Publication Information

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1713, 2284, 2827, 2897, 2944, 2970, 3011, 3015, 3048, 3197, 3241, 3308, 4077, 4129], 'attempt': [86], 'improve': [88, 298], 'global': [89, 299, 2947, 3017, 3541], 'cardiovascular': [90, 208, 257, 375, 515, 1801, 2200, 2231, 2309, 2327, 2902, 3462, 3549, 3570, 3603, 3706, 3731, 3792, 3934, 3937, 4075], 'risk': [91, 135, 300, 407, 438, 491, 512, 739, 769, 868, 1011, 1116, 1154, 1397, 1468, 2172, 2197, 2269, 2328, 2362, 2521, 2658, 2838, 2948, 3054, 3074, 3114, 3157, 3182, 3542, 3568, 3656, 3729, 3773, 3938, 4048, 4072, 4106, 4133], 'prediction,': [92], 'considerable': [93], 'interest': [94, 1999], 'has': [95, 106, 337, 408, 423, 830, 870, 1251, 1671, 1886, 1926, 2000, 2151, 2826, 3193, 3293], 'focused': [96], 'on': [97, 799, 884, 904, 1115, 2388, 2603, 2874, 3057, 3444, 4009, 4164], 'C-reactive': [98, 318, 3536, 3592, 3625, 3664, 3694, 3726, 3764, 3873, 3901, 3928, 3962, 3985, 4010, 4034, 4066, 4100, 4126, 4195, 4217, 4243], 'protein': [99, 319, 1997, 3593, 3626, 3695, 3727, 3902, 3963, 3986, 4011, 4035, 4127, 4218, 4244], '(CRP),': [100], 'a': [101, 184, 191, 204, 273, 292, 328, 338, 348, 353, 361, 379, 386, 398, 487, 735, 992, 1131, 1451, 1540, 1588, 1618, 2003, 2011, 2168, 2452, 2477, 2604, 2761, 2785, 3178, 3200, 3205, 3442, 3491, 3661, 3766, 4018], 'marker': [102, 354, 3768], 'inflammation': [104, 653, 986, 1640, 2016, 3598, 3815, 4165], 'that': [105, 176, 178, 326, 378, 617, 732, 823, 923, 975, 985, 1071, 1109, 1194, 1372, 1441, 1449, 1729, 1786, 1925, 2165, 2258, 2303, 2432, 2517, 2619, 2833, 2904, 3267, 3398, 3453], 'been': [107, 131, 409, 832, 871, 1253, 1271, 1359, 1771, 1888, 1927, 1961, 2065, 2152, 2330, 3294], 'shown': [108, 132, 702, 916, 1135, 1672, 1928, 1962, 2386, 2407, 3064, 3295], 'in': [109, 180, 278, 310, 331, 411, 420, 441, 461, 625, 634, 821, 864, 873, 917, 995, 1076, 1136, 1294, 1339, 1411, 1417, 1425, 1457, 1467, 1494, 1526, 1661, 1668, 1719, 1722, 1806, 1839, 2014, 2055, 2082, 2097, 2154, 2408, 2425, 2480, 2492, 2503, 2571, 2661, 2774, 2832, 2843, 2858, 2984, 3065, 3145, 3275, 3297, 3320, 3335, 3348, 3372, 3407, 3422, 3461, 3544, 3572, 3599, 3605, 3633, 3701, 3733, 3778, 3791, 3907, 3940, 3967, 4046, 4139, 4220], 'multiple': [110], 'prospective': [111, 363, 1191, 3820, 3848], 'epidemiological': [112, 364, 3194, 4250], 'studies': [113, 365, 412, 505, 1192, 1292, 2312, 2376, 3265], 'predict': [115, 134, 796, 1198, 1930, 3270], 'incident': [116, 1199, 3844, 4074], 'myocardial': [117, 523, 1931, 3988, 4051], 'infarction,': [118], 'stroke,': [119], 'peripheral': [120, 3676], 'arterial': [121, 3677], 'disease,': [122, 656, 1646], 'sudden': [124, 3883], 'cardiac': [125, 1081, 3286, 3884], 'death.': [126, 3885], 'CRP': [127, 200, 238, 268, 284, 308, 336, 384, 403, 475, 485, 508, 622, 698, 707, 733, 778, 797, 822, 839, 860, 905, 924, 940, 974, 1019, 1028, 1089, 1110, 1139, 1176, 1195, 1250, 1323, 1414, 1448, 1500, 1531, 1542, 1568, 1632, 1678, 1709, 1720, 1738, 1749, 1768, 1781, 1816, 1831, 1892, 1904, 1913, 2063, 2072, 2105, 2158, 2166, 2190, 2279, 2290, 2305, 2334, 2350, 2364, 2391, 2442, 2495, 2534, 2558, 2568, 2586, 2632, 2650, 2688, 2709, 2723, 2738, 2786, 2801, 2818, 2831, 2854, 2862, 2878, 2887, 2895, 2927, 2939, 2972, 3013, 3050, 3109, 3151, 3173, 3226, 3260, 3268, 3319, 3333, 3347, 3371, 3405], 'levels': [128, 220, 228, 239, 269, 476, 509, 623, 662, 783, 788, 798, 840, 906, 930, 946, 953, 1029, 1090, 1119, 1140, 1177, 1196, 1374, 1394, 1552, 1569, 1574, 1630, 1679, 1721, 1739, 1757, 1870, 2351, 2392, 2559, 2591, 2799, 2879, 2954, 3001, 3041, 3125, 3269, 3406, 3700, 3879, 3964], 'have': [129, 267, 477, 614, 680, 1270, 1358, 1392, 1599, 1752, 1770, 1878, 1900, 1959, 1978, 2052, 2064, 2137, 2292, 2329, 2384, 3073, 3122, 3365, 3415], 'also': [130, 189, 730, 1054, 1107, 2163, 2825, 2885], 'both': [137, 752, 1236, 2015, 