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Results for 'SN-38'
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Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.
Publication Year: 1991
DOI: DOI not
available
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Authors:
Yasuyoshi Kawato
Masashi Aonuma
Yasuhide Hirota
Hiroshi Kuga
Keiki Sato
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.
Publication Year: 1998
DOI: https://doi.org/10.1172/jci915
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Authors:
Lalitha Iyer
Christopher D. King
P. F. Whitington
M D Green
Sandip Kumar Roy
Thomas R. Tephly
Birgit L. Coffman
Mark J. Ratain
A micro-indentation study of superplasticity in Pb, Sn, and Sn-38 wt% Pb
Publication Year: 1988
DOI: https://doi.org/10.1016/0001-6160(88)90319-7
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Authors:
Merrilea J. Mayo
William D. Nix
Common Human <i>UGT1A</i> Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38)
Publication Year: 2002
DOI: https://doi.org/10.1124/mol.62.3.608
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Authors:
Jean-François Gagné
Valérie Montminy
Patrick Bélanger
Kim Journault
Geneviève Gaucher
Chantal Guillemette
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism
Publication Year: 1999
DOI: https://doi.org/10.1016/s0009-9236(99)70078-0
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Authors:
Lalitha Iyer
Diana Hall
Sudip Das
M.P. Mortell
Jorge H Ramírez
S KIM
Anna Di Rienzo
Mark J. Ratain
Enhanced Delivery of SN-38 to Human Tumor Xenografts with an Anti-Trop-2–SN-38 Antibody Conjugate (Sacituzumab Govitecan)
Publication Year: 2015
DOI: https://doi.org/10.1158/1078-0432.ccr-15-0670
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Authors:
Robert M. Sharkey
William J. McBride
Thomas M. Cardillo
Serengulam V. Govindan
Yang Wang
Edmund A. Rossi
Chien‐Hsing Chang
David M. Goldenberg
Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 <b> <i>in Vitro</i> </b>
Publication Year: 2004
DOI: https://doi.org/10.1158/0008-5472.can-03-3344
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Authors:
Peter J. Houghton
Glen S. Germain
Franklin C. Harwood
John D. Schuetz
Clinton F. Stewart
Elisabeth Buchdunger
Peter Traxler
Novel SN-38–Incorporating Polymeric Micelles, NK012, Eradicate Vascular Endothelial Growth Factor–Secreting Bulky Tumors
Publication Year: 2006
DOI: https://doi.org/10.1158/0008-5472.can-06-1605
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Authors:
Fumiaki Koizumi
Masayuki Kitagawa
Takahito Negishi
Takeshi Onda
Shin-ichi Matsumoto
Tetsuya Hamaguchi
Yasuhiro Matsumura
Development and characterization of a novel liposome-based formulation of SN-38
Publication Year: 2003
DOI: https://doi.org/10.1016/j.ijpharm.2003.10.015
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Authors:
J.Allen Zhang
Tong Xuan
Manjeet M. Parmar
Lan Ma
Sydney O. Ugwu
Shahid Ali
Imran Ahmad
Milatuzumab–SN-38 Conjugates for the Treatment of CD74+ Cancers
Publication Year: 2013
DOI: https://doi.org/10.1158/1535-7163.mct-12-1170
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Authors:
Serengulam V. Govindan
Thomas M. Cardillo
Robert M. Sharkey
Fatma Tat
David V. Gold
David M. Goldenberg
UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan
Publication Year: 1998
DOI: https://doi.org/10.1023/a:1008438109725
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Authors:
Yukio Ando
Hideo Saka
Gyo Asai
Shigeki Sugiura
Kaoru Shimokata
Tetsuya Kamataki
First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors
Publication Year: 2015
DOI: https://doi.org/10.1158/1078-0432.ccr-14-3321
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Authors:
Alexander Starodub
Allyson J. Ocean
Manish A. Shah
Michael J. Guarino
Vincent J. Picozzi
Linda T. Vahdat
Sajeve Thomas
Serengulam V. Govindan
Pius Maliakal
William A. Wegener
Steven A. Hamburger
Robert M. Sharkey
David M. Goldenberg
Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody–Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers
Publication Year: 2015
DOI: https://doi.org/10.1021/acs.bioconjchem.5b00223
Abstract:
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Authors:
Thomas M. Cardillo
Serengulam V. Govindan
Robert M. Sharkey
Preeti Trisal
Roberto Arrojo
Donglin Liu
Edmund A. Rossi
Chien‐Hsing Chang
David M. Goldenberg
Humanized Anti-Trop-2 IgG-SN-38 Conjugate for Effective Treatment of Diverse Epithelial Cancers: Preclinical Studies in Human Cancer Xenograft Models and Monkeys
Publication Year: 2011
DOI: https://doi.org/10.1158/1078-0432.ccr-10-2939
Abstract:
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Authors:
Thomas M. Cardillo
Serengulam V. Govindan
Robert M. Sharkey
Preeti Trisal
David M. Goldenberg
Population pharmacokinetic model for irinotecan and two of its metabolites, SN-38 and SN-38 glucuronide
Publication Year: 2002
DOI: https://doi.org/10.1067/mcp.2002.129502
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