Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2121855384', 'doi': 'https://doi.org/10.1093/hmg/ddp472', 'title': 'Genetic control of the alternative pathway of complement in humans and age-related macular degeneration', 'display_name': 'Genetic control of the alternative pathway of complement in humans and age-related macular degeneration', 'publication_year': 2009, 'publication_date': '2009-10-13', 'ids': {'openalex': 'https://openalex.org/W2121855384', 'doi': 'https://doi.org/10.1093/hmg/ddp472', 'mag': '2121855384', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19825847', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2792151'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/hmg/ddp472', 'pdf_url': 'https://academic.oup.com/hmg/article-pdf/19/1/209/17251084/ddp472.pdf', 'source': {'id': 'https://openalex.org/S166515463', 'display_name': 'Human Molecular Genetics', 'issn_l': '0964-6906', 'issn': ['0964-6906', '1460-2083'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/hmg/article-pdf/19/1/209/17251084/ddp472.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008306589', 'display_name': 'Laura A. Hecker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I2802423016', 'display_name': 'WinnMed', 'ror': 'https://ror.org/02s47w807', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802423016']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laura A. Hecker', 'raw_affiliation_strings': ['Department of Ophthalmology, Mayo Clinic, Rochester, MN, 55905, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Mayo Clinic, Rochester, MN, 55905, USA', 'institution_ids': ['https://openalex.org/I1330342723', 'https://openalex.org/I2802423016']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048200396', 'display_name': 'Albert O. Edwards', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Albert O. Edwards', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052975209', 'display_name': 'Euijung Ryu', 'orcid': 'https://orcid.org/0000-0001-6281-8738'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Euijung Ryu', 'raw_affiliation_strings': ['Department of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082931849', 'display_name': 'Nirubol Tosakulwong', 'orcid': 'https://orcid.org/0000-0002-2385-6835'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nirubol Tosakulwong', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031579560', 'display_name': 'Keith H. Baratz', 'orcid': 'https://orcid.org/0000-0002-0676-7646'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Keith H. Baratz', 'raw_affiliation_strings': ['Department of Ophthalmology and'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036162164', 'display_name': 'William L. Brown', 'orcid': 'https://orcid.org/0000-0001-5354-9468'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William L. Brown', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073328427', 'display_name': 'Peter Charbel Issa', 'orcid': 'https://orcid.org/0000-0002-0351-6673'}, 'institutions': [{'id': 'https://openalex.org/I135140700', 'display_name': 'University of Bonn', 'ror': 'https://ror.org/041nas322', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I135140700']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['DE', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Peter Charbel Issa', 'raw_affiliation_strings': ['University of Bonn', 'University of Oxford'], 'affiliations': [{'raw_affiliation_string': 'University of Bonn', 'institution_ids': ['https://openalex.org/I135140700']}, {'raw_affiliation_string': 'University of Oxford', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059328359', 'display_name': 'Hendrik P. N. Scholl', 'orcid': 'https://orcid.org/0000-0002-7312-0316'}, 'institutions': [{'id': 'https://openalex.org/I135140700', 'display_name': 'University of Bonn', 'ror': 'https://ror.org/041nas322', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I135140700']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hendrik P. Scholl', 'raw_affiliation_strings': ['Department of Ophthalmology, University of Bonn, Bonn, 53127, Germany and'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, University of Bonn, Bonn, 53127, Germany and', 