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'T2-weighted': [7, 104], 'white': [8, 26, 46, 52, 75, 109, 119, 151, 165, 178, 229, 242], 'matter': [9, 27, 53, 76, 110, 120, 148, 152, 166], 'hyperintensity': [10, 105], 'in': [11, 25, 50, 62, 106, 123, 146, 167, 172, 184, 194, 200], 'the': [12, 58, 112, 154, 173, 195, 220], 'context': [13], 'of': [14, 60, 103, 117, 153, 197, 222, 240], 'a': [15, 181, 205], 'previous': [16], 'clinical': [17], 'lacunar': [18], 'stroke.': [19], 'Reduced': [20], 'cerebral': [21], 'blood': [22, 77], 'flow': [23], '(CBF)': [24], 'has': [28], 'been': [29], 'demonstrated,': [30], 'but': [31], 'it': [32], 'is': [33, 38], 'not': [34, 158], 'known': [35], 'whether': [36, 216, 234], 'hypoperfusion': [37, 61], 'confined': [39], 'lesions': [41, 199, 224], 'or': [42], 'extends': [43], 'into': [44], 'normal-appearing': [45, 51, 118, 150, 164, 241], 'matter.': [47, 243], 'Demonstrating': [48], 'changes': [49, 218], 'would': [54, 65], 'provide': [55], 'clues': [56], 'importance': [59], 'pathogenesis': [63], 'and': [64, 84, 100, 111, 149, 202, 225, 231], 'be': [66, 190], 'an': [67, 191], 'obvious': [68], 'target': [69], 'for': [70, 135], 'therapies': [71], 'aimed': [72], 'at': [73], 'restoring': [74], 'flow.': [78], '<b><i><i>Methods:</i></i></b>': [79], 'Twenty-one': [80], 'patients': [81, 127], 'with': [82, 128, 180], 'ILA,': [83, 129], '16': [85], 'age-matched': [86], 'control': [87, 185], 'subjects,': [88], 'underwent': [89], 'exogenous': [90], 'contrast-based': [91], 'quantitative': [92], 'perfusion': [93, 239], 'MRI.': [94], 'CBF': [95, 116, 145, 169], 'was': [96, 121, 170], 'determined': [97], 'both': [98, 107], 'within': [99], 'outside': [101], 'areas': [102], 'periventricular': [108, 124, 177, 198], 'centrum': [113, 155, 174], 'semiovale.': [114], '<b><i><i>Results:</i></i></b>': [115], 'reduced': [122], 'regions': [125], '(for': [126], '17.9': [130], '±': [131, 138], '5.6': [132], 'mL/100': [133, 140], 'g/min;': [134, 141], 'controls,': [136], '21.6': [137], '5.1': [139], '<i>p</i>': [142], '=': [143], '0.046).': [144], 'gray': [147], 'semiovale': [156, 175], 'did': [157], 'differ': [159], 'significantly': [160], 'between': [161], 'groups.': [162], 'In': [163], 'patients,': [168], 'higher': [171], 'than': [176], 'matter,': [179, 230], 'similar': [182], 'trend': [183], 'subjects.': [186], '<b><i><i>Conclusions:</i></i></b>': [187], 'Hypoperfusion': [188], 'may': [189, 203], 'early': [192], 'feature': [193], 'development': [196], 'ILA': [201], 'play': [204], 'direct': [206], 'pathogenic': [207], 'role.': [208], 'Serial': [209], 'studies': [210], 'are': [211], 'now': [212], 'needed': [213], 'determine': [215, 233], 'these': [217], 'herald': [219], 'appearance': [221], 'new': [223], 'represent': [226], '‘at': [227], 'risk’': [228], 'pharmacological': [235], 'agents': [236], 'can': [237], 'restore': [238]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2117359502', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 20}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 20}, {'year': 2017, 'cited_by_count': 28}, {'year': 2016, 'cited_by_count': 28}, {'year': 2015, 'cited_by_count': 22}, {'year': 2014, 'cited_by_count': 25}, {'year': 2013, 'cited_by_count': 22}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-09-10T01:22:58.731761', 'created_date': '2016-06-24'}