Alcohol and Hypertension

Name: Work Video:
Duration: 3 min 30 s
Lawrence J. Beilin; Ian B. Puddey
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365, 384, 408, 417, 474, 640, 766, 961, 976, 1000, 1123, 1158, 1175, 1191, 1566, 1591, 1711, 1791, 1874, 2020, 2297, 2465, 2807, 2865, 2891, 3020, 3218], 'noncardiovascular': [215], 'mortality.': [218, 2118], 'Epidemiologic': [219], 'data': [220, 368, 1095, 1198, 1905, 2019, 3187], 'relating': [221], 'type': [223, 546, 1730, 3152], 'or': [224, 232, 249, 266, 308, 397, 478, 618, 670, 781, 942, 978, 1102, 1113, 1204, 1793, 2066, 2094, 2106, 2137, 2257, 2264], 'quantity': [225], 'consumption': [228, 264, 393, 772, 798, 848, 912, 1297, 1516, 1553, 1659, 1771, 1971, 2031, 2108, 2146, 2464, 2958, 2998, 3046, 3108, 3146, 3173, 3304, 3329, 3485, 3952], 'blood': [230, 326, 641, 865, 914, 931, 962, 1001, 1079, 1106, 1115, 1124, 1139, 1156, 1192, 1460, 1527, 1533, 2132, 2244, 2384, 2734, 2838, 2866, 2892, 3696, 3850], 'pressure': [231, 327, 642, 784, 915, 932, 1002, 1080, 1107, 1116, 1125, 1140, 1193, 1461, 1528, 2133, 2735, 2839, 3697, 3851], 'disease': [234, 830, 1890, 1999, 2299, 2421, 2456, 2467, 3332], 'needs': [235, 1899], 'viewed': [238], 'with': [239, 295, 396, 467, 570, 598, 661, 720, 738, 951, 997, 1019, 1065, 1108, 1126, 1277, 1282, 1287, 1382, 1416, 1421, 1523, 1634, 1663, 1836, 1871, 1909, 1983, 2061, 2087, 2345, 2348, 3047, 3244, 3491, 3695], 'circumspection': [240], 'from': [241, 375, 443, 480, 579, 603, 652, 863, 906, 987, 1096, 1199, 1595, 1647, 1699, 1841, 1940, 1945, 2037, 2053, 2166, 2207, 2236, 2388, 3086, 3188, 3958, 4120], 'a': [242, 435, 475, 483, 580, 585, 627, 739, 824, 834, 840, 899, 952, 1039, 1136, 1148, 1288, 1531, 1557, 1572, 1589, 1622, 1683, 1719, 1760, 1767, 1857, 1936, 1966, 2038, 2046, 2062, 2151, 2195, 2204, 2211, 2351, 2585, 2601, 2663, 2737, 2894, 2968, 3052, 3223, 3404, 3432, 3523, 3603, 3854], 'number': [243, 1720], 'viewpoints.': [245], 'First,': [246], 'heavier': [247, 2255], 'drinkers': [248, 251, 508, 577, 755, 859, 1387, 1644, 2225, 2256, 2279, 2333, 2361, 3399], 'problems': [250], 'far': [253, 1937], 'less': [254], 'likely': [255, 710, 1005, 2293, 2469], 'participate': [257], 'surveys': [259], 'than': [260], 'others.': [261], 'Second,': [262], 'past': [265, 2065], 'present': [267], 'notoriously': [269], 'underreported.': [270], 'Third,': [271], 'difficult': [275], 'quantify': [277], 'often': [279], 'reported': [281, 472, 2090, 2103], 'at': [282, 1037, 2239], 'all.': [283], 'The': [284, 805, 1401, 2119, 2305, 3213, 3278, 3777, 3795, 3844], 'type,': [285, 401], 'quantity,': [286], 'pattern': [288, 388, 423, 2580, 2619, 2656], 'highly': [293], 'correlated': [294], 'socioeconomic': [296], 'other': [298, 351, 444, 998, 1239, 1465], 'lifestyle': [299, 1009, 1240, 2284], 'behaviors,1': [300], 'many': [301, 1828, 2298, 3236], 'which': [303, 455, 1781, 2329], 'may': [304, 860, 1411, 2268], 'measured': [307, 310], 'accurately': [311], 'enough': [312], 'adequate': [314], 'adjustments': [315], 'statistical': [317, 376], 'models.': [318], 'A': [319, 672, 1432, 3877, 3992, 4138, 4151], 'average': [322], 'weekly': [323], 'consumption,': [325, 874, 1329, 1444, 2290], 'level,': [328], 'hypertension': [330, 409, 431, 662, 695, 1334, 1384, 1413, 1745, 2325, 2689, 3699, 3801, 3848, 3924, 3955], 'prevalence': [331, 1625, 1665, 3176, 3796], 'has': [332, 813, 843, 853, 1335, 1451, 1502, 2011], 'been': [333, 814, 844, 855, 894, 1336, 1353, 1452, 2012, 2177, 2447], 'consistent': [334, 569, 658], 'studied': [340, 511], 'populations': [343], 'evaluate': [345], 'its': [346, 1167, 3588], 'contribution': [347, 1497], 'risk': [352, 429, 486, 527, 600, 622, 663, 1332, 2160, 2341, 2369, 2582, 2658, 3082, 3367, 3488, 3524, 3798], 'factors.': [353], 'However,': [354, 647, 1090, 1483, 2142], 'because': [355, 752, 876, 1006, 2350], 'above': [358, 1173, 1396, 2136], 'some': [360, 456, 1922], 'caveats': [361], 'should': [362, 1859], 'put': [364], 'interpretation': [366], 'where': [369], 'authors': [370, 1092, 1402], 'emphatically': [371], 'imply': [372], 'causal': [373], 'relationships': [374, 610], 'associations.The': [377], 'more': [378, 758], 'cross-sectional': [380, 436, 673, 2969, 3184, 3604], 'studies': [381, 908, 989, 1052, 1097, 1703, 2186, 2445], 'have': [382, 714, 893, 2175, 2269, 2295, 3400], 'concentrated': [383], 'without': [398, 540], 'food,': [399], 'beverage': [400, 548, 967, 1631, 2732, 3154], 'relative': [404, 2022, 3306], 'subtypes.Pattern': [410], 'Drinking,': [412], 'Beverage': [413], 'Type,': [414], 'Effects': [416, 2887], 'SubtypesThe': [419], 'relationship': [420, 1574], 'was': [432, 562, 568, 