Dual Function of an Amino-terminal Amphipatic Helix in Androgen Receptor-mediated Transactivation through Specific and Nonspecific Response Elements

Name: Work Video:
Duration: 3 min 30 s
Leen Callewaert; Guy Verrijdt; Valerie Christiaens; Annemie Haelens; Frank Claessens
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[7, 153, 216, 362, 679, 3978, 4888, 5615, 5838, 5899], 'to': [8, 109, 150, 158, 217, 318, 359, 367, 497, 615, 720, 729, 731, 1780, 1910, 2386, 2464, 2566, 2700, 2881, 3101, 3158, 3494, 3713, 3799, 3985, 3997, 4048, 4303, 4311, 4319, 4424, 4474, 4517, 4849, 4862, 4871, 4932, 5471, 5539, 5545, 5759, 5777, 5839, 5937, 5983, 5988, 6020, 6065, 6105, 6119, 6234], 'their': [9, 218, 575, 4738, 5461, 5614], 'response': [10, 97, 219, 306, 425, 428, 431, 703, 3576, 3987, 5371, 5761, 5782], 'elements,': [11, 220, 3670, 3963, 4938], 'regulate': [12, 221], 'the': [13, 27, 33, 46, 65, 74, 77, 81, 84, 100, 105, 124, 129, 155, 159, 163, 168, 177, 182, 196, 199, 222, 236, 242, 255, 274, 283, 286, 290, 293, 309, 314, 333, 338, 364, 368, 372, 377, 386, 391, 405, 408, 457, 460, 465, 468, 484, 498, 503, 514, 518, 529, 567, 584, 597, 603, 616, 681, 697, 732, 903, 1025, 1111, 1352, 1443, 1452, 1455, 1638, 1658, 1697, 1722, 1768, 1774, 1778, 1784, 1806, 1816, 1819, 1828, 1836, 1859, 1862, 1889, 1899, 1904, 1911, 1979, 2000, 2008, 2012, 2030, 2040, 2047, 2050, 2060, 2074, 2086, 2091, 2116, 2119, 2123, 2135, 2139, 2146, 2154, 2181, 2201, 2241, 2249, 2280, 2286, 2350, 2363, 2376, 2388, 2428, 2442, 2466, 2475, 2510, 2540, 2543, 2551, 2574, 2589, 2618, 2633, 2665, 2718, 2731, 2736, 2837, 2853, 2882, 2941, 2949, 2982, 2986, 2994, 2998, 3001, 3030, 3045, 3054, 3081, 3095, 3109, 3135, 3153, 3159, 3167, 3181, 3189, 3200, 3210, 3217, 3263, 3267, 3270, 3283, 3289, 3296, 3302, 3305, 3310, 3315, 3318, 3325, 3328, 3346, 3355, 3399, 3402, 3406, 3411, 3415, 3420, 3539, 3547, 3550, 3554, 3572, 3585, 3590, 3612, 3624, 3632, 3651, 3655, 3714, 3726, 3729, 3744, 3748, 3751, 3800, 3803, 3817, 3821, 3838, 3842, 3850, 3856, 3865, 3871, 3878, 3886, 3889, 3894, 3897, 3900, 3904, 3907, 3911, 3916, 3969, 3982, 3993, 4003, 4018, 4022, 4028, 4043, 4049, 4068, 4081, 4095, 4101, 4107, 4189, 4207, 4211, 4296, 4304, 4314, 4320, 4329, 4336, 4344, 4373, 4383, 4388, 4397, 4425, 4432, 4437, 4443, 4450, 4453, 4489, 4521, 4528, 4532, 4559, 4562, 4568, 4571, 4646, 4732, 4741, 4746, 4769, 4775, 4779, 4782, 4840, 4844, 4847, 4852, 4859, 4866, 4890, 4900, 4907, 4910, 4921, 4924, 4933, 4951, 4959, 4962, 5036, 5040, 5044, 5089, 5092, 5097, 5142, 5145, 5149, 5168, 5174, 5178, 5207, 5214, 5240, 5243, 5334, 5338, 5348, 5357, 5361, 5383, 5387, 5391, 5395, 5408, 5414, 5420, 5431, 5449, 5482, 5499, 5509, 5522, 5550, 5555, 5566, 5575, 5606, 5610, 5618, 5638, 5651, 5658, 5697, 5709, 5725, 5741, 5778, 5840, 5871, 5880, 5883, 5904, 5908, 5919, 5923, 5929, 5933, 5942, 5949, 5953, 5956, 5964, 5969, 5973, 5976, 5985, 5989, 6003, 6009, 6012, 6015, 6047, 6050, 6057, 6072, 6084, 6089, 6093, 6099, 6120, 6123, 6127, 6131, 6142, 6146, 6153, 6155, 6159, 6164, 6167, 6194, 6200], 'expression': [14, 223, 1885, 2009, 2611, 3943, 4000], 'of': [15, 45, 56, 76, 83, 92, 154, 162, 167, 181, 224, 254, 265, 285, 292, 301, 363, 371, 376, 390, 459, 472, 479, 502, 523, 574, 602, 621, 709, 723, 735, 902, 928, 931, 1021, 1027, 1225, 1446, 1454, 1773, 1783, 1818, 1839, 1907, 2020, 2027, 2080, 2094, 2131, 2134, 2248, 2362, 2412, 2432, 2444, 2469, 2524, 2539, 2576, 2610, 2649, 2672, 2704, 2730, 2791, 2800, 2806, 2834, 2906, 2951, 2985, 3053, 3077, 3080, 3094, 3152, 3180, 3188, 3209, 3301, 3314, 3317, 3327, 3335, 3377, 3414, 3498, 3529, 3549, 3566, 3571, 3603, 3660, 3728, 3750, 3802, 3820, 3841, 3874, 3888, 3896, 3899, 3915, 3979, 3992, 4002, 4021, 4042, 4065, 4078, 4098, 4188, 4210, 4316, 4375, 4386, 4419, 4434, 4440, 4445, 4452, 4570, 4748, 4771, 4781, 4835, 4846, 4856, 4909, 4923, 4944, 4954, 5043, 5096, 5148, 5177, 5206, 5251, 5360, 5419, 5435, 5654, 5660, 5711, 5786, 5885, 5918, 5932, 5952, 5972, 5978, 6005, 6011, 6014, 6024, 6049, 6083, 6088, 6092, 6114, 6122, 6133, 6145, 6150, 6166], 'several': [16, 225, 6244], 'target': [17, 226], 'genes': [18, 227], 'via': [19, 228, 1354, 4491], 'direct': [20, 229, 721, 1844, 5249, 5556, 5585, 6069], 'protein': [21, 230, 1172, 1307, 2728, 2738, 2907, 5152], 'interactions': [22, 31, 231, 240, 1632, 6129], 'with': [23, 198, 206, 232, 407, 415, 712, 1351, 1451, 2039, 2073, 2085, 2145, 2482, 2495, 2515, 2607, 2625, 2638, 2735, 2797, 2928, 2940, 3171, 3205, 3225, 3532, 3543, 3589, 3920, 3942, 4076, 4206, 4313, 4343, 4355, 4359, 4365, 4377, 4382, 4410, 4429, 4488, 4740, 4851, 4896, 5438, 5554, 5650, 5716, 6112, 6152], 'transcriptional': [24, 192, 233, 401, 736, 1807, 1872, 3818, 3839, 4483, 5358, 5415, 5494, 5702, 5750], 'coactivators.': [25, 208, 234, 417, 4484], 'For': [26, 235, 2901, 2948, 4449, 5382], 'androgen': [28, 87, 96, 106, 137, 183, 237, 296, 305, 315, 346, 392, 418, 424, 485, 2500, 5215], 'receptor,': [29, 238, 592, 4465], 'additional': [30, 239, 4942, 5797, 6108], 'between': [32, 241, 1796, 1861, 2997, 3398, 3734, 5605], 'amino-': [34, 243], 'and': [35, 94, 244, 303, 467, 470, 495, 528, 566, 593, 910, 1001, 1113, 1166, 1189, 1328, 1657, 1711, 1776, 1800, 1802, 1822, 1845, 1849, 1864, 1896, 1898, 1978, 1985, 2004, 2043, 2056, 2082, 2161, 2167, 2206, 2233, 2244, 2282, 2285, 2441, 2491, 2519, 2531, 2548, 2600, 2632, 2653, 2664, 2688, 2695, 2717, 2722, 2742, 2756, 2831, 2841, 2916, 2935, 3000, 3048, 3064, 3118, 3149, 3163, 3177, 3337, 3352, 3360, 3383, 3388, 3401, 3481, 3492, 3558, 3629, 3664, 3721, 3736, 3762, 3766, 3770, 3785, 3858, 3903, 3906, 3922, 3932, 3949, 3960, 3968, 3981, 4039, 4051, 4067, 4193, 4300, 4379, 4394, 4396, 4408, 4421, 4463, 4778, 5167, 5171, 5345, 5365, 5373, 5390, 5468, 5561, 5609, 5770, 5832, 5834, 5849, 5922, 5958, 5994, 6102, 6130, 6158, 6207, 6224, 6238], 'carboxyl-terminal': [36, 245, 1785, 4019], 'regions': [37, 246], 'have': [38, 247, 1003, 1633, 1834, 2207, 2303, 2972, 3028, 4734, 4788, 6106], 'been': [39, 248, 694, 1005, 1635, 2208, 2305, 4092, 4471, 4515, 4735, 4789, 6139], 'reported.': [40, 249], 'The': [41, 250, 476, 488, 562, 611, 900, 1017, 1537, 1705, 1762, 1791, 1884, 1976, 1993, 2034, 2150, 2176, 2236, 2272, 2328, 2354, 2430, 2498, 2529, 2554, 2570, 2585, 2628, 2642, 2659, 2707, 2713, 2727, 2924, 3073, 3085, 3127, 3207, 3312, 3617, 3754, 3788, 3971, 4009, 4512, 4612, 4854, 5622, 5744, 5823], 'first': [42, 251, 3074, 3082, 3297, 5041, 6085, 6195], 'amino': [43, 179, 252, 388, 1771, 1797, 3299, 6086], 'acids': [44, 180, 253, 389, 1772, 1798, 3300, 4199, 6087], 'amino-terminal': [47, 156, 178, 256, 365, 387, 433, 563, 1770, 2983, 3298, 4208, 6090], 'domain': [48, 157, 201, 257, 366, 410, 434, 436, 438, 520, 531, 564, 1786, 1906, 2089, 2984, 3155, 3162, 4209, 5209, 6091], 'necessary': [50, 259], 'for': [51, 260, 688, 907, 1546, 1805, 1870, 2011, 2115, 2348, 2479, 2559, 2622, 2843, 2858, 3288, 3309, 3354, 3584, 3740, 3764, 3772, 3945, 4204, 4328, 4482, 4645, 4737, 4899, 5213, 5488, 5525, 5617, 5737, 5748, 5825, 5870, 5882, 5903, 5907, 5955, 5975, 6098, 6227, 6242], 'this': [52, 62, 147, 261, 271, 356, 1812, 1840, 3527, 3828, 4032, 4828, 5353, 5570, 5655, 5717], 'amino/carboxyl-terminal': [53, 130, 262, 339, 452, 1543], 'interaction.': [54, 263, 1830, 3219, 3277, 4868], 'Deletion': [55, 264, 4064], 'a': [57, 69, 90, 186, 266, 278, 299, 395, 491, 534, 713, 912, 926, 1355, 1458, 1541, 1823, 1868, 