2083, 2348], 'recurrent': [138], 'ischemia': [139, 3253, 3278, 3325], 'death': [141], 'among': [142, 368, 448, 454, 464, 469, 691, 1178, 1478, 1966, 2582, 2625, 2642, 2850, 3153, 3175, 3358], 'those': [143, 149, 154, 460, 470, 1087, 1098, 1159, 1967, 2120, 2531, 2555, 2565, 2583, 2626, 2643, 2674, 2706, 2720, 2735, 2745, 2779, 2851, 2985, 3154, 3176, 3359, 3428], 'with': [144, 159, 260, 304, 370, 471, 786, 1000, 1033, 1056, 1067, 1088, 1099, 1243, 1516, 1605, 1621, 1731, 1856, 1875, 2121, 2260, 2377, 2532, 2548, 2556, 2562, 2566, 2584, 2627, 2644, 2648, 2675, 2707, 2721, 2736, 2744, 2746, 2780, 2830, 2852, 2952, 2999, 3032, 3039, 3081, 3085, 3094, 3105, 3177, 3360, 3377, 3400, 3965, 4267], 'stable': [145, 1681, 2101], 'unstable': [147, 3255], 'angina,': [148, 3256], 'undergoing': [150], 'percutaneous': [151, 2881], 'angioplasty,': [152], 'presenting': [155], 'emergency': [157, 3350, 3409], 'rooms': [158], 'acute': [160, 1564, 1714, 3251, 3276, 3324, 3638], 'coronary': [161, 519, 867, 2882, 3252, 3277, 3418, 3639, 3775, 3817, 3845, 3904], 'syndromes.': [162], 'These': [163, 444, 1203, 1972], 'highly': [164, 1821, 2074, 2580], 'consistent': [165, 410, 1254, 1515, 1620, 2031], 'clinical': [166, 198, 279, 638, 682, 713, 878, 1078, 1497, 1538, 1743, 1851, 1896, 1979, 1993, 2006, 2056, 2138, 2506, 3316, 4248], 'data': [167, 613, 729, 1204, 1439, 1510, 2162, 2667, 2808, 2865, 3396], 'are': [168, 446, 701, 1044, 1072, 1229, 1335, 1431, 1557, 1633, 1680, 1687, 1740, 1774, 1975, 1988, 2316, 2371, 2654, 2809, 3111, 3412, 3425], 'supported': [169, 3466], 'abundant': [171], 'laboratory': [172], 'experimental': [174], 'evidence': [175, 922, 2302, 2431, 3130], 'demonstrate': [177, 377, 731, 1193, 1694, 3266], 'atherothrombosis,': [179, 1208], 'addition': [181, 282, 2277], 'being': [183, 1008, 1612, 1712, 2319, 2991], 'disease': [185, 376, 1761, 3571, 3604, 3732, 3777, 3906], 'lipid': [187, 787, 844, 854, 862, 2194, 2281, 2909, 3878], 'accumulation,': [188], 'represents': [190], 'chronic': [192], 'inflammatory': [193, 1644, 1923, 3291, 3459], 'process.': [194], 'In': [195, 481, 559, 746, 812, 1288, 1626, 1652, 1823, 2140, 2336, 2536, 3019], 'terms': [196, 626, 635, 865, 1426, 1807, 1840, 2493, 2504], 'application,': [199], 'seems': [201, 1818, 2484], 'be': [203, 347, 825, 848, 1405, 1547, 1581, 1650, 1676, 1820, 1964, 2079, 2235, 2243, 2486, 2634, 2848, 2929, 2941, 3089, 3138, 3213, 3235, 3357, 3391], 'stronger': [205, 736, 2169], 'predictor': [206, 388, 489, 737, 2170, 2899, 4131], 'events': [209, 2903], 'than': [210, 740, 779, 834, 1483, 1554, 1576, 1794, 2173, 3055], 'LDL': [211, 261, 781, 810, 828, 894, 948, 980, 1833, 2179, 2436, 2449, 2459, 2481, 2590, 2629, 2653, 2676, 2726, 2741, 2748, 2782, 2953, 3000, 3040, 3061, 3101, 3238], 'cholesterol,': [212, 805, 808], 'it': [214, 978, 1105, 1442, 1885], 'adds': [215, 925, 1111, 2905, 4036], 'prognostic': [216, 926, 942, 1113, 2906], 'information': [217, 927, 943, 1114, 2907, 3024], 'at': [218, 226, 928, 944, 951, 1009, 1117, 1587, 1968, 2655, 2930, 3112, 3155], 'all': [219, 227, 929, 945, 952, 997, 1118, 1796, 1960, 2345, 2385, 2472, 3021], 'calculated': [222, 3179], 'Framingham': [223, 598, 933, 956, 2918, 3162, 3181], 'Risk': [224, 533, 934, 957, 1917, 2919, 3163], 'metabolic': [231, 1002, 1022, 1050, 1069, 1103, 1124, 1128, 1165, 1185, 2913, 3118, 4069], 'syndrome.': [232, 1186], 'Using': [233], 'widely': [234, 1776], 'available': [235, 616, 1511, 2141], 'high-sensitivity': [236, 1244, 1767, 1876, 2060, 2209, 4216], 'assays,': [237, 1245], '<1,': [241, 664, 717, 908, 1142, 1375], '1': [242, 665, 718, 909, 1143, 1376, 3532], '3,': [244, 667, 720, 911, 919, 1145, 1378], '>3': [246, 270, 669, 722, 913, 1147], 'mg/L': [247, 271, 670, 723, 914, 1095, 1148, 1269, 1357, 1381, 1556, 1578], 'correspond': [248], 'low-,': [250, 672, 1383], 'moderate-,': [251, 673, 1384], 'high-risk': [253, 