'institution_ids': ['https://openalex.org/I135140700']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088084404', 'display_name': 'Beatrix Pollok‐Kopp', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74656192', 'display_name': 'University of Göttingen', 'ror': 'https://ror.org/01y9bpm73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I74656192']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Beatrix Pollok-Kopp', 'raw_affiliation_strings': ['University of Góttingen'], 'affiliations': [{'raw_affiliation_string': 'University of Góttingen', 'institution_ids': ['https://openalex.org/I74656192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026709646', 'display_name': 'Katharina E. Schmid‐Kubista', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Katharina E. Schmid-Kubista', 'raw_affiliation_strings': ['Mayo Clinic Rochester-MN'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic Rochester-MN', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037957960', 'display_name': 'Kent R. Bailey', 'orcid': 'https://orcid.org/0000-0001-8968-643X'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kent R. Bailey', 'raw_affiliation_strings': ['Department of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027813230', 'display_name': 'Martin Oppermann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74656192', 'display_name': 'University of Göttingen', 'ror': 'https://ror.org/01y9bpm73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I74656192']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Martin Oppermann', 'raw_affiliation_strings': ['University of Góttingen'], 'affiliations': [{'raw_affiliation_string': 'University of Góttingen', 'institution_ids': ['https://openalex.org/I74656192']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4181, 'currency': 'USD', 'value_usd': 4181, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 13.351, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 141, 'citation_normalized_percentile': {'value': 0.929614, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '19', 'issue': '1', 'first_page': '209', 'last_page': '215'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10993', 'display_name': 'Role of Complement System in Immune Response', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10166', 'display_name': 'Global Impact of Arboviral Diseases', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/complement-factor-b', 'display_name': 'Complement factor B', 'score': 0.7624341}, {'id': 'https://openalex.org/keywords/complement-component-3', 'display_name': 'Complement component 3', 'score': 0.6186524}, {'id': 'https://openalex.org/keywords/macular-degeneration', 'display_name': 'Macular Degeneration', 'score': 0.538842}, {'id': 'https://openalex.org/keywords/complement-factor-h-polymorphism', 'display_name': 'Complement Factor H Polymorphism', 'score': 0.535576}, {'id': 'https://openalex.org/keywords/complement-component-2', 'display_name': 'Complement component 2', 'score': 0.5098116}], 'concepts': [{'id': 'https://openalex.org/C111684460', 'wikidata': 'https://www.wikidata.org/wiki/Q334848', 'display_name': 'Complement system', 'level': 3, 'score': 0.9086368}, {'id': 'https://openalex.org/C14356644', 'wikidata': 'https://www.wikidata.org/wiki/Q14911975', 'display_name': 'Factor H', 'level': 4, 'score': 0.8815398}, {'id': 'https://openalex.org/C189446657', 'wikidata': 'https://www.wikidata.org/wiki/Q4736500', 'display_name': 'Alternative complement pathway', 'level': 4, 'score': 0.8538002}, {'id': 'https://openalex.org/C182629451', 'wikidata': 'https://www.wikidata.org/wiki/Q18251054', 'display_name': 'Complement factor B', 'level': 4, 'score': 0.7624341}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7380858}, {'id': 'https://openalex.org/C179369057', 'wikidata': 'https://www.wikidata.org/wiki/Q20970075', 'display_name': 'Complement factor I', 'level': 4, 'score': 0.65242696}, {'id': 'https://openalex.org/C203473731', 'wikidata': 'https://www.wikidata.org/wiki/Q14874317', 'display_name': 'Complement component 3', 'level': 5, 'score': 0.6186524}, {'id': 'https://openalex.org/C136015124', 'wikidata': 'https://www.wikidata.org/wiki/Q13566093', 'display_name': 'Complement