596, 736, 750, 785, 983, 1017, 1521, 1556, 1571, 1660, 1686, 1782, 2035, 2199, 2252, 2316, 2335, 2362, 2478], 'addressed': [433], 'study': [437, 573, 631, 651, 674, 761, 1291, 1345, 2039, 2077, 2206, 2308, 2327, 2970, 3055, 3407], '2609': [439], 'New': [440, 654, 1342, 1933, 3089, 3289], 'Yorkers': [441], 'free': [442, 1309, 2481, 3553], 'disease2': [446], 'further': [449, 1338], 'an': [451, 571, 792, 1058, 1127, 1202, 1267, 1293, 1425, 1457, 1524, 1739, 1833, 1894, 1977, 2167, 2180, 2365, 2386, 3241, 3975], 'accompanying': [452, 1268, 1895], 'editorial3': [453], 'key': [459], 'surrounding': [461], 'topic': [463], 'were': [464, 510, 611, 707, 1003, 1247, 1307, 1366, 1380, 1395, 1891, 2072, 2084, 2127, 2135, 2468], 'discussed.': [465], 'Compared': [466, 2086], 'lifetime': [468], 'abstainers,': [469], 'those': [470, 535, 698, 1109, 2101, 2259], 'who': [471, 536, 1306, 1394, 1853, 2089, 2102, 2260], 'daily': [476, 2107, 2862], 'basis': [477, 768, 1815], 'apart': [479], 'food': [481], 'had': [482, 958, 973, 1352, 2109, 2231, 2446], 'significantly': [484], 'higher': [485, 599, 740, 1538, 1938, 4188], 'hypertension,': [488, 746], 'but': [489, 554, 747, 791, 1225, 1242, 1390, 1462], 'effect': [491, 960, 975, 1070, 1131, 1150, 1740, 1787, 2169, 2191, 2860, 3214], 'disappeared': [492], 'after': [493, 936, 1145, 1609], 'accounting': [494], 'amount': [497, 517], 'consumed': [500, 520, 2261], 'previous': [503, 523, 1055], '30': [504, 524], 'days.': [505], 'When': [506], 'current': [507, 2067], 'only': [509, 533, 1391, 1455, 2767], 'adjustment': [513, 1611], 'made': [514], 'days,': [525], 'being': [529, 2343], 'hypertensive': [530, 718, 1364, 1848, 2033, 2314, 2420, 3335, 3645, 4185], 'increased': [531, 621, 1018, 1032, 1299, 1357, 1417, 1978], '(64%)': [532], 'said': [537], 'they': [538, 1246, 2092, 2098], 'drank': [539, 757, 1854, 2096], 'food.': [541], 'Preference': [542], 'any': [544, 715, 974, 1261, 1495, 1706, 1786, 2189, 2459], 'one': [545, 2598], 'did': [549], 'influence': [551], 'association': [553, 1279, 1294, 1321], 'important': [556, 1426], 'potential': [557], 'confounder': [558], 'dietary': [560, 2271], 'habits': [561], 'assessed.': [564], 'Nevertheless': [565], 'finding': [567, 749, 1684, 2144], 'earlier': [572], 'Italian': [575, 2623], 'wine': [576, 858, 944, 957, 972, 995, 1012, 1022, 1643, 1694, 2224, 2806, 2834, 3398], 'coming': [578], 'cultural': [582], 'background,4': [583], 'follow-up': [586, 2215], 'population': [589, 721, 907, 988, 1702, 1843, 2047, 2444, 3804], 'showed': [590, 924, 1920], 'outside': [593, 615], 'meals': [595, 617], 'associated': [597, 737, 1381, 1522, 1662, 1982], 'death': [602], 'causes': [605, 2238], 'disease.': [608, 3530], 'Similar': [609, 2197], 'seen': [612, 1362, 2128, 2253], 'snacks': [619], 'myocardial': [624, 2357, 2661], 'infarction': [625, 2358], 'case': [629], 'control': [630, 3925], 'men.5The': [633], 'individual': [637], 'alcoholic': [638, 1829, 2153, 2731, 2764, 3237], 'beverages': [639, 812, 999], 'continue': [643], 'arouse': [645], 'interest.': [646], 'previously': [649], 'cited': [650], 'western': [653], 'York3': [655], 'found': [656, 696, 1621, 2099, 2330], 'no': [657, 959, 2336, 2480, 3552], 'beverage-specific': [659], 'associations': [660, 681, 3692], 'North': [665], 'Americans': [666], 'beer,': [668, 774, 2275], 'wine,': [669, 1822, 2276], 'spirits.': [671, 2265], 'Chinese': [676, 732, 2692], 'men': [677, 923, 1219, 1305, 1348, 1542, 2051, 2932, 3438], 'examined': [679], 'intake': [684, 703, 836, 1209, 1578, 2541, 2687, 2803, 2864, 2926, 3217, 3428], 'isolated': [686, 693, 744, 1283], 'systolic,': [687], 'combined': [688], 'systolic': [689, 745, 930, 1076, 1284, 2243], 'diastolic,': [691], 'diastolic': [694, 1078], 'highest': [701, 786], 'category': [704], '(≥30': [705], 'drinks/week)': [706], 'twice': [708], 'as': [709, 711, 1036, 1727, 1930, 2148, 2150, 2179, 2194, 2280, 2282, 3522], 'nondrinkers': [712, 2174], 'these': [717, 891, 1091, 1233, 1404, 1563, 2083], 'subtypes': [719, 2690], 'attributable': [722], 'risks': [723, 2008, 2025, 2233, 2405, 3259, 3310], '13.9%,': [725], '13.4%': [726], '12.0%,': [728], 'respectively.6': [729], 'In': [730, 888, 919, 1369, 1505, 1587, 1947, 2171], 'study,6': [733], 'liquor': [734, 754], 'odds': [741, 1581], 'ratio': [742, 1638], 'probably': [751, 1716, 2200, 3551], 'generally': [756], 'alcohol.': [759, 1368, 1946, 2423], 'Another': [760], 'grouped': [762], 'Japanese': [763, 778, 1304, 2739, 3058], 'male': [764], 'workers7': [765], 'their': [770, 1864], 'total': [771, 796, 2041, 2115, 2303], 'sake,': [775], 'shochu': [776, 789], '(traditional': [777], 'spirits),': [779], 