Publication Information

{'id': 'https://openalex.org/W1986586932', 'doi': 'https://doi.org/10.1074/jbc.272.3.2005', 'title': "'Oxidation Inhibits Substrate Proteolysis by Calpain I but Not Autolysis", 'display_name': "'Oxidation Inhibits Substrate Proteolysis by Calpain I but Not Autolysis", 'publication_year': 1997, 'publication_date': '1997-01-01', 'ids': {'openalex': 'https://openalex.org/W1986586932', 'doi': 'https://doi.org/10.1074/jbc.272.3.2005', 'mag': '1986586932', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8999893'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.3.2005', 'pdf_url': 'http://www.jbc.org/article/S0021925819675149/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819675149/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078737409', 'display_name': 'Rodney P. Guttmann', 'orcid': 'https://orcid.org/0000-0001-5553-3099'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Rodney P. Guttmann', 'raw_affiliation_strings': ['From the Departments of Psychiatry and'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Psychiatry and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028063113', 'display_name': 'John S. Elce', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204722609', 'display_name': "Queen's University", 'ror': 'https://ror.org/02y72wh86', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I204722609']}, {'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'John S. Elce', 'raw_affiliation_strings': ["§ Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0017 and § Department of Biochemistry, Queen's University, Kingston, Ontario K71 3N6, Canada"], 'affiliations': [{'raw_affiliation_string': "§ Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0017 and § Department of Biochemistry, Queen's University, Kingston, Ontario K71 3N6, Canada", 'institution_ids': ['https://openalex.org/I204722609', 'https://openalex.org/I32389192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045932322', 'display_name': 'P. Darwin Bell', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P. Darwin Bell', 'raw_affiliation_strings': ['From the Departments of Psychiatry and'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Psychiatry and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009533859', 'display_name': 'J. Clay Isbell', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J. Clay Isbell', 'raw_affiliation_strings': ['From the Departments of Psychiatry and'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Psychiatry and', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025207687', 'display_name': 'Gail V.W. Johnson', 'orcid': 'https://orcid.org/0000-0003-3464-0404'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gail V.W. Johnson', 'raw_affiliation_strings': ['From the Departments of Psychiatry and'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Psychiatry and', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.024, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 118, 'citation_normalized_percentile': {'value': 0.906401, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '272', 'issue': '3', 'first_page': '2005', 'last_page': '2012'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11353', 'display_name': 'Venomous Animal Envenomation and Studies', 'score': 0.9841, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9763, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/autolysis', 'display_name': 'Autolysis (biology)', 'score': 0.9665204}, {'id': 'https://openalex.org/keywords/proteolysis', 'display_name': 'Proteolysis', 'score': 0.942456}], 'concepts': [{'id': 'https://openalex.org/C104810894', 'wikidata': 'https://www.wikidata.org/wiki/Q787099', 'display_name': 'Autolysis (biology)', 'level': 3, 'score': 0.9665204}, {'id': 'https://openalex.org/C2781307694', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Proteolysis', 'level': 3, 'score': 0.942456}, {'id': 'https://openalex.org/C56928146', 