Title: ABSORPTION, EXCRETION AND DISTRIBUTION OF SULFAMETHAZINE
Abstract: The search for the ideal sulfonamide compound has directed our attention to sulfamethazine, the latest of the sulfonamide compounds. Sulfamethazine (2-sulfanilamido-4, 6-dimethylpyrimidine) is the dimethyl homologue of sulfadiazine. The few reports now in the literature credit it with less toxicity than the sulfonamide drugs now in use. Rose, Martin and Bevan<sup>1</sup>compared the solubility of this compound and its acetyl derivative with that of sulfapyridine, sulfadiazine and sulfathiazole. Sulfamethazine was found to be ten times more soluble in the free and five times more soluble in the acetylated form than sulfadiazine. Gilligan and Plummer<sup>2</sup>showed it to be the most soluble of all the sulfonamide compounds in the varying range of urinary<i>p</i>H in both its free and its acetylated form. Clinical studies have been made by Macartney and his associates<sup>3</sup>and others<sup>4</sup>on the use of the drug in the treatment of pneumonia in
Publication Year: 1945
Publication Date: 1945-03-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 8
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot