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293, 308, 368, 599, 644, 803, 937, 1069, 1127, 1150, 1219, 1303, 1320, 1327, 1355, 1375, 1451, 1709, 1781, 1895, 1949, 2043, 2065, 2202, 2220, 2286], 'common.': [145], 'Up': [146], '40%': [148], 'patients': [150, 190, 446, 509, 873, 909, 945, 954, 960, 972, 1073, 1081, 1546, 1715, 1743, 1819, 1824, 1832, 1844, 1869, 1875, 1910, 1953, 2117, 2143, 3029], 'suffer': [154], 'from': [155, 921, 1641], 'these': [158, 934, 1117, 1865, 1908, 1929, 1976, 1997], 'stages,': [160], 'progresses,': [165], 'become': [168], 'more': [169, 197, 345, 1189, 1317, 1363, 1366, 1618, 1885], 'prominent,': [170], 'further': [172], 'cognitive': [173, 223, 1349, 1390, 1466, 1598, 1733, 1860, 2013, 2241], 'deterioration': [174, 1350, 2014], 'dementia': [176, 1887, 2852], 'occur,': [177], 'accompanied': [179], 'paranoid': [181], 'psychotic': [182], 'symptoms.': [183, 624, 1151], 'Apathy': [185, 660, 671, 1270, 1285, 1722, 1811, 2194, 2670, 2749, 2762, 3053, 3099, 3515], 'encountered': [188], 'cerebral': [192, 306, 319, 1720, 1730, 1809, 1956], 'has': [195], 'received': [196, 470, 2353], 'attention': [198], 'recent': [203], 'years.': [204], 'The': [205, 245, 287, 321, 432, 676, 739, 1032, 1126, 1172, 1309, 1372, 1608, 2405, 2421, 2439, 2498, 2582, 2598, 2948, 3014, 3094, 3564], 'prevalence': [206, 2523], 'apathy': [208, 221, 231, 251, 277, 291, 310, 376, 400, 687, 718, 801, 949, 1077, 1160, 1173, 1217, 1305, 1314, 1325, 1340, 1361, 1401, 1412, 1449, 1463, 1482, 1548, 1579, 1707, 1753, 1779, 1789, 1855, 1951, 1970, 2011, 2025, 2041, 2063, 2098, 2176, 2182, 2218, 2231, 2319, 2372, 2546, 2589, 2878, 2896, 3350], 'increases': [209], 'correlations': [217], 'were': [218, 410, 435, 447, 518, 571, 689, 796, 820], 'found': [219, 1338, 1429, 1788, 1848, 1880, 1906, 1969, 2004, 2039], 'between': [220, 230, 290, 366, 825, 901, 933, 1095, 1302, 1400, 1411, 1649, 1706, 1778, 1851, 1928, 1948, 2007, 2062, 2586], 'decline': [224, 1440, 1599, 1861, 2626, 2706], 'also': [229, 393, 562, 683, 965, 978, 1206, 1455, 1510, 1703, 1847, 1919, 1978, 1998], 'number': [233, 913, 1148, 1544], 'CAG': [235, 482], 'repeats,': [236], 'although': [237], 'findings': [238, 397, 1416, 1489, 1498, 1513, 2058], 'not': [240, 1329, 2119, 2156, 2209, 2348, 2751], 'unambiguous.': [241], '2': [242, 789, 860, 1474, 1566], ',': [243, 1902, 1938], '3': [244, 341, 738, 773, 778, 1065, 1091, 1519, 3577], 'clinical': [246, 1345, 2075], 'presentation': [247], 'main': [257, 1310], 'subject': [258], 'our': [260, 390, 1405, 1553, 1613, 1622, 1785, 2105, 2165, 2214, 2337], 'study.': [261, 1554], 'major': [264, 643, 855, 1488, 1582, 1946, 2261], 'depressive': [265, 623, 627, 856, 915, 963, 981], 'disorder,': [266], 'described': [268, 1656], 'DSM-IV,': [271], 'subsyndromal': [272], 'minor': [274], 'may': [282, 314, 1396, 1736, 2138, 2329], 'co-occur': [283], 'depression.': [285, 659, 772, 892, 1403, 1473, 1982, 2591, 2752, 2812, 2920], '4': [286, 1112, 1699], 'precise': [288], 'relationship': [289, 365, 1301, 2061], 'unclear.': [298], 'As': [299, 906, 1783], "Parkinson's": [301, 1826, 3316], 'stroke,': [303], 'other': [305, 1124, 1344, 1359, 1423, 1717, 1802, 1808, 2298, 2358], 'diseases,': [307], 