'wikidata': 'https://www.wikidata.org/wiki/Q2934402', 'display_name': 'Calpain', 'level': 3, 'score': 0.7136125}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.51115066}, {'id': 'https://openalex.org/C2777289219', 'wikidata': 'https://www.wikidata.org/wiki/Q7632154', 'display_name': 'Substrate (aquarium)', 'level': 2, 'score': 0.4380998}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41286486}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40133327}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.31769392}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2821715}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.13333112}], 'mesh': [{'descriptor_ui': 'D002154', 'descriptor_name': 'Calpain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002154', 'descriptor_name': 'Calpain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006868', 'descriptor_name': 'Hydrolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007202', 'descriptor_name': 'Indicators and Reagents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.3.2005', 'pdf_url': 'http://www.jbc.org/article/S0021925819675149/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8999893', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.3.2005', 'pdf_url': 'http://www.jbc.org/article/S0021925819675149/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.63, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1485515194', 'https://openalex.org/W1496031212', 'https://openalex.org/W1546503260', 'https://openalex.org/W1554324315', 'https://openalex.org/W1574047547', 'https://openalex.org/W1903793818', 'https://openalex.org/W1971388737', 'https://openalex.org/W1973507474', 'https://openalex.org/W1984449008', 'https://openalex.org/W1985481233', 'https://openalex.org/W1990777624', 'https://openalex.org/W1994030229', 'https://openalex.org/W1995515835', 'https://openalex.org/W1997876679', 'https://openalex.org/W2002560793', 'https://openalex.org/W2003597344', 'https://openalex.org/W2003689183', 'https://openalex.org/W2017589528', 'https://openalex.org/W2022402045', 'https://openalex.org/W2026101249', 'https://openalex.org/W2032562864', 'https://openalex.org/W2036755018', 'https://openalex.org/W2038231740', 'https://openalex.org/W2040086038', 'https://openalex.org/W2047643460', 'https://openalex.org/W2047685863', 'https://openalex.org/W2050191964', 'https://openalex.org/W2051420538', 'https://openalex.org/W2051909445', 'https://openalex.org/W2052695883', 'https://openalex.org/W2052881212', 'https://openalex.org/W2062125039', 'https://openalex.org/W2062147078', 'https://openalex.org/W2068001868', 'https://openalex.org/W2070772311', 'https://openalex.org/W2074562451', 'https://openalex.org/W2078382210', 'https://openalex.org/W2080322693', 'https://openalex.org/W2081646126', 'https://openalex.org/W2089129165', 'https://openalex.org/W2091905713', 'https://openalex.org/W2092359857', 'https://openalex.org/W2093076184', 'https://openalex.org/W2101108802', 'https://openalex.org/W2108040034', 'https://openalex.org/W2117319108', 'https://openalex.org/W2133451731', 'https://openalex.org/W2140911891', 'https://openalex.org/W2141260882', 'https://openalex.org/W2148184626', 'https://openalex.org/W2159377066', 'https://openalex.org/W2167973356', 'https://openalex.org/W2176903450', 'https://openalex.org/W2326281675', 'https://openalex.org/W2344992701', 'https://openalex.org/W283379564', 'https://openalex.org/W329867832', 'https://openalex.org/W4230147047', 'https://openalex.org/W98528490'], 'related_works': ['https://openalex.org/W2475317774', 'https://openalex.org/W2395261377', 'https://openalex.org/W2084589572', 'https://openalex.org/W2062125039', 'https://openalex.org/W2046968011', 'https://openalex.org/W2020739220', 'https://openalex.org/W1991719291', 'https://openalex.org/W1986586932', 'https://openalex.org/W1971997211', 'https://openalex.org/W1496031212'], 'abstract_inverted_index': {'In': [0, 101, 233, 