1990, 2017, 2332, 2410, 2701, 2865, 2872, 2929, 2990, 3010, 3034, 3039, 3050, 3078, 3089, 3102, 3114, 3131, 3144, 3175, 3333, 3373, 3495, 3533, 3793, 3807, 3954, 4012, 4086, 4186, 4195, 4214, 4339, 4351, 4466, 4477, 4617, 4642, 4832, 5342, 5428, 5514, 5533, 5584, 5589, 6006, 6067, 6080], 'FQNLF': [58, 101, 267, 310, 1712, 1763, 1820, 2120, 2976, 3096, 3110, 3211, 3271, 3319, 3407, 3730, 3745, 3804, 3901, 4066, 4841, 4860, 5483, 5640, 5712, 5920], 'core': [59, 268, 605, 1713, 3805, 4861, 5639, 5921], 'sequence': [60, 269], 'in': [61, 80, 189, 270, 289, 398, 456, 464, 617, 1276, 1457, 1637, 1694, 1699, 1717, 1787, 1827, 2058, 2071, 2076, 2083, 2090, 2138, 2367, 2392, 2396, 2521, 2583, 2596, 2646, 2669, 2744, 2758, 2864, 2958, 2981, 2993, 3033, 3134, 3166, 3213, 3223, 3266, 3282, 3324, 3482, 3524, 3536, 3541, 3600, 3718, 3725, 3806, 3855, 3912, 4017, 4072, 4085, 4213, 4431, 4442, 4476, 4526, 4531, 4539, 4731, 4913, 4916, 5039, 5091, 5173, 5341, 5347, 5386, 5394, 5430, 5460, 5492, 5507, 5513, 5535, 5613, 5730, 5879, 5889, 5897, 5935, 6071, 6110, 6126], 'region': [63, 161, 272, 370, 569, 1359, 1445, 3117, 4020, 4197, 5656], 'blunts': [64, 273], 'interaction,': [66, 131, 275, 340, 5728], 'as': [67, 202, 204, 276, 411, 413, 706, 1223, 2297, 2299, 2425, 2604, 2762, 2967, 3009, 3961, 4458, 4567, 5583, 5586, 5588, 5844, 5887, 5992, 6026], 'does': [68, 133, 277, 342, 699, 3409, 3560, 5926], 'G21E': [70, 125, 279, 334, 3264, 3791, 3851, 3879, 3905, 4069, 4332, 5623, 5872, 5924, 6051], 'mutation.': [71, 280, 3291, 5719], 'We': [72, 281, 3027, 3594, 3814, 4293, 4743, 5236, 5426, 6218, 6231], 'investigated': [73, 282, 4736], 'effect': [75, 284, 3313, 3727, 3861, 3884, 5765, 5960], 'aforementioned': [78, 287, 4029], 'mutations': [79, 288, 3474, 3909, 4030, 4297], 'context': [82, 291, 3326], 'full': [85, 294, 1548, 3329, 3822, 3917], 'size': [86, 295, 3330, 3823, 3918], 'receptor': [88, 107, 138, 165, 184, 297, 316, 347, 374, 393, 419, 421, 423, 450, 486, 505, 1037, 1228, 1640, 1660, 1700, 3416, 3919, 4455, 4460, 5246], 'on': [89, 120, 140, 298, 329, 349, 1540, 1842, 1850, 1874, 1881, 2438, 2536, 2846, 2912, 3332, 3419, 3553, 3774, 3885, 3910, 4927, 5367, 5400, 5440, 5448, 5498, 5521, 5549, 5700, 5740, 5768, 5961, 6053, 6163], 'series': [91, 300, 3334], 'selective': [93, 121, 142, 302, 330, 351, 3336, 6204], 'nonselective': [95, 112, 144, 304, 321, 353, 3338, 3490, 3872, 4935, 5402], 'elements.': [98, 122, 145, 307, 331, 354, 3988, 5453, 5621], 'Strikingly,': [99, 308], 'deletion': [102, 311, 2036, 2121, 3079, 3208, 3316, 3408, 3731, 3746, 3801, 3898, 5710, 5917], 'strongly': [103, 127, 312, 336, 4340, 4864, 5625], 'reduced': [104, 313, 4341], 'capacity': [108, 317, 5434], 'transactivate': [110, 319], 'through': [111, 320, 4106, 6202, 6214], 'motifs': [113, 322, 1366, 4498, 5422, 6157], 'but': [114, 323, 716, 1693, 3112, 4639, 5642], 'did': [115, 324, 5411], 'not': [116, 134, 325, 343, 581, 626, 700, 2494, 3561, 4363, 4614, 5346, 5412, 5424, 5636, 5714, 5901, 5927, 6001], 'affect': [117, 326, 3410, 5413, 5928], 'its': [118, 191, 327, 400, 1167, 1547, 1871, 2567, 4380, 5959], 'activity': [119, 139, 193, 328, 348, 402, 919, 1549, 1701, 1873, 2556, 3548, 3819, 4418, 4530, 4780, 4922, 5359, 5495, 5703, 5739, 5751, 5791, 5931, 5943, 5987], 'Although': [123, 332, 3546], 'mutation': [126, 148, 335, 357, 2126, 3091, 3133, 3265, 3790, 3829, 3852, 3880, 4070, 4083, 4331, 4770, 4855, 5384, 5392, 5410, 5624, 5873, 5925, 6052], 'impairs': [128, 337, 4774], 'it': [132, 341, 579, 1878, 2564, 6137], 'significantly': [135, 344, 3562, 5479], 'influence': [136, 345, 925, 3895, 4031], 'either': [141, 350, 3631], 'or': [143, 352, 1367, 2122, 2459, 2493, 3580, 3654, 3832, 4367, 4412, 5530], 'Surprisingly,': [146, 355, 3262, 3837, 5696], 'leads': [149, 358, 6063], 'an': [151, 360, 1788, 2856, 2913, 2975, 4073, 4941, 5202, 5875, 6021, 6107], 'increased': [152, 361, 4423, 5970], 'glutamine-rich': [160, 369, 448, 1444, 4196], 'steroid': [164, 373, 449, 587, 619, 1036, 3686, 4454, 4523, 5245], 'coactivator-1': [166, 375, 1038], 'p160': [169, 207, 378, 416, 1033, 4190, 6073], 'family.': [170, 379], 'Taken': [171, 380], 'together,': [172, 381], 'these': [173, 382, 1695, 3060, 3378, 3487, 4836, 5456, 5536], 'data': [174, 383, 1856, 5999], 'suggest': [175, 384, 1857, 3294], 'that': [176, 385, 583, 613, 696, 924, 1858, 2974, 3139, 3295, 3565, 4077, 4094, 4527, 4897, 4946, 5201, 5239, 5333, 5504, 5577, 5599, 5635, 5780, 5916, 6141, 6197], 'play': [185, 394, 5532], 'key': [187, 396, 2991], 'role': [188, 397, 1838, 2992, 4908, 5534, 6070, 6082], 'determining': [190, 399], 'by': [194, 403, 483, 608, 680, 922, 1989, 1998, 2129, 2159, 2164, 2200, 2240, 2427, 2562, 2655, 2855, 2910, 3044, 3538, 3611, 3623, 3668, 3682, 3827, 4100, 4889, 4950, 5417, 5481, 5574, 5708, 5724, 5796, 5963, 5968, 6008, 6056, 6199], 'modulating': [195, 404], 'interaction': [197, 205, 406, 414, 1545, 1708, 1841, 1860, 2996, 3012, 3032, 3285, 3307, 3797, 3914, 4205, 4342, 4354, 4374, 4739, 4777, 4912, 5524, 5552, 5628, 6101, 6111, 6148], 'ligand-binding': [200, 409, 437, 530], 'well': [203, 412, 511, 2298, 5587], 'glucocorticoid': [420, 430, 1170], 'nuclear': [422, 504, 515, 4573], 'element': [426, 429, 432], 'hormone': [427, 1227, 4524, 4574, 5781], 'DNA-binding': [435, 519, 5208], 'wild': [439, 3343, 3555, 3591, 4037, 5607], 'type': [440, 3148, 3344, 3556, 3592, 4038, 5608], 'activation': [441, 444, 536, 915, 1808, 3840, 4015, 4074, 4306, 4619, 5416], 'function': [442, 445, 537, 916, 1809, 4016, 4620, 6109], '5': [446, 2449, 2789, 2811], 'cytomegalovirus': [447], 'coactivator': [451, 1191, 4191], 'Androgens': [453], 'involved': [455, 6125], 'differentiation': [458], 'male': [461], 'reproductive': [462], 'organs': [463], 'embryo': [466], 'development': [469], 'maintenance': [471], 'secondary': [473], 'sexual': [474], 'characteristics.': [475], 'biological': [477], 'actions': [478], 'androgens': [480], 'mediated': [482], '(AR).1': [487], 'AR': [489, 682, 733, 904, 908, 932, 1456, 1538, 1706, 1775, 2015, 2352, 2877, 2988, 3182, 3331, 3499, 3752, 3795, 3824, 3890, 4103, 4212, 4513, 4914, 5241, 5335, 5476, 5493, 5505, 5659, 5701, 5738, 5965, 6201], 'is': [490, 580, 727, 905, 920, 1024, 1702, 1765, 1794, 1803, 1879, 2063, 2839, 3099, 3107, 3119, 3141, 3286, 3396, 3423, 3609, 3680, 3732, 3825, 3845, 3853, 3862, 4185, 4333, 4350, 4362, 4447, 4534, 4894, 4940, 5242, 5496, 5503, 5511, 5565, 5593, 5632, 5766, 5792, 5874, 5900, 5966, 6209], 'ligand-activated': [492], 'factor': [494, 1117], 'belongs': [496], 'class': [499, 585, 3684, 4936], 'I': [500, 586, 3685, 4937], 'subgroup': [501, 1020], 'superfamily.': [506], 'Two': [507, 3473, 4784], 'structural': [508], 'domains': [509, 4045], 'conserved': [512, 577, 1363, 1825, 3121, 4494], 'among': [513, 3122, 5657], '(NR):': [517], '(DBD),': [521], 'consisting': [522], 'two': [524, 2246, 3579, 5500, 6147], 'zinc': [525], 'finger': [526], 'modules,': [527], '(LBD),': [532], 'containing': [533, 1360, 2180, 2245, 2279, 2402, 2484, 2676, 3049], '(AF-2)': [538, 4481], '(1Evans': [539, 2186, 2288, 3362, 3634, 3644, 3673, 3776], 'R.M.': [540, 2187, 2289, 3363, 3635, 3645, 3674, 3777, 4583], 'Science.': [541, 631, 1048, 1300, 1378, 2188, 2290, 3364, 3636, 3646, 3675, 3778], '1988;': [542, 2189, 2291, 3365, 3637, 3647, 3676, 3779, 5692], '240:': [543, 2190, 2292, 3366, 3638, 3648, 3677, 3780], '889-895Google': [544, 2191, 2293, 3367, 3639, 3649, 