], '(139)': [1446, 1658], '22Reyes': [1449], 'J.G.': [1450], 'Robayna': [1451], 'I.G.': [1452], 'Delgado': [1453], 'P.S.': [1454], 'Gonzalez': [1455], 'I.H.': [1456], 'Aguiar': [1457], 'J.Q.': [1458], 'Rosas': [1459], 'F.E.': [1460], 'Fanjul': [1461], 'L.F.': [1462], 'Galarreta': [1463], 'C.M.R.': [1464], 'c-Jun': [1465], 'downstream': [1468], 'target': [1469, 2068], 'A431': [1475], 'cells.J.': [1476], '271:': [1480, 1508, 1677], '21375-21380Abstract': [1481], '(60)': [1489], '23Lee': [1492, 1661], 'J.Y.': [1493, 1662, 1988], 'inactivates': [1499, 1668], 'alpha.J.': [1504, 1673], '13169-13174Abstract': [1509, 1678], '(244)': [1517, 1686], '24Salinas': [1520], 'Lopez-Valdaliso': [1522], 'Martin': [1524], 'D.': [1525, 1956, 2115, 2119, 2191, 2195, 2813], 'Alvarez': [1526], 'Cuadrado': [1528], 'Inhibition': [1530], 'PKB/Akt1': [1532], 'C2-ceramide': [1534], 'involves': [1535], 'PC12': [1542], 'cells.Mol.': [1543], 'Cell.': [1544], 'Neurosci.': [1545], '15:': [1547], '156-169Crossref': [1548], '(169)': [1551], '25Cazzolli': [1554], 'Carpenter': [1556], 'Biden': [1558], 'T.J.': [1559], 'Schmitz-Peiffer': [1560], '2A-like': [1567], 'activity,': [1568], 'not': [1570, 1692, 2482, 2708], 'atypical': [1571], 'zeta,': [1575], 'inhibition': [1578, 3244, 3253], 'B/Akt': [1582], 'glycogen': [1584], 'palmitate.Diabetes.': [1587], '50:': [1589], '2210-2218Crossref': [1590], '(119)': [1593], 'Additional': [1596], 'suggest': [1599], 'dephosphorylated': [1604, 1700], 'response': [1606], 'exogenous': [1608], 'ceramide-inducing': [1611], 'agonists': [1612], '(21Chalfant': [1613], 'Nevertheless,': [1689], 'it': [1690], 'fully': [1693], 'established': [1694], 'directly': [1699], 'vivo.': [1704], 'key': [1706, 2027, 2052, 2846, 3114, 3357, 3589, 3823, 4078], 'parameter': [1707], 'determining': [1709], 'specificity': [1711, 1724, 1787, 2274, 2874, 3142, 3385, 3617, 3851, 4106], 'significance': [1713, 1801], 'regulation': [1716], 'we': [1736, 2083, 2158], 'examined': [1737], 'within': [1741, 2637, 2774], 'molecule': [1744], 'necessary': [1745], 'both': [1747], 'association': [1751], 'CAPPs.': [1753], 'even': [1758], 'slight': [1759], 'modifications': [1760], 'greatly': [1765], 'decrease': [1766], 'interact': [1773], 'Thus,': [1778], 'present': [1780], 'shows': [1782], 'high': [1784], 'degree': [1785], 'lends': [1796], 'further': [1797], 'PP2A.': [1810], 'Serinol': [1811], 'general': [1814, 2803, 3101, 3344, 3576, 3812], 'chemicals': [1815], 'purchased': [1817, 1824], 'from': [1818, 1825, 1835, 1871, 1944, 2071, 2081, 2101, 2147, 2156, 2177, 2223, 2629, 2766, 2795, 2971, 3092, 3208, 3335, 3567, 3802, 4051], 'Aldrich.': [1819], '(2S,': [1820, 2231, 2234, 2237, 2241, 2796, 3093, 3336, 3568, 3803], '3S,': [1821, 3094], '4R)-phytosphingosine': [1822, 3095], 'Avanti.': [1826], 'd-erythro-C16': [1827, 2438, 2664], 'obtained': [1834, 1888], 'Lipidomics': [1837], 'Core': [1838], 'at': [1839], 