Publication Information

{'id': 'https://openalex.org/W2131730936', 'doi': 'https://doi.org/10.1152/ajprenal.00072.2002', 'title': 'Phospholipid metabolite production in human urothelial cells after protease-activated receptor cleavage', 'display_name': 'Phospholipid metabolite production in human urothelial cells after protease-activated receptor cleavage', 'publication_year': 2002, 'publication_date': '2002-11-01', 'ids': {'openalex': 'https://openalex.org/W2131730936', 'doi': 'https://doi.org/10.1152/ajprenal.00072.2002', 'mag': '2131730936', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12372769'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajprenal.00072.2002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200780590', 'display_name': 'AJP Renal Physiology', 'issn_l': '1522-1466', 'issn': ['1522-1466', '1931-857X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061017042', 'display_name': 'Alice Rickard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alice Rickard', 'raw_affiliation_strings': ['Department of Pathology St. Louis University School of Medicine St. Louis, Missouri 63104 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology St. Louis University School of Medicine St. Louis, Missouri 63104 USA', 'institution_ids': ['https://openalex.org/I47838141']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016540919', 'display_name': 'Jane McHowat', 'orcid': 'https://orcid.org/0000-0003-3133-3388'}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jane McHowat', 'raw_affiliation_strings': ['Department of Pathology, St. Louis University School of Medicine, St. Louis, Missouri 63104'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, St. Louis University School of Medicine, St. Louis, Missouri 63104', 'institution_ids': ['https://openalex.org/I47838141']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.478, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.609756, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '283', 'issue': '5', 'first_page': 'F944', 'last_page': 'F951'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10881', 'display_name': 'Blood Coagulation and Thrombosis Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10881', 'display_name': 'Blood Coagulation and Thrombosis Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10549', 'display_name': 'Neonatal Respiratory Health Research', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phospholipase-a', 'display_name': 'Phospholipase A', 'score': 0.45018163}], 'concepts': [{'id': 'https://openalex.org/C2778078955', 'wikidata': 'https://www.wikidata.org/wiki/Q407699', 'display_name': 'Arachidonic acid', 'level': 3, 'score': 0.77380997}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.646119}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.644762}, {'id': 'https://openalex.org/C2776551241', 'wikidata': 'https://www.wikidata.org/wiki/Q24768001', 'display_name': 'Phospholipase A2', 'level': 3, 'score': 0.5917352}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.55300534}, {'id': 'https://openalex.org/C12927208', 'wikidata': 'https://www.wikidata.org/wiki/Q210430', 'display_name': 'Phospholipase', 'level': 3, 'score': 0.46901888}, {'id': 'https://openalex.org/C2777292125', 'wikidata': 'https://www.wikidata.org/wiki/Q409166', 'display_name': 'Thrombin', 'level': 3, 'score': 0.45872188}, {'id': 'https://openalex.org/C2776888444', 'wikidata': 'https://www.wikidata.org/wiki/Q7187515', 'display_name': 'Phospholipase A', 'level': 4, 'score': 0.45018163}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.44723043}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4116397}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.411203}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38007405}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3543157}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32854247}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.31100535}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.22702003}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.18217018}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.1486507}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.120113164}], 'mesh': [{'descriptor_ui': 'D010743', 'descriptor_name': 'Phospholipids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018179', 'descriptor_name': 'Receptors, Thrombin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019459', 'descriptor_name': 'Urothelium', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016718', 'descriptor_name': 'Arachidonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054522', 'descriptor_name': 'Group VI Phospholipases A2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006490', 'descriptor_name': 'Hemostatics', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006490', 'descriptor_name': 'Hemostatics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006868', 'descriptor_name': 'Hydrolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010726', 'descriptor_name': 'Phosphodiesterase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010741', 'descriptor_name': 'Phospholipases A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010741', 