Publication Information

{'id': 'https://openalex.org/W2113253442', 'doi': 'https://doi.org/10.1161/hypertensionaha.109.148023', 'title': '“Effective” Plasma Renin Activity: A Derived Measure for Assessing Residual Plasma Renin Activity in Patients Taking Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers', 'display_name': '“Effective” Plasma Renin Activity: A Derived Measure for Assessing Residual Plasma Renin Activity in Patients Taking Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers', 'publication_year': 2010, 'publication_date': '2010-01-19', 'ids': {'openalex': 'https://openalex.org/W2113253442', 'doi': 'https://doi.org/10.1161/hypertensionaha.109.148023', 'mag': '2113253442', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20083722'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hypertensionaha.109.148023', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.148023', 'source': {'id': 'https://openalex.org/S67880631', 'display_name': 'Hypertension', 'issn_l': '0194-911X', 'issn': ['0194-911X', '1524-4563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.148023', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027264952', 'display_name': 'Jean E. Sealey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jean E. Sealey', 'raw_affiliation_strings': ['Department of Medicine, Weill-Cornell Medical College, New York, NY;'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Weill-Cornell Medical College, New York, NY;', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054925247', 'display_name': 'David Parra', 'orcid': 'https://orcid.org/0000-0002-7253-4381'}, 'institutions': [{'id': 'https://openalex.org/I4210126617', 'display_name': 'West Palm Beach VA Medical Center', 'ror': 'https://ror.org/03ghnvz91', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210119004', 'https://openalex.org/I4210126617']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Parra', 'raw_affiliation_strings': ['Veterans’ Affairs Medical Center, West Palm Beach, Fla'], 'affiliations': [{'raw_affiliation_string': 'Veterans’ Affairs Medical Center, West Palm Beach, Fla', 'institution_ids': ['https://openalex.org/I4210126617']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033740758', 'display_name': 'Robert Rosenstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126617', 'display_name': 'West Palm Beach VA Medical Center', 'ror': 'https://ror.org/03ghnvz91', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210119004', 'https://openalex.org/I4210126617']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Rosenstein', 'raw_affiliation_strings': ['Veterans’ Affairs Medical Center, West Palm Beach, Fla'], 'affiliations': [{'raw_affiliation_string': 'Veterans’ Affairs Medical Center, West Palm Beach, Fla', 'institution_ids': ['https://openalex.org/I4210126617']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006936798', 'display_name': 'John H. Laragh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801107848', 'display_name': 'New York Hospital Queens', 'ror': 'https://ror.org/01j17xg39', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801107848']}, {'id': 'https://openalex.org/I1340179700', 'display_name': 'NewYork–Presbyterian Hospital', 'ror': 'https://ror.org/03gzbrs57', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340179700']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}, {'id': 