3678, 3781], 'Scholar,': [545, 635, 655, 666, 756, 776, 796, 817, 836, 859, 877, 949, 966, 979, 1052, 1079, 1096, 1134, 1147, 1209, 1382, 1399, 1410, 1423, 1477, 1498, 1515, 1566, 1579, 1600, 1613, 1678, 1740, 1937, 1954, 3240, 3446, 4145, 4162, 4233, 4254, 4271, 4665, 4678, 4699, 4712, 4805, 4984, 5010, 5067, 5120, 5273, 5294, 5313, 5686], '2Moilanen': [546], 'A.': [547, 743, 764, 802, 844, 861, 879, 1081, 1205, 1239, 1259, 1395, 1427, 1523, 1674, 1917, 1962, 2022, 2217, 2259, 2312, 2766, 3433, 3462, 3506, 3695, 4170, 4279, 4543, 4607, 4971, 5000, 5051, 5069, 5108, 5126, 5156, 5279, 5315, 5807, 5854, 6176, 6235], 'Rouleau': [548, 4544], 'N.': [549, 1263, 3450, 4545, 4988, 5016], 'Ikonen': [550, 4546], 'T.': [551, 1058, 1602, 4547, 4701], 'Palvimo': [552, 1603, 4548, 4702], 'J.J.': [553, 1120, 1149, 1604, 4549, 4703, 6034], 'Janne': [554, 1605, 4550, 4704], 'O.A.': [555, 1606, 4551, 4705], 'FEBS': [556, 4552], 'Lett.': [557, 4553], '1997;': [558, 652, 1185, 1249, 1271, 1301, 1324, 1420, 1610, 4508, 4554, 4709, 5862], '412:': [559, 4555], '355-358Google': [560, 4556], 'Scholar).': [561, 676, 899, 996, 1016, 1348, 1440, 1536, 1629, 1761, 1975, 2112, 2271, 2327, 2786, 2900, 3026, 3261, 3472, 3521, 3710, 4183, 4292, 4511, 4557, 4611, 4728, 4826, 5197, 5235, 5695, 5822, 5865, 6045, 6189], '(NTD)': [565], 'hinge': [568], 'more': [571, 4917, 5547, 5787, 6068], 'divergent.': [572], 'Because': [573], 'highly': [576, 1362, 3120, 4493], 'DBD,': [578], 'surprising': [582], '(AR,': [589], 'GR,': [590, 4462], 'progesterone': [591, 1639, 4464], 'mineralocorticoid': [594], 'receptor)': [595], 'recognize': [596, 702], 'same': [598, 2147, 4426, 4563, 5990], 'palindromic': [599, 5474, 5590], '(inverted)': [600], 'repeats': [601, 708, 722, 5250], '5′-TGTTCT-3′': [604, 710], 'sequence,': [606], 'spaced': [607], 'three': [609, 1361, 2579, 2711, 3066, 3581, 3618, 4492, 5828], 'nucleotides.': [610], 'mechanisms': [612, 6124, 6132], 'lead': [614, 6019], 'vivo': [618], 'specificity': [620, 734, 3500, 3530, 5216], 'gene': [622, 690, 5049, 5100, 5181], 'regulation': [623], 'still': [625, 4309], 'completely': [627, 3215], 'understood': [628], '(3Funder': [629], 'J.W.': [630], '1993;': [632, 673, 3469, 5007], '259:': [633], '1132-1133Google': [634], '4Cleutjens': [636], 'K.B.J.M.': [637], 'Steketee': [638, 1618, 4717], 'K.': [639, 887, 1177, 1581, 1619, 1742, 1925, 2774, 3242, 4680, 4718, 4807, 5183, 5667, 6225], 'van': [640, 643, 952, 4624], 'Eekelen': [641], 'C.C.E.M.': [642], 'der': [644, 953, 4625], 'Korput': [645, 954, 4626], 'H.A.G.M.': [646], 'Brinkmann': [647, 958, 1590, 1622, 1751, 2024, 3251, 4630, 4689, 4721, 4816, 5676, 6237], 'A.O.': [648, 959, 1591, 1623, 1752, 3252, 4631, 4690, 4722, 4817, 5677], 'Trapman': [649, 956, 1592, 1620, 1753, 3253, 4628, 4691, 4719, 4818, 5678], 'J.': [650, 750, 792, 811, 830, 851, 873, 895, 943, 957, 960, 973, 1060, 1106, 1130, 1136, 1161, 1214, 1268, 1283, 1310, 1314, 1342, 1404, 1492, 1530, 1573, 1593, 1595, 1607, 1621, 1754, 1756, 1933, 1969, 2226, 2267, 2321, 2782, 2892, 3020, 3234, 3254, 3256, 3440, 3515, 3702, 4139, 4177, 4248, 4286, 4629, 4632, 4672, 4692, 4694, 4706, 4720, 4799, 4819, 4821, 4880, 4978, 5029, 5063, 5135, 5229, 5269, 5288, 5307, 5327, 5679, 5681, 5814, 6039, 6183], 'Endocrinology.': [651, 1092], '138:': [653], '5293-5300Google': [654], '5Beato': [656], 'M.': [657, 668, 670, 936, 1153, 1429, 2337, 2887, 6239], 'Herrlich': [658], 'P.': [659, 741, 762, 780, 981, 1126, 1157, 1462, 1551, 1587, 1617, 1725, 1748, 1939, 2097, 3248, 3431, 4110, 4218, 4650, 4686, 4716, 4753, 4813, 4969, 5075, 5106, 5257, 5673], 'Schütz': [660], 'G.': [661, 747, 758, 782, 786, 798, 806, 821, 825, 840, 848, 863, 881, 951, 985, 1293, 1466, 1525, 1555, 1682, 1684, 1729, 1919, 1943, 1964, 2101, 2213, 2221, 2257, 2308, 2316, 2338, 2768, 2889, 3437, 3502, 3510, 3691, 3699, 4114, 4172, 4222, 4281, 4623, 4654, 4757, 4975, 5053, 5071, 5102, 5122, 5130, 5220, 5224, 5259, 5263, 5275, 5283, 5298, 5302, 5317, 5803, 5811, 6178, 6240], 'Cell.': [662, 991, 1075, 1142, 1183, 1248, 1472, 1510, 1561, 1735, 1949, 2107, 4120, 4157, 4228, 4266, 4660, 4763, 5083], '1995;': [663, 963, 1049, 1379, 1675, 4635], '83:': [664], '851-857Google': [665], '6Truss': [667], 'Beato': [669], 'Endocr.': [671, 1011], 'Rev.': [672, 1012], '14:': [674], '459-479Google': [675], 'Selective': [677], 'DNA': [678, 2471, 5620, 5859], 'could': [683, 5336, 5734, 5774], 'be': [684, 1867, 4518, 5211, 5518, 5540, 5546, 5572, 5581, 5722, 5735, 5775, 5914], 'one': [685, 4749], 'possible': [686, 3011, 5486], 'mechanism': [687, 5205], 'hormone-specific': [689], 'regulation.': [691], 'It': [692, 4089, 5592, 5631, 5912], 'has': [693, 1777, 3088, 3130, 4090, 4470, 4514, 4561, 6138], 'reported': [695, 4516, 4745], 'AR-DBD': [698], 'only': [701, 3847, 4615, 4948, 5244, 5637], 'elements': [704, 2183, 3488, 3577, 3716, 4957, 5340, 5372, 5403, 5707, 5756, 5762, 5783], 'organized': [705], 'inverted': [707], 'sequences': [711, 4730, 5253], 'three-nucleotide': [714], 'spacer': [715], 'can': [717, 1449, 5580], 'also': [718, 1031, 1221, 1634, 2304, 3007, 3273, 4640, 5643, 5793], 'bind': [719, 1781, 5337], '5′-TGTTCT-3′-like': [724, 5252], 'sequences,': [725, 1714], 'which': [726, 2059, 2142, 3173, 3390, 3422, 4772, 5247, 5508, 5733, 5940, 6017, 6095, 6103], 'proposed': [728, 4093], 'contribute': [730, 6118], 'responses': [737], '(7Claessens': [738, 3428, 4966], 'F.': [739, 770, 790, 810, 829, 838, 871, 893, 983, 1464, 1504, 1529, 1553, 1686, 1727, 1931, 1941, 1968, 2099, 2225, 2265, 2320, 2780, 3429, 3514, 3689, 4112, 4151, 4176, 4220, 4260, 4285, 4652, 4755, 4967, 5061, 5081, 5114, 5134, 5228, 5267, 5287, 5306, 5325, 5688, 5801, 6182], 'Alen': [740, 761, 779, 3430, 4968, 5074, 5105, 5256], 'Devos': [742, 3432, 4970], 'Peeters': [744, 765, 783, 803, 822, 845, 866, 888, 988, 1469, 1558, 1732, 1926, 1946, 2104, 2218, 2313, 2775, 3434, 3507, 3696, 4117, 4225, 4657, 4760, 4972, 5056, 5076, 5109, 5127, 5221, 5260, 5280, 5299, 5320, 5808], 'B.': [745, 766, 784, 804, 823, 846, 867, 889, 989, 1064, 1470, 1559, 1568, 1733, 1927, 1947, 2105, 2219, 2314, 2776, 3015, 3229, 3435, 3508, 3697, 4118, 4226, 4658, 4667, 4761, 4794, 4875, 4973, 5057, 5077, 5110, 5128, 5191, 5222, 5261, 5281, 5300, 5321, 5809, 6030], 'Verhoeven': [746, 785, 805, 824, 847, 984, 1465, 1554, 1728, 1942, 2100, 2220, 2315, 2888, 3436, 3509, 3698, 4113, 4221, 4653, 4756, 4974, 5129, 5223, 5262, 5282, 5301, 5810], 'Rombauts': [748, 767, 787, 807, 826, 849, 868, 890, 986, 1467, 1526, 1556, 1730, 1928, 1944, 1965, 2102, 2222, 2262, 2317, 2777, 3438, 3511, 3700, 4115, 4173, 4223, 4282, 4655, 4758, 4976, 5058, 5078, 5111, 5131, 5225, 5264, 5284, 5303, 5322, 5812, 6179], 'W.': [749, 768, 788, 808, 827, 850, 869, 891, 987, 1468, 1527, 1557, 1731, 1929, 1945, 1966, 2103, 2223, 2263, 2318, 2778, 2891, 3439, 3512, 3701, 4116, 4174, 4224, 4283, 4656, 4759, 4977, 5059, 5079, 5112, 5132, 5226, 5265, 5285, 5304, 5323, 5813, 6180], 'Biol.': [751, 812, 831, 855, 944, 961, 974, 992, 1143, 1184, 1215, 1269, 1343, 1405, 1473, 1493, 1511, 1531, 1562, 1574, 1608, 1736, 1950, 1970, 2108, 2227, 2322, 2896, 3021, 3235, 3441, 3516, 3706, 4121, 4140, 4158, 4178, 4229, 4249, 4267, 4287, 4633, 4661, 4673, 4707, 4764, 4800, 4881, 4979, 5030, 5136, 5230, 5289, 5308, 5818, 5861, 6040, 6184], 'Chem.': [752, 813, 832, 945, 962, 975, 1216, 1270, 1344, 1406, 1494, 1532, 1575, 1609, 1971, 2228, 2323, 3022, 3236, 3442, 3517, 