'Medical': [1841], 'University': [1842], 'South': [1844], 'Carolina.': [1845], '1H-NMR': [1846, 1936, 3000, 3463, 3696, 3930], 'spectra': [1847], 'recorded': [1849], 'Bruker': [1852], 'AVANCE': [1853], '500': [1854], 'MHz': [1855], 'spectrometer': [1856], 'equipped': [1857], 'Oxford': [1860], 'Narrow': [1861], 'Bore': [1862], 'Magnet.': [1863], 'Chemical': [1864], 'shifts': [1865], 'given': [1867], 'ppm': [1869], 'downfield': [1870], 'tetramethylsilane': [1872], 'internal': [1874], 'standard,': [1875], 'listed': [1878, 2373], 'J': [1879, 3005, 3014, 3025, 3051, 3468, 3474, 3482, 3490, 3497, 3508, 3515, 3534, 3701, 3707, 3715, 3760, 3935, 3941, 3948, 3964, 3980, 3986, 4005], 'values': [1880], 'Hz.': [1883], 'Mass': [1884], 'spectral': [1885], 'data': [1886], 'positive': [1890], 'ion': [1891, 1900], 'electrospray': [1892], 'ionization': [1893], '(ESI)': [1894], 'mode': [1895], 'Finnigan': [1898], 'LCQ': [1899], 'trap': [1901], 'mass': [1902], 'spectrometer.': [1903], 'Samples': [1904], 'infused': [1906], 'methanol': [1908], 'solution': [1909], 'ESI': [1912], 'voltage': [1913], '4.5': [1915], 'kV': [1916], 'capillary': [1919], 'temperature': [1920], '200°C.': [1922], 'purity': [1924], 'synthesized': [1927, 2084, 2254, 2331], 'lipids': [1928], '>95%': [1930], 'estimated': [1932], 'TLC': [1934], 'analysis.': [1937], 'All': [1938], 'stereoisomers': [1939], 'C6-ceramide': [1941, 2368], 'prepared': [1943, 2080, 2380, 2794, 3091, 3334, 3566, 3801, 4050], 'their': [1945, 2328], 'corresponding': [1946], 'sphingosines': [1947, 2057], 'previously': [1950, 2257, 2333, 2807, 3105, 3348, 3580], '(26Bielawska': [1951, 2808], 'Crane': [1953, 2810], 'H.M.': [1954, 2811], 'Liotta': [1955, 2118, 2194, 2812], 'Selectivity': [1961, 2818], 'biology.': [1964, 2342, 2821, 2931], 'Lack': [1965, 2822], 'erythro-dihydroceramide.J.': [1969, 2826], '26226-26232Abstract': [1974, 2831], '27Jayadev': [1981], 'Liu': [1983], 'A.E.': [1986], 'Lee': [1987, 3286, 3288], 'Nazaire': [1989], 'F.': [1990], 'Pushkareva': [1991], 'arrest.J.': [2003], '2047-2052Abstract': [2008], '(466)': [2016], '28Bielawska': [2019, 2838], 'Szulc': [2021, 2267, 2299, 2840, 2867, 2899, 3108, 3135, 3167, 3351, 3378, 3410, 3583, 3610, 3642, 3817, 3844, 3876, 4072, 4099, 4131], 'Synthesis': [2025, 2140, 2216, 2844, 3112, 3355, 3587, 3821, 4076], 'precursors': [2028, 2847, 3115, 3358, 3590, 3824, 4079], 'radiolabeled': [2030, 2849, 3117, 3360, 3592, 3826, 4081], 'sphingolipids.Methods': [2031, 2850, 3118, 3361, 3593, 3827, 4082], 'Enzymol.': [2032, 2851, 3119, 3362, 3594, 3828, 4083], '311:': [2034, 2853, 3121, 3364, 3596, 3830, 4085], '518-535Crossref': [2035, 2854, 3122, 3365, 3597, 3831, 4086], '(13)': [2038, 2857, 3125, 3368, 3600, 3834, 4089], 'Sphingosines': [2041], 'stereochemical': [2044], 'foundations': [2045], '[IUB': [2046], 'nomenclature:': [2047], 'd-erythro-(2S,3R);': [2048], 'l-threo-(2S,3S)]': [2049], 'intermediates': [2053], 