Complement Factor H Polymorphism in Age-Related Macular Degeneration

Name: Work Video:
Duration: 3 min 30 s
Robert J. Klein; Caroline J. Zeiss; Emily Y. Chew; Jen-Yue Tsai; Richard S. Sackler; Chad Haynes; Alice K. Henning; John Paul SanGiovanni; Shrikant Mane; Susan T. Mayne; Michael B. Bracken; Frederick L. Ferris; Jürg Ott; Colin J. Barnstable; Josephine Hoh
{'id': 'https://openalex.org/W2113784410', 'doi': 'https://doi.org/10.1126/science.1109557', 'title': 'Complement Factor H Polymorphism in Age-Related Macular Degeneration', 'display_name': 'Complement Factor H Polymorphism in Age-Related Macular Degeneration', 'publication_year': 2005, 'publication_date': '2005-03-11', 'ids': {'openalex': 'https://openalex.org/W2113784410', 'doi': 'https://doi.org/10.1126/science.1109557', 'mag': '2113784410', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15761122', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1512523'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1126/science.1109557', 'pdf_url': 'https://www.science.org/cms/asset/1333f1d2-aacd-4d2f-8a25-77adbbd491fc/pap.pdf', 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.science.org/cms/asset/1333f1d2-aacd-4d2f-8a25-77adbbd491fc/pap.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5015132763', 'display_name': 'Robert J. Klein', 'orcid': 'https://orcid.org/0000-0003-3539-5391'}, 'institutions': [{'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}, {'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert J. Klein', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024405586', 'display_name': 'Caroline J. Zeiss', 'orcid': 'https://orcid.org/0000-0003-1181-3544'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Caroline Zeiss', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090802305', 'display_name': 'Emily Y. Chew', 'orcid': 'https://orcid.org/0000-0003-0999-9802'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Emily Y. Chew', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108221119', 'display_name': 'Jen-Yue Tsai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jen-Yue Tsai', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089592501', 'display_name': 'Richard S. Sackler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard S. Sackler', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103470452', 'display_name': 'Chad Haynes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chad Haynes', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020080453', 'display_name': 'Alice K. Henning', 'orcid': 'https://orcid.org/0000-0002-6338-6890'}, 'institutions': [{'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}, {'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alice K. Henning', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028034153', 'display_name': 'John Paul SanGiovanni', 'orcid': 'https://orcid.org/0000-0001-7199-7053'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John Paul SanGiovanni', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054738149', 'display_name': 'Shrikant Mane', 'orcid': 'https://orcid.org/0000-0002-3267-5139'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shrikant M. Mane', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108480016', 'display_name': 'Susan T. Mayne', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}, {'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan T. Mayne', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108486644', 'display_name': 'Michael B. Bracken', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael B. Bracken', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010240899', 'display_name': 'Frederick L. Ferris', 'orcid': 'https://orcid.org/0000-0002-4933-0639'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}, {'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Frederick L. Ferris', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042072885', 'display_name': 'Jürg Ott', 'orcid': 'https://orcid.org/0000-0002-6188-1388'}, 'institutions': [{'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}, {'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jurg Ott', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001481519', 'display_name': 'Colin J. Barnstable', 'orcid': 'https://orcid.org/0000-0002-7011-4068'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Colin Barnstable', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105836045', 'display_name': 'Josephine Hoh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115849', 'display_name': 'Emmes (United States)', 'ror': 'https://ror.org/027fvqp63', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210115849']}, {'id': 'https://openalex.org/I32971472', 'display_name': 'Yale University', 'ror': 