Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2138476312', 'doi': 'https://doi.org/10.3109/13813459409003943', 'title': 'Comparison of macrophage phospholipid radiolabelling methods for measuring phospholipase A<sub>2</sub>inhibition', 'display_name': 'Comparison of macrophage phospholipid radiolabelling methods for measuring phospholipase A<sub>2</sub>inhibition', 'publication_year': 1994, 'publication_date': '1994-01-01', 'ids': {'openalex': 'https://openalex.org/W2138476312', 'doi': 'https://doi.org/10.3109/13813459409003943', 'mag': '2138476312', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7849275'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/13813459409003943', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210190767', 'display_name': 'Archives Internationales de Physiologie de Biochimie et de Biophysique', 'issn_l': '0778-3124', 'issn': ['0778-3124'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113684891', 'display_name': 'J Petit', 'orcid': None}, 'institutions': [], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'J. Y. Petit', 'raw_affiliation_strings': ['Laboratoire de Pharmacologie et Pharmacocinétique, Faculté de Pharmacie, INRA, Nantes, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Pharmacologie et Pharmacocinétique, Faculté de Pharmacie, INRA, Nantes, France', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060154724', 'display_name': 'P. Boucrot', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314251682', 'display_name': 'Institut National de la Recherche Agronomique', 'ror': 'https://ror.org/05y503v71', 'country_code': 'MA', 'type': 'facility', 'lineage': ['https://openalex.org/I1314251682']}], 'countries': ['MA'], 'is_corresponding': False, 'raw_author_name': 'P. Boucrot', 'raw_affiliation_strings': ['Laboratoire des interactions des molécules alimentaires, INRA, Nantes, France.'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire des interactions des molécules alimentaires, INRA, Nantes, France.', 'institution_ids': ['https://openalex.org/I1314251682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009482796', 'display_name': 'François Lang', 'orcid': 'https://orcid.org/0000-0002-0762-4647'}, 'institutions': [], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'F. Lang', 'raw_affiliation_strings': ['Laboratoire de Pharmacologie et Pharmacocinétique, Faculté de Pharmacie, INRA, Nantes, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Pharmacologie et Pharmacocinétique, Faculté de Pharmacie, INRA, Nantes, France', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051807683', 'display_name': 'L Welin', 'orcid': None}, 'institutions': [], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'L. Welin', 'raw_affiliation_strings': ['Laboratoire de Pharmacologie et Pharmacocinétique, Faculté de Pharmacie, INRA, Nantes, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Pharmacologie et Pharmacocinétique, Faculté de Pharmacie, INRA, Nantes, France', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.365429, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 53, 'max': 61}, 'biblio': {'volume': '102', 'issue': '5', 'first_page': '271', 'last_page': '275'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9935, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11072', 'display_name': 'Peroxisome Proliferator-Activated Receptors', 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phospholipase-a', 'display_name': 'Phospholipase A', 'score': 0.6255118}, {'id': 'https://openalex.org/keywords/phosphocholine', 'display_name': 'Phosphocholine', 'score': 0.6014772}], 'concepts': [{'id': 'https://openalex.org/C2778078955', 'wikidata': 'https://www.wikidata.org/wiki/Q407699', 'display_name': 'Arachidonic acid', 'level': 3, 'score': 0.88401747}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.8407128}, {'id': 'https://openalex.org/C2776551241', 'wikidata': 'https://www.wikidata.org/wiki/Q24768001', 'display_name': 'Phospholipase A2', 'level': 3, 'score': 0.8132945}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.653753}, {'id': 'https://openalex.org/C2780523633', 'wikidata': 'https://www.wikidata.org/wiki/Q380709', 'display_name': 'Labelling', 'level': 2, 'score': 0.6441062}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6325342}, {'id': 'https://openalex.org/C2776888444', 'wikidata': 'https://www.wikidata.org/wiki/Q7187515', 'display_name': 'Phospholipase A', 'level': 4, 'score': 0.6255118}, {'id': 'https://openalex.org/C2776923060', 'wikidata': 'https://www.wikidata.org/wiki/Q576895', 'display_name': 'Phosphocholine', 'level': 5, 'score': 0.6014772}, {'id': 'https://openalex.org/C12927208', 'wikidata': 'https://www.wikidata.org/wiki/Q210430', 'display_name': 'Phospholipase', 'level': 3, 'score': 0.58305544}, {'id': 'https://openalex.org/C543025807', 'wikidata': 'https://www.wikidata.org/wiki/Q61476', 'display_name': 'Fatty acid', 'level': 2, 'score': 0.53572184}, {'id': 'https://openalex.org/C16613235', 'wikidata': 'https://www.wikidata.org/wiki/Q285982', 'display_name': 'Endogeny', 'level': 2, 'score': 0.48020256}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.41064435}, {'id': 