'N-': [2054], '1,3-O-protected': [2056], 'utilized': [2059], 'basic': [2061], 'compounds.': [2069], 'Starting': [2070, 2155], 'known': [2073], 'configurationally': [2074], 'stable': [2075], 'chiral': [2076], 'auxiliary': [2077], "(Garner's": [2078], 'aldehyde': [2079], 'l-serine),': [2082], '(2S)-sphingosines,': [2085], '4,5-dihydro-sphingosines': [2086], '4,5-dehydro-sphingosines': [2088], '(29Garner': [2089, 2165], 'Park': [2091, 2167], 'J.M.': [2092, 2168], 'Malecki': [2093, 2169], 'Stereodivergent': [2095, 2171], 'd-erythro-sphingosine': [2098, 2174], 'd-threo-sphingosine': [2100, 2176], 'l-serine.J.': [2102, 2148, 2178, 2224], 'Org.': [2103, 2149, 2179, 2225], '1988;': [2105, 2131, 2151, 2181, 2207, 2227], '53:': [2106, 2182], '4395-4398Crossref': [2107, 2183], '(203)': [2109, 2185], '30Ninkar': [2112, 2188], 'Menaldino': [2114, 2190], 'Merril': [2116, 2192], 'A.H.': [2117, 2193], 'stereoselective': [2121, 2197], 'sphingosine,': [2124, 2200], 'inhibitor.Tetrahedron': [2129, 2205], 'Lett.': [2130, 2206], '29:': [2132, 2208], '3037-3040Crossref': [2133, 2209], '(121)': [2135, 2211], '31Herold': [2138, 2214], 'P.E.': [2139, 2215], 'd-erythro': [2142, 2218], 'd-threo': [2144, 2220], 'sphingosine': [2145, 2221, 2310, 2910, 3178, 3421, 3653, 3887, 4142], 'derivatives': [2146, 2222], '71:': [2152, 2228], '354-362Google': [2153, 2229], 'd-serine,': [2157], 'access': [2160], 'remaining': [2163], '2R-isomers': [2164], '3R,': [2232, 2235, 2238, 2242, 3337, 3569, 3804], '4Z)-sphingosine,': [2233], '4E)-1-O-methyl–sphingosine,': [2236], '4E)-3-O-methyl–sphingosine,': [2239], '4E)-N-methyl-sphingosine,': [2243], 'well': [2245], 'C16-ceramide': [2248], '(see': [2250], 'Table': [2251], '2),': [2252], 'following': [2255, 2801, 3099, 3206, 3342, 3574, 3809, 4062], 'procedure': [2259, 2805, 3103, 3346, 3578, 3814, 4064], '(32El': [2260], 'Bawab': [2261, 2295, 2861, 2895, 3129, 3163, 3372, 3406, 3604, 3638, 3838, 3872, 4093, 4127], 'Usta': [2263, 2863, 3131, 3374, 3606, 3840, 4095], 'Roddy': [2265, 2297, 2865, 2897, 3133, 3165, 3376, 3408, 3608, 3640, 3842, 3874, 4097, 4129], 'Z.M.': [2268, 2300, 2868, 2900, 3136, 3168, 3379, 3411, 3611, 3643, 3845, 3877, 4100, 4132], 'rat': [2276, 2876, 3144, 3387, 3619, 3853, 4108], 'brain': [2277, 2877, 3145, 3388, 3620, 3854, 4109], 'ceramidase.J.': [2278, 2878, 3146, 3389, 3621, 3855, 4110], 'Lipid': [2279, 2879, 3147, 3390, 3622, 3856, 4111], 'Res.': [2280, 2880, 3148, 3391, 3623, 3857, 4112], '2002;': [2281, 2881, 3149, 3259, 3392, 3624, 3858, 4113], '43:': [2282, 2882, 3150, 3393, 3625, 3859, 4114], '141-148Abstract': [2283, 2883, 3151, 3394, 3626, 3860, 4115], '33Usta': [2292, 2892, 3160, 3403, 3635, 3869, 4124], 'El': [2294, 2894, 3162, 3405, 3637, 3871, 4126], 'Structural': [2305, 2905, 3173, 3416, 3648, 3882, 4137], 'based': [2311, 2911, 3179, 3422, 3654, 3888, 4143], 'ceramidase.Biochemistry.': [2315, 2915, 3183, 3426, 3658, 3892, 