Publication Information

{'id': 'https://openalex.org/W2116471121', 'doi': 'https://doi.org/10.1136/heartjnl-2012-302920a.201', 'title': 'μ-CALPAIN MEDIATES MYOCARDIAL APOPTOSIS DURING ISCHAEMIA-REPERFUSION VIA MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING', 'display_name': 'μ-CALPAIN MEDIATES MYOCARDIAL APOPTOSIS DURING ISCHAEMIA-REPERFUSION VIA MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING', 'publication_year': 2012, 'publication_date': '2012-10-01', 'ids': {'openalex': 'https://openalex.org/W2116471121', 'doi': 'https://doi.org/10.1136/heartjnl-2012-302920a.201', 'mag': '2116471121'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/heartjnl-2012-302920a.201', 'pdf_url': 'https://heart.bmj.com/content/heartjnl/98/Suppl_2/E79.2.full.pdf', 'source': {'id': 'https://openalex.org/S191565391', 'display_name': 'Heart', 'issn_l': '1355-6037', 'issn': ['1355-6037', '1468-201X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://heart.bmj.com/content/heartjnl/98/Suppl_2/E79.2.full.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100711973', 'display_name': 'Tao Luo', 'orcid': 'https://orcid.org/0000-0002-4144-4500'}, 'institutions': [{'id': 'https://openalex.org/I4210108565', 'display_name': 'Affiliated Hospital of North Sichuan Medical College', 'ror': 'https://ror.org/01673gn35', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108565']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tao Luo', 'raw_affiliation_strings': ['Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China', 'institution_ids': ['https://openalex.org/I4210108565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041111707', 'display_name': 'Houxiang Hu', 'orcid': 'https://orcid.org/0000-0002-6520-2477'}, 'institutions': [{'id': 'https://openalex.org/I4210108565', 'display_name': 'Affiliated Hospital of North Sichuan Medical College', 'ror': 'https://ror.org/01673gn35', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108565']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Houxiang Hu', 'raw_affiliation_strings': ['Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China', 'institution_ids': ['https://openalex.org/I4210108565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063595483', 'display_name': 'Rongchuan Yue', 'orcid': 'https://orcid.org/0000-0001-6821-1240'}, 'institutions': [{'id': 'https://openalex.org/I4210108565', 'display_name': 'Affiliated Hospital of North Sichuan Medical College', 'ror': 'https://ror.org/01673gn35', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108565']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rongchuan Yue', 'raw_affiliation_strings': ['Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China', 'institution_ids': ['https://openalex.org/I4210108565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100424046', 'display_name': 'Lei Xu', 'orcid': 'https://orcid.org/0009-0003-7693-5793'}, 'institutions': [{'id': 'https://openalex.org/I4210108565', 'display_name': 'Affiliated Hospital of North Sichuan Medical College', 'ror': 'https://ror.org/01673gn35', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108565']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Xu', 'raw_affiliation_strings': ['Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China', 'institution_ids': ['https://openalex.org/I4210108565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5115603697', 'display_name': 'Shuang Zhang', 'orcid': 'https://orcid.org/0000-0003-4927-7230'}, 'institutions': [{'id': 'https://openalex.org/I4210108565', 'display_name': 'Affiliated Hospital of North Sichuan Medical College', 'ror': 'https://ror.org/01673gn35', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108565']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shuang Zhang', 'raw_affiliation_strings': ['Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China', 'institution_ids': ['https://openalex.org/I4210108565']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100343470', 