'https://ror.org/03v76x132', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32971472']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Josephine Hoh', 'raw_affiliation_strings': ['Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.'], 'affiliations': [{'raw_affiliation_string': 'The EMMES Corporation, 401 North Washington Street, Suite 700, Rockville MD 20850, USA.', 'institution_ids': ['https://openalex.org/I4210115849']}, {'raw_affiliation_string': 'Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA.', 'institution_ids': ['https://openalex.org/I32971472']}, {'raw_affiliation_string': 'Biological Imaging Core, National Eye Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}, {'raw_affiliation_string': 'Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I83399316']}, {'raw_affiliation_string': 'National Eye Institute, Building 10, CRC, 10 Center Drive, Bethesda, MD 20892-1204, USA.', 'institution_ids': ['https://openalex.org/I4210139686']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 294.368, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4313, 'citation_normalized_percentile': {'value': 0.999796, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '308', 'issue': '5720', 'first_page': '385', 'last_page': '389'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10170', 'display_name': 'Retinal Diseases and Treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10170', 'display_name': 'Retinal Diseases and Treatments', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10993', 'display_name': 'Complement system in diseases', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11438', 'display_name': 'Retinal Imaging and Analysis', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/linkage-disequilibrium', 'display_name': 'Linkage Disequilibrium', 'score': 0.741128}, {'id': 'https://openalex.org/keywords/complement-factor-b', 'display_name': 'Complement factor B', 'score': 0.4877275}], 'concepts': [{'id': 'https://openalex.org/C14356644', 'wikidata': 'https://www.wikidata.org/wiki/Q14911975', 'display_name': 'Factor H', 'level': 4, 'score': 0.8727243}, {'id': 'https://openalex.org/C35605836', 'wikidata': 'https://www.wikidata.org/wiki/Q2064311', 'display_name': 'Linkage disequilibrium', 'level': 5, 'score': 0.741128}, {'id': 'https://openalex.org/C2776403814', 'wikidata': 'https://www.wikidata.org/wiki/Q27429789', 'display_name': 'Macular degeneration', 'level': 2, 'score': 0.7182394}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.704298}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.57502365}, {'id': 'https://openalex.org/C153209595', 'wikidata': 'https://www.wikidata.org/wiki/Q501128', 'display_name': 'Single-nucleotide polymorphism', 'level': 4, 'score': 0.56474626}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.55079776}, {'id': 'https://openalex.org/C179369057', 'wikidata': 'https://www.wikidata.org/wiki/Q20970075', 'display_name': 'Complement factor I', 'level': 4, 'score': 0.48819596}, {'id': 'https://openalex.org/C182629451', 'wikidata': 'https://www.wikidata.org/wiki/Q18251054', 'display_name': 'Complement factor B', 'level': 4, 'score': 0.4877275}, {'id': 'https://openalex.org/C84597430', 'wikidata': 'https://www.wikidata.org/wiki/Q106227', 'display_name': 'Locus (genetics)', 'level': 3, 'score': 0.43635228}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.40628123}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3143771}, {'id': 'https://openalex.org/C111684460', 'wikidata': 'https://www.wikidata.org/wiki/Q334848', 'display_name': 'Complement system', 'level': 3, 'score': 0.24839762}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.18778956}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.11984846}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008268', 'descriptor_name': 'Macular Degeneration', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000483', 'descriptor_name': 'Alleles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002829', 'descriptor_name': 'Choroid', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002878', 'descriptor_name': 'Chromosomes, Human, Pair 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017242', 'descriptor_name': 'Complement Factor H', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D015938', 'descriptor_name': 'Complement Membrane Attack Complex', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005819', 'descriptor_name': 'Genetic Markers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006239', 'descriptor_name': 'Haplotypes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006639', 'descriptor_name': 'Histidine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007438', 'descriptor_name': 'Introns', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015810', 'descriptor_name': 'Linkage Disequilibrium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010857', 'descriptor_name': 'Pigment Epithelium of Eye', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012907', 'descriptor_name': 'Smoking', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1126/science.1109557', 'pdf_url': 'https://www.science.org/cms/asset/1333f1d2-aacd-4d2f-8a25-77adbbd491fc/pap.pdf', 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1512523', 'pdf_url': 'https://europepmc.org/articles/pmc1512523?