4147], '40:': [2317, 2917, 3185, 3428, 3660, 3894, 4149], '9657-9668Crossref': [2318, 2918, 3186, 3429, 3661, 3895, 4150], '(54)': [2321, 2921, 3189, 3432, 3664, 3898, 4153], 'd-myristoylaminophenylpropanol': [2324], '(d-MAPP),': [2325], 'l-MAPP': [2326], 'C6-analogs': [2329], '(34Bielawska': [2335], 'Ceramide-mediated': [2341, 2930], 'Determination': [2343, 2932], 'use': [2351, 2940], 'N-acyl-phenylaminoalcohol': [2353, 2942], 'analogs.J.': [2354, 2943], '1992;': [2357, 2946], '267:': [2358, 2947], '18493-18497Abstract': [2359, 2948], 'Analogs': [2366], 'C6-': [2370], 'C16-serinol': [2372], 'Tables': [2375], '2': [2378], 'our': [2382], 'laboratory': [2383], 'characterized': [2385], 'below.TABLE': [2388], '2The': [2389], 'relative': [2390, 3057, 3309, 3541, 3766, 4011], 'affinities': [2392], 'PP2AcCompoundPP2Ac': [2397], 'Binding': [2398], '(Arbitrary': [2399], 'Densitometry': [2400], 'Units)d-e-C16': [2401], 'ceramide9160': [2402], '±': [2403, 2407, 2411, 2417, 2424, 2430, 2467, 2693], '576d-e-dihydro': [2404], 'C16': [2405, 2409, 2413, 2415, 2433], 'ceramide8794': [2406], '321d-e-dehydro': [2408], 'ceramide1131': [2410], '267d-e-cis': [2412], 'ceramideNDPhyto': [2414], 'ceramide1002': [2416, 2429], '652C16': [2418], 'serinolNDC16': [2419], 'd-MAPPNDC16': [2420], 'l-MAPPNDd-e-C16': [2421], 'urea': [2422, 2426, 2555, 2560], 'ceramide1342': [2423], '111l-e-C16': [2425], 'ceramideNDN-methyl-d-e-C16': [2427], 'ceramideND1-O-methyl-d-e-C16': [2428], '2133-O-methyl-d-e-C16': [2431], 'ceramideND3-keto': [2432], 'ceramideNDPP2Ac': [2434], 'complexed': [2436, 2662], 'Materials': [2444, 2670], 'Methods.': [2446, 2672], 'PP2Ac/ceramide': [2447, 2673], 'complexes': [2448, 2674], 'subjected': [2450, 2676], 'PAGE-SDS': [2452, 2678], 'analysis': [2453, 2679], 'Western': [2455, 2681], 'immunoblotting.': [2456, 2682], 'Data': [2457, 2484, 2617, 2636, 2642, 2683, 2710, 2754, 2773, 2779], 'presented': [2459, 2619, 2685, 2756], 'mean': [2462, 2621, 2688, 2758], 'arbitrary': [2464, 2690], 'densitometry': [2465, 2691], 'units': [2466, 2692], 'SE': [2468, 2694], 'visualized': [2474, 2700], 'chemiluminesence': [2476, 2702], 'after': [2477, 2703], 'background': [2478, 2704], 'subtraction.': [2479, 2705], 'ND': [2480, 2706], 'detected.': [2483, 2709], 'representative': [2486, 2644, 2712, 2781], 'three': [2488, 2714], 'separate': [2489, 2647, 2715, 2784], 'determinations': [2490, 2648, 2716, 2785], 'occasions.': [2493, 2651, 2719, 2788], 'Open': [2494, 2654], 'table': [2495, 2655], 'new': [2498, 2658], 'tab': [2499, 2659], 'TABLE': [2500], '1The': [2501], 'trimeric': [2510, 2589, 2726], 'phosphatase-1cαCompoundPP2AcPP2APP1cαVehicle': [2515], 'control193211180d-e-C6': [2516], 'ceramide537': [2517], '(2.8)491': [2518], '(2.3)446': [2519], '(2.5)d-e-dihydro': [2520], 'ceramide45': [2522], '(0.2)24': [2523], '(0.1)32': [2524], '(0.2)l-e-dihydro': [2525], 