'whiskey,': [780], 'wine.': [782], 'Blood': [783, 1600], 'group': [790, 2183], 'analysis': [793, 2387, 3185], 'adjusting': [794], 'resulted': [799], 'disappearance': [801], 'difference.': [804, 2602], 'specific': [811], 'evoked': [815], 'part': [817], 'by': [818, 1061, 1081, 1238, 1718, 1750, 1759, 1772, 1986, 2015, 2161, 2364, 2410, 2473, 3597], 'so-called': [820], 'French': [821, 3409], 'Paradox': [822], 'relatively': [825, 1961], 'low': [826], 'incidence': [827, 2355, 3846], 'coronary': [829, 1168, 1817, 1888, 1912, 1958, 2454, 2466], 'France': [832], 'despite': [833], 'high': [835, 1532, 1678], 'saturated': [838], 'fat,': [839], 'phenomenon': [841], 'attributed': [845, 2416], 'red': [850, 943, 956, 971, 994, 1821, 2805], 'wine.8': [851], 'It': [852, 982, 1351], 'also': [854, 1093, 1656, 1898, 2201], 'suggested': [856, 1243, 1657], 'protected': [862], 'pressure–raising': [866], 'regular': [869, 1778], 'moderate': [870, 910, 1779, 2029, 2125, 2462], 'heavy': [872], 'perhaps': [875], 'antioxidant': [878], 'vasodilator': [880, 1130], 'polyphenolic': [883], 'flavonoids': [884], 'improving': [885], 'endothelial': [886], 'function.9': [887], 'our': [889], 'opinion,': [890], 'suggestions': [892, 905], 'laid': [895], 'rest': [897], 'randomized': [900, 1761, 2897, 3224], 'crossover': [901], 'trial10': [902], 'confirmed': [904, 1053], 'raises': [913], 'regardless': [916, 2129], 'source.': [918], 'study,': [921, 1373, 3605, 3813], 'normotensive': [922, 2841], 'similar': [925, 1066], 'elevations': [926], 'awake': [928], 'ambulatory': [929, 1112], 'heart': [934, 2455, 3549], 'rate': [935], '4': [937, 1775], 'weeks': [938, 1776], 'either': [940], 'beer': [941, 1020, 1692, 2263, 2836], '(40-g': [945], 'ethanol': [946], 'equivalent': [947], 'per': [948], 'day)': [949, 1153], 'compared': [950, 996, 1094, 1633, 2347], 'control-abstinence': [953], 'period.': [954], 'De-alcoholized': [955], 'pressure,': [963, 2385], 'neither': [965], 'nor': [968, 1286], 'containing': [970], 'flow': [977], 'glyceryl': [979], 'trinitrate–mediated': [980], 'dilation.': [981], 'concluded': [984, 1846, 2437], 'results': [986, 1234, 1698], 'suggesting': [990], 'differential': [991], 'confounding': [1008, 1724, 2165, 2198, 2267, 2442], 'differences': [1010, 2272, 3591], 'drinkers.': [1013, 1695], 'Twenty-four–hour': [1014], 'endothelin-1': [1015, 1034], 'excretion': [1016], 'drinking,': [1023, 2433], 'leading': [1024, 1134], 'suggestion': [1027], 'might': [1030, 1164, 1235, 1258, 1831, 3239], 'reflect': [1031], 'vascular': [1033, 1256], 'production': [1035], 'least': [1038], 'contributor': [1040], 'alcohol.10A': [1046], 'systematic': [1047], 'review11': [1048], 'intervention': [1051, 1764], 'findings': [1056, 1271, 1405], 'initial': [1059], 'meta-analysis': [1060, 2895], 'Xin': [1062, 2875], 'et': [1063, 1918, 2435], 'al12': [1064], 'estimates': [1067], 'restriction': [1073], 'reduce': [1075, 1863, 2157], '2.7': [1082], 'mm': [1083, 1087, 2140], 'Hg': [1084], '1.4': [1086], 'Hg,': [1088], 'respectively.': [1089], 'used': [1099], 'conventional': [1100], 'clinic': [1101], 'office': [1103], 'review': [1104, 2857], 'incorporated': [1111], 'home': [1114], 'monitoring,': [1117], 'highlighting': [1118], 'biphasic': [1119], 'early': [1128], 'presumably': [1129], 'reduction': [1137, 1768, 2248, 2323, 2890], '(in': [1141], 'immediate': [1143], 'hours': [1144], 'exposure)': [1146], 'later': [1149], '(the': [1151], 'next': [1152], 'raising': [1155], 'pressure.Effects': [1157], 'Large': [1159], 'Vessel': [1160], 'Structure': [1161], 'FunctionHow': [1163], 'exert': [1166], 'protective': [1169, 1818], 'over': [1171], 'influences': [1174], 'high-density': [1176], 'lipoprotein': [1177], '(HDL)': [1178], 'cholesterol,': [1179, 1674], 'platelet': [1180], 'function,': [1181], 'fibrinogen': [1183], 'face': [1187], 'adverse': [1189], 'homocysteine': [1195], 'metabolism?': [1196], 'Cross-sectional': [1197], 'Holland': [1200], 'described': [1201], 'inverse': [1203, 3691], 'J-shaped': [1205], 'measures': [1211, 1398], 'aortic': [1213, 1300, 1311, 2928, 2962, 2965, 3021, 3050], 'stiffness': [1214, 1301, 2929, 2963, 3001], 'middle-aged': [1216, 1303, 2221, 2738, 3057], 'older': [1218, 1834, 3242], 'pre-': [1221], 'postmenopausal': [1223, 2973], 'women13,14': [1224], 'younger': [1228], 'men.15': [1229], 'They': [1230], 'recognized': [1231], 'confounded': [1237], 'factors': [1241, 3368, 3799], 'if': [1245], 'causally': [1248], 'linked': [1249, 1453], 'direct': [1250], 'improve': [1255], 'compliance': [1257], 'contribute': [1259], 'cardioprotective': [1262], 'effect.': [1263], 'As': [1264], 'discussed': [1265, 1892], 'editorial,16': [1269], 