'display_name': 'Ke Li', 'orcid': 'https://orcid.org/0000-0002-0391-521X'}, 'institutions': [{'id': 'https://openalex.org/I4210108565', 'display_name': 'Affiliated Hospital of North Sichuan Medical College', 'ror': 'https://ror.org/01673gn35', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108565']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ke Li', 'raw_affiliation_strings': ['Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China', 'institution_ids': ['https://openalex.org/I4210108565']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041111707', 'display_name': 'Houxiang Hu', 'orcid': 'https://orcid.org/0000-0002-6520-2477'}, 'institutions': [{'id': 'https://openalex.org/I4210108565', 'display_name': 'Affiliated Hospital of North Sichuan Medical College', 'ror': 'https://ror.org/01673gn35', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108565']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Houxiang Hu', 'raw_affiliation_strings': ['Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China', 'institution_ids': ['https://openalex.org/I4210108565']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 64}, 'biblio': {'volume': '98', 'issue': 'Suppl 2', 'first_page': 'E79.2', 'last_page': 'E79'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.944, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9166, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mptp', 'display_name': 'MPTP', 'score': 0.5842026}, {'id': 'https://openalex.org/keywords/autolysis', 'display_name': 'Autolysis (biology)', 'score': 0.431241}], 'concepts': [{'id': 'https://openalex.org/C56928146', 'wikidata': 'https://www.wikidata.org/wiki/Q2934402', 'display_name': 'Calpain', 'level': 3, 'score': 0.9536275}, {'id': 'https://openalex.org/C13591479', 'wikidata': 'https://www.wikidata.org/wiki/Q6881880', 'display_name': 'Mitochondrial permeability transition pore', 'level': 4, 'score': 0.6486783}, {'id': 'https://openalex.org/C196795494', 'wikidata': 'https://www.wikidata.org/wiki/Q1624817', 'display_name': 'TUNEL assay', 'level': 3, 'score': 0.63754463}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.607534}, {'id': 'https://openalex.org/C2778674702', 'wikidata': 'https://www.wikidata.org/wiki/Q239816', 'display_name': 'MPTP', 'level': 4, 'score': 0.5842026}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.51006037}, {'id': 'https://openalex.org/C2780114680', 'wikidata': 'https://www.wikidata.org/wiki/Q1413991', 'display_name': 'Reperfusion injury', 'level': 3, 'score': 0.50049233}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4557341}, {'id': 'https://openalex.org/C104810894', 'wikidata': 'https://www.wikidata.org/wiki/Q787099', 'display_name': 'Autolysis (biology)', 'level': 3, 'score': 0.431241}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.42659685}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.38272324}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36437526}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29206955}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28586096}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.2627291}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2543738}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.058555573}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/heartjnl-2012-302920a.201', 'pdf_url': 'https://heart.bmj.com/content/heartjnl/98/Suppl_2/E79.2.full.pdf', 'source': {'id': 'https://openalex.org/S191565391', 'display_name': 'Heart', 'issn_l': '1355-6037', 'issn': ['1355-6037', '1468-201X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/heartjnl-2012-302920a.201', 'pdf_url': 'https://heart.bmj.com/content/heartjnl/98/Suppl_2/E79.2.full.pdf', 'source': {'id': 'https://openalex.org/S191565391', 'display_name': 'Heart', 'issn_l': '1355-6037', 'issn': ['1355-6037', '1468-201X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.63, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4309666802', 'https://openalex.org/W2395261377', 