274, 675, 1386, 2239], 'groups': [254], 'future': [256, 390, 405, 1589, 2901, 3772], 'events.': [258, 516, 3640, 3707], 'Individuals': [259, 3104], 'cholesterol': [262, 287, 429, 829, 949, 981, 1624, 1732, 1789, 2677, 2934, 3102, 3671, 3699, 4045], 'below': [263, 1093, 2593, 2680, 2691, 3042], '130': [264, 897, 3003, 3043], 'mg/dL': [265, 902, 2686, 2957], 'who': [266, 2241, 3364], 'represent': [272, 671], 'group': [275, 1005, 1528], 'often': [276], 'missed': [277], 'practice.': [280, 443], 'The': [281, 395, 856, 1778, 3342], 'standard': [286, 1788, 3670], 'evaluation': [288, 1790, 2127, 2177, 2282, 2460, 3239, 3334, 3388], 'may': [289, 1221, 1402, 1835, 2136, 2291, 2633, 3390], 'thus': [290, 2457, 3209, 3354, 3386], 'provide': [291], 'simple': [293, 637, 712], 'inexpensive': [295, 1827], 'method': [296, 2465, 3243], 'prediction': [301, 869, 1430, 2286, 3601, 3703], 'compliance': [303, 2259, 2995, 3029], 'preventive': [305], 'approaches.Evidence': [306], 'Supporting': [307], 'Use': [309], 'Primary': [311], 'PreventionComposed': [312], 'five': [314], '23': [315], 'kDa': [316], 'subunits,': [317], '(CRP)': [320], 'is': [321, 343, 385, 677, 734, 741, 791, 915, 921, 982, 1024, 1084, 1106, 1130, 1369, 1443, 1514, 1544, 1594, 1656, 1700, 1725, 1783, 1919, 2073, 2095, 2167, 2255, 2263, 2298, 2429, 2501, 2509, 2527, 2659, 2770, 2896, 2989, 2996, 3131, 3148, 3210, 3227, 3261, 3353, 3375, 3439, 4128], 'hepatically': [323], 'derived': [324], 'pentraxin': [325, 2102], 'plays': [327, 991], 'key': [329], 'role': [330, 994, 3258], 'innate': [333, 1217], 'immune': [334, 1218], 'response.': [335], 'long': [339, 1550, 1683, 1735, 2108], 'plasma': [340, 2087, 2109, 3877, 4192], 'half-life': [341, 2004, 2110], 'now': [344, 1775, 2318], 'understood': [345], 'mediator': [349], 'as': [350, 352, 450, 452, 457, 459, 850, 920, 1007, 1027, 1134, 1162, 1182, 1211, 1273, 1366, 1382, 1433, 1435, 1549, 1551, 1642, 1734, 1736, 1863, 1905, 1947, 2041, 2119, 2132, 2397, 2399, 2560, 2636, 2638, 2943, 3076, 3078, 3158, 3230, 3328, 3380, 3382, 3441, 3673, 3880], 'well': [351, 451, 458, 2256, 3381], 'atherothrombotic': [356], 'disease.': [357, 2201, 3550, 3678], 'To': [358, 1763], 'date,': [359, 751], 'over': [360, 815, 1682], 'dozen': [362], 'carried': [366], 'out': [367], 'individuals': [369, 694, 1179, 1524, 1724, 2240, 2951, 2998, 3038, 3071, 3080], 'no': [371, 793, 1464, 1696, 1701, 2300], 'prior': [372], 'history': [373], 'single,': [380], 'non-fasting': [381], 'measure': [382, 3150], 'strong': [387, 488], 'vascular': [391, 406, 655, 1454, 1616, 1760, 1882, 1970, 2354, 2361, 2657], 'events1–14': [392], '(Figure': [393, 630, 640, 2159], '1).': [394], 'relationship': [396, 651], 'between': [397, 652, 3002, 3183], 'patient’s': [399], 'baseline': [400, 507, 697, 1175, 2798], 'level': [401, 1446, 2973], 'from': [413, 726, 961, 979, 1188, 2220, 2668, 2805, 3307, 3475, 3496, 3737, 3784, 3850], 'United': [415, 1296], 'States': [416], 'Europe,': [418], 'most': [421, 1537, 2373, 3343], 'cases': [422], 'proven': [424, 2053, 2358], 'independent': [425, 1112, 2898, 4130], 'age,': [427, 463], 'smoking,': [428], 'levels,': [430, 2482, 2587], 'blood': [431, 497, 1036, 1706, 2044, 2251], 'pressure,': [432, 1037], 'diabetes,': [434], 'major': [436, 993, 1290, 1560], '“traditional”': [437], 'factors': [439, 2198, 3657, 3939], 'evaluated': [440, 1525], 'daily': [442], 'effects': [445, 1424], 'present': [447], 'women': [449, 1328, 1388, 1401, 1471], 'men,': [453], 'elderly': [456], 'middle': [462], 'smokers': [465], 'non-smokers,': [467], 'without': [473, 1101, 2088], 'diabetes.': [474], 'long-term': [478, 3383], 'predictive': [479, 1843, 3283, 4039], 'value.': [480], 'one': [482, 1371], 'recent': [483], 'study,': [484], 'was': [486, 1463, 2551, 2579, 2703, 2717, 2731, 3465], 'even': [492, 1155, 2588], '20': [493, 2114], 'years': [494, 1809], 'after': [495, 2402], 'initial': [496], 'samples': [498, 1707], 'were': [499, 774, 1476, 2592], 'obtained.15Download': [500], 'figureDownload': [501, 685, 937, 1167, 2184, 2790], 'PowerPointFigure': [502, 686, 938, 1168, 2185, 2791], '1.': [503], 'Prospective': [504, 3870], 'relating': [506], 'first': [514, 3705, 4050], 'CHD': [517], 'indicates': [518, 2203, 3014], 'heart': [520, 3776, 3818, 3846, 3905], 'disease;': [521, 528, 561], 'MI,': [522], 'infarction;': [524], 'PAD,': [525], 'pulmonary': [526], 'artery': [527], 'CV,': [529], 'cardiovascular;': [530], 'MRFIT,': [531], 'Multiple': [532, 3264], 'Factor': [534], 'Intervention': [535], 'Trial;': [536], 'PHS,': [537], 'Physicians’': [538], 'Health': [539, 543, 547, 552, 603, 1300, 1304, 1308, 1420, 1460, 2671, 3740, 3745, 3853], 'Study;': [540, 544, 553, 565, 569, 574, 578, 582, 589, 596, 600], 'CHS,': [541], 'RHPP,': [545], 'Rural': [546, 3744], 'Promotion': [548, 3746], 'Project;': [549], 'WHS,': [550], 'MONICA,': [554], 'MONItoring': [555], 'trends': [556, 3788], 'determinants': [558, 3790], 'CArdiovascular': [560], 'HELSINKI,': [562], 'Helsinki': [563], 'Heart': [564, 568, 573, 577, 581, 599, 608, 3436, 3943], 'CAERPHILLY,': [566], 'Caerphilly': [567], 'BRHS,': [570], 'British': [571], 'Regional': [572], 'LEIDEN,': [575], 'Leiden': [576], 'SPEEDWELL,': [579], 'Speedwell': [580], 'WOSCOPS,': [583], 'West': [584, 4141], 'Scotland': [586, 4143], 'Coronary': [587, 593, 1314, 4144], 'AFCAPS,': [590], 'Air': [591, 1312], 'Force': [592], 'Atherosclerosis': [594, 1315], 'FHS,': [597], 'WHI,': [601], 'Initiative;': [604], 'HHS,': [606], 'Honolulu': [607], 'Study.Very': [609], 'recently,': [610], 'event-free': [611, 689, 1082, 1171, 2701, 2729, 2794], 'survival': [612, 690, 1083, 1172, 2666, 2702, 2716, 2730, 2795], 'become': [615], 'allow': [618], 'clinicians': [619, 3167], 'interpret': [621], 'either': [624, 803, 1501, 1989], 'population-based': [628, 704, 2032, 2142], 'quintiles': [629, 705], '2,': [631, 641], 'left)': [632], 'or': [633, 809, 1092, 1504, 1563, 1572, 1609, 1647, 1868, 1995, 2047, 2679, 2690, 2993, 3302, 3432], 'cut-points': [639, 714, 892, 1284, 1343, 1475, 1498, 3317], 'right).6': [642], 'Although': [643, 1080, 1884, 2601, 3190], 'former': [645], 'approach': [646, 659, 879, 1828, 3144, 3198], 'demonstrates': [647], 'robust': [649], 'linear': [650], 'latter': [658, 2499], '(in': [660], 'which': [661, 1043, 2664], 'groups)': [676], 'likely': [678, 1545, 3211, 3304, 3355], 'greater': [681, 776, 1575], 'appeal.': [683], 'Download': [684, 936], '2.': [687], 'apparently': [692, 3573], 'healthy': [693, 3574, 3780, 4084, 4221], 'according': [695, 1012, 1173, 2796], 'levels.': [699, 2335, 2365, 2535, 2727, 3103, 3368], 'Data': [700, 959], 'using': [703, 710], '(left)': [708], '3': [711, 3067], 'CRP,': [716, 1604], '(right).': [724], 'Adapted': [725, 1187, 2219, 2804], 'reference': [727, 962, 1189, 2221, 2806], '6.Prospective': [728], 'low-density': [742, 3697], 'lipoprotein': [743, 807, 2217, 3698], '(LDL)': [744], 'cholesterol.': [745, 811, 2218], 'largest': [748], 'study': [749, 2682, 2693, 3821, 3871], 'area': [754], 'under': [755, 1803], 'receiver': [757], 'operator': [758], 'characteristic': [759], '(ROC)': [760], 'curve': [761], '(0.64': [762], 'versus': [763, 772, 3310], '0.60)': [764], 'population': [767, 1247, 1509], 'attributable': [768, 2523, 2840], 'percent': [770], '(40': [771], '19)': [773], 'significantly': [775], 'cholesterol.6CRP': [782], 'minimally': [784], 'correlate': [785, 1032, 1055], 'there': [790, 1462, 1655, 1699, 2428, 2483], 'virtually': [792], 'way': [794], 'basis': [801, 2607, 2876, 3059], 'total': [804, 1521, 3932, 4042], 'high-density': [806, 2212, 2216], 'evaluations': [813], 'including': [814], '25': [816], '000': [817, 2768], 'patients,': [818, 2117], 'variance': [820], 'can': [824, 1566, 2242, 2940], 'ascribed': [826], 'consistently': [831], 