Publication Information

{'id': 'https://openalex.org/W1946967684', 'doi': None, 'title': 'Potentiation of topoisomerase inhibitor-induced DNA strand breakage and cytotoxicity by tumor necrosis factor: enhancement of topoisomerase activity as a mechanism of potentiation.', 'display_name': 'Potentiation of topoisomerase inhibitor-induced DNA strand breakage and cytotoxicity by tumor necrosis factor: enhancement of topoisomerase activity as a mechanism of potentiation.', 'publication_year': 1990, 'publication_date': '1990-05-01', 'ids': {'openalex': 'https://openalex.org/W1946967684', 'mag': '1946967684', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2158396'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2158396', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077000893', 'display_name': 'Teruhiro Utsugi', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T Utsugi', 'raw_affiliation_strings': ['Department of Immunology, Smith Kline & French Laboratories, King of Prussia, Pennsylvania 19406.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Smith Kline & French Laboratories, King of Prussia, Pennsylvania 19406.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041975716', 'display_name': 'Michael R. Mattern', 'orcid': 'https://orcid.org/0000-0002-8595-000X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M R Mattern', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019123596', 'display_name': 'Christopher K. Mirabelli', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C K Mirabelli', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074473587', 'display_name': 'Nabil Hanna', 'orcid': 'https://orcid.org/0000-0002-3288-5486'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'N Hanna', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.314, 'has_fulltext': False, 'cited_by_count': 59, 'citation_normalized_percentile': {'value': 0.794049, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '50', 'issue': '9', 'first_page': '2636', 'last_page': '40'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9942, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/amsacrine', 'display_name': 'Amsacrine', 'score': 0.93699867}, {'id': 'https://openalex.org/keywords/teniposide', 'display_name': 'Teniposide', 'score': 0.89430654}, {'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.8920127}, {'id': 'https://openalex.org/keywords/topoisomerase-inhibitor', 'display_name': 'Topoisomerase inhibitor', 'score': 0.63669354}], 'concepts': [{'id': 'https://openalex.org/C2780500152', 'wikidata': 'https://www.wikidata.org/wiki/Q2784004', 'display_name': 'Amsacrine', 'level': 4, 'score': 0.93699867}, {'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.9092929}, {'id': 'https://openalex.org/C2778707968', 'wikidata': 'https://www.wikidata.org/wiki/Q417555', 'display_name': 'Teniposide', 'level': 4, 'score': 0.89430654}, {'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.8920127}, {'id': 'https://openalex.org/C2778119113', 'wikidata': 'https://www.wikidata.org/wiki/Q418817', 'display_name': 'Etoposide', 'level': 3, 'score': 0.86879265}, {'id': 'https://openalex.org/C2778616834', 'wikidata': 'https://www.wikidata.org/wiki/Q281044', 'display_name': 'Topoisomerase inhibitor', 'level': 4, 'score': 0.63669354}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.568864}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.45748487}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.4444529}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4301095}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4126693}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.39263517}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37622467}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.34186137}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.201466}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.17051518}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.105103135}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D059005', 'descriptor_name': 'Topoisomerase II Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000677', 'descriptor_name': 'Amsacrine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000677', 'descriptor_name': 'Amsacrine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D004250', 'descriptor_name': 'DNA Topoisomerases, Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004250', 'descriptor_name': 'DNA Topoisomerases, Type II', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2158396', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.54, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1514525963', 'https://openalex.org/W1529230134', 'https://openalex.org/W1536538430', 'https://openalex.org/W1551187478', 'https://openalex.org/W1566761847', 'https://openalex.org/W1598282819', 'https://openalex.org/W1644277640', 'https://openalex.org/W1776295853', 'https://openalex.org/W1954622523', 'https://openalex.org/W1973057627', 'https://openalex.org/W1982323444', 'https://openalex.org/W1987000956', 'https://openalex.org/W2007451263', 'https://openalex.org/W2016254453', 'https://openalex.org/W2043047471', 'https://openalex.org/W2052450573', 'https://openalex.org/W2081482521', 'https://openalex.org/W2093993014', 'https://openalex.org/W2105054347', 'https://openalex.org/W2128635872', 'https://openalex.org/W2403137753', 'https://openalex.org/W96728624'], 'related_works': ['https://openalex.org/W2396796971', 'https://openalex.org/W2344056970', 'https://openalex.org/W2122525202', 'https://openalex.org/W2099238800', 'https://openalex.org/W2013048947', 'https://openalex.org/W2006380088', 'https://openalex.org/W1995556774', 'https://openalex.org/W1946967684', 'https://openalex.org/W1598282819', 'https://openalex.org/W1531780611'], 'abstract_inverted_index': {'A': [0], 'combination': [1, 38], 'of': [2, 39, 47, 52, 64, 69, 125, 131, 145, 167, 179, 192, 201, 221, 234, 237, 239, 263, 265], 'tumor': [3, 53], 'necrosis': [4], 'factor': [5], '(TNF)': [6], 'and': [7, 19, 41, 114, 173, 183, 195, 232, 241], 'the': [8, 14, 26, 45, 50, 62, 67, 89, 132, 143, 162, 199, 222, 230, 235, 260], 'topoisomerase': [9, 15, 57, 78, 90, 226, 269], 'I': [10, 58, 182], 'inhibitor,': [11], 'camptothecin,': [12, 115], 'or': [13, 59, 121, 139, 147, 207], 'II': [16, 60], 'inhibitors,': [17, 61], 'teniposide': [18], 'amsacrine,': [20, 116], 'produced': [21, 170], 'dose-dependent': [22], 'synergistic': [23, 245], 'cytotoxicity': [24], 'against': [25], 'murine': [27], 'L929': [28, 82, 168, 266], 'fibrosarcoma': [29], 'cells.': [30], 'Similar': [31], 'synergy': [32], 'was': [33, 80], 'not': [34, 101], 'observed': [35, 157], 'with': [36, 88, 112, 134, 161, 252], 'a': [37, 171, 253], 'TNF': [40, 48, 65, 98, 113, 135, 165, 193, 240], 'bleomycin.': [42], 'To': [43], 'define': [44], 'role': [46, 254], 'in': [49, 75, 150, 158, 176, 212, 224, 259], 'augmentation': [51], 'cell': [54, 216], 'killing': [55, 264], 'by': [56, 77, 196, 268], 'effect': [63], 'on': [66], 'production': [68], 'enzyme-linked': [70], 'DNA': [71, 103, 257], 'strand': [72, 94, 104, 126, 153], 'breaks': [73, 127, 154], 'induced': [74], 'cells': [76, 83, 108, 133, 159, 169, 267], 'inhibitors': [79, 91, 242], 'investigated.': [81], 'incubated': [84, 110, 160], 'for': [85, 136, 243, 255], '1': [86], 'h': [87, 141], 'contained': [92], 'protein-linked': [93], 'breaks.': [95], 'In': [96], 'contrast,': [97], 'alone': [99], 'did': [100], 'induce': [102], 'breakage.': [105], 'However,': [106], 'when': [107], 'were': [109, 128, 187, 204], 'simultaneously': [111], 'Adriamycin,': [117], 'actinomycin': [118], 'D,': [119], 'teniposide,': [120], 'etoposide,': [122], 'increased': [123], 'numbers': [124], 'produced.': [129], 'Preincubation': [130], '30': [137, 197], 'min': [138, 191, 198], '3': [140], 'before': [142], 'addition': [144, 238], 'camptothecin': [146], 'etoposide': [148], 'resulted': [149], 'no': [151], 'more': [152], 'than': [155, 209], 'that': [156], 'drugs': [163], 'alone.': [164], 'treatment': [166, 194], 'rapid': [172], 'transient': [174, 219], 'increase': [175, 223], 'specific': [177], 'activity': [178, 227], 'extractable': [180, 202, 225], 'topoisomerases': [181], 'II.': [184], 'These': [185, 247], 'increases': [186], 'maximum': [188], 'at': [189], '2-5': [190], 'activities': [200], 'enzymes': [203], 'equal': [205], 'to': [206], 'less': [208], 'those': [210], 'detected': [211], 'extracts': [213], 'from': [214], 'untreated': [215], 'controls.': [217], 'The': [218], 'nature': [220], 'may': [228], 'explain': [229], 'kinetics': [231], 'significance': [233], 'order': [236], 'maximal': [244], 'activity.': [246], 'data': [248], 'are': [249], 'consistent': [250], 'also': [251], 'topoisomerase-linked': [256], 'lesions': [258], 'TNF-mediated': [261], 'potentiation': [262], 'inhibitors.': [270]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1946967684', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-08T04:06:40.774362', 'created_date': '2016-06-24'}