'easy': [1274], 'reconcile': [1276], 'hypertension6': [1285], '9-year': [1289, 3053], 'longitudinal': [1290, 1344, 1372, 3054], 'showing': [1292], 'initially': [1308, 2219], 'stiffness.17Alcohol,': [1312], 'Metabolic': [1314], 'Syndrome,': [1315], 'DiabetesThe': [1317], 'nature': [1318], 'liver': [1323, 1423, 1998, 3079], 'enzymes,': [1324, 3080], 'body': [1325, 3687], 'fat': [1326, 1419, 3077], 'distribution,': [1327, 1420, 3078], 'explored': [1337], 'York': [1343, 3090], '1455': [1347], 'women.18': [1350], 'assumed': [1354], 'γ': [1358], 'glutamyltransferase': [1359], '(γGT)': [1360], 'levels': [1361, 1375, 2134, 2241, 2431], 'subjects': [1365], 'caused': [1367, 1985], '6-year': [1371], 'γGT': [1374, 1410], 'within': [1376, 1926], 'normal': [1378], 'range': [1379], 'incident': [1383], 'both': [1386, 1541, 1547], 'nondrinkers,': [1389], 'participants': [1393, 1594], 'median': [1397], 'fatness.': [1400], 'interpreted': [1403], 'indicate': [1407], 'serum': [1409, 1676], 'predict': [1412], 'among': [1414, 1688, 1691, 3371, 3599, 3802, 3926, 4146], 'individuals': [1415, 2088], 'central': [1418, 1477], 'fatty': [1422], 'representing': [1424], 'mechanism': [1428], 'association.': [1431], 'closely': [1433], 'related': [1434], 'area': [1435], 'concerns': [1438], 'link': [1441], 'diabetes,': [1445], 'metabolic': [1448, 1500, 1585, 1713, 1748, 3111, 3148, 3179, 3885], 'syndrome.': [1449, 1586], 'Alcohol': [1450, 1806, 2540, 2686, 2925, 2957, 2997, 3012, 3107, 3145, 3172, 3254, 3303, 3328, 3484, 3521, 3546, 3763, 3897, 3972, 4082, 4113], 'increase': [1458, 1473, 1488, 1525, 1559, 2366, 3048], 'several': [1464, 1667, 1700], 'elements': [1466], 'syndrome,': [1469, 1671], 'particular': [1471], 'triglyceride': [1475], 'levels,': [1476, 1490], 'adiposity,': [1478], 'elevated': [1480, 1675], 'uric': [1481], 'acid.': [1482], 'simultaneously': [1485], 'acts': [1486], 'HDL-cholesterol': [1489, 3694], 'so': [1491], 'whether': [1492, 2131], 'makes': [1494, 2600], 'significant': [1496, 1558, 2111, 2247], 'syndrome': [1501, 1628, 1714, 1749, 3112, 3180], 'remained': [1503], 'controversial.': [1504], '1998': [1507, 3117], 'Korean': [1508, 3114, 3118], 'National': [1509, 1597, 1650, 3119, 3191, 3771], 'Nutrition': [1512, 1653, 3122, 3194, 3774, 4160], 'Examination': [1513, 1654, 3123, 3195, 3775], 'Survey19': [1514], '>30': [1518], 'g': [1519, 2229], 'alcohol/d': [1520], 'men,': [1530], 'glucose': [1534, 1792], 'women,': [1536, 1544], 'triglycerides': [1539], 'whereas': [1545], 'sexes': [1548], 'across': [1550, 1629, 1907, 3849], 'categories': [1554, 3852], 'HDL-cholesterol.': [1561], 'Despite': [1562], 'contrasting': [1564, 1697], 'components,': [1568], 'overall': [1569, 1707, 2158, 2375], 'dose–response': [1573], 'increasing': [1576], 'having': [1583], 'contrast,': [1588], 'report': [1590], '4510': [1592], 'white': [1593], 'Heart': [1598, 1603, 2552], 'Institute': [1601], 'Family': [1602], 'Study': [1604, 2057], 'United': [1607], 'States,': [1608], 'careful': [1610], 'confounders': [1613, 3370], 'including': [1614, 2286], 'education,': [1615], 'diet,': [1616], 'physical': [1618], 'activity,20': [1619], 'actually': [1620], 'substantially': [1623], 'reduced': [1624, 2114], '"never': [1635], 'drinkers"': [1636], '(odds': [1637], 'down': [1639], '0.32': [1641], 'only).': [1645], 'Data': [1646], 'Third': [1649, 3190, 3770], 'Survey21': [1655], 'inversely': [1661], 'components': [1668], 'low-serum': [1672], 'HDL': [1673], 'triglycerides,': [1677], 'waist': [1679], 'circumference,': [1680], 'hyperinsulinemia,': [1682], 'strongest': [1687], 'whites': [1689], 'suggest': [1704], 'dictated': [1717], 'competing': [1722], 'influences,': [1725], 'such': [1726, 1929, 2185], 'volume': [1728], 'consumed,': [1733], 'gender,': [1734], 'race,': [1735], 'ethnicity.': [1737], 'Therefore,': [1738], 'induce': [1744], 'impairing': [1751], 'insulin': [1752, 1794, 3219], 'resistance': [1753], 'doubtful.': [1755], 'This': [1756, 1866], 'supported': [1758], 'controlled': [1762, 2898, 3225], 'trial': [1765], 'involving': [1766], '80%': [1773], 'drinkers,22': [1780], 'unable': [1783], 'detect': [1785], 'changing': [1789], 'homeostasis.Safe': [1795], 'Levels': [1796], 'Drinking': [1798, 2618, 2655], 'Hypertensive': [1800, 1812], 'People': [1801], 'Context': [1804], 'Global': [1809, 2394], 'Burden': [1810, 2395], 'DiseaseOn': [1813], 'Bulpitt': [1823, 3233], 'posed': [1824], 'question': [1826], '"How': [1827], 'drinks': [1830, 1856, 2599, 3238], 'benefit': [1832, 3240], 'person': [1835, 3243], 'hypertension?"23': [1837], 'Largely': [1838], 'using': [1839], 'meta-analyses': [1840], 'general': [1842], 'studies,': [1844], 