Publication Information

{'id': 'https://openalex.org/W2120879724', 'doi': 'https://doi.org/10.1071/ch02005', 'title': 'Glycosynthases: Mutant Glycosidases for Glycoside Synthesis', 'display_name': 'Glycosynthases: Mutant Glycosidases for Glycoside Synthesis', 'publication_year': 2002, 'publication_date': '2002-01-01', 'ids': {'openalex': 'https://openalex.org/W2120879724', 'doi': 'https://doi.org/10.1071/ch02005', 'mag': '2120879724'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1071/ch02005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91238560', 'display_name': 'Australian Journal of Chemistry', 'issn_l': '0004-9425', 'issn': ['0004-9425', '1445-0038'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320302', 'host_organization_name': 'CSIRO Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320302'], 'host_organization_lineage_names': ['CSIRO Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5021413336', 'display_name': 'Spencer J. Williams', 'orcid': 'https://orcid.org/0000-0001-6341-4364'}, 'institutions': [{'id': 'https://openalex.org/I1292875679', 'display_name': 'Commonwealth Scientific and Industrial Research Organisation', 'ror': 'https://ror.org/03qn8fb07', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I1292875679', 'https://openalex.org/I2801453606', 'https://openalex.org/I4387156119']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'S. J. Williams', 'raw_affiliation_strings': ['CSIRO'], 'affiliations': [{'raw_affiliation_string': 'CSIRO', 'institution_ids': ['https://openalex.org/I1292875679']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111802438', 'display_name': 'Stephen G. Withers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'S. G. Withers', 'raw_affiliation_strings': ['University of British Columbia'], 'affiliations': [{'raw_affiliation_string': 'University of British Columbia', 'institution_ids': ['https://openalex.org/I141945490']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.942, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 76, 'citation_normalized_percentile': {'value': 0.999945, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '55', 'issue': '2', 'first_page': '3', 'last_page': '3'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10835', 'display_name': 'Carbohydrate Chemistry and Synthesis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10835', 'display_name': 'Carbohydrate Chemistry and Synthesis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11617', 'display_name': 'Enzyme Production and Characterization', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glycosidic-bond', 'display_name': 'Glycosidic bond', 'score': 0.85870135}, {'id': 'https://openalex.org/keywords/glycoconjugate', 'display_name': 'Glycoconjugate', 'score': 0.6232958}, {'id': 'https://openalex.org/keywords/biocatalysis', 'display_name': 'Biocatalysis', 'score': 0.55298084}, {'id': 'https://openalex.org/keywords/glycosyl-donor', 'display_name': 'Glycosyl donor', 'score': 0.53158695}, {'id': 'https://openalex.org/keywords/saturated-mutagenesis', 'display_name': 'Saturated mutagenesis', 'score': 0.47320265}, {'id': 'https://openalex.org/keywords/residue', 'display_name': 'Residue (chemistry)', 'score': 0.42378822}], 'concepts': [{'id': 'https://openalex.org/C150487720', 'wikidata': 'https://www.wikidata.org/wiki/Q422553', 'display_name': 'Glycosidic bond', 'level': 3, 'score': 0.85870135}, {'id': 'https://openalex.org/C196032511', 'wikidata': 'https://www.wikidata.org/wiki/Q375795', 'display_name': 'Glycoside hydrolase', 'level': 3, 'score': 0.8149971}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7901015}, {'id': 'https://openalex.org/C13426554', 'wikidata': 'https://www.wikidata.org/wiki/Q416019', 'display_name': 'Glycoconjugate', 'level': 2, 'score': 0.6232958}, {'id': 'https://openalex.org/C191503008', 'wikidata': 'https://www.wikidata.org/wiki/Q16007026', 'display_name': 'Biocatalysis', 'level': 4, 'score': 0.55298084}, {'id': 'https://openalex.org/C49783314', 'wikidata': 'https://www.wikidata.org/wiki/Q17054443', 'display_name': 'Glycosyl donor', 'level': 3, 'score': 0.53158695}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.5223145}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.5020635}, {'id': 'https://openalex.org/C9418097', 'wikidata': 'https://www.wikidata.org/wiki/Q440681', 'display_name': 'Directed evolution', 'level': 4, 'score': 0.4870239}, {'id': 'https://openalex.org/C178907741', 'wikidata': 'https://www.wikidata.org/wiki/Q745930', 'display_name': 