'less': [833, 1553, 1793, 2810, 3214, 3218, 3228, 3303], '3%': [835], '5%.4,6,16': [837], 'Thus,': [838, 1126, 2274], 'do': [841, 1750], 'not': [842, 988, 1025, 1030, 1073, 1329, 1432, 1688, 1751, 1887, 1920, 3426], 'supplant': [843], 'evaluation,': [845], 'but': [846, 1053, 2630, 2651, 2784], 'must': [847], 'considered': [849, 3139], 'adjunct': [852, 2945, 3539], 'evaluation.': [855, 1625, 2007], 'additive': [857], 'value': [858, 1493, 1608, 1844, 3284, 4040], 'screening': [863, 1782, 1802, 1817, 1834, 1860, 2232, 3672], 'demonstrated': [872, 1410, 1879, 2660], 'several': [874, 2192], 'settings.1,3,4,6,17': [875], 'A': [876], 'simplified': [877], 'issue': [882, 2315], 'based': [883], 'Adult': [886], 'Treatment': [887], 'Panel': [888], 'III': [889, 1016, 1049, 2599, 2963, 3035, 3096], '(ATP': [890], 'III)': [891], '<130,': [896], '160,': [899], '>160': [901], 'Figure': [918, 1137, 2662, 3188], 'Score.': [935, 958, 3164], '3.': [939], 'provides': [941, 1894, 2283, 3240], 'adapted': [960], '6.CRP,': [963], 'Metabolic': [965], 'Syndrome,': [966], 'Type': [968], '2': [969, 1601, 2513, 4110], 'DiabetesA': [970], 'unique': [971], 'feature': [972], 'further': [976, 1205], 'distinguishes': [977], 'fact': [984], '(but': [987], 'elevated': [989, 1965, 2533, 2557, 2585, 2649, 2708, 2711, 2737, 2747, 2853, 2971, 3012, 3016, 3049, 3113, 3370, 3959], 'LDL)': [990], 'almost': [996, 1695, 1795, 3020], 'processes': [998], 'associated': [999, 1066, 1730, 2547, 3376], 'syndrome,': [1003, 1104, 2914, 4070], 'another': [1004], 'highlighted': [1006], 'increased': [1010, 1969, 3378, 4191], 'current': [1014, 3033, 3395], 'ATP': [1015, 1048, 2598, 2962, 3034, 3095], 'guidelines.': [1017], 'That': [1018], 'reflects': [1020], 'syndrome': [1023, 1051, 1070, 1129, 3119], 'surprising,': [1026], 'only': [1031, 1922, 2317, 3152, 3174], 'triglycerides,': [1034], 'obesity,': [1035], 'fasting': [1039, 1705, 3123], 'glucose': [1040, 3124], '(all': [1041], 'components': [1045], 'definition),': [1052], 'insulin': [1057], 'sensitivity,': [1058], 'endothelial': [1059], 'dysfunction,': [1060], 'impaired': [1062], 'fibrinolysis': [1063], '(factors': [1064], 'additionally': [1065, 1197], 'easily': [1074], 'discerned': [1075], 'usual': [1077], 'practice).18': [1079], 'similar': [1085, 1727], 'above': [1091, 2678, 2689, 2787, 2891, 2955], '3.0': [1094], 'clear': [1108], 'severity': [1121], 'syndrome.18': [1125], 'heterogenous': [1132], 'condition;': [1133], '4,': [1138], 'differentiate': [1149], 'low,': [1150], 'moderate,': [1151], 'high': [1153, 2631, 2656, 3077, 4241], 'when': [1156, 1474, 1591, 1854, 2589, 2742, 2936], 'applied': [1157], 'already': [1160, 1180, 2965, 3234], 'defined': [1161, 1181, 1745, 3159], 'having': [1163, 1183, 1495, 3116], 'syndrome.18Download': [1166], '4.': [1169], '18.Several': [1190], 'type': [1200, 4109], 'II': [1201], 'diabetes.19,20': [1202], 'link': [1206], 'inflammation,': [1207, 2039, 3770], 'diabetes': [1210, 4111, 4138], 'tightly': [1212], 'interrelated': [1213], 'disorders': [1214], 'system': [1219], 'help': [1222], 'explain': [1224], 'why': [1225], 'diet': [1226], 'exercise': [1228], 'so': [1230], 'important': [1231, 2502], 'prevention': [1234, 2575, 2764, 2845, 3147, 3547, 3636], 'diseases.The': [1237], 'Population': [1238], 'Distribution': [1239], 'CRPWhen': [1241], 'measured': [1242], 'distribution': [1248], 'generally': [1252], 'across': [1255, 2067], 'sex': [1256, 1503], 'ethnic': [1258], 'groups,': [1259], 'values': [1261, 1674], '0.3,': [1263], '0.6,': [1264], '1.5,': [1265], '3.5,': [1266], '6.6': [1268], 'reported': [1272, 2815], 'estimates': [1274, 1398, 1469, 3075], '10th,': [1277], '25th,': [1278], '50th,': [1279], '75th,': [1280], '90th': [1282], 'percentile': [1283], 'middle-aged': [1286, 3781], 'Americans.6': [1287], '4': [1289], 'cohort': [1291, 4022], 'performed': [1293, 2602], 'States,': [1297], 