Publication Information

{'id': 'https://openalex.org/W2113257066', 'doi': 'https://doi.org/10.1161/01.hyp.35.1.480', 'title': 'Gender Differences in Development of Hypertension in Spontaneously Hypertensive Rats', 'display_name': 'Gender Differences in Development of Hypertension in Spontaneously Hypertensive Rats', 'publication_year': 2000, 'publication_date': '2000-01-01', 'ids': {'openalex': 'https://openalex.org/W2113257066', 'doi': 'https://doi.org/10.1161/01.hyp.35.1.480', 'mag': '2113257066', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10642345'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.hyp.35.1.480', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.35.1.480', 'source': {'id': 'https://openalex.org/S67880631', 'display_name': 'Hypertension', 'issn_l': '0194-911X', 'issn': ['0194-911X', '1524-4563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.35.1.480', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085377296', 'display_name': 'Jane F. Reckelhoff', 'orcid': 'https://orcid.org/0000-0002-6606-4133'}, 'institutions': [{'id': 'https://openalex.org/I29606459', 'display_name': 'University of Mississippi Medical Center', 'ror': 'https://ror.org/044pcn091', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I29606459', 'https://openalex.org/I4210141039']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jane F. Reckelhoff', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson 39216-4505, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson 39216-4505, USA.', 'institution_ids': ['https://openalex.org/I29606459']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100381131', 'display_name': 'Huimin Zhang', 'orcid': 'https://orcid.org/0000-0002-7343-5641'}, 'institutions': [{'id': 'https://openalex.org/I29606459', 'display_name': 'University of Mississippi Medical Center', 'ror': 'https://ror.org/044pcn091', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I29606459', 'https://openalex.org/I4210141039']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Huimin Zhang', 'raw_affiliation_strings': ['From the Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson.', 'institution_ids': ['https://openalex.org/I29606459']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019157205', 'display_name': 'Kumud Srivastava', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I29606459', 'display_name': 'University of Mississippi Medical Center', 'ror': 'https://ror.org/044pcn091', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I29606459', 'https://openalex.org/I4210141039']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kumud Srivastava', 'raw_affiliation_strings': ['From the Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson.', 'institution_ids': ['https://openalex.org/I29606459']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.141, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 266, 'citation_normalized_percentile': {'value': 0.924255, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '35', 'issue': '1', 'first_page': '480', 'last_page': '483'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10529', 'display_name': 'Stress Responses and Cortisol', 'score': 0.9888, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10529', 'display_name': 'Stress Responses and Cortisol', 'score': 0.9888, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9778, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/spontaneously-hypertensive-rat', 'display_name': 'Spontaneously hypertensive rat', 'score': 0.6113679}, {'id': 'https://openalex.org/keywords/essential-hypertension', 'display_name': 'Essential hypertension', 'score': 0.49243364}], 'concepts': [{'id': 'https://openalex.org/C2778086073', 'wikidata': 'https://www.wikidata.org/wiki/Q7579064', 'display_name': 'Spontaneously hypertensive rat', 'level': 3, 'score': 0.6113679}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.56036353}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5573077}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.5018077}, {'id': 'https://openalex.org/C2777097880', 'wikidata': 'https://www.wikidata.org/wiki/Q988405', 'display_name': 'Essential hypertension', 'level': 3, 'score': 0.49243364}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.44458622}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.34187514}], 'mesh': [{'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D007703', 'descriptor_name': 'Peptidyl-Dipeptidase A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012084', 'descriptor_name': 'Renin-Angiotensin System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012727', 'descriptor_name': 'Sex Characteristics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000806', 'descriptor_name': 'Angiotensin-Converting Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000806', 'descriptor_name': 'Angiotensin-Converting Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004656', 'descriptor_name': 'Enalapril', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004656', 'descriptor_name': 'Enalapril', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009919', 'descriptor_name': 'Orchiectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009929', 'descriptor_name': 'Organ Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010052', 'descriptor_name': 'Ovariectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007703', 'descriptor_name': 'Peptidyl-Dipeptidase A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011507', 'descriptor_name': 'Proteinuria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011507', 'descriptor_name': 'Proteinuria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011918', 'descriptor_name': 'Rats, Inbred SHR', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012084', 'descriptor_name': 'Renin-Angiotensin System', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012084', 'descriptor_name': 'Renin-Angiotensin System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.hyp.35.1.480', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.35.1.480', 'source': {'id': 'https://openalex.org/S67880631', 'display_name': 'Hypertension', 'issn_l': '0194-911X', 'issn': ['0194-911X', '1524-4563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10642345', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.hyp.35.1.480', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.HYP.35.1.480', 'source': {'id': 'https://openalex.org/S67880631', 'display_name': 'Hypertension', 'issn_l': '0194-911X', 'issn': ['0194-911X', '1524-4563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.45}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1487940695', 'https://openalex.org/W1521596432', 'https://openalex.org/W181221880', 'https://openalex.org/W1838353535', 'https://openalex.org/W1969694803', 'https://openalex.org/W1970288923', 'https://openalex.org/W1981256690', 'https://openalex.org/W1989899692', 'https://openalex.org/W2007642910', 'https://openalex.org/W2012757283', 'https://openalex.org/W2012816393', 'https://openalex.org/W2013059053', 'https://openalex.org/W2032266156', 'https://openalex.org/W2038433324', 'https://openalex.org/W2048596747', 'https://openalex.org/W2053664727', 'https://openalex.org/W2071342149', 'https://openalex.org/W2079183193', 'https://openalex.org/W2095904587', 'https://openalex.org/W2109396042', 'https://openalex.org/W2122246441', 'https://openalex.org/W2124199849', 'https://openalex.org/W2128635872', 'https://openalex.org/W2162471541', 'https://openalex.org/W2165580350', 'https://openalex.org/W2167128829', 'https://openalex.org/W2171926119', 'https://openalex.org/W2191491521', 'https://openalex.org/W2220371426', 'https://openalex.org/W2286212970', 'https://openalex.org/W2318855346', 'https://openalex.org/W2341854053', 'https://openalex.org/W2409390948', 'https://openalex.org/W2418523296', 'https://openalex.org/W2418644578', 'https://openalex.org/W4285719527', 'https://openalex.org/W4293247451', 'https://openalex.org/W4299321756', 'https://openalex.org/W80391022'], 'related_works': ['https://openalex.org/W4387497383', 'https://openalex.org/W3183948672', 'https://openalex.org/W3173606202', 'https://openalex.org/W3110381201', 'https://openalex.org/W2948807893', 'https://openalex.org/W2778153218', 'https://openalex.org/W2758277628', 'https://openalex.org/W2748952813', 'https://openalex.org/W2067618602', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'Abstract': [0], '—Previous': [1], 'data': [2, 239, 260], 'strongly': [3], 'support': [4], 'a': [5, 274], 'role': [6], 'for': [7, 98], 'androgens': [8, 40, 264], 'in': [9, 14, 16, 52, 74, 95, 155, 192, 202, 233, 246, 270], 'promoting': [10], 'the': [11, 17, 23, 43, 48, 62, 70, 144, 163, 223, 236, 242, 255, 259, 266, 277], 'gender': [12, 87, 204], 'difference': [13], 'hypertension': [15, 51, 73, 245, 269], 'spontaneously': [18], 'hypertensive': [19], 'rat(s)': [20], '(SHR),': [21], 'but': [22], 'mechanism': [24, 275], 'is': [25, 252], 'not': [26], 'clear.': [27], 'Because': [28], 'males': [29, 207], 'develop': [30], 'higher': [31, 135, 215], 'blood': [32, 137, 150, 185], 'pressures': [33, 138, 151], 'than': [34, 142, 221], 'do': [35], 'females,': [36], 'we': [37], 'hypothesize': [38], 'that': [39, 241, 263], 'may': [41], 'affect': [42], 'renin-angiotensin': [44, 256, 278], 'system': [45], 'to': [46, 60, 100, 113, 152, 160, 189, 199], 'promote': [47, 265], 'development': [49, 71, 243], 'of': [50, 64, 72, 116, 130, 171, 217, 235, 244, 249, 268], 'male': [53, 132, 271], 'SHR.': [54, 75], 'The': [55, 175], 'present': [56], 'study': [57], 'was': [58, 166], 'performed': [59], 'determine': [61], 'effect': [63, 230], 'converting': [65], 'enzyme': [66], 'inhibition': [67], '(CEI)': [68], 'on': [69, 231], 'Male,': [76], 'female,': [77], 'castrated': [78], 'male,': [79], 'and': [80, 121, 147, 184, 208, 226], 'ovariectomized': [81], '(ovx)': [82], 'female': [83], 'SHR': [84, 247, 272], '(n=10': [85], 'per': [86, 88], 'treatment': [89], 'group)': [90], 'received': [91], 'enalapril': [92], '(250': [93], 'mg/L)': [94], 'drinking': [96], 'water': [97], '8': [99], '10': [101], 'weeks.': [102], 'Some': [103], 'ovx': [104, 176, 209], 'females': [105, 177, 210], 'were': [106, 125], 'also': [107], 'given': [108, 211], 'testosterone': [109, 180, 183, 212], 'chronically.': [110], 'At': [111, 158], '17': [112, 159], '19': [114, 161], 'weeks': [115, 129], 'age,': [117, 131], '24-hour': [118], 'protein': [119, 219], 'excretion': [120, 220], 'mean': [122, 172, 196], 'arterial': [123, 173, 197], 'pressure': [124, 186, 198], 'measured.': [126], 'By': [127], '13': [128], 'rats': [133], 'had': [134, 181, 213, 228], 'systolic': [136], 'by': [139, 168, 254], 'tail': [140], 'plethysmography': [141], 'did': [143, 222], 'other': [145, 224], 'rats,': [146], 'CEI': [148, 194, 227], 'reduced': [149, 195], 'similar': [153, 188, 200], 'levels': [154, 187, 201, 216], 'all': [156, 203], 'groups.': [157, 205], 'weeks,': [162], 'same': [164], 'trend': [165], 'found': [167, 191], 'direct': [169], 'measurement': [170], 'pressure.': [174], 'treated': [178], 'with': [179], 'serum': [182], 'those': [190], 'males.': [193], 'Untreated': [206], 'significantly': [214], 'urinary': [218], 'groups,': [225], 'no': [229], 'proteinuria': [232], 'any': [234], 'rats.': [237], 'These': [238], 'suggest': [240, 262], 'regardless': [248], 'sex': [250], 'steroids': [251], 'mediated': [253], 'system.': [257, 279], 'However,': [258], 'further': [261], 'exacerbation': [267], 'via': [273], 'involving': [276]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2113257066', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2025-01-06T03:43:02.233454', 'created_date': '2016-06-24'}