component 2', 'level': 5, 'score': 0.5098116}, {'id': 'https://openalex.org/C197754878', 'wikidata': 'https://www.wikidata.org/wiki/Q80711', 'display_name': 'Haplotype', 'level': 4, 'score': 0.50794345}, {'id': 'https://openalex.org/C68873052', 'wikidata': 'https://www.wikidata.org/wiki/Q349856', 'display_name': 'Genetic variation', 'level': 3, 'score': 0.46829692}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.44797343}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4452956}, {'id': 'https://openalex.org/C2776403814', 'wikidata': 'https://www.wikidata.org/wiki/Q27429789', 'display_name': 'Macular degeneration', 'level': 2, 'score': 0.44448802}, {'id': 'https://openalex.org/C171279029', 'wikidata': 'https://www.wikidata.org/wiki/Q5128320', 'display_name': 'Classical complement pathway', 'level': 4, 'score': 0.42201746}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.4008451}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3817736}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.119849324}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.09532866}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003170', 'descriptor_name': 'Complement Pathway, Alternative', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008268', 'descriptor_name': 'Macular Degeneration', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008268', 'descriptor_name': 'Macular Degeneration', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003167', 'descriptor_name': 'Complement Activation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003167', 'descriptor_name': 'Complement Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003170', 'descriptor_name': 'Complement Pathway, Alternative', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003165', 'descriptor_name': 'Complement System Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003165', 'descriptor_name': 'Complement System Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056426', 'descriptor_name': 'Genetic Loci', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056426', 'descriptor_name': 'Genetic Loci', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006239', 'descriptor_name': 'Haplotypes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006239', 'descriptor_name': 'Haplotypes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008268', 'descriptor_name': 'Macular Degeneration', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008268', 'descriptor_name': 'Macular Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008957', 'descriptor_name': 'Models, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012727', 'descriptor_name': 'Sex Characteristics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/hmg/ddp472', 'pdf_url': 'https://academic.oup.com/hmg/article-pdf/19/1/209/17251084/ddp472.pdf', 'source': {'id': 'https://openalex.org/S166515463', 'display_name': 'Human Molecular Genetics', 'issn_l': '0964-6906', 'issn': ['0964-6906', '1460-2083'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2792151', 'pdf_url': 'https://europepmc.org/articles/pmc2792151?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792151', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19825847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/hmg/ddp472', 'pdf_url': 'https://academic.oup.com/hmg/article-pdf/19/1/209/17251084/ddp472.pdf', 'source': {'id': 'https://openalex.org/S166515463', 'display_name': 'Human Molecular Genetics', 'issn_l': '0964-6906', 'issn': ['0964-6906', '1460-2083'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.72, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1545493605', 'https://openalex.org/W1570453996', 'https://openalex.org/W1603903339', 'https://openalex.org/W180812339', 'https://openalex.org/W1926196210', 'https://openalex.org/W1979008403', 'https://openalex.org/W1980565738', 'https://openalex.org/W1990057691', 'https://openalex.org/W1993383034', 'https://openalex.org/W1995006312', 'https://openalex.org/W1997288094', 'https://openalex.org/W1997617084', 'https://openalex.org/W2005447579', 'https://openalex.org/W2006264045', 'https://openalex.org/W2009256817', 'https://openalex.org/W2023198573', 'https://openalex.org/W2027707278', 