334], 'this': [1, 234], 'study,': [2, 235], 'the': [3, 27, 38, 64, 85, 92, 107, 116, 126, 131, 173, 192, 219, 229, 236, 260, 271, 297, 318, 325, 340, 349, 359, 364, 406, 425, 452, 462], 'effects': [4, 237], 'of': [5, 23, 31, 36, 57, 63, 67, 84, 105, 118, 171, 194, 204, 221, 228, 238, 256, 264, 269, 290, 296, 300, 317, 338, 351, 404, 427, 437, 454, 461], 'oxidation': [6, 186, 239, 419], 'on': [7, 240], 'calpain': [8, 68, 208, 241, 301, 441], 'I': [9, 17, 69, 121, 138, 155, 212, 242, 250, 302, 354, 371, 388, 445], 'autolysis': [10, 83, 205, 243, 316, 438], 'and': [11, 33, 40, 54, 176, 244, 266, 273, 287, 409], 'calpain-mediated': [12, 245], 'proteolysis': [13, 246], 'were': [14, 247], 'examined.': [15, 248], 'Calpain': [16, 120, 137, 154, 211, 249, 353, 370, 387, 444], 'was': [18, 43, 70, 77, 96, 112, 123, 139, 157, 180, 223, 251, 276, 303, 310, 329, 345, 356, 372, 390, 413, 456], 'incubated': [19, 252], 'with': [20, 253], 'increasing': [21, 254], 'concentrations': [22, 148, 165, 197, 255, 381, 398, 430], 'free': [24, 74, 93, 146, 257, 307, 326, 379], 'calcium': [25, 75, 94, 147, 164, 258, 308, 327, 380, 397], 'in': [26, 200, 259, 433], 'presence': [28, 117, 193, 220, 261, 350, 426, 453], 'or': [29, 109, 130, 262, 342, 363], 'absence': [30, 263], 'oxidant,': [32, 265], 'autolytic': [34, 103, 190, 267, 336, 423], 'conversion': [35, 62, 104, 268, 295, 337], 'both': [37, 52, 172, 270, 285, 405], '80-': [39, 108, 272, 341], '30-kDa': [41, 86, 110, 274, 319, 343], 'subunits': [42, 275], 'measured': [44, 124, 277, 357], 'by': [45, 115, 160, 218, 226, 278, 348, 393, 451, 459], 'immunoblotting': [46, 279], 'utilizing': [47, 280], 'monoclonal': [48, 281], 'antibodies': [49, 282], 'which': [50, 283], 'recognize': [51, 284], 'autolyzed': [53, 177, 286, 410], 'non-autolyzed': [55, 174, 288, 407], 'forms': [56, 179, 289, 412], 'each': [58, 291], 'subunit,': [59, 292], 'respectively.': [60, 293], 'Autolytic': [61, 294], '80-kDa': [65, 175, 298, 408], 'subunit': [66, 87, 111, 299, 320, 344], 'not': [71, 89, 113, 188, 304, 322, 346, 421], 'detected': [72, 305], 'until': [73, 91, 306, 324], 'concentration': [76, 95, 309, 328], 'greater': [78, 97, 311, 330], 'than': [79, 98, 312, 331], '40': [80, 313], 'μM,': [81, 314], 'whereas': [82, 185, 315, 418], 'did': [88, 187, 198, 321, 420, 431], 'occur': [90, 323], '100': [99, 332], 'μM.': [100, 333], 'addition,': [102, 335], 'either': [106, 339], 'inhibited': [114, 159, 217, 347, 392, 450], 'oxidant.': [119, 352], 'activity': [122, 144, 156, 170, 213, 355, 377, 389, 403, 446], 'using': [125, 358], 'fluorescent': [127, 360], 'peptide': [128, 361], 'N-succinyl-L-leucyl-L-leucyl-L-valyl-L-tyrosine-7-amido-4-methylcoumarin': [129, 362], 'microtubule-associated': [132, 365], 'protein': [133, 366], 'tau': [134, 367], 'as': [135, 368], 'substrate.': [136, 369], 'found': [140, 373], 'to': [141, 182, 374, 415], 'have': [142, 375], 'proteolytic': [143, 169, 209, 376, 402, 442], 'at': [145, 162, 378, 395], 'below': [149, 382], 'that': [150, 168, 214, 383, 401, 447], 'required': [151, 384], 'for': [152, 385], 'autolysis.': [153, 386], 'strongly': [158, 391], 'oxidant': [161, 222, 394, 455], 'all': [163, 396], 'studied,': [166, 399], 'suggesting': [167, 400], '76-kDa': [178, 411], 'susceptible': [181, 414], 'oxidation.': [183, 416], 'Interestingly,': [184, 417], 'inhibit': [189, 422], 'conversion,': [191, 424], 'high': [195, 428], 'substrate': [196, 429], 'result': [199, 432], 'a': [201, 434], 'significant': [202, 435], 'reduction': [203, 436], 'without': [206, 439], 'altering': [207, 440], 'activity.': [210, 443], 'had': [215, 448], 'been': [216, 449], 'recovered': [224, 457], 'immediately': [225, 458], 'addition': [227, 460], 'reducing': [230, 463], 'agent': [231, 464], 'dithiothreitol.': [232, 465]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1986586932', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-13T04:06:43.938002', 'created_date': '2016-06-24'}