'be': [315, 761, 1690, 1791, 2139, 2271, 2295, 2330, 2374], 'consequences': [316], 'degenerative': [318], 'changes.': [320, 2733], 'syndromal': [322, 367], 'approach,': [323], 'according': [324, 602], 'DSM-IV': [327, 605, 622, 640, 1142, 2122], 'criteria,': [328], 'could': [329, 1689, 2155, 2270], 'hinder': [330], 'research': [331], 'Craufurd': [338, 775, 1062, 1516, 2558, 2721], 'et': [339, 776, 1063, 1426, 1504, 1517, 1564, 1768, 2021, 2540, 2621, 2699, 2723, 2747, 2779, 2807, 2849, 2873, 2911], 'al.': [340, 777, 1064, 1427, 1505, 1518, 1769, 2022], 'have': [342, 1702], 'suggested': [343, 1646], 'a': [344, 350, 438, 457, 471, 587, 648, 665, 733, 1068, 1135, 1431, 1569, 1581, 1660, 1671, 1760, 1849, 1912, 1925, 1941, 1945, 2005, 2092, 2128, 2248, 2307, 2321, 2367, 2517, 2643, 2788, 3035, 3312, 3450], 'dimensional': [346, 370, 666], 'approach': [347], 'developed': [349], 'specific': [351, 491, 1921, 2368], 'scoring': [352], 'tool': [353], 'achieve': [355], 'this.': [356], 'We': [357, 498, 539], 'applied': [358], 'different': [359, 1523, 2081, 3031], 'diagnostic': [360, 2086], 'tools': [361], 'study': [363, 458, 841, 845, 1108, 1292, 1406, 1447, 1477, 1520, 1561, 1751, 2106, 2166, 2338, 3314], 'measures': [371, 2587, 3193], 'observed': [373, 1704, 1725, 1944], 'behavior': [374], '34': [378, 848], 'mildly': [379], 'moderately': [381], 'ill': [382], 'patients.': [385, 758, 905], 'this': [387, 793, 1050, 1476], 'cross-sectional': [388], 'study,': [389, 794, 1786], 'aim': [391], 'was': [392, 531, 584, 600, 629, 655, 661, 715, 788, 894, 927, 941, 1040, 1047, 1153, 1341, 1356, 1362, 1408, 1549, 1556, 1615, 1774, 1812, 1888, 2118, 2125, 2339], 'confirm': [395], 'earlier': [396, 1644], 'progressive': [399, 1841], 'advancing': [402], 'METHODSParticipants': [405], 'Procedures': [407], 'All': [408, 467, 569], 'participants': [409, 468, 570, 1531, 1678], 'still': [411], 'living': [412, 544], 'at': [413, 488, 2127, 2371], 'home': [414], 'visiting': [416], 'outpatient': [418], 'clinic': [419], 'department': [422], 'neurology': [424], 'Radboud': [427, 2416, 2436, 2453, 2467], 'University': [428, 2417, 2454, 2468], 'Nijmegen': [429, 2418, 2455, 2469], 'Medical': [430, 2419, 2451, 2456, 2470], 'Centre,': [431, 2420], 'Netherlands.': [433], 'They': [434, 1846, 2003, 2038], 'assessed': [436, 519, 532, 540, 1960], 'multidisciplinary': [439], 'team': [440], 'specializing': [441], 'Consecutive': [445], 'asked': [448], 'give': [450], 'their': [451, 512], 'informed': [452], 'consent': [453], 'participate': [455], 'mood': [462, 1046, 2032], 'had': [469], 'genetically': [472], 'confirmed': [473, 1511], 'diagnosis': [474, 641, 1143], 'available': [479], 'data': [480, 504], 'repeat': [483], 'length,': [484], 'showed': [487, 874, 966, 979, 1134, 1456, 1679, 1920, 1993], 'least': [489], 'some': [490], 'mild': [492, 1540], 'motor': [493, 1200], 'signs': [494, 515], 'illness.': [497], 'recorded': [499], 'both': [500, 1795, 2097], 'demographic': [501], 'medication': [503, 2328, 2369], 'provided': [506], 'themselves': [510], 'Neurological': [514], 'symptoms': [517, 628, 781, 916, 1058, 1694, 1930, 3308, 3446], 'using': [520, 554, 590, 2790], 'Unified': [522, 2602], 'Disease': [524, 990, 1000, 1014, 1027, 