'https://openalex.org/W2028283509', 'https://openalex.org/W2037699290', 'https://openalex.org/W2044722821', 'https://openalex.org/W2072681952', 'https://openalex.org/W2082625132', 'https://openalex.org/W2096904991', 'https://openalex.org/W2097222143', 'https://openalex.org/W2104511958', 'https://openalex.org/W2105479207', 'https://openalex.org/W2107143742', 'https://openalex.org/W2107356267', 'https://openalex.org/W2110554841', 'https://openalex.org/W2113784410', 'https://openalex.org/W2117386992', 'https://openalex.org/W2136501493', 'https://openalex.org/W2138610380', 'https://openalex.org/W2140644434', 'https://openalex.org/W2140653050', 'https://openalex.org/W2159589041', 'https://openalex.org/W2395525054', 'https://openalex.org/W2411292281', 'https://openalex.org/W2993945016', 'https://openalex.org/W3145351529', 'https://openalex.org/W315197452', 'https://openalex.org/W4238550599', 'https://openalex.org/W95909858'], 'related_works': ['https://openalex.org/W31716195', 'https://openalex.org/W2888786192', 'https://openalex.org/W2560154882', 'https://openalex.org/W2121855384', 'https://openalex.org/W2034181914', 'https://openalex.org/W2028283509', 'https://openalex.org/W1992456349', 'https://openalex.org/W1989747234', 'https://openalex.org/W1521618974', 'https://openalex.org/W121889566'], 'abstract_inverted_index': {'Activation': [0, 176], 'of': [1, 5, 22, 29, 63, 100, 106, 110, 126, 139, 158, 177, 181, 200, 209, 230, 235, 242], 'the': [2, 20, 30, 45, 107, 159, 167, 178, 207, 224, 228], 'alternative': [3, 31, 108, 179], 'pathway': [4, 32, 109, 180], 'complement': [6, 34, 48, 72, 111, 127, 132, 171, 182, 201, 225, 237, 243], 'is': [7, 185], 'implicated': [8], 'in': [9, 25, 36, 40, 74, 78, 86, 112, 118, 134, 154, 161, 173, 183, 202, 219, 223, 245], 'common': [10, 23, 64], 'neurodegenerative': [11], 'diseases': [12], 'including': [13], 'age-related': [14], 'macular': [15], 'degeneration': [16], '(AMD).': [17], 'We': [18], 'explored': [19], 'impact': [21], 'variation': [24, 43, 117, 169, 195, 222], 'genes': [26, 46], 'encoding': [27, 47], 'proteins': [28], 'on': [33, 71, 97], 'activation': [35, 73, 104, 141, 172, 199, 238, 244], 'human': [37, 113, 135, 174, 203], 'blood': [38, 75, 184, 204], 'and': [39, 55, 68, 88, 94, 103, 144, 146, 189, 239], 'AMD.': [41, 210], 'Genetic': [42], 'across': [44], 'factor': [49, 52], 'H': [50], '(CFH),': [51], 'B': [53], '(CFB)': [54], 'component': [56], '3': [57], '(C3)': [58], 'was': [59, 76, 163], 'determined.': [60], 'The': [61, 193], 'influence': [62, 122], 'haplotypes': [65, 85], 'defining': [66], 'transcriptional': [67], 'translational': [69], 'units': [70], 'determined': [77], 'a': [79, 216, 233], 'quantitative': [80], 'genomic': [81], 'association': [82], 'study.': [83], 'Individual': [84], 'CFH': [87, 119], 'CFB': [89], 'were': [90, 152], 'associated': [91, 196], 'with': [92, 191, 197, 215], 'distinct': [93], 'novel': [95], 'effects': [96], 'plasma': [98, 131], 'levels': [99, 133], 'precursors,': [101], 'regulators': [102], 'products': [105], 'blood.': [114, 136, 175], 'Further,': [115], 'genetic': [116, 168, 187, 194, 221], 'thought': [120], 'to': [121], 'cell': [123], 'surface': [124], 'regulation': [125, 241], 'did': [128], 'not': [129], 'alter': [130], 'Plasma': [137], 'markers': [138], 'chronic': [140], '(split-products': [142], 'Ba': [143], 'C3d)': [145], 'an': [147], 'activating': [148], 'enzyme': [149], '(factor': [150], 'D)': [151], 'elevated': [153], 'AMD': [155, 162, 231], 'subjects.': [156], 'Most': [157], 'elevation': [160], 'accounted': [164], 'for': [165], 'by': [166, 232], 'controlling': [170], 'under': [186], 'control': [188], 'increases': [190, 227], 'age.': [192], 'increased': [198, 206], 'also': [205], 'risk': [208, 229], 'Our': [211], 'data': [212], 'are': [213], 'consistent': [214], 'disease': [217], 'model': [218], 'which': [220], 'system': [226], 'combination': [234], 'systemic': [236], 'abnormal': [240], 'local': [246], 'tissues.': [247]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2121855384', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 22}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2024-09-10T02:00:48.490827', 'created_date': '2016-06-24'}