'https://openalex.org/I4210096498', 'display_name': 'Presbyterian Hospital', 'ror': 'https://ror.org/00n2w1t65', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1321404777', 'https://openalex.org/I4210096498']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John H. Laragh', 'raw_affiliation_strings': ['Cardiovascular Center, Department of Cardiothoracic Surgery, New York Presbyterian Hospital and, Weill Cornell Medical College, New York, NY'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular Center, Department of Cardiothoracic Surgery, New York Presbyterian Hospital and, Weill Cornell Medical College, New York, NY', 'institution_ids': ['https://openalex.org/I2801107848', 'https://openalex.org/I1340179700', 'https://openalex.org/I205783295', 'https://openalex.org/I4210096498']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.887194, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '55', 'issue': '3', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10144', 'display_name': 'Blood Pressure and Hypertension Studies', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10144', 'display_name': 'Blood Pressure and Hypertension Studies', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12075', 'display_name': 'Sodium Intake and Health', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System Studies', 'score': 0.9852, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/plasma-renin-activity', 'display_name': 'Plasma renin activity', 'score': 0.78839326}, {'id': 'https://openalex.org/keywords/angiotensin-receptor-blockers', 'display_name': 'Angiotensin Receptor Blockers', 'score': 0.48752543}], 'concepts': [{'id': 'https://openalex.org/C198710026', 'wikidata': 'https://www.wikidata.org/wiki/Q898218', 'display_name': 'Renin–angiotensin system', 'level': 3, 'score': 0.8273697}, {'id': 'https://openalex.org/C138976137', 'wikidata': 'https://www.wikidata.org/wiki/Q7201790', 'display_name': 'Plasma renin activity', 'level': 4, 'score': 0.78839326}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5230485}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5007436}, {'id': 'https://openalex.org/C2910553456', 'wikidata': 'https://www.wikidata.org/wiki/Q285044', 'display_name': 'Angiotensin Receptor Blockers', 'level': 4, 'score': 0.48752543}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.48009446}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45619848}, {'id': 'https://openalex.org/C2908929049', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin II', 'level': 3, 'score': 0.4319478}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.42229313}, {'id': 'https://openalex.org/C123915805', 'wikidata': 'https://www.wikidata.org/wiki/Q15332826', 'display_name': 'Angiotensin II receptor type 1', 'level': 4, 'score': 0.41692346}, {'id': 'https://openalex.org/C27016395', 'wikidata': 'https://www.wikidata.org/wiki/Q128861', 'display_name': 'Angiotensin-converting enzyme', 'level': 3, 'score': 0.41130623}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.38475478}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35021392}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19955236}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.19085151}], 'mesh': [{'descriptor_ui': 'D047228', 'descriptor_name': 