'Physicians': [1299], 'Study,': [1301, 1305, 3796], 'Initiative,': [1309], 'Force/Texas': [1313], 'Study': [1317, 2672, 3741], '(AFCAPS/TexCAPS),2,3,4,6,10': [1318], 'quintile': [1320, 1342], 'distributions': [1321], 'men': [1325], 'taking': [1330, 1389, 1472, 2474], 'hormone': [1331, 3840], 'replacement': [1332, 3841, 4188], 'therapy': [1333, 2526, 2624, 2983, 3632, 4008, 4189, 4269], '(HRT)': [1334], 'remarkably': [1336], 'similar,': [1337], 'practice': [1340, 1619], 'approximate': [1341], '<0.5,': [1345], '0.5': [1346], '1.0,': [1348], '1.0': [1349], '2.0,': [1351], '2.0': [1352, 2788], '4.0,': [1354], '>4.0': [1356], 'suggested': [1360, 1367], 'use.': [1362], 'An': [1363, 3369], 'alternative': [1364, 1636, 1798, 3143], 'approach,': [1365], 'above,': [1368], 'simply': [1370], 'emphasizes': [1373], '>3.0': [1380], 'groups.Because': [1387], 'HRT': [1390, 1416, 1473, 1481, 1506], 'will': [1391, 2306, 3072], 'higher': [1393, 3053], 'CRP,21,22': [1396], 'such': [1400, 1641, 1653, 1673, 1862, 2040, 2118, 2131, 3070, 3135, 3196], 'need': [1403, 1702], 'calibrated': [1406], 'downward.': [1407], 'As': [1408, 2406, 2698, 3063], 'recently': [1409], 'analyses': [1412, 1490], 'Initiative,10': [1421], 'however,': [1422, 1974, 2144], 'these': [1423, 1438, 1487, 1517, 2149, 2759], 'actual': [1428], 'event': [1429, 2310, 2507, 2613], 'large': [1434, 1488, 2529, 2637], 'anticipated.': [1436], 'Further,': [1437, 3288], 'suggest': [1440, 1491, 2516, 2866, 3397], 'expressed': [1445, 3421], 'determines': [1450], 'given': [1452, 1723], 'woman’s': [1453], 'risk.': [1455, 3018], 'Finally,': [1456], 'Study,3,6': [1461], 'substantive': [1465], 'difference': [1466], 'determined': [1477, 1889], 'users': [1479], 'rather': [1482], 'non-users.': [1484], 'Taken': [1485], 'together,': [1486], 'outcome': [1489], 'little': [1492, 2430], 'separate': [1496], 'use.The': [1507], 'sparse': [1508], 'blacks': [1513], 'findings.': [1518], 'However,': [1519, 2321, 2470, 2728, 3314], 'number': [1522], 'remains': [1529, 2451], 'small.Interpreting': [1530], 'Assays,': [1532], 'Cost-Effectiveness,': [1533], 'Serial': [1535], 'AssessmentIn': [1536], 'settings,': [1539, 1825, 2427, 2922], 'single': [1541], 'assessment': [1543, 1893, 1987, 3543], 'adequate': [1548, 1753], '10': [1555, 1577], 'observed.': [1558], 'Because': [1559, 2752], 'infections,': [1561], 'trauma,': [1562], 'hospitalizations': [1565], 'elevate': [1567], '(usually': [1570], '100-fold': [1571], 'more),': [1573], 'should': [1579, 1649, 2234, 2461, 2928, 2974, 3025, 3088, 3121, 3137, 3233], 'initially': [1580, 3779, 4083], 'ignored': [1582], 'test': [1585], 'repeated': [1586], 'date': [1590], 'patient': [1593, 3299], 'clinically': [1595], 'stable.': [1596], 'Many': [1597], 'investigators': [1598], 'recommended': [1600], 'measures': [1602, 1937, 2036, 2077], 'lower': [1607, 2333], 'average': [1611], 'used': [1613, 2942, 2992], 'determine': [1615], 'risk,': [1617], 'recommendations': [1622, 2262], 'rare': [1627], 'instances': [1628, 2986], 'where': [1629, 2987, 2994], 'markedly': [1634, 2122], 'elevated,': [1635], 'sources': [1637], 'systemic': [1639, 2038, 3659], 'lupus,': [1643], 'bowel': [1645], 'endocarditis': [1648], 'considered.': [1651], 'cases,': [1654, 3022], 'usually': [1657], 'accompanying': [1659], 'elevation': [1660], 'erythrocyte': [1663, 2049], 'sedimentation': [1664, 2050], 'rate.': [1665], 'Accumulated': [1666], 'experience': [1667], 'outpatient': [1669, 2921], 'settings': [1670], 'infrequent.Because': [1677], 'periods': [1684], 'time,': [1686], 'affected': [1689], 'food': [1691], 'intake,': [1692], 'circadian': [1697], 'variation,': [1698], 'obtain': [1704], 'assessment.': [1710], 'Despite': [1711], 'phase': [1715], 'reactant,': [1716], 'variability': [1718], 'quite': [1726], 'screening,': [1733, 2910, 2935], 'within': [1741, 1871], 'range': [1744, 1873], 'above.23Traditional': [1746], 