'Nucleophile', 'level': 3, 'score': 0.4831664}, {'id': 'https://openalex.org/C109129352', 'wikidata': 'https://www.wikidata.org/wiki/Q7426583', 'display_name': 'Saturated mutagenesis', 'level': 4, 'score': 0.47320265}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.45256758}, {'id': 'https://openalex.org/C2781338088', 'wikidata': 'https://www.wikidata.org/wiki/Q903495', 'display_name': 'Residue (chemistry)', 'level': 2, 'score': 0.42378822}, {'id': 'https://openalex.org/C2777313579', 'wikidata': 'https://www.wikidata.org/wiki/Q898365', 'display_name': 'Glycosylation', 'level': 2, 'score': 0.4158229}, {'id': 'https://openalex.org/C2780906977', 'wikidata': 'https://www.wikidata.org/wiki/Q2855177', 'display_name': 'Glycosyl', 'level': 2, 'score': 0.38361043}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.31221455}, {'id': 'https://openalex.org/C94412978', 'wikidata': 'https://www.wikidata.org/wiki/Q103135', 'display_name': 'Hydrolysis', 'level': 2, 'score': 0.2788404}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.27567858}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.23255482}, {'id': 'https://openalex.org/C65024703', 'wikidata': 'https://www.wikidata.org/wiki/Q373406', 'display_name': 'Reaction mechanism', 'level': 3, 'score': 0.10738295}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1071/ch02005', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91238560', 'display_name': 'Australian Journal of Chemistry', 'issn_l': '0004-9425', 'issn': ['0004-9425', '1445-0038'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320302', 'host_organization_name': 'CSIRO Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320302'], 'host_organization_lineage_names': ['CSIRO Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4206954498', 'https://openalex.org/W2952441076', 'https://openalex.org/W2952290038', 'https://openalex.org/W2951207642', 'https://openalex.org/W2131848808', 'https://openalex.org/W2108387799', 'https://openalex.org/W2083049833', 'https://openalex.org/W2031318672', 'https://openalex.org/W2002217917', 'https://openalex.org/W1628171761'], 'abstract_inverted_index': {'Glycosynthases': [0], 'are': [1, 22], 'engineered': [2], 'mutant': [3, 103], 'glycosidases': [4], 'that': [5, 65, 95], 'catalyse': [6], 'the': [7, 27, 80, 84, 97, 122, 134, 145, 159], 'formation': [8], 'of': [9, 26, 30, 47, 51, 83, 100, 102, 124, 147, 164], 'a': [10, 14, 31, 35, 49, 89, 129, 141], 'glycosidic': [11], 'bond': [12], 'from': [13], 'glycosyl': [15], 'donor': [16], 'and': [17, 69, 88, 132, 150, 161], 'an': [18], 'acceptor': [19], 'alcohol.': [20], 'They': [21], 'constructed': [23], 'by': [24, 128], 'mutation': [25], 'enzymic': [28], 'nucleophile': [29], 'retaining': [32], 'glycosidase': [33, 131], 'to': [34, 55, 120, 156], 'small': [36], 'non-nucleophilic': [37], 'residue.': [38], 'To': [39], 'date,': [40], 'five': [41], 'glycosynthases': [42, 104, 149], 'have': [43, 62, 78], 'been': [44, 63, 93, 118], 'reported': [45], 'capable': [46], 'synthesizing': [48], 'range': [50], 'β-glycosidic': [52], 'linkages.': [53], 'Methods': [54], 'integrate': [56], 'protecting': [57], 'groups': [58], 'into': [59], 'glycosynthase-mediated': [60], 'glycosylations': [61], 'developed': [64, 94, 119], 'broaden': [66], 'their': [67, 151], 'applicability': [68], 'enable': [70], 'finer': [71], 'control': [72], 'over': [73], 'product': [74], 'formation.': [75], 'Mutagenesis': [76], 'studies': [77], 'improved': [79, 108], 'catalytic': [81], 'power': [82], 'original': [85], 'Abg': [86], 'glycosynthase,': [87], 'general': [90], 'methodology': [91], 'has': [92, 117], 'allows': [96], 'rapid': [98, 160], 'screening': [99], 'libraries': [101], 'for': [105, 112, 144], 'catalysts': [106, 155], 'with': [107], 'activity.': [109], 'A': [110], 'method': [111], 'determining': [113], 'aglycon': [114], 'substrate': [115, 125], 'specificity': [116], 'define': [121], 'limits': [123], 'variation': [126], 'tolerated': [127], 'parent': [130], 'thence': [133], 'derived': [135], 'glycosynthase.': [136], 'Together,': [137], 'these': [138], 'developments': [139], 'portend': [140], 'bright': [142], 'future': [143], 'discovery': [146], 'new': [148], 'widespread': [152], 'application': [153], 'as': [154], 'assist': [157], 'in': [158], 'efficient': [162], 'assembly': [163], 'complex': [165], 'glycoconjugates.': [166]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2120879724', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-08T06:46:34.448662', 'created_date': '2016-06-24'}