2604, 2966, 3521], 'Rating': [525, 594, 634, 1606, 2605, 2651], 'Scale': [526, 595, 635, 673, 2196, 2652, 3100], '(UHDRS).': [527], '5': [528], 'Cognitive': [529, 2542, 3260], 'function': [530], 'Mini': [535], 'Mental': [536, 2397, 2480], 'State': [537], 'Examination.': [538], 'activity': [541, 1442, 3069], 'daily': [543, 1444, 2264], '(ADL)': [545], 'instrumental': [547], 'ADL': [548], 'functioning': [549, 2265], 'estimate': [551], 'severity': [553, 786, 1853, 2009], 'Shoulson': [555], "Fahn's": [557], 'total': [558, 619, 677, 881, 1147, 1212], 'functional': [559, 882, 1213, 1352, 1541, 2244, 2625, 2705, 3163], 'capacity': [560], 'scale,': [561], 'part': [563], 'UHDRS.': [566], '6Psychiatric': [567], 'Evaluation': [568, 672, 2195, 2671, 3529], 'interviewed': [572], 'afternoon': [575], 'avoid': [577], 'influence': [578], 'diurnal': [580], 'variation.': [581], 'Psychiatric': [582, 2506, 3220, 3503], 'interviewing': [583], 'guided': [585], 'semistructured': [588], 'interview': [589], 'Comprehensive': [592, 2649], 'Psychopathology': [593], '(CPRS).': [596, 2653], '7': [597], 'Syndromal': [598], 'diagnosed': [601], 'criteria': [606, 853, 1980, 2000], 'help': [608], 'Mini-International': [611], 'Neuropsychiatric': [612, 3531], 'Interview': [613], '(MINI).': [614], 'addition,': [616], 'we': [617, 693, 722, 779, 795, 809, 1337, 1529, 1879, 1905, 2154], 'calculated': [618, 821], 'numbers': [620], 'Severity': [625], 'measured': [630, 1601], 'Hamilton': [633, 1425, 2693], '(HAM-D).': [638], 'A': [639, 706, 1983, 2933, 3264], 'combination': [646, 1727, 2054], 'score': [649, 678, 707, 887, 920, 932, 939, 1184, 1611, 1663, 1673], 'HAM-D': [652, 919, 1140], 'above': [653], '18': [654, 953, 971, 1080, 1959], 'classified': [656, 762], 'severe': [658, 717, 948, 962, 967, 974, 980, 1696], 'separately': [662, 2045], 'rated': [663], 'way': [667], 'Marin': [670, 1655, 1698, 2576, 2659, 2678], '(AES).': [674], '8': [675, 720, 1676], 'AES': [681, 710, 931, 1187, 1610, 1635, 1662, 1967], 'scores': [685, 1098, 1121, 1637, 1648], 'subsyndromes': [688], 'determined.': [690], 'Following': [691], 'Marin,': [692], 'distinguished': [694], 'three': [695, 764], 'subcomponents': [696], 'apathy:': [698], 'cognitive,': [700], 'motor,': [701], 'emotional': [703, 3234], 'components.': [704], '9': [705], '40': [712, 1626], 'higher': [714], 'considered': [716, 1691], 'symptomatology.': [719, 982], 'Finally,': [721], 'presented': [723], 'Problem': [725, 1131, 1177, 1223, 2185, 2205], 'Behavior': [726, 1132, 1178, 1224, 2186, 2206, 2725], 'Assessment': [727, 1133, 1179, 1225, 2187, 2207], '(PBA-HD)': [731], 'close': [734], 'relative': [735], 'caregiver.': [737], 'PBA-HD': [740, 1039, 1101, 1237, 1250, 1264, 1279, 1508], 'instrument': [743, 1051], '(dimensionally)': [745], 'rating': [746, 787, 2646], 'presence,': [748], 'severity,': [749], 'frequency': [751], 'abnormalities': [754, 2702], 'Items': [759], 'can': [760], 'factors': [765, 1118, 1220], '(problem)': [767], 'behavior:': [768], 'Like': [774], 'counted': [780], 'present': [783, 942], 'if': [784], 'higher.': [791], 'For': [792], 'only': [797, 976, 1539, 1680], 'interested': [798], 'factors.': [804], 'Statistical': [805], 'AnalysisFor': [806], 'statistical': [807], 'analysis,': [808], 'used': [810, 1478, 2084], 'SPSS': [812], 'Windows,': [814], 'version': [815], '12.0.': [816], 'Pearson': [817], 'correlation': [818, 1094, 1115, 1137, 1155, 1410, 1777, 1850, 1927, 2006], 'coefficients': [819], 'assess': [823], 'associations': [824], 'various': [827, 866, 1103, 1120, 1755, 1807], 'scales.RESULTSGeneral': [828], 'Characteristics': [829, 986, 996, 1242, 1255, 1271, 1286], 'Study': [832, 991, 1001, 1015, 1028, 1245, 1258, 1274, 1289, 2600, 2631], 'GroupTable': [833], 'summarizes': [835], 'general': [837], 'characteristics': [838, 1105, 1346], 'group.': [842, 2019], 'group': [846, 1571, 1614, 1761, 1799], 'participants,': [849, 2344], '10': [850, 1428], 'fulfilled': [851, 1999], 'disorder': [857, 2033], '(29%).': [858], 'Table': [859, 1111], 'shows': [861, 1092, 1113], 'results': [863, 1421, 1509, 1933, 2215], 'depression,': [867, 1145, 1686, 2301], 'assessments.': [871], 'Depressed': [872, 1045], 'no': [875, 895, 928, 1154, 1409, 1469, 1633, 1775], 'difference': [876, 896, 929], 'age,': [878], 'sex,': [879], 'mean': [880, 885, 918, 1609, 1661, 1672], 'capacity,': [883], 'MMSE': [886, 1209], 'compared': [888], 'those': [890, 1501, 2191], 'without': [891, 1990, 2786], 'There': [893, 1152], 'use': [898, 1229, 2161], 'antidepressants': [900, 2363], 'depressed': [902, 908, 1668, 1909, 1987, 2346], 'nondepressed': [904, 923], 'expected,': [907], 'did': [910], 'differ': [911], 'patients,': [924, 1766], 'but': [925, 1331, 1687, 2124], 'there': [926, 1407, 1631, 1773], 'groups.': [935], 'Severe': [936], '(HAM-D': [938], '>18)': [940], 'four': [944, 959], '(12%)': [946], '(AES': [950], '>40)': [951], '(52%).': [955, 1082], 'Only': [956, 1940], 'two': [957, 977], 'symptomatology': [964], 'apathy.': [968, 1697, 2002], 'Of': [969], 'TABLE': [983, 1233], '1.': [984, 994], 'General': [985, 995], 'Group': [992, 1002, 1016, 1029], '(N=34)TABLE': [993, 1017], '(N=34)Enlarge': [1003, 1030], 'tableTABLE': [1004, 1260], '2.': [1005, 1018], 'Depression,': [1006, 1019], 'Apathy,': [1007, 1020], 'Behavioral': [1009, 1022, 2564, 2701], 'Disturbances': [1010, 1023], 'symptom': [1035, 1913, 2827], 'reported': [1036, 1048], 'loss': [1041], 'energy': [1043], '(55%).': [1044], '43%': [1053], 'participants.': [1055], 'Clustering': [1056], 'proposed': [1060], 'resulted': [1066], 'syndrome': [1070, 1078], '13': [1072, 1748], '(39%)': [1074], 'Coherence': [1083], 'Various': [1085], 'Approaches': [1086], 'ApathyTable': [1090], 'factor': [1097, 1128, 1174], 'baseline': [1104], 'group,': [1109], 'instruments.': [1125], 'score,': [1141], 'any': [1157, 1163], 'subscales,': [1161], 'illness': [1164], 'characteristic': [1165], 'age.': [1171, 1414], 'correlated': [1180, 1226, 1438], 'significantly': [1181], 'and,': [1188, 2257], 'specifically,': [1190], 'subscale': [1194], 'AES,': [1197], 'level': [1201], 'capacity.': [1214], 'Both': [1215, 1867], 'antidepressant': [1231, 2327], 'medication.': [1232, 2163], '3.': [1234, 1247], 'Correlation': [1235, 1248, 1262, 1277], 'Factor': [1238, 1251, 1265, 1280], 'Scores': [1239, 1252, 1266, 1281], 'Baseline': [1241, 1254], 'GroupTABLE': [1246, 1275], 'GroupEnlarge': [1259, 1290], '4.': [1261, 1276], 'tableDISCUSSIONThis': [1291], 'one': [1294, 1750], 'few': [1297, 1942], 'focusing': [1298], 'finding': [1311, 2335], 'that': [1313, 1339, 1374, 1386, 1430, 1483, 1578, 1594, 1638, 1758, 1772, 1884, 1907, 1994, 2040, 2108, 2153, 2217, 2340], 'far': [1316], 'than': [1319, 1619, 1897], 'Moreover,': [1324], 'related': [1330, 1393, 2235, 2544], 'largely': [1333], 'distinct': [1334], 'dimensions,': [1335], 'linked': [1342], 'such': [1347, 1470, 2360], 'decline,': [1353], 'whereas': [1354], 'not.': [1357], 'words,': [1360], 'frequent': [1364], 'advanced': [1367, 1729, 1886], 'stages': [1368, 1534, 1589, 2290], 'fact': [1373, 1577, 2152], 'event': [1379], 'possibility': [1385], 'older': [1387], 'age': [1388, 2159], 'deficits': [1391], 'explain': [1397], 'dissociation': [1399, 1705], 'Our': [1415, 1497, 1507, 1677], 'supported': [1418], 'studies.': [1424], 'composite': [1432], 'apathy/executive': [1433], 'dysfunction': [1434, 1734, 2242, 2856, 2914], 'index': [1436], 'strongly': [1437], 'living.': [1445], 'Another': [1446], 'association': [1458, 1471], 'presence': [1461], 'frontal,': [1465], 'measures,': [1467], 'another': [1479], 'measure': [1480], 'makes': [1484], 'comparisons': [1485], 'difficult,': [1486], 'it': [1491, 1595], 'accordance': [1494], 'ours.': [1496], 'concur': [1499], 'Thompson': [1503, 2560, 2717], '11': [1506], 'regarding': [1521, 2059], 'domains': [1524], 'problem': [1526, 1583], 'behavior.': [1527], 'included': [1530, 1759], 'disability,': [1542], 'quite': [1550], 'high': [1551], 'This': [1555], 'line': [1558], 'Baudic': [1563, 2534], 'al.,': [1565], 'who': [1567], 'studied': [1568, 2024], 'similar': [1570, 1984], 'subjects': [1573, 1623, 1805, 1961, 1977, 1989, 2027, 2050, 2783], 'underlined': [1575], 'even': [1584], 'middle': [1588], 'co-occurs': [1596], 'Mattis': [1604], 'Dementia': [1605, 3257], 'Scale.': [1607, 2672], '40.3,': [1616], 'half': [1620], 'scored': [1624], 'over': [1625, 3181], 'AES.': [1629], 'reliable': [1634], 'cutoff': [1636], 'separate': [1639], 'apathetic': [1640, 1892, 1917, 2350], 'nonapathetic': [1642], 'subjects,': [1643], 'reports': [1645], '"normal"': [1647], '25–35.': 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'supranuclear': [1842], 'palsy': [1843], '(20/22).': [1845], 'degree': [1858], 'vascular': [1877, 2811], 'dementia,': [1878], 'previous': [1882], 'studies': [1883, 1943], 'associated': [1889, 3364], 'aspects': [1893], 'rather': [1896], 'mood-related': [1899], 'aspects.': [1900], '14': [1901], '15': [1903], 'Furthermore': [1904], 'profile': [1914], 'predominant': [1916], 'neuropsychological': [1922, 2830], 'deficits,': [1923], 'negative': [1926], 'frontal': [1935], 'tasks.': [1936], '16': [1937], '17': [1939], 'overlap': [1947], 'Starkstein': [1958, 2867], '37%,': [1972], '64%': [1974], 'fulfilling': [1979], 'assessment': [1985, 2082], '32%': [1995], 'Kant': [2020, 2888], '19': [2023], 'after': [2034], 'closed': [2035], 'head': [2036, 2898], 'injury.': [2037, 2899], 'occurred': [2044, 2052], 'about': [2047], '10%': [2048], '60%.': [2056], 'Contradictory': [2057], 'probably': [2067], 'due': [2068, 2258], 'methodological': [2070], 'issues.': [2071], 'These': [2072], 'include': [2073], 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