4141, 4179, 4250, 4288, 4634, 4674, 4708, 4801, 4882, 4980, 5031, 5137, 5231, 5290, 5309, 6041, 6185], '1996;': [753, 976, 1076, 1093, 1131, 1206, 1396, 3443, 4981], '271:': [754, 977, 3444, 4982], '19013-19016Google': [755, 3445, 4983], '8Verrijdt': [757], 'Schoenmakers': [759, 799, 841, 2214, 2260, 2309, 3503, 3692, 5072, 5103, 5123, 5276, 5804], 'E.': [760, 778, 800, 819, 842, 1098, 1138, 1414, 2215, 2261, 2310, 3504, 3693, 4502, 5073, 5104, 5124, 5218, 5255, 5277, 5296, 5805, 5856], 'Haelens': [763, 801, 843, 1522, 1961, 2216, 2258, 2311, 3505, 3694, 4169, 4278, 5107, 5125, 5278, 5806, 6175], 'Claessens': [769, 789, 809, 828, 870, 892, 982, 1463, 1503, 1528, 1552, 1726, 1930, 1940, 1967, 2098, 2224, 2264, 2319, 2779, 3513, 4111, 4150, 4175, 4219, 4259, 4284, 4651, 4754, 5060, 5080, 5113, 5133, 5227, 5266, 5286, 5305, 5324, 6181], 'Mol.': [771, 854, 990, 1141, 1182, 1471, 1509, 1560, 1624, 1651, 1687, 1734, 1948, 2106, 2895, 3467, 3705, 4119, 4156, 4227, 4265, 4659, 4723, 4762, 5005, 5082, 5115, 5161, 5192, 5817], 'Endocrinol.': [772, 1625, 1652, 1688, 3468, 4724, 5006, 5084, 5116, 5162, 5193], '1999;': [773, 793, 993, 1474, 1512, 1563, 1653, 1737, 1951, 2109, 4122, 4159, 4230, 4268, 4662, 4765, 5085, 5117, 5270, 6042], '13:': [774, 1654, 5118], '1558-1570Google': [775, 5119], '9Schoenmakers': [777], 'Verrijdt': [781, 820, 839, 862, 880, 1524, 1918, 1963, 2767, 3690, 4171, 4280, 5052, 5070, 5219, 5258, 5297, 5316, 5802, 6177], 'Biochem.': [791, 853, 872, 894, 1596, 1757, 1932, 2266, 2781, 2894, 3257, 3704, 4695, 4822, 5062, 5268, 5326, 5682, 5816], '341:': [794, 5271], '515-521Google': [795, 5272], '10Verrijdt': [797, 2212, 5121, 5274], '2000;': [814, 833, 1576, 2229, 2324, 3023, 3237, 3518, 4675, 4802, 4883, 5138, 5232, 5291, 5310], '275:': [815, 834, 1577, 2230, 2325, 3024, 3238, 3519, 4676, 4803, 4884, 5139, 5233, 5292, 5311], '12298-12305Google': [816, 2231, 2326, 3520, 5140, 5293], '11Schoenmakers': [818, 5295], '12290-12297Google': [835, 5234, 5312], '12Claessens': [837], '2001;': [856, 874, 1689, 3707, 4608, 5064, 5194, 5328, 5819], '76:': [857, 3708, 5820], '23-30Google': [858, 3709, 5821], '13Haelens': [860, 5314], 'Callewaert': [864, 882, 1520, 1920, 1959, 2769, 4167, 4276, 5054, 5318, 6173], 'L.': [865, 883, 1056, 1241, 1521, 1921, 1960, 2770, 4168, 4277, 5022, 5055, 5319, 6174], '353:': [875, 5065, 5329], '611-620Google': [876, 5066, 5330], '14Haelens': [878], 'Christiaens': [884, 1922, 2771], 'V.': [885, 1155, 1481, 1517, 1923, 1956, 2772, 4128, 4164, 4237, 4273, 6170], 'Schauwaers': [886, 1924, 2773], '2003;': [896, 1934, 2783], '369:': [897, 1935, 2784], '141-151Google': [898, 1936, 2785], 'NTD': [901, 1453, 1723, 2999, 4108, 4337, 4893, 5974, 6010, 6059], 'indispensable': [906], 'transactivation': [909, 3161, 3537, 5477, 5962, 6198, 6213], 'contains': [911, 4011, 4194, 5827], 'strong': [913, 1542, 3534, 4013, 4618], '(AF-1).': [917], 'Its': [918], 'affected': [921, 3826, 5480], 'coregulators': [923, 999], 'number': [927], 'functional': [929, 1837, 3496, 4833], 'properties': [930], '(15Simental': [933], 'J.A.': [934, 1140, 1570, 3017, 3231, 4669, 4796, 4877, 6032], 'Sar': [935], 'Lane': [937], 'M.V.': [938], 'French': [939], 'F.S.': [940], 'Wilson': [941, 1571, 3018, 3232, 4670, 4797, 4878, 6037], 'E.M.': [942, 1572, 1665, 3019, 3233, 4671, 4798, 4879, 6038], '1991;': [946, 5163], '266:': [947], '510-518Google': [948], '16Jenster': [950], 'H.A.': [955, 4627], '270:': [964, 1050, 1380, 4636], '7341-7346Google': [965, 4637], '17Chamberlain': [967], 'N.L.': [968], 'Whitacre': [969], 'D.C.': [970], 'Miesfeld': [971], 'R.L.': [972, 1235, 1285], '26772-26778Google': [978], '18Alen': [980, 1938], '19:': [994, 1475, 1513, 1564, 1738, 1952, 2110, 4123, 4160, 4231, 4269, 4663, 4766], '6085-6097Google': [995, 1476, 1565, 1739, 1953, 2111, 4124, 4232, 4664, 4767], 'Several': [997], 'putative': [998], '(coactivators': [1000], 'corepressors)': [1002], 'already': [1004, 4091, 4744], 'described': [1006, 1914, 2209, 2254, 2306, 2426, 2605, 2763, 2968, 6140], '(19Heinlein': [1007], 'C.A.': [1008, 1583, 1615, 1744, 3244, 4682, 4714, 4809, 5669], 'Chang': [1009], 'C.': [1010, 1124, 1320, 4581, 5185], '2002;': [1013, 1533, 1597, 1758, 1972, 2268, 3258, 4180, 4289, 4696, 4823, 5683, 6186], '23:': [1014], '175-200Google': [1015], 'best': [1018], 'characterized': [1019], 'receptor-interacting': [1022, 1171], 'proteins': [1023, 2937], 'family': [1026, 4192], '160-kDa': [1028], 'NR': [1029, 1368], 'coactivators,': [1030], 'called': [1032, 4201], 'proteins,': [1034, 2954], 'comprising': [1035], '(SRC-1)': [1039], '(20Oñate': [1040, 1370], 'S.A.': [1041, 1371, 1479, 1646, 3456, 4126, 4235, 4994], 'Tsai': [1042, 1044, 1372, 1374, 1484, 1486, 4131, 4133, 4240, 4242], 'S.Y.': [1043, 1373, 1485, 4132, 4241], 'M.J.': [1045, 1179, 1375, 1487, 1642, 4134, 4243], "O'Malley": [1046, 1376, 1490, 4137, 4246], 'B.W.': [1047, 1377, 1491, 4138, 4247], '1354-1357Google': [1051, 1381], '21Kamei': [1053], 'Y.': [1054, 1089, 1245, 1316, 4587, 5158], 'Xu': [1055], 'Heinzel': [1057], 'Torchia': [1059], 'Kurokawa': [1061], 'R.': [1062, 1247, 1335, 1433, 1589, 1680, 1750, 3250, 3460, 4598, 4688, 4815, 4998, 5026, 5675, 6220], 'Gloss': [1063], 'Lin': [1065, 1232, 5021], 'S.-C.': [1066], 'Heyman': [1067], 'R.A.': [1068], 'Rose': [1069, 1311], 'D.W.': [1070, 1312], 'Glass': [1071, 1319], 'C.K.': [1072], 'Rosenfeld': [1073, 1321], 'M.G.': [1074, 1104, 1322, 1418, 1508, 4155, 4264, 4506], '85:': [1077], '403-414Google': [1078], '22Takeshita': [1080], 'Yen': [1082], 'P.M.': [1083], 'Misti': [1084], 'S.': [1085, 1204, 1318, 1394, 1416, 1425, 1431, 1502, 1673, 2885, 4149, 4258, 4504, 4606, 5012], 'Cardona': [1086, 1260], 'G.R.': [1087, 1261], 'Liu': [1088], 'Chin': [1090, 1266], 'W.W.': [1091, 1267], '137:': [1094], '3594-3597Google': [1095], '23Kalkhoven': [1097], 'Valentin': [1099], 'J.E.': [1100, 4591], 'Heery': [1101, 1505, 4152, 4261], 'D.M.': [1102, 1412, 1506, 4153, 4262, 4500, 5160, 5858], 'Parker': [1103, 1417, 1507, 2339, 4154, 4263, 4505, 6241], 'EMBO': [1105, 1129, 1160], '1998;': [1107, 1144, 1162, 1217, 1345, 1407, 1437, 1495, 1626, 4142, 4251, 4725], '17:': [1108, 1163, 1186], '232-243Google': [1109], 'Scholar),': [1110, 1188, 1220, 1252, 1274, 1304, 1327, 1692, 4768, 4886, 5035, 5088, 5141, 5166, 5331], 'human': [1112, 2014, 2876, 2987, 5045, 5098], 'rat': [1114, 2250, 3055, 4963], 'intermediary': [1116], '2': [1118, 2859, 3720, 5560], '(24Voegel': [1119], 'Heine': [1121, 1150], 'M.J.S.': [1122, 1151], 'Zechel': [1123], 'Chambon': [1125, 1156], 'Gronemeyer': [1127, 1158, 6035], 'H.': [1128, 1159, 1175, 1194, 1211, 1231, 1384, 1401, 3458, 4996, 5020, 6036, 6222], '15:': [1132, 1690, 5195], '3667-3675Google': [1133], '25Leers': [1135], 'Treuter': [1137], 'Gustaffson': [1139], '18:': [1145], '6001-6013Google': [1146], '26Voegel': [1148], 'Tini': [1152], 'Vivat': [1154], '507-519Google': [1164], 'Scholar)': [1165, 1656, 2294, 3640, 4638], 'mouse': [1168, 5150], 'orthologue': [1169], '1': [1173, 1256, 2608, 2623, 2798, 2821, 2826, 2832, 3071, 3184, 3196, 3812, 4347, 4903, 5664, 5946], '(27Hong': [1174], 'Kohli': [1176], 'Garabedian': [1178], 'Stallcup': [1180], 'M.R.': [1181], '2735-2744Google': [1187], 'receptor-associated': [1190, 1254], '3': [1192], '(28Li': [1193], 'Gomes': [1195, 1385], 'P.J.': [1196, 1386], 'Chen': [1197, 1212, 1387, 1402], 'D.J.': [1198, 1388], 'Proc.': [1199, 1389, 1668, 4601], 'Natl.': [1200, 