Supporting Figures S5-S8 from Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

Name: Work Video:
Duration: 3 min 30 s
Description: &lt;p&gt;S5: UT-155 prevents nuclear localization of AR and AR v567es. S6: UT-155 binds to AR AF-1 domain. S7: Results from microarray with SARDs.S8: UT-155 inhibits transactivation of AD1 and D567es AR transactivation. Metabolism properties of SARDs.&lt;/p&gt;
Suriyan Ponnusamy; Christopher C. Coss; Thirumagal Thiyagarajan; Kate Watts; Dong‐Jin Hwang; Yali He; Luke A. Selth; Iain J. McEwan; C. B. Duke; Jayaprakash Pagadala; Geetika Singh; Robert Wake; Christopher Ledbetter; Wayne D. Tilley; Tudor Moldoveanu; James T. Dalton; Duane D. Miller; Ramesh Narayanan
{'id': 'https://openalex.org/W4361876095', 'doi': 'https://doi.org/10.1158/0008-5472.22416662', 'title': 'Supporting Figures S5-S8 from Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer', 'display_name': 'Supporting Figures S5-S8 from Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer', 'publication_year': 2023, 'publication_date': '2023-03-31', 'ids': {'openalex': 'https://openalex.org/W4361876095', 'doi': 'https://doi.org/10.1158/0008-5472.22416662'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22416662', 'pdf_url': 'https://aacr.figshare.com/ndownloader/files/39862718', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://aacr.figshare.com/ndownloader/files/39862718', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047077102', 'display_name': 'Suriyan Ponnusamy', 'orcid': 'https://orcid.org/0000-0001-8257-3993'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Suriyan Ponnusamy', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047984092', 'display_name': 'Christopher C. Coss', 'orcid': 'https://orcid.org/0000-0002-8184-9190'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Christopher C. Coss', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058014595', 'display_name': 'Thirumagal Thiyagarajan', 'orcid': 'https://orcid.org/0000-0002-7813-0556'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Thirumagal Thiyagarajan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067078592', 'display_name': 'Kate Watts', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kate Watts', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073936438', 'display_name': 'Dong‐Jin Hwang', 'orcid': 'https://orcid.org/0000-0002-0055-1916'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Dong-Jin Hwang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100516545', 'display_name': 'Yali He', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yali He', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018718250', 'display_name': 'Luke A. Selth', 'orcid': 'https://orcid.org/0000-0002-4686-1418'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Luke A. Selth', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056247791', 'display_name': 'Iain J. McEwan', 'orcid': 'https://orcid.org/0000-0003-2087-0663'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Iain J. McEwan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017977887', 'display_name': 'C. B. Duke', 'orcid': 'https://orcid.org/0000-0003-4649-7246'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Charles B. Duke', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087515124', 'display_name': 'Jayaprakash Pagadala', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jayaprakash Pagadala', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101940237', 'display_name': 'Geetika Singh', 'orcid': 'https://orcid.org/0000-0003-2388-995X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Geetika Singh', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036686407', 'display_name': 'Robert Wake', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Robert W. Wake', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069546645', 'display_name': 'Christopher Ledbetter', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Christopher Ledbetter', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020285542', 'display_name': 'Wayne D. Tilley', 'orcid': 'https://orcid.org/0000-0003-1893-2626'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wayne D. Tilley', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000423818', 'display_name': 'Tudor Moldoveanu', 'orcid': 'https://orcid.org/0000-0003-0791-318X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tudor Moldoveanu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002243266', 'display_name': 'James T. Dalton', 'orcid': 'https://orcid.org/0000-0002-3915-7326'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'James T. Dalton', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016676195', 'display_name': 'Duane D. Miller', 'orcid': 'https://orcid.org/0000-0002-6093-0985'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Duane D. Miller', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067659573', 'display_name': 'Ramesh Narayanan', 'orcid': 'https://orcid.org/0000-0001-5490-0790'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ramesh Narayanan', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 68}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10519', 'display_name': 'Advanced Proteomics Techniques and Applications', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9822, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/androgen-receptor-antagonists', 'display_name': 'Androgen Receptor Antagonists', 'score': 0.48676133}], 'concepts': [{'id': 'https://openalex.org/C1292079', 'wikidata': 'https://www.wikidata.org/wiki/Q3817769', 'display_name': 'Transactivation', 'level': 4, 'score': 0.9868257}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.87793}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8082442}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.54524785}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5114988}, {'id': 'https://openalex.org/C2910322876', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Androgen Receptor Antagonists', 'level': 5, 'score': 0.48676133}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.45559832}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.44417414}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41420633}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37077993}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3368801}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.30063552}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19842374}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.17290056}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11786026}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22416662', 'pdf_url': 'https://aacr.figshare.com/ndownloader/files/39862718', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-17-0976', 'pdf_url': 'https://cancerres.aacrjournals.org/content/canres/77/22/6282.full.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Supporting_Figures_S5-S8_from_Novel_Selective_Agents_for_the_Degradation_of_Androgen_Receptor_Variants_to_Treat_Castration-Resistant_Prostate_Cancer/22416662', 'pdf_url': 'https://figshare.com/ndownloader/files/39862718', 'source': {'id': 'https://openalex.org/S4306400572', 'display_name': 'OPAL (Open@LaTrobe) (La Trobe University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I196829312', 'host_organization_name': 'La Trobe University', 'host_organization_lineage': ['https://openalex.org/I196829312'], 'host_organization_lineage_names': ['La Trobe University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Supporting_Figures_S1-S4_from_Novel_Selective_Agents_for_the_Degradation_of_Androgen_Receptor_Variants_to_Treat_Castration-Resistant_Prostate_Cancer/22416665', 'pdf_url': 'https://figshare.com/ndownloader/files/39862721', 'source': {'id': 'https://openalex.org/S4306400572', 'display_name': 'OPAL (Open@LaTrobe) (La Trobe University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I196829312', 'host_organization_name': 'La Trobe University', 'host_organization_lineage': ['https://openalex.org/I196829312'], 'host_organization_lineage_names': ['La Trobe University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22416662', 'pdf_url': 'https://aacr.figshare.com/ndownloader/files/39862718', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.69, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4361805108', 'https://openalex.org/W4361246756', 'https://openalex.org/W3196377280', 'https://openalex.org/W3111390827', 'https://openalex.org/W3003527055', 'https://openalex.org/W2969931138', 'https://openalex.org/W2888003396', 'https://openalex.org/W2464082044', 'https://openalex.org/W2162507254', 'https://openalex.org/W2042646980'], 'abstract_inverted_index': {'&lt;p&gt;S5:': [0], 'UT-155': [1, 11, 23], 'prevents': [2], 'nuclear': [3], 'localization': [4], 'of': [5, 26, 34], 'AR': [6, 8, 14, 30], 'and': [7, 28], 'v567es.': [9], 'S6:': [10], 'binds': [12], 'to': [13], 'AF-1': [15], 'domain.': [16], 'S7:': [17], 'Results': [18], 'from': [19], 'microarray': [20], 'with': [21], 'SARDs.S8:': [22], 'inhibits': [24], 'transactivation': [25], 'AD1': [27], 'D567es': [29], 'transactivation.': [31], 'Metabolism': [32], 'properties': [33], 'SARDs.&lt;/p&gt;': [35]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4361876095', 'counts_by_year': [], 'updated_date': '2024-12-06T01:55:37.662244', 'created_date': '2023-04-05'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
