Title: Studies concerning the inhibition of cellular reproduction by deoxyribonucleosides
Abstract: Inhibition of the reproduction of L5178Y and P815Y cells by high concentrations of thymidine can be prevented by relatively low concentrations of deoxycytidine. Neither cytidine nor any other pyrimidine or purine ribo- or deoxyribonucleoside can duplicate this effect. Whole-cell experiments on the uptake of radioisotopes demonstrate that grown-inhibitory levels of thymidine inhibit the synthesis of acid-soluble deCMP. Moreover, a phosphorylated derivative of thymidine effectively inhibits the conversion of CMP to deCMP, thereby causing a deficiency of one of the precursors of DNA, a circumstance which leads primarily to a failure of DNA synthesis and secondarily of cell division.
Publication Year: 1963
Publication Date: 1963-01-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 124
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