1390, 1669, 4602], 'Acad.': [1201, 1391, 1670, 4603], 'Sci.': [1202, 1392, 1671, 4604], 'U.': [1203, 1393, 1672, 4605], '94:': [1207, 1397], '8479-8484Google': [1208, 1398], '29Li': [1210, 1400], 'D.': [1213, 1237, 1403], '273:': [1218, 1346, 1408, 1496, 4143, 4252], '5948-5954Google': [1219, 1409], 'known': [1222, 3425], 'activator': [1224], 'thyroid': [1226, 1253], '(ACTR)': [1229], '(30Chen': [1230], 'R.J.': [1233, 5028], 'Schiltz': [1234], 'Chakravarti': [1236], 'Nash': [1238], 'Nagy': [1240], 'Privalsky': [1242], 'M.L.': [1243], 'Nakatani': [1244], 'Evans': [1246], '90:': [1250], '569-580Google': [1251], 'molecule': [1255], '(TRAM-1)': [1257], '(31Takeshita': [1258], 'Koibuchi': [1262], 'Suen': [1264], 'C.S.': [1265, 1331], '272:': [1272, 1611, 4710], '27629-27634Google': [1273], 'amplified': [1275], 'breast': [1277], 'cancer': [1278], '(AIB)': [1279], '(32Anzick': [1280], 'S.L.': [1281], 'Kononen': [1282], 'Walker': [1284], 'Azorsa': [1286], 'D.O.': [1287], 'Tanner': [1288], 'M.M.': [1289], 'Guan': [1290], 'X.Y.': [1291], 'Sauter': [1292], 'Kallioniemi': [1294], 'O.P.': [1295], 'Trent': [1296], 'J.M.': [1297], 'Meltzer': [1298], 'P.S.': [1299, 3448, 4986, 5014], '277:': [1302, 1534, 1973, 4181, 4290, 6187], '965-968Google': [1303], 'p300/CBP': [1305], 'co-integrator-associated': [1306], '(p/CIP)': [1308], '(33Torchia': [1309], 'Inostroza': [1313], 'Kamei': [1315], 'Westin': [1317], 'Nature.': [1323, 1419, 4507], '387:': [1325, 1421, 4509], '677-684Google': [1326], 'SRC-3': [1329], '(34Suen': [1330], 'Berrodin': [1332], 'T.J.': [1333], 'Mastroeni': [1334], 'Cheskis': [1336], 'B.J.': [1337], 'Lyttle': [1338], 'C.R.': [1339], 'Frail': [1340], 'D.E.': [1341], '27645-27653Google': [1347], 'They': [1349, 2414], 'interact': [1350, 1450, 4312, 4487, 4850], 'LBD': [1353, 3284, 4490, 4533, 4648, 4887, 5957], 'centrally': [1356], 'located': [1357, 1766, 1795], 'NR-interacting': [1358], 'α-helical': [1364, 1719, 3116, 4495], 'LXXLL': [1365, 4496, 6156], 'boxes': [1369], '28Li': [1383], '35Heery': [1411], 'Kalkhoven': [1413, 4501], 'Hoare': [1415, 1501, 4148, 4257, 4503], '733-736Google': [1422, 4510], '36Schmidt': [1424], 'Baniahmad': [1426], 'Eggert': [1428], 'Schneider': [1430], 'Renkawitz': [1432], 'Nucleic': [1434, 5689], 'Acids': [1435, 5690], 'Res.': [1436, 5691], '26:': [1438], '1191-1197Google': [1439], 'In': [1441, 1811, 1831, 2787, 3059, 3278, 3404, 3711, 4827, 4869, 5352, 5406, 6075, 6190], 'addition,': [1442, 1832, 6191], 'SRC-1': [1447, 1902, 1908, 4184, 5886, 6134, 6151], '(Qr)': [1448], 'ligand-independent': [1459, 4014, 4215], 'manner': [1460, 4216], '(18Alen': [1461, 1550, 1724, 2096, 4109, 4217, 4649], '37Oñate': [1478, 4234], 'Boonyaratanakornkit': [1480, 4127, 4236], 'Spencer': [1482, 4129, 4238], 'T.E.': [1483, 4130, 4239], 'Edwards': [1488, 1649, 4135, 4244], 'D.P.': [1489, 1648, 1650, 4136, 4245], '12101-12108Google': [1497, 4144, 4253], '38Bevan': [1499, 4146, 4255], 'C.L.': [1500, 1519, 1958, 4147, 4166, 4256, 4275, 6172], '8383-8392Google': [1514, 4161, 4270], '39Christiaens': [1516, 1955, 4163, 4272], 'Bevan': [1518, 1957, 4165, 4274, 6171], '49230-49237Google': [1535, 1974, 4182, 4291, 6188], 'depends': [1539], '(N/C)': [1544], '40He': [1567, 4666], 'Kemppainen': [1569, 3016, 3230, 4668, 4795, 4876, 6031], '22986-22994Google': [1578, 3025, 3239, 4677, 4804, 4885], '41Steketee': [1580, 1741, 3241, 4679, 4806], 'Berrevoets': [1582, 1743, 3243, 4681, 4808, 5668], 'Dubbink': [1584, 1745, 3245, 4683, 4810, 5670], 'H.J.': [1585, 1746, 3246, 4684, 4811, 5671], 'Doesburg': [1586, 1616, 1747, 3247, 4685, 4715, 4812, 5672], 'Hersmus': [1588, 1749, 3249, 4687, 4814, 5674], 'Eur.': [1594, 1755, 3255, 4693, 4820, 5680], '269:': [1598, 1759, 3259, 4697, 4824, 5033, 5684], '5780-5791Google': [1599, 1760, 3260, 4698, 4825, 5685], '42Ikonen': [1601, 4700], '29821-29828Google': [1612, 4711], '43Berrevoets': [1614, 4713], '12:': [1627, 4726], '1172-1183Google': [1628, 4727], 'These': [1630, 2065, 3220, 4485, 6116], 'N/C': [1631, 1707, 1829, 3031, 3276, 3796, 4776, 4867, 4911, 5523, 5551, 5627, 6100], 'demonstrated': [1636, 4473, 5237], '(44Tetel': [1641], 'Giangrande': [1643], 'P.H.': [1644], 'Leonhardt': [1645], 'McDonnell': [1647], '910-924Google': [1655], 'estrogen': [1659, 4459], 'α': [1661], '(45Kraus': [1662], 'W.L.': [1663], 'McInerney': [1664], 'Katzenellenbogen': [1666], 'B.S.': [1667, 3466, 5004], '92:': [1676], '12314-12318Google': [1677], '46Metivier': [1679], 'Penot': [1681], 'Flouriot': [1683], 'Pakdel': [1685], '1953-1970Google': [1691], 'implication': [1698], 'less': [1703, 5519], 'pronounced.': [1704], 'involves': [1709], 'LKDIL': [1710, 1792, 5396], 'both': [1715], 'present': [1716, 5038], 'predicted': [1718, 3115], 'structures': [1720], 'within': [1721, 1767, 3477], 'motif': [1764, 1793, 1821, 2977, 3004, 3083, 3111, 3137, 3212, 3320, 3902, 4842, 5389, 5641], 'thirty': [1769], 'ability': [1779, 4385, 4845], 'AF-2': [1782, 4529], 'androgen-dependent': [1789, 2995], 'manner.': [1790], '178': [1799], '183': [1801], 'important': [1804], 'AF-1.': [1810], 'paper,': [1813], 'we': [1814, 1833, 3062, 3293, 3957, 3964, 4059, 4830, 4919, 5199, 5355, 5746, 6192], 'describe': [1815], 'involvement': [1817, 4747], 'flanking': [1824, 4858, 5645], 'Gly': [1826, 3106], 'analyzed': [1835, 3323, 4920], 'isolated': [1843, 2182, 3715, 5760, 6058], 'indirect': [1846], 'repeat': [1847, 3052, 5557], 'AREs': [1848, 3339, 3357, 3834, 4945, 5457, 5502, 5558, 6205], 'AR-specific': [1851, 5567], 'versus': [1852, 5369, 5754], 'nonspecific': [1853, 1875, 3356, 3737, 3833, 3921, 3962, 5370, 5441, 5742, 5755, 5771], 'enhancers.': [1854, 5772], 'Our': [1855, 5998], 'AR-NTD': [1863, 3067, 3154, 3303, 4010, 4023, 4044, 4378, 4613, 4733, 4848], '-LBD': [1865], 'may': [1866], 'prerequisite': [1869], 'HREs,': [1876, 3393, 5442], 'whereas': [1877, 3370, 3671, 4080, 4436, 5443], 'dispensable': [1880], 'specific': [1882, 3735, 3831, 3923, 3955, 5339, 5368, 5450, 5501, 5705, 5753, 5769], 'HREs.': [1883, 5743], 'vectors': [1886, 2114, 3944], 'pSG5AR538–919': [1887], '(encoding': [1888], 'hAR-DBD-LBD),': [1890], 'pSG5AR': [1891, 2140], '(expressing': [1892, 1903], 'FLAG-tagged': [1893], 'full-length': [1894, 2013], 'hAR),': [1895], 'pSG5SRC-1e': [1897, 4413], 'vector': [1900, 2010, 2356, 2461], 'Qr': [1901, 1905, 4315, 4356, 4376, 5884, 5898, 5977, 6054, 6113, 6160], 'fused': [1909, 3157, 4047, 4302, 4318], 'Gal4-DBD)': [1912], 'elsewhere': [1915, 2210], '(14Haelens': [1916, 2765], 'Gal4-DBD': [1977, 2075, 4050, 4321], 'VP16': [1980, 2087, 2952, 3160, 3190, 4305], 'fusion': [1981, 2953, 3191], 'constructs': [1982, 2179, 3192, 3380, 3599, 3620, 4389, 5362], 'hAR1–529,': [1983], 'hAR1–529ΔFQNLF,': [1984], 'hAR1–529L435P': [1986], 'were': [1987, 2053, 2069, 2127, 2170, 2365, 2390, 2415, 2477, 2512, 2534, 2594, 2601, 2620, 2635, 2644, 2667, 2709, 2733, 2743, 2752, 2908, 2926, 2938, 2956, 3156, 3164, 3193, 3475, 3934, 3940, 4046, 4402, 5446, 5713, 5842], 'made': [1988, 1997, 2128, 2957], 'PCR-based': [1991], 'method.': [1992], 'construct': [1994, 2152, 2238, 2278, 2302, 2330, 2435, 3042, 3075, 3087, 3129, 3587, 3608, 3844, 4401], 'hAR1–529': [1995], 'was': [1996, 2032, 2037, 2143, 2157, 2162, 2253, 2346, 2357, 2436, 2446, 2462, 2503, 2557, 2630, 2662, 2715, 2720, 2795, 2850, 2878, 2965, 3006, 3322, 3868, 3876, 3995, 5404, 5478], 'using': [1999, 2417, 2542, 3038, 3342, 3928], 'following': [2001, 2051], 