'he': [1845], 'patients': [1849, 2034], 'aged': [1850], '>60': [1851], 'years': [1852], '>16': [1855], 'week': [1858], 'advised': [1861], 'consumption.': [1865], 'broadly': [1868], 'accord': [1870], 'international': [1872], 'guidelines': [1873], 'management': [1876], 'Some': [1879], 'pitfalls': [1882], 'limiting': [1884], 'focus': [1886], 'artery': [1889], 'editorial.24': [1896], 'Care': [1897], 'taken': [1902], 'extrapolating': [1904], 'quantitatively': [1906], 'cultures': [1908], 'widely': [1910], 'differing': [1911], 'rates': [1913], 'circumstances.': [1916], 'Connor': [1917, 3268, 3542], 'al25': [1919], 'how': [1921], 'ethnic': [1923], 'communities': [1924], 'living': [1925], 'Westernized': [1927], 'populations,': [1928], 'Maoris': [1931], 'Zealand,': [1934], 'show': [1935], 'burden': [1939, 3279, 3528], 'death,': [1941, 1957, 3281], 'disease,': [1942, 3282], 'disability': [1944, 3284], 'Japan': [1948], 'stroke': [1949], 'remains': [1950], 'common': [1953], 'cause': [1954], 'deaths': [1959, 2074, 2235], 'low,': [1962], 'linear': [1967], 'hemorrhagic': [1973], 'stroke.': [1974], 'Youthfulness': [1975], 'carries': [1976], 'share': [1979], 'patterns,': [1988], 'risky': [1989], 'behaviors,': [1990], 'greater': [1992], 'periods': [1993], 'exposure': [1995], 'alcohol-related': [1997], 'cancers,': [2001], 'age': [2004], 'dependence': [2005], 'well': [2013, 2281], 'illustrated': [2014], 'Jackson': [2016, 2434, 3276, 3299, 3538, 4068], 'Beaglehole.26Further': [2018], 'light': [2027, 2123], 'provided': [2036], 'mortality': [2044, 2251, 3333], '14': [2049], '125': [2050], 'derived': [2052], 'Physicians': [2055], 'cohort': [2058, 3406, 3856], 'identified': [2060], 'history': [2063], 'treatment': [2068], 'hypertension.27': [2070], 'There': [2071], '1018': [2073], 'during': [2075], 'period,': [2078], 'about': [2080], 'half': [2081], 'cardiovascular.': [2085], 'rarely': [2093], 'never': [2095], 'monthly,': [2104], 'weekly,': [2105], 'increasingly': [2110], 'trends': [2112], 'beneficial': [2120, 2190], 'below': [2138], '140/90': [2139], 'Hg.': [2141], 'little': [2149], 'single': [2152], 'drink': [2154], 'monthly': [2155], 'could': [2156], '18%': [2162], 'strongly': [2163], 'suggests': [2164], 'unmeasured': [2168], 'modifier.': [2170], 'regard,': [2173], 'recently': [2176], 'characterized': [2178], 'inappropriate': [2181], 'comparison': [2182], 'overestimate': [2188], 'result.28': [2196], 'operative': [2202], 'new': [2205], 'France29': [2208], 'involved': [2210], '13-': [2212], '21-year': [2214], '36': [2217], '583': [2218], 'healthy': [2220, 2972], 'men.': [2222, 2693, 2842, 3003, 3059, 3336, 3410], 'Moderate': [2223, 3397], '(their': [2226], 'definition': [2227], '<60': [2228], 'alcohol/d)': [2230], 'lower': [2232, 3401], 'pressure.': [2245, 2867], 'No': [2246], 'all-cause': [2250], 'predominantly': [2262], 'Unmeasured': [2266], 'included': [2270], 'differentiate': [2274], 'spirits': [2278], 'marked': [2283], 'differences,': [2285], 'impacted': [2296], 'processes': [2300], 'contributing': [2301], 'mortality.30': [2304], 'measuring': [2309], 'outcomes': [2311], 'people': [2315], 'Losartan': [2319], 'Intervention': [2320], 'For': [2321], 'Endpoint': [2322], '(LIFE)': [2326], 'cohort,31': [2328], 'decrease': [2337, 2352], 'composite': [2339], 'when': [2342, 2597], 'treated': [2344, 3930], 'losartan': [2346], 'atenolol': [2349], 'offset': [2363], 'stroke.In': [2371], 'terms': [2372], 'elevate': [2383, 2837], 'landmark': [2390], 'World': [2391], 'Organization': [2393], 'Disease': [2397], '2000': [2398], 'Comparative': [2399], 'Risk': [2400, 2624, 3743], 'Analysis': [2401], 'study32': [2402], 'assessed': [2403], 'region': [2411], 'then': [2413], 'globally': [2414], '16%': [2417], 'To': [2424], 'add': [2425], 'controversy': [2428], '"safe"': [2430], 'al33': [2436], 'bidirectional': [2441], 'underestimated': [2448], 'outweighed': [2472], 'harmful': [2474], '(ie,': [2476], '"probably': [2479], 'lunch").FootnotesCorrespondence': [2482], 'Beilin,': [2486], 'Professor': [2487], 'Medicine,': [2489], 'Unit,': [2493], 'Level': [2503], '4,': [2504], 'Medical': [2505, 3995], 'Research': [2506, 4158], 'Foundation': [2507], 'Bldg,': [2508], 'Rear,': [2509], '50': [2510], 'Murray': [2511], 'St,': [2512], 'Perth,': [2513], 'E-mail': [2517], '[email': [2518], 'protected]': [2519], 'References': [2520], 'Ruidavets': [2522], 'JB,': [2523], 'Bataille': [2524], 'V,': [2525, 2824, 3206, 4133], 'Dallongeville': [2526], 'J,': [2527, 2640, 2681, 2713, 2717, 2785, 2878, 3073, 3269, 3271, 3273, 3361, 3506, 3541, 3543, 3723, 3833, 3909, 4013, 4017, 4021, 4039], 'Simon': [2528], 'C,': [2529, 3424, 3580, 3672, 