Publication Information

{'id': 'https://openalex.org/W2118924840', 'doi': 'https://doi.org/10.1152/ajpheart.00563.2003', 'title': 'Inotropic effects of ET<sub>B</sub>receptor stimulation and their modulation by endocardial endothelium, NO, and prostaglandins', 'display_name': 'Inotropic effects of ET<sub>B</sub>receptor stimulation and their modulation by endocardial endothelium, NO, and prostaglandins', 'publication_year': 2004, 'publication_date': '2004-05-11', 'ids': {'openalex': 'https://openalex.org/W2118924840', 'doi': 'https://doi.org/10.1152/ajpheart.00563.2003', 'mag': '2118924840', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15130886'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpheart.00563.2003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S87338489', 'display_name': 'AJP Heart and Circulatory Physiology', 'issn_l': '0363-6135', 'issn': ['0363-6135', '1522-1539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060298206', 'display_name': 'Adelino Leite‐Moreira', 'orcid': 'https://orcid.org/0000-0001-7808-3596'}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Adelino F. Leite-Moreira', 'raw_affiliation_strings': ['Department of Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052974638', 'display_name': 'Carmen Brás‐Silva', 'orcid': 'https://orcid.org/0000-0003-1527-3776'}, 'institutions': [{'id': 'https://openalex.org/I182534213', 'display_name': 'Universidade do Porto', 'ror': 'https://ror.org/043pwc612', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I182534213']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Carmen Brás-Silva', 'raw_affiliation_strings': ['Department of Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal', 'institution_ids': ['https://openalex.org/I182534213']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.584, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.708938, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '287', 'issue': '3', 'first_page': 'H1194', 'last_page': 'H1199'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11217', 'display_name': 'Cardiac Arrhythmias and Treatments', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7259259}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.7228095}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.7213057}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.69315135}, {'id': 'https://openalex.org/C144980905', 'wikidata': 'https://www.wikidata.org/wiki/Q24721308', 'display_name': 'Endothelin receptor', 'level': 3, 'score': 0.6082837}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.54782957}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.49316782}, {'id': 'https://openalex.org/C149601957', 'wikidata': 'https://www.wikidata.org/wiki/Q390566', 'display_name': 'Endothelin 1', 'level': 3, 'score': 0.46688524}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.45121813}, {'id': 'https://openalex.org/C163415756', 'wikidata': 'https://www.wikidata.org/wiki/Q126473', 'display_name': 'Contraction (grammar)', 'level': 2, 'score': 0.44785717}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.18861467}], 'mesh': [{'descriptor_ui': 'D004699', 'descriptor_name': 'Endocardium', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011453', 'descriptor_name': 'Prostaglandins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044023', 'descriptor_name': 'Receptor, Endothelin B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004699', 'descriptor_name': 'Endocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019332', 'descriptor_name': 'Endothelin-1', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019332', 'descriptor_name': 'Endothelin-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016232', 'descriptor_name': 'Endothelins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016232', 'descriptor_name': 'Endothelins', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D016232', 'descriptor_name': 'Endothelins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004727', 'descriptor_name': 'Endothelium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004727', 'descriptor_name': 'Endothelium', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011453', 'descriptor_name': 'Prostaglandins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020033', 'descriptor_name': 'Protein Isoforms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044023', 'descriptor_name': 'Receptor, Endothelin B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014757', 'descriptor_name': 'Viper Venoms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014757', 'descriptor_name': 'Viper Venoms', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D014757', 'descriptor_name': 'Viper Venoms', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpheart.00563.2003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S87338489', 'display_name': 'AJP Heart and Circulatory Physiology', 'issn_l': '0363-6135', 'issn': ['0363-6135', '1522-1539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15130886', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.43}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W1531734841', 'https://openalex.org/W1842217482', 'https://openalex.org/W1889745175', 'https://openalex.org/W1969264369', 'https://openalex.org/W1969824861', 'https://openalex.org/W1970616759', 'https://openalex.org/W1970733000', 'https://openalex.org/W1973304156', 'https://openalex.org/W1975260965', 'https://openalex.org/W1977343715', 'https://openalex.org/W1979026148', 'https://openalex.org/W1979395246', 