'assays': [1747, 1769, 1877, 1983, 2061], 'sensitivity': [1754, 4242], 'detect': [1756], 'required': [1758, 1984], 'prediction.': [1762], 'alleviate': [1764], 'problem,': [1766], 'developed': [1772], 'available.24': [1777], 'cost': [1779], 'comparable': [1784], 'far': [1792, 1857], 'other': [1797, 2129, 2193, 2426, 2446, 2812, 3595], 'approaches': [1799, 1861], 'consideration.': [1804], 'Both': [1805], 'life': [1811], 'saved': [1812], 'cost-to-benefit': [1814], 'ratios,': [1815], 'effective.25': [1822], 'many': [1824, 2068, 2322], 'adding': [1830], 'yield': [1836], 'immediate': [1837], 'cost-savings': [1838], 'negative': [1842, 3366, 3401, 3404], 'subsequent': [1847], 'avoidance': [1848], 'unnecessary': [1850], 'testing,': [1852], 'particularly': [1853, 2528], 'compared': [1855, 2561, 2743], 'expensive': [1859], 'electron': [1864], 'beam': [1865], 'calcium': [1866], 'tomography': [1867], 'MRI.CRP': [1869], 'detected': [1874], 'specificity': [1880], 'events.26': [1883], 'whether': [1890], 'serial': [1891, 2458, 4215], 'incremental': [1895], 'value,': [1897], 'some': [1898, 3079], 'physicians': [1899, 2977], 'elected': [1901], 'use': [1903, 1994, 2026, 2550, 2578, 2925, 3345, 3457], 'part': [1906, 2098], 'their': [1908, 1986], 'annual': [1909], 'physical': [1910], 'examination.Comparison': [1911], 'Other': [1915, 2034], 'Novel': [1916, 3655], 'FactorsCRP': [1918], 'biomarker': [1924, 2012], 'infarction': [1932], 'stroke.': [1934], 'More': [1935], 'sophisticated': [1936], 'cytokine': [1939], 'activity,': [1940], 'cellular': [1941], 'adhesion,': [1942], 'immunologic': [1944], 'function': [1945], '(such': [1946], 'interleukin-6,': [1948], 'intercellular': [1949, 2205], 'adhesion': [1950, 2206], 'molecule-1,': [1951], 'macrophage': [1952], 'inhibitory': [1953], 'cytokine-1,': [1954], 'soluble': [1956, 2204], 'CD40': [1957], 'ligand)': [1958], 'risk.27': [1971], 'approaches,': [1973], 'unlikely': [1976, 3413], 'utility': [1980, 3224], 'because': [1981, 2275], 'inappropriate': [1990], 'routine': [1992], 'too': [2001], 'short': [2002], 'Measures': [2008], 'fibrinogen,': [2010, 3666], 'involved': [2013], 'thrombosis,': [2018], 'remain': [2019, 2462, 3326], 'poorly': [2020], 'standardized,': [2021], 'methodological': [2023], 'issues': [2024], 'limit': [2025], 'parameter': [2029], 'despite': [2030, 3099], 'data.': [2033], 'broad': [2035], 'white': [2043], 'cell': [2045], 'count': [2046], 'rate,': [2051], 'unreliable': [2054], 'settings.': [2057], 'By': [2058, 3393], 'contrast,': [2059, 3394], 'standardized': [2066], 'commercial': [2069], 'platforms.': [2070], 'Moreover,': [2071], 'stable,': [2075], 'allowing': [2076], 'made': [2080], 'accurately': [2081], 'fresh': [2084], 'frozen': [2086], 'requirements': [2089], 'special': [2091], 'collection': [2092], 'procedures.': [2093], 'This': [2094], 'due': [2096], 'structure': [2103], 'its': [2107], '18': [2112], 'hours.In': [2115], 'selected': [2116], 'premature': [2123], 'unexplained': [2125], 'atherosclerosis,': [2126], 'markers,': [2130], 'lipoprotein(a)': [2133], 'homocysteine,': [2135, 3667, 3875], 'utility.': [2139], 'studies,': [2143], 'relative': [2146, 2837], 'magnitude': [2147, 2434, 2440, 2519, 2544, 2835], 'biomarkers': [2150], 'small': [2153], 'direct': [2155, 2859], 'comparison': [2156, 2188, 3662], '5).': [2160], 'Recent': [2161], 'indicate': [2164], 'nuclear': [2174], 'magnetic': [2175], 'resonance-based': [2176], 'particle': [2180], 'size': [2181], 'concentration.28Download': [2183], '5.': [2186], 'Direct': [2187], 'non-lipid': [2196], 'SICAM-1': [2202], 'molecule-1;': [2207], 'hs-CRP,': [2208], 'CRP;': [2210], 'HDL,': [2211], 'lipoprotein;': [2213], 'HDLC,': [2215], '3.Goals': [2222], 'Screening': [2224], 'Therapeutic': [2226], 'OptionsThe': [2227], 'primary': [2228, 2464, 2574, 2844, 2893, 2924, 3146, 3546, 3635], 'goal': [2229], 'programs': [2233], 