'Angiotensin II Type 1 Receptor Blockers', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000806', 'descriptor_name': 'Angiotensin-Converting Enzyme Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D047228', 'descriptor_name': 'Angiotensin II Type 1 Receptor Blockers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000806', 'descriptor_name': 'Angiotensin-Converting Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012084', 'descriptor_name': 'Renin-Angiotensin System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012084', 'descriptor_name': 'Renin-Angiotensin System', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012084', 'descriptor_name': 'Renin-Angiotensin System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hypertensionaha.109.148023', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.148023', 'source': {'id': 'https://openalex.org/S67880631', 'display_name': 'Hypertension', 'issn_l': '0194-911X', 'issn': ['0194-911X', '1524-4563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20083722', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/hypertensionaha.109.148023', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.109.148023', 'source': {'id': 'https://openalex.org/S67880631', 'display_name': 'Hypertension', 'issn_l': '0194-911X', 'issn': ['0194-911X', '1524-4563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 4, 'referenced_works': ['https://openalex.org/W1980020681', 'https://openalex.org/W1985025184', 'https://openalex.org/W2018469076', 'https://openalex.org/W2145989311'], 'related_works': ['https://openalex.org/W2418574610', 'https://openalex.org/W2126797993', 'https://openalex.org/W2088924510', 'https://openalex.org/W2077998387', 'https://openalex.org/W2047608102', 'https://openalex.org/W2044747643', 'https://openalex.org/W2038571733', 'https://openalex.org/W2016647631', 'https://openalex.org/W1977123261', 'https://openalex.org/W1975291885'], 'abstract_inverted_index': {'HomeHypertensionVol.': [0], '55,': [1, 1295], 'No.': [2, 584], '3"Effective"': [3], 'Plasma': [4, 13, 41, 50, 756, 900, 990, 1027, 1079, 1103, 1144, 1176, 1240, 1249], 'Renin': [5, 14, 42, 51, 901, 991, 1028, 1080, 1104, 1145, 1177, 1241, 1250], 'Activity:': [6, 43, 1242], 'A': [7, 44, 751, 785, 816, 937, 985, 1022, 1098, 1243], 'Derived': [8, 45, 1244], 'Measure': [9, 46, 1245], 'for': [10, 47, 531, 569, 578, 588, 605, 1073, 1107, 1246], 'Assessing': [11, 48, 1247], 'Residual': [12, 49, 1248], 'Activity': [15, 52, 902, 992, 1029, 1146, 1251], 'in': [16, 53, 189, 203, 291, 300, 317, 356, 419, 427, 487, 638, 718, 764, 801, 829, 865, 869, 916, 944, 964, 1001, 1038, 1153, 1252], 'Patients': [17, 54, 1076, 1253], 'Taking': [18, 55, 1254], 'Angiotensin-Converting': [19, 56, 1255], 'Enzyme': [20, 57, 1256], 'Inhibitors': [21, 58, 1257], 'or': [22, 59, 210, 343, 370, 408, 435, 538, 1258], 'Angiotensin': [23, 60, 1259], 'Receptor': [24, 61, 1260], 'Blockers': [25, 62, 1066], 'Free': [26], 'AccessLetterPDF/EPUBAboutView': [27], 'PDFView': [28], 'EPUBSections': [29], 'ToolsAdd': [30], 'to': [31, 224, 245, 261, 264, 274, 276, 412, 477, 484, 502, 526, 593, 631, 735, 942, 994, 1031, 1191, 1238], 'favoritesDownload': [32], 'citationsTrack': [33], 'citationsPermissions': [34], 'ShareShare': [35], 'onFacebookTwitterLinked': [36], 'InMendeleyReddit': [37], 'Jump': [38], 