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1512523', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15761122', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1126/science.1109557', 'pdf_url': 'https://www.science.org/cms/asset/1333f1d2-aacd-4d2f-8a25-77adbbd491fc/pap.pdf', 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.61, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W112356114', 'https://openalex.org/W1487528435', 'https://openalex.org/W1882059917', 'https://openalex.org/W1883306593', 'https://openalex.org/W1963661835', 'https://openalex.org/W1966318341', 'https://openalex.org/W1967253078', 'https://openalex.org/W1968744211', 'https://openalex.org/W1978477807', 'https://openalex.org/W1985849948', 'https://openalex.org/W2000399151', 'https://openalex.org/W2006264045', 'https://openalex.org/W2017909854', 'https://openalex.org/W2021311336', 'https://openalex.org/W2027707278', 'https://openalex.org/W2028243947', 'https://openalex.org/W2042103448', 'https://openalex.org/W2058401000', 'https://openalex.org/W2060170269', 'https://openalex.org/W2069769149', 'https://openalex.org/W2074250865', 'https://openalex.org/W2074286693', 'https://openalex.org/W2076794120', 'https://openalex.org/W2096201017', 'https://openalex.org/W2105123991', 'https://openalex.org/W2111050441', 'https://openalex.org/W2152664025', 'https://openalex.org/W2163683630', 'https://openalex.org/W2168511422', 'https://openalex.org/W2412462048', 'https://openalex.org/W2419363608', 'https://openalex.org/W2598520882', 'https://openalex.org/W2740785417', 'https://openalex.org/W4248715188'], 'related_works': ['https://openalex.org/W4240259803', 'https://openalex.org/W3026010145', 'https://openalex.org/W2808064981', 'https://openalex.org/W2121855384', 'https://openalex.org/W2103941977', 'https://openalex.org/W2010462285', 'https://openalex.org/W1993423085', 'https://openalex.org/W1963905188', 'https://openalex.org/W1910602244', 'https://openalex.org/W118979360'], 'abstract_inverted_index': {'Age-related': [0], 'macular': [1], 'degeneration': [2], '(AMD)': [3], 'is': [4, 48, 70, 104, 119], 'a': [5, 15, 73, 85, 95, 106, 125], 'major': [6], 'cause': [7], 'of': [8, 18, 68, 75, 108], 'blindness': [9], 'in': [10, 39, 87, 105, 124, 131], 'the': [11, 40, 63, 66, 91], 'elderly.': [12], 'We': [13], 'report': [14], 'genome-wide': [16], 'screen': [17], '96': [19], 'cases': [20], 'and': [21, 36, 113], '50': [22], 'controls': [23], 'for': [24, 62], 'polymorphisms': [25, 32], 'associated': [26, 50], 'with': [27, 51, 90], 'AMD.': [28], 'Among': [29], '116,204': [30], 'single-nucleotide': [31], 'genotyped,': [33], 'an': [34], 'intronic': [35], 'common': [37], 'variant': [38], 'complement': [41], 'factor': [42, 74], 'H': [43], 'gene': [44, 118], '(': [45], 'CFH': [46, 109, 117], ')': [47], 'strongly': [49], 'AMD': [52, 69, 130], '(nominal': [53], 'P': [54], 'value': [55], '&lt;10': [56], '-7': [57], ').': [58], 'In': [59], 'individuals': [60], 'homozygous': [61], 'risk': [64, 92], 'allele,': [65], 'likelihood': [67], 'increased': [71], 'by': [72], '7.4': [76], '(95%': [77], 'confidence': [78], 'interval': [79], '2.9': [80], 'to': [81, 129], '19).': [82], 'Resequencing': [83], 'revealed': [84], 'polymorphism': [86, 103], 'linkage': [88], 'disequilibrium': [89], 'allele': [93], 'representing': [94], 'tyrosine-histidine': [96], 'change': [97], 'at': [98], 'amino': [99], 'acid': [100], '402.': [101], 'This': [102], 'region': [107, 126], 'that': [110], 'binds': [111], 'heparin': [112], 'C-reactive': [114], 'protein.': [115], 'The': [116], 'located': [120], 'on': [121], 'chromosome': [122], '1': [123], 'repeatedly': [127], 'linked': [128], 'family-based': [132], 'studies.': [133]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2113784410', 'counts_by_year': [{'year': 2024, 'cited_by_count': 110}, {'year': 2023, 'cited_by_count': 131}, {'year': 2022, 'cited_by_count': 159}, {'year': 2021, 'cited_by_count': 171}, {'year': 2020, 'cited_by_count': 147}, {'year': 2019, 'cited_by_count': 142}, {'year': 2018, 'cited_by_count': 158}, {'year': 2017, 'cited_by_count': 181}, {'year': 2016, 'cited_by_count': 187}, {'year': 2015, 'cited_by_count': 232}, {'year': 2014, 'cited_by_count': 255}, {'year': 2013, 'cited_by_count': 268}, {'year': 2012, 'cited_by_count': 296}], 'updated_date': '2024-12-16T13:56:03.607166', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
