Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1590322197', 'doi': None, 'title': '12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase.', 'display_name': '12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase.', 'publication_year': 1998, 'publication_date': '1998-05-15', 'ids': {'openalex': 'https://openalex.org/W1590322197', 'mag': '1590322197', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9605775'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9605775', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026692219', 'display_name': 'Mark Garzotto', 'orcid': 'https://orcid.org/0000-0002-0546-1397'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M Garzotto', 'raw_affiliation_strings': ['Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079622486', 'display_name': 'M White-Jones', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M White-Jones', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054097288', 'display_name': 'Yang Jiang', 'orcid': 'https://orcid.org/0000-0002-5364-1421'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Y Jiang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018650323', 'display_name': 'Desiree Ehleiter', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D Ehleiter', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076636659', 'display_name': 'Wen‐Chieh Liao', 'orcid': 'https://orcid.org/0000-0001-7848-2124'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'W C Liao', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039007636', 'display_name': 'Adriana Haimovitz–Friedman', 'orcid': 'https://orcid.org/0000-0002-4884-0581'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A Haimovitz-Friedman', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080794141', 'display_name': 'Zvi Fuks', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Z Fuks', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036438521', 'display_name': 'Richard Kolesnick', 'orcid': 'https://orcid.org/0000-0002-4914-2945'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R Kolesnick', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.294, 'has_fulltext': False, 'cited_by_count': 139, 'citation_normalized_percentile': {'value': 0.901402, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '58', 'issue': '10', 'first_page': '2260', 'last_page': '4'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.9821, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11613', 'display_name': 'Phytochemistry and Biological Activities', 'score': 0.9797, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ceramide-synthase', 'display_name': 'Ceramide synthase', 'score': 0.90535426}, {'id': 'https://openalex.org/keywords/12-o-tetradecanoylphorbol-13-acetate', 'display_name': '12-O-Tetradecanoylphorbol-13-acetate', 'score': 0.5325213}], 'concepts': [{'id': 'https://openalex.org/C2777851122', 'wikidata': 'https://www.wikidata.org/wiki/Q424213', 'display_name': 'Ceramide', 'level': 3, 'score': 0.9661891}, {'id': 'https://openalex.org/C2779237115', 'wikidata': 'https://www.wikidata.org/wiki/Q3958691', 'display_name': 'Ceramide synthase', 'level': 4, 'score': 0.90535426}, {'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.79061764}, {'id': 'https://openalex.org/C180899940', 'wikidata': 'https://www.wikidata.org/wiki/Q117982', 'display_name': 'Lipid signaling', 'level': 3, 'score': 0.7840949}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.7314771}, {'id': 'https://openalex.org/C2781429003', 'wikidata': 'https://www.wikidata.org/wiki/Q420762', 'display_name': 'Fumonisin B1', 'level': 3, 'score': 0.6221668}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.5565893}, {'id': 'https://openalex.org/C2777168633', 'wikidata': 'https://www.wikidata.org/wiki/Q416716', 'display_name': '12-O-Tetradecanoylphorbol-13-acetate', 'level': 5, 'score': 0.5325213}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.45702502}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4091226}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4015544}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39422375}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31852657}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.23282024}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.19531786}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.12505695}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C3017695315', 'wikidata': 'https://www.wikidata.org/wiki/Q37713691', 'display_name': 'Phorbol ester', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C84699730', 'wikidata': 'https://www.wikidata.org/wiki/Q422449', 'display_name': 'Mycotoxin', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000581', 'descriptor_name': 'Amidohydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D002273', 'descriptor_name': 'Carcinogens', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002518', 'descriptor_name': 'Ceramides', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D037341', 'descriptor_name': 'Fumonisins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000581', 'descriptor_name': 'Amidohydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000581', 'descriptor_name': 'Amidohydrolases', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002264', 'descriptor_name': 'Carboxylic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002264', 'descriptor_name': 'Carboxylic Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002273', 'descriptor_name': 'Carcinogens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002274', 'descriptor_name': 'Carcinogens, Environmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002274', 'descriptor_name': 'Carcinogens, Environmental', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D055572', 'descriptor_name': 'Ceramidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002518', 'descriptor_name': 'Ceramides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9605775', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.62, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2185984381', 'https://openalex.org/W2160893951', 'https://openalex.org/W2126544407', 'https://openalex.org/W2077576009', 'https://openalex.org/W2018474075', 'https://openalex.org/W2013646403', 'https://openalex.org/W1992615534', 'https://openalex.org/W1981141889', 'https://openalex.org/W1968091649', 'https://openalex.org/W1590322197'], 'abstract_inverted_index': {'Protein': [0], 'kinase': [1], 'C': [2], '(PKC)': [3], 'activation': [4, 25], 'is': [5, 61], 'often': [6], 'antiapoptotic,': [7], 'although': [8], 'in': [9, 35, 116, 166], 'a': [10, 131, 160, 175], 'few': [11], 'cell': [12], 'types': [13], 'PKC': [14, 27, 179], 'initiates': [15], 'apoptosis': [16, 34, 81, 153, 165], 'by': [17, 29, 71, 84, 177], 'an': [18, 114], 'unknown': [19], 'mechanism.': [20], 'Recent': [21], 'investigations': [22], 'showed': [23], 'that': [24, 51, 102, 120], 'of': [26, 46, 97, 135, 174], 'alpha': [28], '12-O-tetradecanoylphorbol': [30], '13-acetate': [31], '(TPA)': [32], 'induced': [33, 64, 113], 'LNCaP': [36, 167], 'prostate': [37], 'cancer': [38], 'cells.': [39, 168], 'The': [40], 'present': [41], 'studies': [42], 'examine': [43], 'the': [44, 57, 95, 171], 'mechanism': [45, 96], 'this': [47], 'effect': [48], 'and': [49, 74, 87, 104, 142], 'show': [50], 'de': [52], 'novo': [53], 'ceramide': [54, 59, 66, 99, 117, 136, 140, 156], 'generation': [55, 100], 'through': [56], 'enzyme': [58], 'synthase': [60, 118], 'required.': [62], 'TPA': [63, 112], 'rapid': [65], 'generation,': [67], 'which': [68, 178], 'was': [69, 82, 88], 'detectable': [70], '1': [72], 'h': [73, 86], 'increased': [75], 'linearly': [76], 'for': [77, 90, 122, 163], '12': [78, 85], 'h.': [79, 92, 126], 'TPA-induced': [80, 98, 143, 164], 'measurable': [83], 'progressive': [89], '48': [91], 'Investigations': [93], 'into': [94], 'revealed': [101], 'acid': [103], 'neutral': [105], 'sphingomyelinase': [106], 'activities': [107], 'were': [108], 'not': [109], 'enhanced.': [110], 'However,': [111], 'increase': [115], 'activity': [119], 'persisted': [121], 'at': [123], 'least': [124], '16': [125], 'Treatment': [127], 'with': [128], 'fumonisin': [129, 148], 'B1,': [130], 'specific': [132], 'natural': [133], 'inhibitor': [134], 'synthase,': [137], 'abrogated': [138], 'both': [139], 'production': [141], 'apoptosis.': [144, 182], 'Ceramide': [145], 'analogues': [146], 'bypassed': [147], 'B1': [149], 'inhibition': [150], 'to': [151, 158], 'initiate': [152], 'directly.': [154], 'Thus,': [155], 'appears': [157], 'be': [159], 'necessary': [161], 'signal': [162, 181], 'This': [169], 'represents': [170], 'first': [172], 'description': [173], 'pathway': [176], 'may': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1590322197', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-24T16:29:49.273903', 'created_date': '2016-06-24'}