'toFree': [39], 'AccessLetterPDF/EPUB"Effective"': [40], 'Jean': [63, 74], 'E.': [64, 75, 77], 'Sealey': [65, 78, 596, 622, 1054, 1138, 1172, 1211], 'David': [66, 89], 'Parra': [67, 91, 933, 987, 1024, 1100], 'and': [68, 100, 298, 458, 463, 468, 495, 524, 548, 563, 581, 590, 752, 783, 799, 814, 853, 896, 903, 913, 935, 957, 966, 986, 1023, 1060, 1099, 1118, 1140, 1149, 1171, 1187, 1210, 1218, 1233, 1273], 'Robert': [69, 101], 'Rosenstein': [70, 103], 'John': [71, 112], 'H.': [72, 113, 115], 'Laragh': [73, 116, 598, 624, 1061, 1141, 1169, 1208], 'SealeyJean': [76], 'Department': [79, 119], 'of': [80, 120, 141, 150, 173, 198, 228, 258, 271, 287, 295, 332, 392, 398, 415, 540, 558, 665, 672, 711, 772, 792, 818, 923, 971, 1008, 1045, 1084, 1110, 1115, 1160, 1182, 1197], 'Medicine,': [81], 'Weill': [82, 128], 'Cornell': [83, 129], 'Medical': [84, 94, 106, 130], 'College,': [85, 131], 'New': [86, 123, 132], 'York,': [87, 133], 'NY': [88, 134], 'ParraDavid': [90], "Veterans'": [92, 104], 'Affairs': [93, 105], 'Center,': [95, 107, 118], 'West': [96, 108], 'Palm': [97, 109], 'Beach,': [98, 110], 'Fla': [99, 111], 'RosensteinRobert': [102], 'LaraghJohn': [114], 'Cardiovascular': [117, 1075], 'Cardiothoracic': [121], 'Surgery,': [122], 'York': [124], 'Presbyterian': [125], 'Hospital': [126], 'and,': [127], 'Originally': [135, 1303], 'published18': [136], 'Jan': [137], '2010https://doi.org/10.1161/HYPERTENSIONAHA.109.148023Hypertension.': [138], '2010;55:e16Other': [139], 'version(s)': [140], 'this': [142, 151, 410], 'articleYou': [143], 'are': [144, 235], 'viewing': [145], 'the': [146, 162, 170, 174, 179, 195, 199, 219, 225, 283, 288, 312, 348, 357, 372, 380, 388, 393, 406, 413, 461, 474, 520, 546, 601, 666, 790, 793, 806, 819, 826, 1108, 1180], 'most': [147], 'recent': [148], 'version': [149], 'article.': [152], 'Previous': [153, 158, 733], 'versions:': [154], 'January': [155], '18,': [156, 1305], '2010:': [157], 'Version': [159], '1': [160, 280], 'To': [161], 'Editor:The': [163], 'plasma': [164, 232, 627, 866, 1216], 'renin': [165, 183, 346, 505, 603, 609, 628, 757, 867, 1217], 'activity': [166, 172, 197, 316, 401, 507, 758, 868], '(PRA)': [167, 629, 1147], 'test': [168, 193], 'quantifies': [169], 'circulating': [171, 200, 313], 'renin-angiotensin': [175, 201, 314, 381, 667], 'system': [176, 202, 220, 315, 382, 506, 821], 'by': [177, 231, 405, 491, 496, 512, 545, 822], 'measuring': [178], 'rate': [180], 'at': [181, 221, 454], 'which': [182, 420], 'forms': [184], 'angiotensin': [185, 211], 'I': [186, 230, 260], '(Ang': [187], 'I)': [188], 'plasma.': [190], 'The': [191, 450, 921, 1113, 1175], 'PRA': [192, 250, 289, 331, 374, 493], 'overestimates': [194], 'true': [196], 'patients': [204, 234, 292, 301, 318, 534, 640, 765, 871], 'taking': [205, 236, 293, 302, 319, 336, 367, 432, 642], 'angiotensin-converting': [206, 686], 'enzyme': [207, 687], 'inhibitors': [208], '(ACEIs)': [209], 'receptor': [212], 'blockers': [213], '(ARBs)': [214], 'because': [215, 396], 'these': [216, 237, 296], 'drugs': [217], 'block': [218], 'sites': [222], 'distal': [223], 'enzymatic': [226], 'release': [227], 'Ang': [229, 259, 265, 272, 277], 'renin.1,2When': [233], 'drugs,': [238], 'a': [239, 327, 330, 337, 344, 438, 485, 567, 576, 669, 673, 680, 725, 760, 917, 1002, 1039, 1154], 'simple': [240], 