4023], 'Bingham': [2530], 'A,': [2531, 2613, 2727, 2828, 2910, 2912, 2942, 2984, 3420, 3576, 3717, 3721, 3752, 4104], 'Amouyel': [2532], 'P,': [2533, 2537, 2567, 2648, 2677, 3390, 3479, 3572, 3674, 3754], 'Arveiler': [2534], 'D,': [2535, 3392, 4037], 'Ducimetiere': [2536], 'Ferrieres': [2538], 'diet': [2543, 3430], 'France,': [2545], 'prominent': [2547], 'lifestyle.': [2550], 'Eur': [2551, 3531], '2004;': [2554, 2589, 2604, 2668, 2755, 2979, 3006, 3129, 3158, 3199, 3340, 3415, 3501], '25:': [2555], '1153–1162.CrossrefMedlineGoogle': [2556], 'Scholar2': [2557], 'Stranges': [2558, 3066], 'S,': [2559, 2725, 2779, 3040, 3067, 3363, 3460, 3481, 3574, 3618, 3620, 3630, 4096], 'Wu': [2560, 4028, 4032], 'T,': [2561, 2652, 2701, 2703, 2709, 2719, 3570, 3624, 3658, 4175], 'Dorn': [2562, 2639, 3070], 'JM,': [2563, 2826, 3071, 3394], 'Freudenheim': [2564, 2649], 'JL,': [2565, 2650], 'Muti': [2566, 2647], 'Farinaro': [2568], 'E,': [2569, 2611, 3616, 3719, 4067, 4092, 4100], 'Russell': [2570, 2643], 'M,': [2571, 2609, 2638, 2644, 2646, 2777, 2781, 2787, 2789, 2986, 3069, 3422, 3510, 3622, 3715, 3756, 3870, 4102, 4106], 'Nochajski': [2572], 'TH,': [2573], 'Trevisan': [2574, 2608, 2637, 3068], 'M.': [2575], 'Relationship': [2576], 'hypertension:': [2584, 2596, 3084, 3256], 'population-based': [2586, 2664, 3855], 'study.': [2587, 2666, 3497], 'Hypertension.': [2588, 2603, 2771, 2843, 2900, 3092], '44:': [2590, 2605], '813–819.LinkGoogle': [2591], 'Scholar3': [2592], 'Klatsky': [2593], 'AL.': [2594], 'Alcohol-associated': [2595], '805–806.LinkGoogle': [2606], 'Scholar4': [2607], 'Schisterman': [2610], 'Mennotti': [2612], 'Farchi': [2614], 'G,': [2615, 2679, 3208, 3353, 3462, 3512, 3656, 3668, 3670, 4094, 4098], 'Conti': [2616], 'S.': [2617, 3545], 'mortality:': [2621, 3403], 'Factor': [2625], 'Life': [2627], 'Expectancy': [2628], 'Pooling': [2629], 'project.': [2630], 'Ann': [2631], 'Epidemiol.': [2632], '2001;': [2633, 2817, 2901, 3062], '11:': [2634], '312–319.CrossrefMedlineGoogle': [2635], 'Scholar5': [2636], 'Falkner': [2641], 'K,': [2642, 2705, 2721, 2783, 2791, 2795, 2797, 3034, 3036, 3471, 3514, 3626, 3676, 3831, 4005], 'Ram': [2645], 'Nochajaski': [2651], 'Hovey': [2653], 'K.': [2654, 3042, 3426], 'non-fatal': [2660], 'infarction:': [2662], 'case-control': [2665], 'Addiction.': [2667], '99:': [2669], '313–322.CrossrefMedlineGoogle': [2670], 'Scholar6': [2671], 'Wildman': [2672], 'RP,': [2673], 'Gu': [2674, 4045], 'DF,': [2675], 'Muntner': [2676], 'Huang': [2678, 4004, 4038], 'Chen': [2680, 4016], 'Duan': [2682], 'X,': [2683, 2876, 3664, 4007, 4019, 4029, 4033], 'He': [2684, 2877], 'J': [2694, 2752, 2815, 2869, 2935, 3004, 3023, 3126, 3246, 3262, 3378, 3412, 3442, 3498, 3680], 'Hypertens.': [2695, 2754, 2870, 2936, 3005, 3024, 3247, 3263, 3500], '2005;': [2696, 2772, 2844, 2871, 2937, 3025, 3093, 3248, 3264, 3295, 3381, 3556], '23:': [2697, 2938, 3026, 3249, 3265], '737–743.CrossrefMedlineGoogle': [2698], 'Scholar7': [2699], 'Okamura': [2700], 'Tanaka': [2702], 'Yoshita': [2704], 'Chiba': [2706], 'N,': [2707, 3030, 3516, 3907], 'Takebayashi': [2708], 'Kikuchi': [2710], 'Y,': [2711, 3568, 3628, 3835, 4035, 4041], 'Tamaki': [2712], 'Tamura': [2714], 'U,': [2715, 3465, 3829], 'Minai': [2716], 'Kadowaki': [2718], 'Miura': [2720], 'Nakagawa': [2722], 'H,': [2723, 2793, 3032, 3038, 3469, 3660, 4173, 4177], 'Tanihara': [2724], 'Okayama': [2726], 'Ueshima': [2728], 'H.': [2729, 3483], 'Specific': [2730], 'population:': [2740], 'High-risk': [2742], 'Population': [2744], 'Strategy': [2745], 'Occupational': [2747], 'Promotion': [2749], '(HIPOP-OHP)': [2750], 'Study.': [2751, 3091], 'Hum': [2753], '18:': [2756, 2872, 3502], '9–16.CrossrefMedlineGoogle': [2757], 'Scholar8': [2758], 'Fuchs': [2759], 'FD.': [2760], 'Vascular': [2761], 'beverages—is': [2765], 'matters?': [2770], '45:': [2773, 2845], '851–852.LinkGoogle': [2774], 'Scholar9': [2775], 'Hashimoto': [2776], 'Kim': [2778, 3105], 'Eto': [2780], 'Iijima': [2782], 'Ako': [2784], 'Yoshizumi': [2786], 'Akishita': [2788], 'Kondo': [2790], 'Itakura': [2792], 'Hosoda': [2794], 'Toba': [2796], 'Ouchi': [2798], 'Y.': [2799], 'Effect': [2800], 'acute': [2802], 'flow-mediated': [2808], 'vasodilatation': [2809], 'brachial': [2812], 'artery.': [2813], 'Am': [2814, 2868, 3125, 3377, 3411, 3441], 'Cardiol.': [2816], '88:': [2818], '1457–1460.CrossrefMedlineGoogle': [2819], 'Scholar10': [2820], 'Zilkens': [2821, 3203], 'RR,': [2822, 3204], 'Burke': [2823, 3205], 'Hodgson': [2825], 'Barden': [2827], 'LJ,': [2830, 3210], 'IB.': [2832, 3212], 'Red': [2833], '874–879.LinkGoogle': [2846], 'Scholar11': [2847], 'McFadden': [2848], 'CB,': [2849], 