'primers:': [2002], '5′-GGCAGATCTCCATGGAAGTGCAGTTAGGGCTGGG-3′': [2003], '5′-GGATCCTCAACGCATGTCCCCGTAAGGTCCGGA-3′.': [2005], 'As': [2006, 3198, 3522, 3953, 4056], 'template,': [2007], '(pSV-AR),': [2016], 'kind': [2018, 2333], 'gift': [2019, 2334], 'Dr.': [2021, 2336], 'O.': [2023, 6236], '(Erasmus': [2025], 'University': [2026], 'Nijmegen,': [2028, 2029], 'Netherlands)': [2031], 'used.': [2033, 3836], 'ΔFQNLF': [2035, 3551, 3586], 'generated': [2038, 2158], 'oligonucleotides': [2041, 2052, 2751], '5′-CCTACCGAGGAGCTCAGAGCGTCCGCGAAGTG-3′': [2042], '5′-CGCGGACGCTCTGAGCTCCTCGGTAGGTCT-3′.': [2044], 'To': [2045, 2869, 3892, 4025, 4371, 4905], 'generate': [2046], 'L435P': [2048, 2124, 3908, 4082, 4891, 5385, 5409, 5909, 5938], 'mutation,': [2049, 5939], 'used:': [2054], '5′-CCTGGCACACTCCCTTCACAGCCGAAG-3′': [2055], '5′-CTGGCCTTCTTCGGCTGTGAAGGGAGTGTGCCAGGATGAG-3′,': [2057], 'mutated': [2061, 3100, 3142, 3573, 4892, 4925, 5459, 5910], 'base': [2062], 'underlined.': [2064], 'PCR-generated': [2066], 'hAR-NTD': [2067], 'fragments': [2068], 'inserted': [2070], 'frame': [2072, 2084], 'theBamHI': [2077], 'restriction': [2078, 2148], 'site': [2079, 2093, 3013, 3308], 'pABGal4': [2081, 2460], 'activating': [2088, 5433], 'BglII': [2092], 'pSNATCH-II': [2095], 'Expression': [2113, 3186], 'hAR': [2117, 2156], 'carrying': [2118], 'point': [2125, 3090, 3132, 3789, 4330, 5718], 'insertion': [2130], 'aEco52I/Eco81I': [2132], 'fragment': [2133, 2296, 3179, 3202], 'PCR': [2136], 'products': [2137], 'construct,': [2141, 4058], 'cut': [2144], 'enzymes.': [2149], 'pSG5': [2151], 'expressing': [2153], 'G21E-mutated': [2155], 'coincidence': [2160], 'detected': [2163], 'sequencing.': [2165], 'Restriction': [2166], 'modifying': [2168], 'enzymes': [2169], 'obtained': [2171, 2358, 2374], 'from': [2172, 2335, 2359, 2375, 2505, 2546, 2852, 3564, 4520, 4961, 5144, 5595, 6212], 'MBI': [2173], 'Fermentas': [2174], 'GmbH.': [2175], 'luciferase': [2177, 2433, 2530, 2555, 3040, 3597, 4399], 'reporter': [2178, 2237, 2277, 2329, 2434, 3041, 3379, 3598, 3742, 4057, 4400], 'TAT-GRE,slp-HRE3,': [2184], 'C3': [2185, 2287, 3361, 3633], 'Scholar)ARE,': [2192], 'slp-HRE2,sc-ARE1.2,': [2193], 'slp-HRE2': [2194, 3478, 3557, 3867, 3875, 3966, 5143, 5451], 'mut-4T-A;+2A-T,': [2195], 'andsc-ARE1.2': [2196, 5452], 'mut-4T-A;−2A-T': [2197], 'driven': [2199, 2239, 3043, 3610, 3622], 'thymidine': [2202, 2273, 3625], 'kinase': [2203, 2274, 3626], 'minimal': [2204, 2275, 3627], 'promotor': [2205, 2243, 3047, 3615, 3628, 4965, 5176], '(Ref.': [2211], 'Scholar': [2232], 'references': [2234], 'therein).': [2235], 'E1b': [2242, 3046], 'copies': [2247], 'tyrosine': [2251, 3056], 'aminotransferase-GRE': [2252, 3057], 'previously': [2255, 2764], '(47Verrijdt': [2256], '361:': [2269], '97-103Google': [2270], 'promotor-driven': [2276, 2301], 'slp': [2281], 'scupstream': [2283], 'enhancers': [2284, 5374, 6168], 'intronic': [2295, 3641], 'thepb': [2300], '(10Verrijdt': [2307, 3501], '(Gal4)5TATA-Luc,': [2331], '(Imperial': [2340], 'Cancer': [2341], 'Research': [2342], 'Fund,': [2343], 'London,': [2344], 'UK),': [2345], 'used': [2347, 2757, 3958, 3965, 4060], 'measuring': [2349], 'AF-1': [2351], 'activity.': [2353, 2569, 3545], 'pCMV-β-galactosidase': [2355, 2445], 'Stratagene.': [2360], 'All': [2361], 'transfections': [2364, 3602], 'performed': [2366, 2582, 2966, 3935, 3996, 4831], 'COS-7': [2368, 2592, 3604, 3938, 4054, 4406], 'African': [2369], 'green': [2370], 'monkey': [2371], 'kidney': [2372], 'cells,': [2373], 'American': [2377], 'Type': [2378], 'Culture': [2379], 'Collection': [2380], '(Manassas,': [2381], 'VA).': [2382], 'One': [2383, 3607, 5563], 'day': [2384], 'prior': [2385, 2880], 'transfection,': [2387, 2474, 2617], 'cells': [2389, 2476, 2511, 2593, 2619, 2634, 2643, 2666, 3605, 3939, 4407, 4541], 'seeded': [2391], '96-well': [2393], 'culture': [2394], 'plates': [2395], "Dulbecco's": [2397], 'modified': [2398], "Eagle's": [2399], 'medium': [2400, 2483, 2629], '(Invitrogen)': [2401, 2518], '5%': [2403, 2485, 2866], 'dextran-coated': [2404, 2486], 'charcoal-stripped': [2405, 2487], 'fetal': [2406, 2488], 'bovine': [2407, 2489], 'serum': [2408, 2490], 'at': [2409, 2448, 2577, 2724, 2861, 2978, 5704, 5752], 'density': [2411], '104cells/well.': [2413], 'transfected': [2416, 2470, 2603, 3941, 4052, 4404], 'FuGENE': [2418], '6': [2419, 4007, 5597], 'transfection': [2420, 2560], 'reagent': [2421, 2943], '(Roche': [2422], 'Molecular': [2423], 'Biochemicals)': [2424], 'manufacturer.': [2429], 'amount': [2431, 2443, 2468], 'fixed': [2437, 2447], '100': [2439, 2670, 2818], 'ng/well,': [2440], 'ng/well.': [2450], 'Where': [2451], 'applicable,': [2452], 'empty': [2453, 2455, 2457], 'pGEM-T,': [2454], 'pSG5,': [2456, 4390], 'pSNATCH-II,': [2458], 'added': [2463, 2699, 2840, 2879], 'keep': [2465], 'total': [2467, 2792], 'constant.': [2472], 'After': [2473], 'incubated': [2478, 2842], '24': [2480, 2614], 'h': [2481, 2615, 2624, 2860], 'supplemented': [2492], 'hormones': [2496], '(10−8m).': [2497, 2627], 'synthetic': [2499], 'R1881': [2501, 2626], '(methyltrienolone)': [2502], 'purchased': [2504], 'PerkinElmer': [2506], 'Life': [2507, 2946], 'Sciences.': [2508], 'Finally,': [2509], 'washed': [2513, 2636], 'twice': [2514, 2637], 'phosphate-buffered': [2516, 2640, 2651, 2660], 'saline': [2517, 2661], 'lysed': [2520], '25': [2522], 'μl': [2523, 2538, 2671, 2790, 2799, 2805, 2822, 2827, 2833], 'passive': [2525, 2959], 'lysis': [2526, 2960], 'buffer': [2527, 2675], '(Promega).': [2528], 'β-galactosidase': [2532, 2568], 'activities': [2533], 'measured': [2535, 5888], '2.5': [2537], 'extracts': [2541, 2732, 2955, 3994], 'assay': [2544, 2739, 3170, 3810], 'systems': [2545], 'Promega': [2547], 'Tropix': [2549], '(Westburg,': [2550], 'Netherlands),': [2552], 'respectively.': [2553, 3787], 'corrected': [2558], 'efficiency': [2561], 'normalizing': [2563], 'according': [2565], 'values': [2571], 'shown': [2572, 2973, 3523], 'averages': [2575], 'least': [2578], 'independent': [2580], 'experiments': [2581, 3061], 'triplicate.': [2584], 'error': [2586], 'bars': [2587], 'S.E.': [2590, 4585], 'values.': [2591], 'plated': [2595], '10-cm': [2597], 'Petri': [2598], 'dishes': [2599], 'transiently': [2602, 4403], 'above': [2606], 'μg': [2609], 'vectors.': [2612], 'At': [2613], 'after': [2616], 'stimulated': [2621], 'removed,': [2631, 2663], 'ice-cold': [2639, 2650, 2673], 'saline.': [2641], 'collected': [2645], '1.5': [2647], 'ml': [2648], 'saline/dish': [2652], 'pelleted': [2654], 'centrifugation': [2656], '(1': [2657, 2802, 3951], 'min).': [2658], 'resuspended': [2668], 'extraction': [2674], '20': [2677, 2844], 'mm': [2678, 2683, 2686, 2809, 2814, 2819], 'Hepes-KOH,': [2679], 'pH': [2680], '7.8,': [2681], '450': [2682], 'NaCl,': [2684], '0.4': [2685], 'EDTA,': [2687, 2815], '25%': [2689], 'glycerol.': [2690], 'Immediately': [2691], 'before': [2692], 'use,': [2693], 'dithiothreitol': [2694, 2823], 'phenylmethylsulfonyl': [2696], 'fluoride': [2697], 'final': [2702], 'concentration': [2703], '0.5': [2705], 'mm.': [2706], 'samples': [2708], 'freeze-thawed': [2710], 'times.': [2712], 'pellet': [2714], 'collected,': [2716], 'supernatant': [2719], 'removed': [2721], 'stored': [2723], '−80': [2725], '°C.': [2726], 'concentrations': [2729], 'determined': [2734], 'Coomassie': [2737], 'kit': [2740], '(Pierce)': [2741], 'each': [2745], 'case': [2746], '∼4': [2747], 'μg/μl.': [2748], 'Synthetic': [2749], 'complementary': [2750], 