'ceramide43': [2527], '(0.2)21': [2528], '(0.1)37': [2529], '(0.2)d-e-dehydro': [2530], 'ceramide192': [2532], '(1.0)52': [2533], '(0.3)183': [2534], '(1.0)d-e-cis': [2535], 'ceramide190': [2537], '(1.0)183': [2538], '(0.9)171': [2539], '(1.0)Phyto': [2540], 'ceramide213': [2542], '(1.1)82': [2543], '(0.4)160': [2544], '(0.9)C6-serinol201': [2545], '(1.0)137': [2546], '(0.7)181': [2547], '(1.0)C6-d-MAPP190': [2548], '(1.0)53': [2549], '(0.3)175': [2550], '(1.0)C6-l-MAPP202': [2551], '(1.0)61': [2552], '(0.3)171': [2553], '(1.0)d-e-C6': [2554], 'ceramide198': [2556], '(1.0)229': [2557], '(1.1)127': [2558], '(0.7)l-e-C6': [2559], 'ceramide210': [2561], '(1.1)210': [2562], '(1.0)141': [2563], '(0.8)N-methyl-d-e-C6': [2564], 'ceramide182': [2565], '(0.9)200': [2566], '(1.0)157': [2567], '(0.9)1-O-methyl': [2568], 'd-e-C6': [2569, 2574], 'ceramide193': [2570], '(1.0)86': [2571], '(0.4)173': [2572], '(1.0)3-O-methyl': [2573], 'ceramide196': [2575], '(1.0)92': [2576], '(0.4)169': [2577], '(0.9)3-keto': [2578], 'ceramide181': [2580], '(0.9)99': [2581], '(0.5)179': [2582], '(1.0)Catalytic': [2583], '(10': [2593, 2599, 2730, 2736], 'mU),': [2594, 2731], 'phosphatase-1cα': [2597, 2734], '(PP1cα)': [2598, 2735], 'mU)': [2600, 2737], 'assayed': [2602, 2739], '(35)': [2605, 2742], 'presence': [2608, 2745], '15': [2610, 2747], 'μM': [2611, 2748], 'indicated': [2614, 2751], 'analogs.': [2616, 2753], 'fmoles': [2625, 2762], '32P': [2627, 2764], 'release': [2628, 2765], '32P-MBP': [2630, 2767], 'per': [2631, 2768], 'minute': [2632, 2769], '(n': [2633, 2770], '4).': [2635, 2772], 'parentheses': [2638, 2775], 'depicts': [2639, 2776], 'fold': [2640, 2777], 'stimulation.': [2641, 2778], 'four': [2646, 2783], 'MAPP,': [2652, 2789], 'myristoylaminophenylpropanol.': [2653, 2790], 'Catalytic': [2720], 'compound': [2792, 3089, 3332, 3564, 3799, 4048], '3R)-4,5-dehydro-sphingosine': [2797], 'hexanoyl': [2799, 3097, 3340, 3572, 3807], 'chloride': [2800, 3098, 3341, 3573, 3808], 'acylation': [2804, 3102, 3345, 3577, 3813], '32El': [2860, 3128, 3371, 3603, 3837, 4092], '34Bielawska': [2924], 'crude': [2956, 3193, 3436, 3668, 3902, 4157], 'product': [2957, 3194, 3437, 3669, 3903, 4158], 'flash': [2961, 3198, 3441, 3673, 3907, 4162], 'column': [2962, 3199, 3442, 3674, 3908, 4163], 'chromatography': [2963, 3200, 3443, 3675, 3909, 4164], '(elution': [2964, 3201, 3444, 3676, 3910, 4165], 'CHCl3-MeOH,': [2966, 2995, 3203, 3228, 3446, 3458, 3678, 3691, 3912, 3925, 4167], '94:6,': [2967, 3447], 'v/v)': [2968, 2975, 3205, 3212, 3448, 3680, 3914, 4169], 'crystallized': [2970], 'ethyl': [2972, 3209], 'acetate-hexane': [2973], '(3:1,': [2974], 'give': [2977, 3214], 'pure': [2979, 3216], 'white': [2985, 3220, 3920], 'microcrystalline': [2986, 3221], 'powder': [2987, 3222], '[melting': [2988], 'point': [2989], '(mp)': [2990], '73–75°C,': [2991], '72%': [2992], 'yield].': [2993], 'TLC,': [2994, 3227, 3457, 3690, 3924], '10:1,': [2996, 3204, 3229, 3459, 