'https://openalex.org/W1996736509', 'https://openalex.org/W2000322240', 'https://openalex.org/W2003055862', 'https://openalex.org/W2004382577', 'https://openalex.org/W2004874253', 'https://openalex.org/W2008070910', 'https://openalex.org/W2012828668', 'https://openalex.org/W2019600599', 'https://openalex.org/W2021838680', 'https://openalex.org/W2023566877', 'https://openalex.org/W2024021751', 'https://openalex.org/W2025252445', 'https://openalex.org/W2029816807', 'https://openalex.org/W2032093326', 'https://openalex.org/W2033411054', 'https://openalex.org/W2034373437', 'https://openalex.org/W2037008180', 'https://openalex.org/W2044527943', 'https://openalex.org/W2054733362', 'https://openalex.org/W2056709201', 'https://openalex.org/W2059369537', 'https://openalex.org/W2060411128', 'https://openalex.org/W2067636590', 'https://openalex.org/W2069629971', 'https://openalex.org/W2079063592', 'https://openalex.org/W2081164098', 'https://openalex.org/W2081639214', 'https://openalex.org/W2090303578', 'https://openalex.org/W2092591926', 'https://openalex.org/W2104840130', 'https://openalex.org/W2106607972', 'https://openalex.org/W2113130764', 'https://openalex.org/W2113299996', 'https://openalex.org/W2121432106', 'https://openalex.org/W2144796862', 'https://openalex.org/W2151869895', 'https://openalex.org/W2158990159', 'https://openalex.org/W2162804111', 'https://openalex.org/W2167077199', 'https://openalex.org/W2171117648', 'https://openalex.org/W2171952998', 'https://openalex.org/W2260186455', 'https://openalex.org/W2270108916', 'https://openalex.org/W2279139711', 'https://openalex.org/W2303660595', 'https://openalex.org/W2322508982', 'https://openalex.org/W2334342212', 'https://openalex.org/W2412961266', 'https://openalex.org/W2413213201', 'https://openalex.org/W2437427433', 'https://openalex.org/W4249581077', 'https://openalex.org/W4302410937', 'https://openalex.org/W64111220', 'https://openalex.org/W99062900'], 'related_works': ['https://openalex.org/W2382515547', 'https://openalex.org/W2377343248', 'https://openalex.org/W2125471807', 'https://openalex.org/W2114161702', 'https://openalex.org/W2081767905', 'https://openalex.org/W2033181528', 'https://openalex.org/W2028774514', 'https://openalex.org/W1992367101', 'https://openalex.org/W1979020445', 'https://openalex.org/W1968790869'], 'abstract_inverted_index': {'Endothelin': [0], '(ET)-1': [1], 'acts': [2], 'on': [3, 21], 'ETA': [4], 'and': [5, 13, 88, 160, 255, 260, 275], 'ETB': [6, 38], 'receptors.': [7], 'The': [8, 54], 'latter': [9], 'include': [10], 'ETB1': [11, 249], '(endothelial)': [12], 'ETB2': [14, 283], '(muscular)': [15], 'subtypes,': [16], 'which': [17], 'mediate': [18], 'opposite': [19], 'effects': [20, 36, 55, 99], 'vascular': [22], 'tone.': [23], 'This': [24], 'study': [25], 'investigated,': [26], 'in': [27, 45, 71, 82, 91, 103, 126, 169, 192, 216, 231], 'rabbit': [28], 'papillary': [29], 'muscles': [30, 72, 132, 193, 217], '(n': [31], '=': [32], '84),': [33], 'the': [34, 46, 83, 92, 104, 127, 170, 178, 232, 240, 263], 'myocardial': [35, 143], 'of': [37, 50, 56, 85, 94, 106, 129, 172, 180, 234], 'stimulation.': [39, 284], 'ET-1': [40, 110], '(10(-9)': [41], 'M)': [42, 61, 68, 148, 191, 215], 'was': [43, 158, 200, 204, 224, 228, 271], 'given': [44], 'absence': [47], 'or': [48, 62, 75, 165, 174, 230, 236, 273], 'presence': [49, 84, 93, 105, 128, 171, 179, 233], 'BQ-123': [51], '(ETA': [52], 'antagonist).': [53, 109], 'IRL-1620': [57, 206], '(ETB1': [58], 'agonist,': [59, 66], '10(-10)-10(-6)': [60, 67], 'sarafotoxin': [63, 136, 182], 'S6c': [64, 98, 137, 146, 183], '(ETB': [65], 'were': [69, 100], 'evaluated': [70], 'with': [73, 133, 194, 218], 'intact': [74, 80, 89, 134, 195, 219, 253], 'damaged': [76, 159, 229, 272], 'endocardial': [77], 'endothelium': [78], '(EE);': [79], 'EE,': [81, 90, 135, 196, 220, 254], 'NG-nitro-L-arginine': [86], '(L-NNA);': [87], 'indomethacin': [95], '(Indo).': [96], 'Sarafotoxin': [97, 145], 'also': [101, 207], 'studied': [102], 'BQ-788': [107], '(ETB2': [108], 'alone': [111, 138], 'increased': [112], '64': [113], '+/-': [114, 124, 154, 163, 167, 187, 211], '18%': [115], 'active': [116], 'tension': [117], '(AT)': [118], 'but': [119], 'decreased': [120, 184, 208], 'it': [121], 'by': [122, 152, 161, 258], '4': [123], '2%': [125], 'BQ-123.': [130], 'In': [131, 177, 238], 'did': [139], 'not': [140], 'significantly': [141], 'alter': [142], 'performance.': [144], '(10(-6)': [147], 'increased,': [149], 'however,': [150], 'AT': [151, 185, 209], '120': [153], '27%': [155], 'when': [156, 202, 226, 269], 'EE': [157, 203, 227, 270], '39': [162], '8%': [164], '23': [166], '6%': [168], 'l-NNA': [173], 'Indo,': [175], 'respectively.': [176], 'BQ-788,': [181], '(21': [186], '3%': [188, 212], 'at': [189, 213], '10(-6)': [190, 214], 'an': [197, 221, 252], 'effect': [198, 222, 244], 'that': [199, 223], 'abolished': [201, 225], 'damaged.': [205], '(22': [210], 'L-NNA': [235], 'Indo.': [237], 'conclusion,': [239], 'ETB-mediated': [241, 264], 'negative': [242], 'inotropic': [243, 266], 'is': [245, 256, 279], 'presumably': [246, 280], 'due': [247, 281], 'to': [248, 282], 'stimulation,': [250], 'requires': [251], 'mediated': [257], 'NO': [259, 274], 'prostaglandins,': [261], 'whereas': [262], 'positive': [265], 'effect,': [267], 'observed': [268], 'prostaglandins': [276], 'synthesis': [277], 'inhibited,': [278]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2118924840', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-13T17:51:15.211318', 'created_date': '2016-06-24'}