'calculation': [241], 'can': [242, 518], 'be': [243, 262], 'used': [244], 'determine': [246, 503], 'their': [247], 'residual': [248], '"effective"': [249], '(ePRA).': [251], 'At': [252], 'clinical': [253], 'doses,': [254], 'ACEIs': [255, 513, 537], 'allow': [256, 269], '≈10%': [257, 270, 286, 391], 'converted': [263], 'II,': [266], 'whereas': [267], 'ARBs': [268], 'II': [273, 278], 'bind': [275], 'type': [279, 873], 'receptors.3': [281], 'Therefore,': [282], 'ePRA': [284, 349, 389, 451], 'is': [285, 335, 350, 365, 375, 390, 566, 575, 676], 'value': [290], 'one': [294], 'agents': [297], '≈1%': [299], 'both': [303, 460], 'agents.': [304], 'In': [305], 'contrast,': [306], 'PRA,': [307, 395], 'per': [308], 'se,': [309], 'truly': [310, 351], 'reflects': [311], 'other': [320], 'antihypertensive': [321], 'drug': [322, 521, 635], 'types.': [323], 'For': [324], 'example,': [325], 'if': [326, 361], 'patient': [328, 364], 'with': [329, 443, 536, 684, 720, 766, 872], '2': [333, 352, 874], 'ng/mL/h': [334], 'diuretic,': [338], 'calcium': [339], 'channel': [340], 'blocker,': [341], 'β-blocker,': [342], 'direct': [345], 'inhibitor,': [347], 'ng/mL/h,': [353, 377, 470], 'that': [354, 362, 379], 'is,': [355], 'medium': [358], 'range.': [359], 'However,': [360], 'same': [363], 'also': [366], 'an': [368, 433, 436, 685], 'ACEI': [369, 407, 434], 'ARB,': [371, 437], 'effective': [373, 678], '≈0.2': [376], 'demonstrating': [378], 'has': [383, 402, 508, 759], 'been': [384, 403, 448, 509], 'adequately': [385, 510], 'blocked.': [386], 'Thus,': [387], 'reported': [394], '≈90%': [397], 'its': [399, 613], 'functional': [400], 'blocked': [404, 511], 'ARB.Applying': [409], 'reasoning': [411], 'report': [414], 'Pimenta': [416, 696, 1231], 'et': [417], 'al,4': [418], 'dietary': [421, 480, 528, 712, 858], 'sodium': [422, 444, 481, 529, 713], 'deprivation': [423, 482], 'lowered': [424], 'blood': [425, 440, 475, 716], 'pressure': [426, 441, 476, 717], 'resistant': [428, 721], 'hypertensives': [429], 'who': [430], 'were': [431], 'significant': [439], 'fall': [442, 478, 486], 'restriction': [445], 'could': [446], 'have': [447], 'anticipated.': [449], 'was': [452, 543], 'suppressed': [453], 'baseline': [455], '(0.11': [456], 'ng/mL/h)': [457], 'during': [459, 796, 825], '250-': [462], '50-mmol': [464], 'salt': [465, 859], 'diets': [466], '(<0.06': [467], '0.27': [469], 'respectively),': [471], 'thereby': [472], 'allowing': [473], 'when': [479], 'led': [483], 'body': [488], 'sodium.In': [489], 'summary,': [490], 'using': [492], 'testing': [494, 630], 'calculating': [497], 'ePRA,': [498], 'it': [499], 'becomes': [500], 'possible': [501], 'whether': [504], 'and/or': [514], 'ARBs.': [515], 'This': [516], 'approach': [517], 'simplify': [519], 'selection': [522], 'process': [523], 'lead': [525], 'appropriate': [527], 'recommendations': [530], 'uncontrolled': [532], 'hypertensive': [533, 639, 870], 'treated': [535], 'ARBs.Sources': [539], 'FundingThis': [541], 'work': [542], 'supported': [544], 'May': [547, 1067], 'Samuel': [549], 'Rudin': [550], 'Family': [551], 'Foundation,': [552, 556, 562], 'Lawrence': [553], 'M.': [554, 661], 'Gelb': [555], 'Trust': [557], 'Frederick': [559], 'Schwartz,': [560], 'Starr': [561], 'Wallace': [564], 'Foundation.DisclosuresJ.E.S.': [565], 'consultant': [568, 577], 'Diasorin': [570, 579, 594], 