Title: Therapeutic effect of antagonizing endothelin on traumatic shock in rats
Abstract:Objective To investigate the therapeutic effect of antagonizing endothelin [including selective ETA receptor antagonist (BQ-123),non-selective ETA/B receptor antagonist (PD 142893)and ET antagonist,ca...Objective To investigate the therapeutic effect of antagonizing endothelin [including selective ETA receptor antagonist (BQ-123),non-selective ETA/B receptor antagonist (PD 142893)and ET antagonist,caffeic acid (CFA)]on the treatment of traumatic shock in rats.Methods Experimental model of traumatic shock in Sprague-Dawlay rats were made and randomly divided into 5 groups:group S (shock), group B(shock+BQ-123),group P(shock+PD 142893),group C(shock+CFA)and group L(shock+BQ-123+CFA)based on the difference of resuscitation.Plasma ET levels and PaO 2 were detected at pre-shock,post-shock and/or 1,3 5 h after resuscitation.Meanwhile,hemodynamic data and survival time of the rats were monitored and recorded.Results There was statistically significant difference in plasma ET levels and PaO 2 among all the groups before and after shock( P 0 05).In group B at 1,3 h,group C and group L at 5 h after resuscitation,plasma ET levels and mean survival time were significantly different compared with group S.Although in group L,plasma ET levels and PaO 2 were not significantly different compared with group C,the mean survival time was longer( P 0 05) Conclusion ET plays important roles in the pathogenesis of traumatic shock.Selective ETA receptor antagonist (BQ-123)and ET antagonist,caffeic acid (CFA)can improve PaO 2 and prolong the mean survival time.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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