3692, 3926], 'v/v;': [2997, 3230, 3235, 3460, 3693, 3927], 'Rf': [2998, 3231, 3236, 3461, 3694, 3928], '0.61.': [2999, 3929], '(CDCl3),': [3001, 3464, 3931], 'δ': [3002, 3465, 3698, 3932], '6.25': [3003], '(d,': [3004, 3467, 3700, 3934], '7.4,': [3007], 'NH),': [3008, 3471, 3704, 3938], '4.58': [3009], '(m,': [3010, 3020, 3037, 3045, 3503, 3520, 3524, 3528, 3722, 3726, 3730, 3734, 3742, 3750, 3754, 3955, 3959, 3970, 3991, 3999], '1H,': [3011, 3021, 3504, 3723, 3727, 3731, 3735, 3956, 3960, 3971], '3-H),': [3012, 3494, 3724, 3968], '4.11(dd,': [3013], '11.4,': [3016], '3.7,': [3017, 3967], '1-H),': [3018, 3029, 3501, 3512, 3732, 3736, 3957, 3972], '4.03': [3019], '2-H),': [3022, 3505, 3728, 3961], '3.73': [3023], '(dd,': [3024, 3489, 3496, 3507, 3963], '11.3,': [3027, 3476], '3.5,': [3028, 3511], '2.23': [3030], '[m,': [3031, 3041, 3746, 3995], '4H,': [3032], 'C(6)H2': [3033], 'COCH2],': [3035], '1.63': [3036], '2H,': [3038, 3042, 3521, 3525, 3743, 3747, 3751, 3979, 3992, 3996], 'COCH2CH2),': [3039, 3752, 3993], '1.49': [3040], 'C(7)H2],': [3043, 3997], '1.25': [3044], '24H,': [3046, 4000], 'CH2),': [3047, 3530, 3756, 4001], '0.86': [3048], '(t,': [3049, 3514, 3532, 3758, 3978, 4003], '6H,': [3050, 3533, 3759, 4004], '7.0,': [3053, 3762], 'CH3).': [3054, 3538, 3763, 4008], 'EI-MS': [3055, 3307, 3539, 3764, 4009], '(CH3OH;': [3056, 3308, 3540, 3765, 4010], 'intensity,': [3058, 3310, 3542, 3767, 4012], '%)': [3059, 3311, 3543, 3768, 4013], 'm/z': [3060, 3086, 3312, 3329, 3544, 3561, 3769, 3796, 4014, 4045], '813.2': [3061], '([2M': [3062, 3067, 3314, 3546, 3771, 4016, 4021], '+': [3063, 3068, 3070, 3315, 3547, 3772, 4017, 4022, 4027], 'Na]+,': [3064, 3316, 3548, 3773, 4023, 4028], '100),': [3065, 3320, 3549, 3774, 4024], '613.2': [3066], 'Na': [3069], 'H': [3071], '−': [3072, 3080, 3323, 3555, 3781, 3786, 3788, 3790, 4035, 4037, 4039], 'COC5H11]+,': [3073, 3791, 4040], '65),': [3074], '396.2': [3075], '([MH]+,': [3076, 3319, 3551, 4031], '38),': [3077], '378.3': [3078], '([MH': [3079, 3322, 3554, 3780, 3785], 'H2O]+,': [3081, 3324, 3556, 3782], '20).': [3082], 'Calculated': [3083, 3326, 3558, 3793, 4042], 'C24H45NO3': [3085], '395.3.': [3087], '(28Bielawska': [3106, 3349, 3581, 3815, 4070], 'crystallization': [3207], 'acetate-acetone': [3210], '(1:1,': [3211], 'phyto-C6-ceramide': [3217], '(mp': [3223], '88–90°C,': [3224], '68%': [3225], 'yield).': [3226, 3456, 3689, 3923], '0.41;': [3232], 'CH2Cl2-MeOH,': [3233], '9:1,': [3234], '0.40': [3237], '(35Jones': [3238], 'J.A.': [3239], 'Tight': [3242], 'acid.': [3250], 'Specificity': [3251], 'phospholipid.J.': [3256], '277:': [3260], '15530-15538Abstract': [3261], '45Hwang': [3272], 'O.': [3273], 'Kim': [3274, 3278], 'G.': [3275, 3281], 'Joo': [3276], 'S.W.': [3279], 'Choi': [3280, 3282], 'H.J.': [3283], 'Jeon': [3284], 'S.Y.': [3285], 'D.G.': [3287], 'J.D.': [3289], 'Synthetic': [3290], 'phytoceramides': [3291], 