'Inc': [571, 580], '(Stillwater,': [572], 'MN).': [573], 'J.H.L.': [574], 'licensed': [582], 'patent': [583], '09/657': [585], '027,': [586], '"Method': [587], 'Evaluating': [589], 'Treating': [591], 'Hypertension,"': [592], 'Inc.1': [595], 'JE,': [597, 623], 'JH.': [599, 625], 'Aliskiren,': [600], 'first': [602], 'inhibitor': [604], 'treating': [606], 'hypertension:': [607, 722], 'reactive': [608], 'secretion': [610], 'may': [611], 'limit': [612], 'effectiveness.': [614], 'Am': [615, 645], 'J': [616, 646, 1062, 1139, 1142, 1170, 1173, 1209, 1212], 'Hypertens.': [617, 647], '2007;': [618], '20:': [619], '587–597.CrossrefMedlineGoogle': [620], 'Scholar2': [621], 'Using': [626], 'design': [632], 'follow': [633], 'up': [634], 'treatment': [636], 'strategies': [637], 'already': [641], 'antirenin': [643], 'drugs.': [644], '2009;': [648, 729], '22:': [649], '950–950.CrossrefMedlineGoogle': [650], 'Scholar3': [651], 'Hasler': [652], 'CJN,': [653], 'Maillard': [654], 'M,': [655, 741, 1057, 1207], 'Forclaz': [656], 'A,': [657, 838], 'Brunner': [658], 'HR,': [659], 'Burnier': [660], 'Sustained': [662], '24-hour': [663], 'blockade': [664], 'system:': [668], 'high': [670], 'dose': [671, 682], 'long-acting': [674], 'blocker': [675], 'as': [677, 679], 'lower': [681], 'combined': [683], 'inhibitor.': [688], 'Clin': [689], 'Pharmacol': [690], 'Ther.': [691], '2005;': [692], '78:': [693], '501–507.CrossrefMedlineGoogle': [694], 'Scholar4': [695], 'E,': [697, 745, 844], 'Gaddam': [698], 'KK,': [699], 'Oparil': [700], 'S,': [701, 705, 842, 981, 1018, 1131, 1137], 'Aban': [702], 'I,': [703], 'Husain': [704], "Dell'Italia": [706], 'LJ,': [707], 'Calhoun': [708, 1234], 'DA.': [709], 'Effects': [710], 'reduction': [714], 'on': [715], 'subjects': [719], 'results': [723], 'from': [724, 805], 'randomized': [726], 'trial.': [727], 'Hypertension.': [728], '54:': [730], '475–481.LinkGoogle': [731], 'Scholar': [732], 'Back': [734], 'top': [736], 'Next': [737], 'FiguresReferencesRelatedDetailsCited': [738], 'By': [739], 'Hartford': [740], 'Herlitz': [742, 748], 'H,': [743, 893], 'Perers': [744], 'Karlsson': [746], 'T,': [747], 'J,': [749, 887, 889, 1055, 1129, 1133], 'Persson': [750], 'Caidahl': [753], 'K': [754, 782, 895], '(2021)': [755], 'complex': [761], 'prognostic': [762], 'role': [763], 'acute': [767], 'coronary': [768], 'syndromes,': [769], 'International': [770], 'Journal': [771, 922, 970, 1083, 1114, 1159, 1196], 'Cardiology,': [773], '10.1016/j.ijcard.2020.12.062,': [774], '329,': [775], '(198-204),': [776], 'Online': [777, 882, 929, 951, 976, 1013, 1050, 1089, 1124, 1165, 1202, 1227, 1265], 'publication': [778, 883, 930, 952, 977, 1014, 1051, 1090, 1125, 1166, 1203, 1228, 1266], 'date:': [779, 884, 931, 953, 978, 1015, 1052, 1091, 1126, 1167, 1204, 1229, 1267], '1-Apr-2021.': [780], 'Satué': [781, 810], 'Muñoz': [784, 815], '(2020)': [786], 'Scientific': [787], 'Evidences': [788], 'Supporting': [789], 'Activation': [791], 'Renin-Angiotensin-Aldosterone': [794], 'System': [795, 998, 1035, 1065], 'Estral': [797], 'Cycle': [798], 'Pregnancy': [800], 'Mares': [802], 'Selected': [803], 'Chapters': [804], 'Renin-Angiotensin': [807, 1064, 1188], 'System,': [808, 1157], '10.5772/intechopen.88052': [809], 'K,': [811, 1135], 'Montesinos': [812], 'P': [813], 'Modulation': [817], 'renin–angiotensin–aldosterone': [820], 