'descriptor_name': 'Phospholipases A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010743', 'descriptor_name': 'Phospholipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011753', 'descriptor_name': 'Pyrones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011753', 'descriptor_name': 'Pyrones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044463', 'descriptor_name': 'Receptor, PAR-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044464', 'descriptor_name': 'Receptor, PAR-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018179', 'descriptor_name': 'Receptors, Thrombin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013917', 'descriptor_name': 'Thrombin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013917', 'descriptor_name': 'Thrombin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D053802', 'descriptor_name': 'Tryptases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014513', 'descriptor_name': 'Ureter', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014513', 'descriptor_name': 'Ureter', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D019459', 'descriptor_name': 'Urothelium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019459', 'descriptor_name': 'Urothelium', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D019459', 'descriptor_name': 'Urothelium', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajprenal.00072.2002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S200780590', 'display_name': 'AJP Renal Physiology', 'issn_l': '1522-1466', 'issn': ['1522-1466', '1931-857X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12372769', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1437823482', 'https://openalex.org/W1512190887', 'https://openalex.org/W1584652055', 'https://openalex.org/W1656256413', 'https://openalex.org/W1958081034', 'https://openalex.org/W1970050155', 'https://openalex.org/W1975015953', 'https://openalex.org/W1983478202', 'https://openalex.org/W1988683617', 'https://openalex.org/W200190746', 'https://openalex.org/W2003662832', 'https://openalex.org/W2015483949', 'https://openalex.org/W2022363810', 'https://openalex.org/W2031843235', 'https://openalex.org/W2032320245', 'https://openalex.org/W2034280066', 'https://openalex.org/W2041299660', 'https://openalex.org/W2048400887', 'https://openalex.org/W2070216091', 'https://openalex.org/W2082095075', 'https://openalex.org/W2087408808', 'https://openalex.org/W2092447733', 'https://openalex.org/W2125779675', 'https://openalex.org/W2126747820', 'https://openalex.org/W2152311269', 'https://openalex.org/W2181522000', 'https://openalex.org/W2186282826', 'https://openalex.org/W2300552860', 'https://openalex.org/W2395162568', 'https://openalex.org/W2410869147', 'https://openalex.org/W2416533822'], 'related_works': ['https://openalex.org/W30752666', 'https://openalex.org/W2419707610', 'https://openalex.org/W2418737946', 'https://openalex.org/W2408898930', 'https://openalex.org/W2138747713', 'https://openalex.org/W2138476312', 'https://openalex.org/W210240653', 'https://openalex.org/W2053106656', 'https://openalex.org/W2017575247', 'https://openalex.org/W153398886'], 'abstract_inverted_index': {'Our': [0], 'laboratory': [1], 'demonstrated': [2], 'previously': [3], 'that': [4, 140], 'stimulation': [5, 120], 'of': [6, 21, 56, 64, 76, 87, 95, 121, 138], 'protease-activated': [7], 'receptors': [8], '(PARs)': [9], 'on': [10, 69, 125], 'the': [11, 54, 93, 112, 136, 148], 'human': [12, 48], 'urothelial': [13, 49], 'carcinoma': [14], 'cell': [15], 'line': [16], 'RT4': [17], 'results': [18], 'in': [19, 46, 135], 'activation': [20, 45, 86], 'a': [22, 88], 'calcium-independent': [23], 'phospholipase': [24], 'A': [25], '2': [26, 28, 36, 91, 102, 114, 130], '(iPLA': [27], '),': [29], 'leading': [30, 52], 'to': [31, 53, 85, 128, 147], 'arachidonic': [32, 98], 'acid': [33], 'and': [34, 67, 92, 100], 'PGE': [35, 101], 'release.': [37], 'In': [38], 'this': [39], 'study,': [40], 'we': [41], 'have': [42], 'examined': [43], 'PAR': [44], 'normal': [47], 'cells': [50], '(HUR)': [51], 'production': [55, 94, 137], 'inflammatory': [57], 'or': [58, 80, 123, 144], 'cytoprotective': [59], 'phospholipid': [60, 132], 'metabolites.': [61], 'The': [62], 'presence': [63], 'both': [65], 'PAR-1': [66, 77, 122], 'PAR-2': [68, 81, 124], 'HUR': [70, 126], 'was': [71], 'confirmed': [72], 'by': [73, 82, 109], 'immunoblotting.': [74], 'Stimulation': [75], 'with': [78, 111], 'thrombin': [79], 'tryptase': [83], 'leads': [84, 127], 'membrane-associated': [89], 'iPLA': [90, 113, 129], 'platelet-activating': [96], 'factor,': [97], 'acid,': [99], '.': [103], 'These': [104], 'responses': [105], 'were': [106], 'all': [107], 'blocked': [108], 'pretreatment': [110], '-selective': [115], 'inhibitor': [116], 'bromoenol': [117], 'lactone.': [118], 'Thus': [119], '-catalyzed': [131], 'hydrolysis,': [133], 'resulting': [134], 'metabolites': [139], 'may': [141], 'mediate': [142], 'inflammation': [143], 'provide': [145], 'cytoprotection': [146], 'bladder.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2131730936', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-13T17:58:06.882386', 'created_date': '2016-06-24'}