Title: The multiple routes of MHC-I cross-presentation
Abstract: <h2>Abstract</h2> Cross-presentation of phagocytosed antigens on major histocompatibility (MHC) class I molecules is known to occur via two alternative routes; one involving processing and loading of the antigenic peptides inside a vacuolar compartment, the other requiring processing inside the cytosol and loading to MHC-I in the endoplasmic reticulum. A new pathway has been described recently in which antigens are transported to the cytosol, processed by phagosome-associated proteasomes and returned back to the phagosome for MHC-I loading.
Publication Year: 2004
Publication Date: 2004-05-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 20
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