Publication Information

{'id': 'https://openalex.org/W2119998088', 'doi': 'https://doi.org/10.2174/156720112800234558', 'title': 'Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer', 'display_name': 'Delivery Methods of Camptothecin and Its Hydrosoluble Analogue Irinotecan for Treatment of Colorectal Cancer', 'publication_year': 2012, 'publication_date': '2012-03-01', 'ids': {'openalex': 'https://openalex.org/W2119998088', 'doi': 'https://doi.org/10.2174/156720112800234558', 'mag': '2119998088', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22283650'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/156720112800234558', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S16973894', 'display_name': 'Current Drug Delivery', 'issn_l': '1567-2018', 'issn': ['1567-2018', '1875-5704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016876491', 'display_name': 'Adriano Mollica', 'orcid': 'https://orcid.org/0000-0002-7242-4860'}, 'institutions': [{'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Adriano Mollica', 'raw_affiliation_strings': ["Dipartimento di Scienze del Farmaco; Università di Chieti-Pescara “G. d'Annunzio”; Via dei Vestini 31; 66100; Chieti; Italy"], 'affiliations': [{'raw_affiliation_string': "Dipartimento di Scienze del Farmaco; Università di Chieti-Pescara “G. d'Annunzio”; Via dei Vestini 31; 66100; Chieti; Italy", 'institution_ids': ['https://openalex.org/I39387349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046245260', 'display_name': 'Azzurra Stefanucci', 'orcid': 'https://orcid.org/0000-0001-7525-2913'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Azzurra Stefanucci', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041303335', 'display_name': 'Federica Feliciani', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Federica Feliciani', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079217444', 'display_name': 'Ivana Cacciatore', 'orcid': 'https://orcid.org/0000-0001-6253-0443'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ivana Cacciatore', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109094861', 'display_name': 'Catia Cornacchia', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Catia Cornacchia', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009307390', 'display_name': 'Francesco Pinnen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Francesco Pinnen', 'raw_affiliation_strings': ['Dipartimento di Scienze del Farmaco, Università di Chieti-Pescara "G. d\'Annunzio", Via dei Vestini 31,66100 Chieti, Italy.,Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Scienze del Farmaco, Università di Chieti-Pescara "G. d\'Annunzio", Via dei Vestini 31,66100 Chieti, Italy.,Italy', 'institution_ids': ['https://openalex.org/I39387349']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5009307390'], 'corresponding_institution_ids': ['https://openalex.org/I39387349'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.258, 'has_fulltext': False, 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.425269, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '9', 'issue': '2', 'first_page': '122', 'last_page': '131'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10073', 'display_name': 'Hepatocellular Carcinoma Treatment and Prognosis', 'score': 0.9782, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.9350345}, {'id': 'https://openalex.org/keywords/sn-38', 'display_name': 'SN-38', 'score': 0.6068355}], 'concepts': [{'id': 'https://openalex.org/C2780259306', 'wikidata': 'https://www.wikidata.org/wiki/Q412197', 'display_name': 'Irinotecan', 'level': 4, 'score': 0.9560255}, {'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.9350345}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.6850386}, {'id': 'https://openalex.org/C2780508388', 'wikidata': 'https://www.wikidata.org/wiki/Q1750127', 'display_name': 'SN-38', 'level': 5, 'score': 0.6068355}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.48100838}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.37459922}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3345489}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3008575}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.21755302}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08267751}], 'mesh': [{'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077146', 'descriptor_name': 'Irinotecan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/156720112800234558', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S16973894', 'display_name': 'Current Drug Delivery', 'issn_l': '1567-2018', 'issn': ['1567-2018', '1875-5704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22283650', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.87, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4225948320', 'https://openalex.org/W3028060764', 'https://openalex.org/W2941541752', 'https://openalex.org/W2741955981', 'https://openalex.org/W2740933763', 'https://openalex.org/W2131063689', 'https://openalex.org/W2099983360', 'https://openalex.org/W2014550324', 'https://openalex.org/W2010936618', 'https://openalex.org/W1999929317'], 'abstract_inverted_index': {'Camptothecins': [0], 'are': [1, 67, 101], 'a': [2, 16, 25], 'family': [3], 'of': [4, 35, 99, 105, 113, 116], 'alkaloids': [5], 'originally': [6], 'extracted': [7], 'from': [8], 'the': [9, 33, 57, 111, 114], 'Chinese': [10], 'tree': [11], 'Camptotheca': [12], 'acuminata,': [13], 'Nyssaceae,': [14], 'exhibiting': [15], 'strong': [17], 'activity': [18], 'against': [19], 'colorectal': [20, 128], 'cancer': [21, 129], '(CRC).': [22], 'CRC': [23, 78], 'is': [24, 79, 108], 'common': [26], 'malignancy': [27], 'worlwide.': [28], 'Despite': [29], 'significant': [30], 'developments': [31], 'in': [32], 'treatment': [34], 'this': [36, 106], 'disease,': [37], 'it': [38], 'still': [39], 'causes': [40], 'considerable': [41], 'morbidity': [42], 'and': [43, 52, 65, 87, 96, 118], 'mortality.': [44], 'Recent': [45], 'advances': [46], 'include': [47], 'both': [48], 'newer': [49], 'cytotoxic': [50], 'chemotherapies': [51], 'novel': [53], 'biological': [54], 'agents': [55], 'including': [56], 'more': [58], 'hydrosoluble': [59], 'camptothecin': [60, 117], 'derivative,': [61], 'namely': [62], 'irinotecan.': [63], 'Camptothecin': [64], 'irinotecan': [66], 'selective': [68], 'human': [69], 'topoisomerase': [70], 'I': [71, 132], 'inhibitors': [72], 'but': [73], 'their': [74, 82], 'application': [75], 'for': [76], 'curing': [77], 'compromised': [80], 'by': [81], 'intrinsic': [83], 'high': [84], 'toxicity,': [85], 'insolubility': [86], 'instability.': [88], 'Furthermore,': [89], 'pharmacology': [90], 'studies': [91], 'have': [92], 'determined': [93], 'that': [94], 'continuously': [95], 'prolonged': [97], 'schedules': [98], 'administration': [100], 'required.': [102], 'The': [103], 'aim': [104], 'work': [107], 'to': [109], 'review': [110], 'state': [112], 'art': [115], 'its': [119], 'derivative': [120], 'irinotecans': [121], 'delivery': [122], 'methods.': [123], 'Keywords:': [124], 'Camptothecin,': [125], 'irinotecan,': [126], 'topotecan,': [127], '(CRC),': [130], 'Topoisomerase': [131], '(TOP': [133], 'I),': [134], 'pro-drugs,': [135], 'multi-wall': [136], 'carbon': [137], 'nanotubes,': [138], 'nanoemulsions,': [139], 'Drug': [140], 'eluting': [141], 'beads,': [142], 'liposomes,': [143], 'Micelles,': [144], 'Miniemulsions': [145]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2119998088', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-10T04:04:11.007765', 'created_date': '2016-06-24'}