'https://openalex.org/W2151482910', 'https://openalex.org/W2087805943', 'https://openalex.org/W2078250464', 'https://openalex.org/W2072091889', 'https://openalex.org/W2046968011', 'https://openalex.org/W2013343698', 'https://openalex.org/W1986586932', 'https://openalex.org/W1985586004'], 'abstract_inverted_index': {'<h3>Objectives</h3>': [0], 'Calpains': [1], 'have': [2], 'been': [3], 'implicated': [4, 135], 'in': [5, 34, 56, 63, 119, 136, 154, 163, 204, 219, 224, 238], 'myocardial': [6, 137], 'ischaemia-reperfusion': [7], '(I/R)': [8], 'injury.': [9], 'The': [10, 227], 'mitochondrial': [11, 173], 'permeability': [12], 'transition': [13], 'pore': [14], '(mPTP)': [15], 'subsequently': [16, 289], 'triggers': [17, 290], 'apoptotic': [18, 67, 291], 'cell': [19, 68, 292], 'death': [20, 293], 'during': [21, 36], 'I/R.': [22, 277], 'However,': [23, 206], 'the': [24, 52, 99, 131, 140, 143, 147, 169, 192, 195, 199, 207, 210, 214, 225, 239, 249, 266, 271, 284], 'mechanistic': [25], 'link': [26], 'among': [27], 'calpain': [28, 55, 102, 116, 133], 'activity,': [29], 'mPTP': [30, 64, 105, 161, 269, 296], 'opening': [31, 162, 267], 'and': [32, 65, 80, 85, 88, 106, 125, 152, 172, 232, 242, 253, 270], 'apoptosis': [33], 'myocardium': [35], 'I/R': [37, 57, 95, 138, 251, 280], 'remains': [38], 'to': [39, 49, 82, 91, 191, 283], 'be': [40], 'elucidated.': [41], '<h3>Aim</h3>': [42], 'This': [43], 'aim': [44], 'of': [45, 54, 78, 101, 142, 146, 150, 194, 198, 202, 209, 213, 217, 229, 244, 255, 262, 268, 273, 286], 'this': [46], 'study': [47], 'was': [48, 121, 165, 221, 235], 'investigate': [50], 'whether': [51], 'activation': [53, 285], 'cardiomyocytes': [58, 75, 120, 155, 164, 220, 231, 263], 'is': [59], 'associated': [60], 'with': [61, 111, 181, 248], 'alterations': [62], 'subsequent': [66], 'death.': [69], '<h3>Methods</h3>': [70], 'Primary': [71], 'cultured': [72], 'neonatal': [73], 'mouse': [74], 'were': [76, 109, 156], 'deprived': [77], 'oxygen': [79, 87], 'glucose': [81], 'simulate': [83, 92], 'ischaemia,': [84, 186, 189], 'restored': [86], 'sugar': [89], 'supply': [90], 'reperfusion': [93], '(simulated': [94], 'injury).': [96], 'To': [97, 129], 'determine': [98], 'influence': [100], 'activity': [103, 127, 234], 'on': [104], 'apoptosis,': [107], 'cells': [108, 179], 'pretreated': [110], 'PD150606': [112], '(PD,': [113], 'a': [114], 'specific': [115], 'inhibitor).': [117], 'Apoptosis': [118], 'determined': [122], 'by': [123, 158, 167, 177, 276, 294], 'TUNEL-staining': [124], 'caspase-3': [126, 233], 'analysis.': [128, 160], 'identify': [130], 'activated': [132], 'isoform': [134], 'injury,': [139], 'autolysis': [141, 193, 208], 'N-terminal': [144, 196, 211], 'domains': [145, 197, 212], 'catalytic': [148, 200, 215], 'subunit': [149, 201, 216], 'm-': [151], 'm-calpain': [153, 203, 218], 'detected': [157], 'immunoblot': [159], 'assessed': [166], 'using': [168], 'calcein–cobalt': [170], 'method': [171], 'membrane': [174], 'potential': [175], '(Δym)': [176], 'imaging': [178], 'loaded': [180], 'JC-1.': [182], '<h3>Results</h3>': [183], 'Reperfusion': [184], 'following': [185], 'rather': [187], 'than': [188], 'led': [190], 'cardiomyocytes.': [205], 'not': [222], 'observed': [223], 'investigation.': [226], 'percentage': [228], 'TUNEL-positive': [230], 'significantly': [236], 'less': [237], 'PD': [240], '(20.38%±2.23%': [241], 'fold': [243, 254], 'changes,': [245, 256], '1.43±0.13)': [246], 'compared': [247], 'untreated': [250], '(31.48%±1.65%': [252], '2.21±0.17)': [257], 'group.': [258], 'Moreover,': [259], 'pD': [260], 'pretreatment': [261], 'dramatically': [264], 'suppressed': [265], 'loss': [272], 'Δym': [274], 'caused': [275], '<h3>Conclusions</h3>': [278], 'Myocardial': [279], 'can': [281], 'lead': [282], 'm-calpain,': [287], 'which': [288], 'inducing': [295], 'opening.': [297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2116471121', 'counts_by_year': [], 'updated_date': '2024-12-24T14:06:45.168101', 'created_date': '2016-06-24'}