'Brensinger': [2850], 'CM,': [2851], 'Berlin': [2852], 'JA,': [2853], 'Townsend': [2854], 'RR.': [2855], 'Systematic': [2856], '276–286.CrossrefMedlineGoogle': [2873], 'Scholar12': [2874], 'Frontini': [2879], 'MG,': [2880], 'Ogden': [2881], 'LG,': [2882], 'Motsamai': [2883], 'OI,': [2884], 'Whelton': [2885, 3727], 'PK.': [2886], 'pressure:': [2893], 'trials.': [2899], '38:': [2902], '1112–1117.CrossrefMedlineGoogle': [2903], 'Scholar13': [2904], 'van': [2905, 2945, 2987], 'den': [2906], 'Elzen': [2907], 'AP,': [2908], 'Sierksma': [2909, 2941, 2983], 'Oren': [2911], 'Vos': [2913], 'LE,': [2914], 'Witteman': [2915], 'JG,': [2916], 'Grobbee': [2917, 2949, 2991], 'DE,': [2918, 2950, 2992], 'Hendriks': [2919, 2953, 2993], 'HF,': [2920, 2954, 2994], 'Uiterwaal': [2921], 'CS,': [2922], 'Bots': [2923, 2955, 2995], 'ML.': [2924, 2956, 2996], 'young': [2931], 'women.': [2934, 2974, 3440], '731–735.CrossrefMedlineGoogle': [2939], 'Scholar14': [2940], 'Lebrun': [2943], 'CE,': [2944], 'der': [2946, 2988], 'Schouw': [2947, 2989], 'YT,': [2948, 2990], 'Lamberts': [2951], 'SW,': [2952, 3100], 'wave': [2966], 'reflections:': [2967], 'Arterioscler': [2975], 'Thromb': [2976], 'Vasc': [2977], 'Biol.': [2978], '24:': [2980], '342–348.LinkGoogle': [2981], 'Scholar15': [2982], 'Muller': [2985], 'arterial': [3000], '22:': [3007], '357–362.CrossrefMedlineGoogle': [3008], 'Scholar16': [3009], 'L.': [3011, 3253], 'disease:': [3015, 3550], 'protection': [3017], 'via': [3018], 'stiffness.': [3022], '703–705.CrossrefMedlineGoogle': [3027], 'Scholar17': [3028], 'Nakanishi': [3029], 'Kawashimo': [3031], 'Nakamura': [3033], 'Suzuki': [3035], 'Yoshida': [3037], 'Uzura': [3039], 'Tatara': [3041], 'Association': [3043], 'stiffness:': [3051], 'Ind': [3060], 'Health.': [3061], '39:': [3063], '24–28.CrossrefMedlineGoogle': [3064], 'Scholar18': [3065], 'Dmochowski': [3072], 'Donahue': [3074], 'RP.': [3075], 'Body': [3076], 'evidence': [3085, 3957], '46:': [3094], '1186–1193.LinkGoogle': [3095], 'Scholar19': [3096], 'Yoon': [3097], 'YS,': [3098], 'Oh': [3099], 'Baik': [3101], 'HW,': [3102], 'Park': [3103], 'HS,': [3104, 3275], 'WY.': [3106], 'adults:': [3115], 'Survey.': [3124, 3196], 'Clin': [3127, 3413, 3443], 'Nutr.': [3128, 3414, 3444], '80:': [3130, 3416], '217–224.CrossrefMedlineGoogle': [3131], 'Scholar20': [3132], 'Djousse': [3133], 'L,': [3134, 3837, 3911, 4025, 4031], 'Arnett': [3135], 'DK,': [3136], 'Eckfeldt': [3137], 'JH,': [3138], 'Province': [3139], 'MA,': [3140], 'Singer': [3141], 'MR,': [3142], 'Ellison': [3143, 3170], 'RC.': [3144, 3171], 'syndrome:': [3149], 'does': [3150], 'matter?': [3155], 'Obesity': [3156], 'Research.': [3157], '12:': [3159], '1375–1385.CrossrefMedlineGoogle': [3160], 'Scholar21': [3161], 'Freiberg': [3162], 'MS,': [3163, 3477], 'Cabral': [3164], 'HJ,': [3165], 'Heeren': [3166], 'TC,': [3167], 'Vasan': [3168], 'RS,': [3169], 'US–a': [3183], 'Diab': [3197, 3227], 'Care.': [3198, 3228], '27:': [3200], '2954–2959.CrossrefMedlineGoogle': [3201], 'Scholar22': [3202], 'Watts': [3207], 'sensitivity': [3220, 4189], 'men:': [3222], 'trial.': [3226], '2003;': [3229, 3534], '26:': [3230], '608–612.CrossrefMedlineGoogle': [3231], 'Scholar23': [3232], 'CJ.': [3234], 'How': [3235], 'hypertension?': [3245], '1947–1951.CrossrefMedlineGoogle': [3250], 'Scholar24': [3251], 'balancing': [3257], 'benefits.': [3261, 3312], '1953–1955.CrossrefMedlineGoogle': [3266], 'Scholar25': [3267], 'Broad': [3270, 3540], 'Rehm': [3272, 3505], 'Vander': [3274], 'R.': [3277, 3302], 'due': [3285], 'Zealand.': [3290], 'N': [3291], 'Z': [3292], 'Med': [3293], '118:': [3296], 'U1412.MedlineGoogle': [3297], 'Scholar26': [3298], 'R,': [3300, 3388, 3508, 3539, 3578], 'Beaglehole': [3301], 'guidelines:': [3305], 'safety': [3307], 'vs': [3308], 'absolute': [3309], 'Lancet.': [3313, 3555], '1995;': [3314], '346:': [3315], '716.CrossrefMedlineGoogle': [3316], 'Scholar27': [3317], 'Malinski': [3318], 'MK,': [3319, 3355], 'Sesso': [3320], 'HD,': [3321], 'Lopez-Jimenez': [3322], 'F,': [3323, 3467, 3678, 4009, 4011, 4027], 'Buring': [3324], 'JE,': [3325], 'Gaziano': [3326], 'JM.': [3327], 'Arch': [3337], 'Int': [3338], 'Med.': [3339, 3380], '164:': [3341], '623–628.CrossrefMedlineGoogle': [3342], 'Scholar28': [3343], 'Naimi': [3344, 3362], 'TS,': [3345], 'Brown': [3346], 'DW,': [3347, 3359], 'Brewer': [3348], 'RD,': [3349], 'Giles': [3350], 'WH,': [3351], 'Mensah': [3352], 'Serdula': [3354], 'Mokdad': [3356], 'AH,': [3357], 'Hungerford': [3358], 'Lando': [3360], 'Stroup': [3364], 'DF.': [3365], 'Cardiovascular': [3366, 3742, 3861], 'nondrinking': [3372], 'moderate-drinking': [3374], 'U.S.': [3375], 'adults.': [3376], 