'hybridized,': [2753], 'radioactively': [2754], 'labeled,': [2755], 'band': [2759, 3925], 'shift': [2760, 3973], 'assays': [2761, 3927, 3974, 5891], 'brief,': [2788], 'cell': [2793], 'extract': [2794], 'preincubated': [2796], 'poly(dI-dC)': [2801], 'μg/μl),': [2803], '10': [2804], 'D100': [2807], '(20': [2808, 2824], 'Hepes,': [2810], 'mmMgCl2,': [2812], '0.1': [2813], '17%': [2816], 'glycerol,': [2817], 'NaCl),': [2820], 'mm),': [2825], 'Triton': [2828], 'X-100': [2829], '(1%),': [2830], 'water.': [2835], 'Subsequently,': [2836], 'probe': [2838, 2849, 2883], 'min': [2845], 'ice.': [2847], 'Bound': [2848], 'separated': [2851, 2909], 'free': [2854], 'electrophoresis': [2857], '120': [2862], 'V': [2863], 'polyacrylamide': [2867], 'gel.': [2868], 'obtain': [2870], 'supershifts,': [2871], 'rabbit': [2873], 'antiserum': [2874], 'against': [2875], '(48Marivoet': [2884], 'Hertogen': [2886], 'Heyns': [2890], '1990;': [2897], '37:': [2898], '39-45Google': [2899], 'Western': [2902, 2962, 3989], 'blotting,': [2903], 'equal': [2904, 3999], 'amounts': [2905], 'SDS-PAGE': [2911], '8%': [2914], 'gel': [2915, 3972], 'blotted': [2917], 'onto': [2918], 'polyvinylidene': [2919], 'difluoride': [2920], 'membranes': [2921, 2925], '(Amersham': [2922], 'Biosciences).': [2923], 'probed': [2927], 'monoclonal': [2930], 'M2': [2931], 'anti-FLAG': [2932], 'antibody': [2933], '(Stratagene),': [2934], 'immunoreactive': [2936], 'visualized': [2939], 'chemiluminescence': [2942], 'plus': [2944], '(PerkinElmer': [2945], 'Sciences).': [2947], 'detection': [2950], 'buffer.': [2961], 'blot': [2963, 3990], 'analysis': [2964, 3991, 4834], 'above.': [2969], 'Previous': [2970], 'studies': [2971], 'position': [2979], '23': [2980], 'plays': [2989], 'LBD.': [3002, 4742], 'Another': [3003], '(432WHTLF436)': [3005], 'postulated': [3008, 6027], '(40He': [3014, 3228, 4793, 4874], 'studied': [3029], 'mammalian': [3035, 3168, 3808, 4540], 'two-hybrid': [3036, 3169, 3809], 'system': [3037], 'tandem': [3051], '(2×TAT-GRE(E1b)-Luc).': [3058], 'tested': [3063, 3418, 3595, 3717, 3815, 4294, 4538, 5421], 'compared': [3065, 3588, 4358, 4428, 5356, 5437, 5553], '(AR1–529)': [3068], 'mutants': [3069, 4381], '(Fig.': [3070, 3183, 3195, 3811, 4006, 4322, 4346, 4414, 4902, 5663, 5892, 5945, 6060], 'A).': [3072, 3937, 4063], 'consists': [3076], '(AR1–529ΔFQNLF).': [3084], 'second': [3086, 5867], 'immediately': [3092], 'amino-terminally': [3093], 'motif;': [3097], 'Gly21': [3098, 4857], 'Glu': [3103, 4863], '(AR1–529G21E).': [3104], 'This': [3105, 4361, 5648, 5720, 5773, 5895], 'outside': [3108, 3269], 'inside': [3113], 'different': [3123, 3986, 4004, 4519, 4928, 5619, 5661, 6211], 'species': [3124, 5662], '(Fig.1': [3125, 5629], 'B).': [3126, 4008, 4324, 4370, 5894], 'third': [3128], 'WHTLF': [3136, 5388], 'so': [3138], 'Leu435': [3140], 'into': [3143, 3489, 4053, 4405], 'Pro': [3145], '(AR1–529L435P).': [3146], 'Wild': [3147], 'mutant': [3150, 3552, 3873, 3983, 4040, 5611], 'forms': [3151, 4041], 'coexpressed': [3165], 'pSG5AR538–919,': [3172], 'encodes': [3174], 'DBD-': [3176], 'LBD-containing': [3178], 'C).': [3185, 3813, 4416, 4904, 5630, 5947, 5997], 'levels': [3187, 4001], 'similar': [3194, 3798, 3977], 'D).': [3197], 'expected,': [3199], 'AR1–529': [3201, 3214], 'interacts': [3203], 'hormone-dependently': [3204], 'AR538–919.': [3206], 'abolished': [3216], 'R1881-dependent': [3218], 'findings': [3221, 6078], 'agreement': [3224], 'previous': [3226], 'reports': [3227], 'NTD,': [3268, 5934], 'motif,': [3272, 4751, 5397], 'markedly': [3274, 3374], 'reduces': [3275, 3747, 5626, 5941], 'contrast,': [3279, 3405], 'no': [3280, 3394, 3723, 3859, 3883, 5398, 5444, 5490, 5602, 5764], 'difference': [3281, 3395, 3724, 5399], 'observed': [3287, 4898, 5427, 5447, 5497, 5715, 5729, 5747], 'AR1–529L435P': [3290, 4368], 'Therefore,': [3292], 'form': [3304, 5784], 'predominant': [3306], 'AR-LBD.': [3311, 4853], '(hARΔFQNLF)': [3321], '(Fig.2).': [3340], 'When': [3341, 3870], 'AR,': [3345, 3857, 6094, 6154], 'induction': [3347, 3376, 3569, 3756], '16.5,': [3350], '19.9,': [3351], '8.9': [3353], 'TAT-GRE,': [3358], 'slp-HRE3,': [3359], 'Scholar)-ARE,': [3368], 'respectively,': [3369], 'ARΔFQNLF': [3371, 3540, 3773, 4441, 5436, 5749], 'showed': [3372, 3975], 'decreased': [3375, 3794, 3846, 4087], '(6.0,': [3381], '8.7,': [3382], '3.1,': [3384], 'respectively).': [3385], 'However,': [3386, 4558, 5454, 6046], 'forslp-HRE2': [3387], 'sc-ARE1.2,': [3389], 'androgen-specific': [3392, 3426, 3669, 4956], 'seen': [3397, 3733, 3863, 4364, 5699, 5767, 5902], 'wtAR': [3400, 3544, 3765, 3980, 4430, 5439, 5993], 'ARΔFQNLF.': [3403], 'transactivating': [3412], 'abilities': [3413], 'when': [3417, 3830, 3849, 3864, 4357, 4537, 5455], 'PB-ARE2,': [3421, 5568], 'another': [3424, 4872], 'ARE': [3427], '49Rennie': [3447, 4985], 'Bruchovsky': [3449, 4987, 5015], 'Leco': [3451, 4989], 'K.J.': [3452, 4990], 'Sheppard': [3453, 4991, 5017], 'P.C.': [3454, 4992, 5018], 'McQueen': [3455, 4993], 'Cheng': [3457, 4995, 5019], 'Snoek': [3459, 4997, 5025], 'Hamel': [3461, 4999], 'Bock': [3463, 5001], 'M.E.': [3464, 4593, 5002], 'MacDonald': [3465, 5003], '7:': [3470, 5008], '23-36Google': [3471, 5009], 'introduced': [3476, 3854], '(slp-HRE2': [3479, 5466, 6206], 'mut-4T-A;+2A-T)': [3480], 'sc-ARE1.2': [3483, 5090, 5469], '(sc-ARE1.2': [3484], 'mut-4T-A;−2A-T),': [3485], 'changing': [3486], 'ones': [3491], 'leading': [3493], 'loss': [3497, 3528], 'Fig.': [3525, 5596], '3,': [3526, 3722, 5377], 'correlates': [3531, 5649], 'decrease': [3535, 5429, 5491], 'comparison': [3542], 'thesc-ARE1.2': [3559], 'differ': [3563], 'wtAR,': [3567, 3929, 3946], 'androgen-mediated': [3568], 'sc': [3574, 3656], 'andslp': [3575], 'times': [3582], 'lower': [3583], 'AR.': [3593, 4783, 4952], 'four': [3596], 'transient': [3601], '(Fig.4).': [3606], 'probasin': [3613, 4964], 'proximal': [3614, 5175], '(pPB-Luc).': [3616], 'other': [3619, 4522, 4572, 4785, 5528, 5835, 6215], 'contain': [3630], 'enhancer': [3642, 3657, 5095, 5147], '(pC3': [3643], 'Scholar)-TATA-Luc),': [3650], 'slpenhancer': [3652], '(pSLP-TATA-Luc),': [3653], '(pSC-TATA-Luc).': [3658], 'Three': [3659], 'them': [3661], '(pPB-Luc,': [3662], 'pSLP-TATA-Luc,': [3663, 3784], 'pSC-TATA-Luc)': [3665], 'controlled': [3667, 5795], 'pC3': [3672, 3775], 'Scholar)-TATA-Luc': [3679], 'activated': [3681], 'all': [3683, 3741], '(12Claessens': [3688, 5800], 'contrast': [3712, 4870, 5936], 'Figs.': [3719], 'enhancers,': [3738, 5789], 'because': [3739, 5763], 'constructs,': [3743], 'potency': [3749], '∼2-fold.': [3753], 'average': [3755], '15.0,': [3759], '15.6,': [3760], '35.0,': [3761], '49.8': [3763], '6.2,': [3767], '4.6,': [3768], '19.0,': [3769], '17.0': [3771], 'Scholar)-TATA-Luc,': [3782], 'pPB-Luc,': [3783], 'pSC-TATA-Luc,': [3786], 'shows': [3792, 4338], 'whether': [3816, 4027, 4295], 'TAT-GRE': [3843], 'marginally': [3848], 'clear': [3860, 5594, 5634], 'androgen-selective': [3866], 'tested.': [3869], 'used,': [3877], 'again': [3881], 'had': [3882], 'functionality': [3887, 4915], '(Fig.5).': [3891], 'analyze': [3893, 4026], 'vitro': [3913], 'AREs,': [3924], 'shifts': [3926], 'ARΔFQNLF,': [3930, 3947, 5363], 'ARG21E,': [3931, 3948, 5364], 'ARL435P': [3933, 3950, 4422, 5366, 5995], '(Fig.6': [3936], 'μg).': [3952], 'ARE,': [3956], 'slp-HRE2,': [3959], 'mut-4T-A;+2A-T': [3967, 5467], 'TAT-GRE.': [3970], 'very': [3976], 'ARs': [3984], 'assess': [3998], '(Tau-5).': [4024], 