'induce': [3292], 'apoptosis': [3293], 'higher': [3295], 'potency': [3296], 'than': [3297], 'ceramides.Mol.': [3298], 'Pharm.': [3299], '591249Crossref': [3301], '(43)': [3304], '853.8': [3313], '35),': [3317, 3552], '416.3': [3318], '398.4': [3321], '22).': [3325], 'C24H49NO4': [3328], '415.4.': [3330], '4Z)-sphingosine': [3338], 'isolated': [3450, 3683, 3916], 'waxy': [3453, 3686, 3919, 4172], 'semisolid': [3454, 3687, 3921], '(65%': [3455], '0.57.': [3462], '6.21': [3466], '7.1,': [3470, 3988, 4007], '5.60': [3472], '(dtd,': [3473, 3706, 3940], '9.0,': [3477], '1.0,': [3478, 3944], '5-H),': [3479, 3712, 3945], '5.49': [3480], '(ddt,': [3481, 3714, 3947], '11.2,': [3484, 3510, 3717, 3950], '9.2,': [3485, 3951], '1.5,': [3486, 3952], '4-H),': [3487, 3720, 3953], '4.62': [3488], '8.5,': [3492], '4.2,': [3493], '4.1': [3495], '11.1,': [3499], '3.6,': [3500], '3.84': [3502], '3.70': [3506], '2.21': [3513, 3977], '7.5,': [3517], 'COCH2),': [3518, 3744, 3983], '2.2': [3519], 'C(6)H2),': [3522], '1.65': [3523, 3749], 'C(7)H2),': [3526], '1.26': [3527], '26H,': [3529, 3755], '0.90': [3531], '7.': [3536], '1,': [3537], '817.6': [3545], '398.3': [3550], '380.3': [3553], '10).': [3557], 'C24H47NO3': [3560], '397.4.': [3562], '4E)-1-O-methyl-sphingosine': [3570], '96:4,': [3679, 3913, 4168], '(62%': [3688], '0.65.': [3695], '(CDCl3):': [3697], '6.12': [3699], '6.7,': [3703], '5.85': [3705], '11.8,': [3709], '7.9,': [3710], '1.6,': [3711], '5.45': [3713], '9.6,': [3718], '1.3,': [3719], '4.13': [3721], '4.02': [3725], '3.69': [3729], '3.55–3.46': [3733], '3.32': [3737], '(s,': [3738, 3974], '3H,': [3739, 3975], 'OCH3),': [3740, 3976], '2.20': [3741], '2.08': [3745], 'C(6)H2],': [3748, 3989], '1.24': [3753], '0.87': [3757, 4002], '845.0': [3770], '637.1(75),': [3775], '411.9': [3776], '(MH+,': [3777], '25),': [3778], '394.1': [3779], '73),': [3783], '264.2': [3784], 'CH3OH': [3787, 4036], 'H2O': [3789, 4038], '8).': [3792], 'C25H49NO3': [3795, 4044], '411.4.': [3797, 4046], '4E)-3-O-methyl-sphingosine': [3805], 'same': [3811], '(60%': [3922], '6.18': [3933], '7.7,': [3937], '5.74': [3939], '11.1,8.9,': [3943], '5.35': [3946], '3.95': [3954], '3.90': [3958], '3.83': [3962], '7.8,': [3966], '3.55': [3969], '3.25': [3973], '7.6,': [3982], '2.06': [3984], '[q,': [3985], '1.62': [3990], '1.35': [3994], '1.21': [3998], '877.4': [4015], '2Na]+,': [4018], '12),': [4019], '845.1': [4020], '637.1(15),': [4025], '434.2([M': [4026], '15),': [4029], '411.7': [4030], '8),': [4032], '380.1(12),': [4033], '264.2([MH': [4034], '5).': [4041], 'd-erythro-C6-ceramide': [4052], 'selective': [4055], 'oxidation': [4056], 'its': [4058], 'N-acetyl': [4068], 'derivative': [4069], 'sem': [4173]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2135425001', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-16T20:01:31.763249', 'created_date': '2016-06-24'}
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