'Prev': [3379], '28:': [3382], '369–373.CrossrefMedlineGoogle': [3383], 'Scholar29': [3384], 'Renaud': [3385], 'SC,': [3386], 'Gueguen': [3387], 'Conard': [3389], 'Lanzmann-Petithory': [3391], 'Orgogozo': [3393], 'Henry': [3395], 'O.': [3396], 'hypertension-related': [3402], 'prospective': [3405], '621–625.CrossrefMedlineGoogle': [3417], 'Scholar30': [3418], 'Tjonneland': [3419], 'Gronbaek': [3421], 'Stripp': [3423], 'Overvad': [3425], 'Wine': [3427], 'random': [3433], 'sample': [3434], '48763': [3436], 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[3685], 'mass': [3688], 'index': [3689], 'changes': [3690], 'positive': [3701], 'associations,': [3702], 'Journal': [3703, 3779, 3814], '10.1038/s41371-021-00548-x,': [3707], '36:6,': [3708], '(570-579),': [3709], '1-Jun-2022.': [3713], 'Goetsch': [3714], 'Wagle': [3716], 'Valilis': [3718], 'Razavi': [3720], 'McEvoy': [3722], 'Blumenthal': [3724], 'S': [3728, 3758], 'Dietary': [3730], 'Lifestyle': [3732], 'Modification': [3733], 'Prevention': [3736], 'Treatment': [3738], 'Current': [3741, 4157], '10.1007/s12170-021-00683-7,': [3745], '15:10,': [3746], '1-Oct-2021.': [3750], 'Aladin': [3751], 'Chevli': [3753], 'Ahmad': [3755], 'Rasool': [3757], 'Herrington': [3760], 'D': [3761, 3793, 3918, 4046, 4111], 'Consumption': [3764, 4114], 'Systemic': [3766], '(from': [3768], 'Survey),': [3776], 'American': [3778], 'Cardiology,': [3781], '10.1016/j.amjcard.2021.08.033,': [3782], '160,': [3783], '(60-66),': [3784], '1-Dec-2021.': [3788, 3868], 'Swain': [3789], 'P': [3790], 'Banerjee': [3792], 'adult': [3803], 'four': [3806], 'major': [3807], 'states': [3808], 'India:': [3810], 'An': [3811], 'exploratory': [3812], 'Preventive': [3816], 'Holistic': [3819], 'Health,': [3820, 3961], '10.18231/j.jpmhh.2021.023,': [3821], '7:2,': [3822], '(121-130),': [3823], '28-Nov-2021.': [3827], 'Lindblad': [3828], 'Lundholm': [3830], 'Eckner': [3832], 'Li': [3834, 4012, 4034], 'Råstam': [3836], 'Hellgren': [3838], 'I': [3839], 'Daka': [3841], 'B': [3842, 3945, 4072], '10-year': [3845], 'southwestern': [3858], 'Sweden,': [3859], 'BMC': [3860], 'Disorders,': [3862], '10.1186/s12872-021-02334-6,': [3863], '21:1,': [3864], 'Faulkner': [3869], 'Momenan': [3871], 'Leggio': [3874], 'L': [3875], 'neuroimaging': [3878], 'investigation': [3879], 'into': [3880], 'peripheral': [3884], 'biomarkers': [3886], 'anticipation': [3889], 'reward': [3891], 'use,': [3894], 'Drug': [3895], 'Dependence,': [3898], '10.1016/j.drugalcdep.2021.108638,': [3899], '221,': [3900], '(108638),': [3901], '1-Apr-2021.': 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[3991], 'Co-occurring': [3994], 'Disorders': [3996], 'Absolute': [3997], 'Addiction': [3998], 'Psychiatry': [3999], 'Review,': [4000], '10.1007/978-3-030-33404-8_21,': [4001], '(327-333),': [4002], 'Liang': [4008], 'Liu': [4010, 4018, 4040], 'Xiao': [4014], 'Cao': [4020], 'Shen': [4022], 'Yu': [4024], 'Lu': [4026, 4042], 'Zhao': [4030], 'X': [4043], 'Long-Term': [4048], 'Exposure': [4049], 'Fine': [4051], 'Particulate': [4052], 'Matter': [4053], 'Incidence': [4056], 'China,': [4058], '73:6,': [4060], '(1195-1201),': [4061], '1-Jun-2019.': [4065], 'Shimomura': [4066], 'G': [4069], 'Paul': [4071], 'Cocaine,': [4074, 4076], 'Crack': [4075], 'Ethanol': [4078], 'Critical': [4079], 'Issues': [4080], 'Drugs': [4084], 'Abuse': [4086], 'Testing,': [4087], '10.1016/B978-0-12-815607-0.00017-4,': [4088], '(215-224),': [4089], 'Oikonomou': [4091], 'Lazaros': [4093], 'Tsalamandris': [4095], 'Vogiatzi': [4097], 'Christoforatou': [4099], 'Papakonstantinou': [4101], 'Goliopoulou': [4103], 'Tousouli': [4105], 'Chasikidis': [4107], 'C': [4108, 4182], 'Tousoulis': [4110], 'Aortic': [4116], 'Root': [4117], 'Dilatation:': [4118], 'Insights': [4119], 'Corinthia': [4122], 'Study,': [4123, 4156], '10.1177/0003319719848172,': [4125], '70:10,': [4126], '(969-977),': [4127], '1-Nov-2019.': [4131], 'Thapliyal': [4132], 'Singh': [4134], 'Joshi': [4137], '(2018)': [4139, 4183], 'Associated': [4142], 'Factors': [4143], 'Adults': [4147], 'Rural': [4149], 'Uttarakhand:': [4150], 'Community': [4152], 'Based': [4153], 'Cross': [4154], 'Sectional': [4155], 'Food': [4162], 'Science': [4163], 'Journal,': [4164], '10.12944/CRNFSJ.6.2.22,': [4165], '6:2,': [4166], '(481-490),': [4167], '28-Aug-2018.': [4171], 'Lin': [4172, 4178], 'Cheng': [4174], 'Lo': [4176], 'Lai': [4181], 'Spontaneously': [4184], 'rats': [4186], 'exhibit': [4187], 'ethanol-induced': [4191], 'hypotensive': [4192], 'effects:': [4193], 'NMDA': [4196], 'receptors': [4197], 'nitric': [4199], 'oxide': [4200], 'rostral': [4202], 'ventr': 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