'identification': [2237], 'targeted': [2244], 'smoking': [2246, 2343], 'cessation,': [2247], 'diet,': [2248, 2340], 'exercise,': [2249, 2341], 'pressure': [2252], 'control.': [2253], 'It': [2254], 'established': [2257], 'lifestyle': [2261, 3097], 'directly': [2264], 'related': [2265], 'absolute': [2268], 'perceived': [2270], 'individual': [2272], 'patients.': [2273], 'improved': [2285], 'tool,': [2287], 'consideration': [2288], 'usefulness': [2293], 'reason': [2296], 'alone.There': [2297], 'currently': [2299, 2510, 2990], 'definitive': [2301], 'lowering': [2304], 'necessarily': [2307, 3427], 'reduce': [2308, 2326, 2360, 2817, 2886], 'rates;': [2311], 'addressing': [2313], 'designed.': [2320], 'interventions': [2323], 'known': [2324], 'linked': [2331], 'particular,': [2337], 'weight': [2338], 'loss,': [2339], 'cessation': [2344], 'lead': [2346, 3026], 'reduced': [2349, 2353], 'risk.Several': [2355], 'pharmacological': [2356, 2982], 'agents': [2357, 2814], 'influence': [2363], 'Of': [2366], 'these,': [2367], 'statin': [2369, 2468, 2525, 2623, 2763, 3141, 3246, 3631, 4007, 4268], 'drugs': [2370], 'important,': [2374], 'pravastatin,': [2378], 'lovastatin,': [2379], 'cerivastatin,': [2380], 'simvastatin,': [2381], 'atorvastatin': [2383], 'that,': [2387], 'average,': [2389], 'median': [2390, 2683, 2694], 'decline': [2393], '15%': [2394], '25%': [2396], 'early': [2398, 2775, 3271], '6': [2400], 'weeks': [2401], 'initiation': [2403], 'therapy.': [2405], 'large-scale': [2410, 2762], 'Cholesterol': [2411], 'And': [2412], 'Recurrent': [2413], 'Events': [2414], '(CARE)29': [2415], 'PRavastatin': [2417], 'INflammation/CRP': [2418], 'Evaluation': [2419, 4016, 4237], '(PRINCE)16': [2420], 'trials': [2421, 2515], 'subsequently': [2423], 'confirmed': [2424], 'reduction': [2437, 2450, 2479, 2508, 2522, 2839], 'predicts': [2438, 3771], 'reduction.': [2443, 2496], 'On': [2444], 'hand,': [2447], 'aggressive': [2448, 3231, 3309], 'critical': [2453], 'therapeutic': [2454, 2968], 'goal,': [2455], 'monitor': [2467], 'compliance.': [2469], 'whereas': [2471, 2713], 'subjects': [2473], 'statins': [2475, 2491], 'achieve': [2476], 'beneficial': [2478], 'responders': [2487], 'non-responders': [2489], 'Whether': [2497], 'observation': [2500], 'unknown.Analyses': [2511], 'randomized': [2514, 3128, 4019], 'CARE': [2538], 'trial': [2539, 2765, 3129, 4020], 'secondary': [2541, 3220], 'prevention,': [2542, 2894, 3221], 'benefit': [2546, 2621, 2640, 3306], 'pravastatin': [2549], 'nearly': [2552], '55%': [2553], '30%': [2563], 'low': [2567, 2612, 2628, 2652, 2722, 2725, 2740, 2750, 3107], 'levels.30': [2569], 'Similarly,': [2570], 'AFCAPS/TexCAPS': [2573, 2616], 'trial,': [2576], 'lovastatin': [2577], 'effective': [2581, 3296], 'thresholds': [2594], 'set': [2595], 'guidelines.4': [2600], 'post': [2605], 'hoc': [2606], 'limited': [2609], 'relatively': [2611], 'rates,': [2614], 'analysis': [2617, 3849], 'suggests': [2618], 'just': [2635], 'observed': [2641, 2718], 'overt': [2645, 3082], 'hyperlipidemia.That': [2646], 'patients': [2647, 2979, 3136, 3399], '6,': [2663, 3069, 4103], 'shows': [2665], '124': [2685], '1.52': [2696], 'mg/L.6': [2697], 'expected,': [2699], 'overall': [2700], 'poorest': [2704], 'LDL,': [2712], 'best': [2715], 'actually': [2732], 'worse': [2733], 'CRP.': [2751], 'public': [2755], 'health': [2756], 'implications': [2757, 4246], 'data,': [2760], '15': [2767], 'patents': [2769, 3445], 'scheduled': [2771], 'begin': [2773], '2003': [2776], 'specifically': [2777], 'targeting': [2778, 3629], 'native': [2781], '<130': [2783], 'mg/L.31Download': [2789], '6.': [2792], 'LDL.': [2803], '6.Although': [2807], 'robust,': [2811], 'lipid-lowering': [2813], 'include': [2819], 'niacin,': [2820], 'fibrates,': [2821], 'gemfibrozil.': [2823], 'Aspirin': [2824], 'intriguing': [2828], 'interaction': [2829], 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