Title: Synthesis of Certain N1- and N4-(5-Nitro-2-pyridyl)-Substituted Sulfonamides
Abstract: The condensation of 2-chloro-5-nitropyridine with a number of sulfonamides is described. Sulfadiazine, sulfamerazine, sulfathiazole, sulfapyridine, sulfisoxazole, sulfamethoxypyridazine, and sulfadimethoxine afforded the N4 derivatives via the application of Banks' procedure. 4-Homosulfanilamide using Ullmann's and Mangini's conditions, yielded the N1 and N4 derivatives, respectively. With benzylsulfonamide and benzenesulfonamide adopting Ullmann's method the corresponding N-substituted derivatives were obtained. The condensation of 2-chloro-5-nitropyridine with a number of sulfonamides is described. Sulfadiazine, sulfamerazine, sulfathiazole, sulfapyridine, sulfisoxazole, sulfamethoxypyridazine, and sulfadimethoxine afforded the N4 derivatives via the application of Banks' procedure. 4-Homosulfanilamide using Ullmann's and Mangini's conditions, yielded the N1 and N4 derivatives, respectively. With benzylsulfonamide and benzenesulfonamide adopting Ullmann's method the corresponding N-substituted derivatives were obtained.
Publication Year: 1969
Publication Date: 1969-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 1
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