'https://openalex.org/C2776330855', 'wikidata': 'https://www.wikidata.org/wiki/Q650187', 'display_name': 'Phosphatidylcholine', 'level': 4, 'score': 0.32436183}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.18814665}], 'mesh': [{'descriptor_ui': 'D000001', 'descriptor_name': 'Calcimycin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D010741', 'descriptor_name': 'Phospholipases A', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D010742', 'descriptor_name': 'Phospholipid Ethers', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000001', 'descriptor_name': 'Calcimycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010741', 'descriptor_name': 'Phospholipases A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054467', 'descriptor_name': 'Phospholipases A2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010742', 'descriptor_name': 'Phospholipid Ethers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014316', 'descriptor_name': 'Tritium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/13813459409003943', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210190767', 'display_name': 'Archives Internationales de Physiologie de Biochimie et de Biophysique', 'issn_l': '0778-3124', 'issn': ['0778-3124'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7849275', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.41, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W1600965850', 'https://openalex.org/W1602490654', 'https://openalex.org/W1667375729', 'https://openalex.org/W1870017110', 'https://openalex.org/W1969475832', 'https://openalex.org/W1999515079', 'https://openalex.org/W2008895179', 'https://openalex.org/W2023433009', 'https://openalex.org/W2030252068', 'https://openalex.org/W2033225718', 'https://openalex.org/W2047534694', 'https://openalex.org/W2063465553', 'https://openalex.org/W2078247164', 'https://openalex.org/W2094138436', 'https://openalex.org/W2129745051', 'https://openalex.org/W2152311269', 'https://openalex.org/W2208167499', 'https://openalex.org/W2233109541', 'https://openalex.org/W2418737946'], 'related_works': ['https://openalex.org/W2328119327', 'https://openalex.org/W2250299148', 'https://openalex.org/W2208167499', 'https://openalex.org/W2093616069', 'https://openalex.org/W2062750305', 'https://openalex.org/W2036548555', 'https://openalex.org/W2014691624', 'https://openalex.org/W1974496203', 'https://openalex.org/W1968792623', 'https://openalex.org/W1826923758'], 'abstract_inverted_index': {'Rat': [0], 'peritoneal': [1], 'macrophages': [2, 49], 'activated': [3, 126], 'by': [4, 34, 117], 'ionophore': [5], 'A': [6], '23187,': [7], 'were': [8, 58], 'labelled': [9, 128], 'after': [10], 'introduction': [11], 'in': [12, 36, 125], 'the': [13, 67, 76, 85, 105, 147, 157, 165, 185], 'culture': [14, 68], 'medium': [15, 63, 69], 'of': [16, 23, 107, 150, 187], '1-0-stearoyl': [17], '2-0-[3H]': [18], 'arachidonylglycero-3-phosphocholine': [19], '(as': [20], 'unique': [21], 'source': [22], 'tritiated': [24, 51, 118, 130], 'arachidonic': [25, 29, 108, 138], 'acid),': [26], 'or': [27, 40, 73], '[3H]': [28, 137], 'acid': [30, 109, 121, 139], 'which': [31, 57], 'was': [32, 123], 'esterified': [33], 'cells': [35, 127], 'phospholipids': [37], 'and': [38, 55, 62, 110, 156, 183], 'triglycerides': [39], 'remained': [41], 'non': [42], 'esterified.': [43], 'With': [44], 'either': [45, 96], 'cell-labelling': [46], 'method,': [47], 'stimulated': [48], 'produced': [50], 'nonesterified': [52, 119], 'fatty': [53, 120], 'acids': [54], 'eicosanoids': [56], 'isolated': [59], 'from': [60], 'cell': [61], 'lipids.When': [64], 'introduced': [65], 'into': [66, 164], 'at': [70], '1,': [71], '5': [72], '10': [74], 'μM,': [75], 'membrane': [77], 'phospholipid': [78, 131, 172], 'analogue': [79, 87], '1,2': [80], 'di-O-hexadecylglycerophosphocholine': [81], '(dihexadecyl-GPC),': [82], 'but': [83], 'not': [84], 'lysolecithin': [86], '1-0-octadecyl': [88], '2-0-methylglycero': [89], 'phosphocholine,': [90], 'lowered': [91], 'phospholipase': [92, 154, 180, 189], 'A2': [93, 155, 181], 'activity': [94, 182], 'with': [95, 129, 136, 162], 'labelling': [97, 173], 'method.': [98], 'Dihexadecyl-GPC': [99], 'had': [100], 'an': [101], 'inhibitory': [102, 148], 'effect': [103, 149], 'on': [104, 152], 'release': [106], 'eicosanoids.': [111], 'Moreover,': [112], 'this': [113], 'effect,': [114], 'as': [115], 'measured': [116], 'formation,': [122], 'greater': [124], '(IC50': [132, 140], '6': [133], 'μM)': [134], 'than': [135], '60': [141], 'μM).': [142], 'This': [143], 'is': [144, 174], 'attributable': [145], 'to': [146], 'dihexadecyl-GPC': [151], 'endogenous': [153, 158], 'enzyme': [159], 'excreted': [160], 'together': [161], 'lysosomes': [163], 'medium.It': [166], 'may': [167], 'be': [168], 'concluded': [169], 'that': [170], 'radioactive': [171], 'a': [175], 'sensitive': [176], 'method': [177], 'for': [178], 'measuring': [179], 'assessing': [184], 'effects': [186], 'potential': [188], 'inhibitors.': [190]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2138476312', 'counts_by_year': [], 'updated_date': '2024-12-08T21:04:51.331325', 'created_date': '2016-06-24'}