'constitutively': [4033], 'active': [4034], 'Tau-5': [4035], 'function,': [4036], 'cells.': [4055], '(Gal4)5-TATA-Luc': [4061], '(Fig.7': [4062, 4369, 5996], 'resulted': [4071, 4084], 'comparable': [4075, 4895], 'wtAR-NTD,': [4079], 'activation.': [4088], 'efficient': [4096], 'recruitment': [4097, 4479, 6023, 6055], 'coactivators': [4099, 4486, 6025], 'native': [4102], 'occurs': [4104], 'primarily': [4105], 'Scholar,37Oñate': [4125], 'member': [4187], '(amino': [4198], '989–1240)': [4200], 'Qr,': [4202], 'needed': [4203], 'AR1–529ΔFQNLF,': [4298], 'AR1–529G21E,': [4299], 'AR1–529L435P,': [4301], 'domain,': [4307], 'able': [4310], 'SRC-1,': [4317], '7': [4323, 4415, 5893, 6061], 'A': [4325, 5485, 5598, 5866], 'striking': [4326], 'characteristic': [4327], 'although': [4335, 5569], 'AR-LBD': [4345, 4560], 'C),': [4348], 'there': [4349, 4939, 5600], '2.5-fold': [4352], 'better': [4353], 'wtAR-NTD.': [4360], 'AR1–529ΔFQNLF': [4366], 'compare': [4372], 'coactivation': [4384, 4439], 'SRC-1e,': [4387, 4435], 'pSG5wtAR,': [4391], 'pSG5ΔFQNLF,': [4392], 'pSG5G21E,': [4393], 'pSG5L435P': [4395], '2×TAT-GRE(E1b)': [4398], 'cotransfected': [4409], 'pGEM-T': [4411], 'Transcriptional': [4417], 'ARG21E': [4420, 5986], 'level': [4427, 5991], 'presence': [4433, 4444], 'net': [4438], 'SRC-1e': [4446, 5980], 'lower.': [4448], 'members': [4451], 'superfamily': [4456], 'such': [4457, 4955], 'α,': [4461], 'ligand-induced': [4467], 'conformational': [4468], 'change': [4469], 'clearly': [4472], 'result': [4475], 'hydrophobic': [4478], 'surface': [4480], 'signature': [4497], '(35Heery': [4499], 'quite': [4535], 'low': [4536], '(2Moilanen': [4542], 'overall': [4564], 'three-dimensional': [4565], 'structure': [4566], 'LBDs': [4569], '(50Sack': [4576], 'J.S.': [4577], 'Kish': [4578], 'K.F.': [4579], 'Wang': [4580], 'Attar': [4582], 'Kiefer': [4584], 'An': [4586], 'Wu': [4588], 'G.Y.': [4589], 'Scheffler': [4590], 'Salvati': [4592], 'Krystek': [4594], 'Jr.,': [4595], 'S.R.': [4596], 'Weinmann': [4597], 'Einspahr': [4599], 'H.M.': [4600], '98:': [4609], '4904-4909Google': [4610], 'harbors': [4616], '(AF-1)': [4621], '(16Jenster': [4622], 'displays': [4641], 'high': [4643], 'affinity': [4644, 5881, 5951, 5971], 'liganded': [4647], 'LXXLL-related': [4729], 'LXXLL-like': [4750], '179LKDIL183(18Alen': [4752], '(I182A/L183A)': [4773], 'candidate': [4786], 'motives': [4787], 'described:': [4790], '23FQNLF27': [4791], 'and432WHTLF436': [4792], 'study,': [4829, 5354], 'latter': [4837], 'motifs.': [4838], 'Deleting': [4839], 'destroys': [4843], 'attenuates': [4865], 'report': [4873], 'wtAR-NTD': [4901], 'investigate': [4906], 'detail,': [4918], 'responsive': [4929], 'constructs.': [4930], 'Next': [4931], 'classical': [4934, 6216], 'group': [4943], 'recognized': [4949], 'Examples': [4953], 'PB-ARE2': [4960, 5578], '51Kasper': [5011], 'Rennie': [5013], 'Shiu': [5023], 'R.P.': [5024], 'Matusik': [5027], '1994;': [5032], '31763-31769Google': [5034], 'SC-ARE': [5037], 'exon': [5042], 'secretory': [5046], 'component': [5047], '(SC)': [5048], '(13Haelens': [5050], '52Haelens': [5068], '153:': [5086], '91-102Google': [5087], 'far': [5093], 'upstream': [5094, 5146], 'SC': [5099], '(8Verrijdt': [5101], 'sex-limited': [5151], '(53Adler': [5153], 'A.J.': [5154], 'Scheller': [5155, 5853], 'Hoffman': [5157], 'Robins': [5159, 5857], '5:': [5164], '1587-1596Google': [5165], 'Pem': [5169], 'ARE-1': [5170], 'ARE-2': [5172], 'murine': [5179], 'pem': [5180], '(54Barbulescu': [5182], 'Geserick': [5184], 'Schuttke': [5186], 'I.': [5187], 'Schleuning': [5188], 'W.D.': [5189], 'Haendler': [5190], '1803-1816Google': [5196], 'Elsewhere,': [5198], 'hypothesized': [5200], 'alternative': [5203], 'dimerization': [5204], 'would': [5210, 6018], 'responsible': [5212], '(11Schoenmakers': [5217], 'indeed': [5238], 'binds': [5248], '(9Schoenmakers': [5254], 'indicating': [5332], 'head-to-tail': [5343, 5515], 'configuration': [5344], 'conventional': [5349], 'head-to-head': [5350], 'configuration.': [5351], '(Figs.': [5375, 5559], 'Figure': [5376, 5378, 5380], '4,': [5379], '5).': [5381], 'I182A/L183A': [5393], 'selectiveversus': [5401], 'seen.': [5405], 'fact,': [5407], 'any': [5418], '(data': [5423], 'shown).': [5425], 'changes': [5445], 'left': [5462], 'and/or': [5463], 'right': [5464], 'half-sites': [5465], 'mut-4T-A;−2A-T)': [5470], 'become': [5472], 'partial': [5473], 'repeats,': [5475], 'deletion.': [5484], 'explanation': [5487], 'why': [5489], 'dimers,': [5506], 'DBD': [5510], 'dimerized': [5512], 'conformation,': [5516], 'might': [5517, 5571, 5721], 'dependent': [5520, 5548], 'transactivation.': [5526], 'Whether': [5527], 'cofactors': [5531], 'differences': [5537, 5604, 5698, 5745], 'remains': [5538], 'elucidated.': [5541], 'Nonspecific': [5542], 'HREs': [5543], 'seem': [5544, 6104], '3).': [5562], 'exception': [5564], 'explained': [5573, 5723], 'fact': [5576, 5779], '(5′-GGTTCTnnnAGTACT-3′)': [5579], 'considered': [5582], 'repeat.': [5591], 'obvious': [5603], 'characteristics': [5616], 'therefore': [5633], 'some': [5644, 6203], 'residues': [5646], 'contribute.': [5647], 'stronger': [5652], 'conservation': [5653], 'B)': [5665, 6062], '(41Steketee': [5666], '55Corpet': [5687], '16:': [5693, 5863], '10881-10890Google': [5694], 'versusnonspecific': [5706], 'residual': [5726], 'AR-NTDG21E/AR-LBD': [5727], 'Fig.1': [5731], 'C,': [5732], 'sufficient': [5736], 'limited': [5758], 'due': [5776], 'part': [5785], 'complex': [5788], 'whose': [5790], 'tightly': [5794], 'slpenhancer,': [5824], 'example,': [5826], 'HREs:': [5829], 'HRE-1,': [5830], 'HRE-2,': [5831], 'HRE-3,': [5833], 'slp-ARU': [5841], 'identified': [5843], 'NFκB,': [5845], 'octamer': [5846], 'factor,': [5848], 'AML3/CBFα1': [5850], '(56Scarlett': [5851], 'C.O.': [5852], 'Thompson': [5855], 'Cell': [5860], '45-57Google': [5864], 'interesting': [5868], 'feature': [5869], 'almost': [5876], '3-fold': [5877], 'increase': [5878, 5896], 'double-hybrid': [5890], 'AR-NTDΔFQNLF': [5905], 'nor': [5906], 'AR-NTD.': [5911], 'should': [5913], 'noted': [5915], 'intrinsic': [5930], '2-fold': [5944], 'Possibly,': [5948], 'lowered': [5950], 'NTDG21E': [5954], 'compensated': [5967], 'SRC-1.': [5979, 6115], 'coexpression': [5981], 'seems': [5982], 'rescue': [5984], 'do': [6000], 'exclude': [6002], 'possibility': [6004], 'stabilization': [6007], 'conformation': [6013], 'LBD,': [6016], 'enhanced': [6022], 'earlier': [6028], '(57He': [6029], 'Voegel': [6033], '274:': [6043], '37219-37225Google': [6044], 'effects': [6048], 'us': [6064], 'propose': [6066], 'recruitment.': [6074, 6135], 'summary,': [6076], 'our': [6077], 'demonstrate': [6079], 'dual': [6081], 'essential': [6097], 'results': [6117], 'unraveling': [6121], 'AR-N/C': [6128], 'Recently,': [6136], 'relative': [6143], 'contribution': [6144], 'sites': [6149], 'region,': [6161], 'depend': [6162], 'nature': [6165], '(39Christiaens': [6169], 'provide': [6193], 'indication': [6196], 'sc-ARE1.2)': [6208], 'structurally': [6210], 'AREs.': [6217], 'thank': [6219], 'Bollen,': [6221], 'Debruyn,': [6223], 'Bosmans': [6226], 'excellent': [6228], 'technical': [6229], 'assistance.': [6230], 'indebted': [6233], 'providing': [6243], 'plasmids.': [6245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2126299378', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-07T11:29:54.149643', 'created_date': '2016-06-24'}
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