'steroid': [823], 'hormones': [824], 'oestrous': [827], 'cycle': [828], 'mares,': [830], 'Acta': [831], 'Veterinaria': [832], 'Hungarica,': [833], '10.1556/004.2020.00011,': [834], '68:1,': [835], '(79-84)': [836], 'Chen': [837], 'Jerums': [839], 'G,': [840, 846, 848], 'Baqar': [841], 'Lambert': [843], 'Somarajah': [845], 'Thomas': [847], "O'Callaghan": [849], 'C,': [850, 983, 1020], 'MacIsaac': [851], 'R': [852], 'Ekinci': [854], 'E': [855, 1232, 1275], '(2015)': [856], 'Short-term': [857], 'supplementation': [860], 'blunts': [861], 'telmisartan': [862], 'induced': [863], 'increases': [864], 'diabetes': [875], 'mellitus,': [876], 'Clinical': [877, 924], 'Science,': [878], '10.1042/CS20140536,': [879], '129:5,': [880], '(415-422),': [881], '1-Sep-2015.': [885], 'Sim': [886, 1128], 'Shi': [888, 1132], 'Al-Moomen': [890], 'R,': [891], 'Behayaa': [892], 'Kalantar-Zadeh': [894, 1134], 'Jacobsen': [897], 'S': [898], '(2014)': [899, 938, 960], 'Its': [904], 'Association': [905], 'With': [906, 1004, 1041, 1077], 'Ischemic': [907], 'Heart': [908, 911, 1222], 'Disease,': [909], 'Congestive': [910], 'Failure,': [912], 'Cerebrovascular': [914], 'Disease': [915], 'Large': [918, 1155], 'Hypertensive': [919], 'Cohort,': [920], 'Hypertension,': [925, 945, 972, 1006, 1043, 1085, 1111, 1161, 1198, 1262], '10.1111/jch.12419,': [926], '16:11,': [927], '(805-813),': [928], '1-Nov-2014.': [932], 'D': [934, 988, 1025, 1101, 1235], 'Hough': [936, 984, 1021, 1097], 'Current': [939, 946], 'Therapeutic': [940], 'Approaches': [941], 'Cardio-Protection': [943], 'Hypertension': [947], 'Reports,': [948], '10.1007/s11906-014-0457-5,': [949], '16:8,': [950], '1-Aug-2014.': [954], 'Furberg': [955, 1058], 'C': [956, 1059], 'Alderman': [958, 1056, 1206], 'M': [959], 'JNC': [961], '8:': [962], 'Shortcomings': [963], 'Process': [965], 'Treatment': [967], 'Recommendations,': [968], 'American': [969, 1082, 1158, 1195], '10.1093/ajh/hpu158,': [973], '27:12,': [974], '(1443-1445),': [975], '1-Dec-2014.': [979], 'Shah': [980, 1017], 'Coakley': [982, 1019], '(2013)': [989, 1026, 1063, 1276], 'Testing': [993, 1030], 'Guide': [995, 1032], 'Triple': [996, 1033], 'Antirenin': [997, 1034], 'Drug': [999, 1036, 1119, 1151], 'Therapy': [1000, 1037], 'Patient': [1003, 1040], 'Difficult-to-Treat': [1005, 1042], 'Annals': [1007, 1044], 'Pharmacotherapy,': [1009, 1046], '10.1177/1060028013512788,': [1010], '48:2,': [1011], '(279-285),': [1012], '1-Feb-2014.': [1016], '10.1177/1060028013501142,': [1047], '47:11,': [1048], '(1562-1568),': [1049], '1-Nov-2013.': [1053], 'Create': [1068], 'More': [1069, 1214], 'Risk': [1070], 'Than': [1071], 'Reward': [1072], 'Sodium-Depleted': [1074], 'High': [1078], 'Levels,': [1081], '10.1093/ajh/hpt034,': [1086], '26:6,': [1087], '(727-738),': [1088], '1-Jun-2013.': [1092], 'Olson': [1093], 'N,': [1094], 'DeJongh': [1095], 'B,': [1096], '(2012)': [1102, 1143], 'Activity-Guided': [1105], 'Strategy': [1106], 'Management': [1109], 'Pharmacotherapy:': [1112], 'Human': [1116], 'Pharmacology': [1117], 'Therapy,': [1120], '10.1002/j.1875-9114.2012.01031.x,': [1121], '32:5,': [1122], '(446-455),': [1123], '1-May-2012.': [1127], 'Bhandari': [1130], 'Rasgon': [1136], 'Levels': [1148], 'Antihypertensive': [1150], 'Use': [1152], 'Healthcare': [1156], '10.1038/ajh.2011.216,': [1162], '25:3,': [1163], '(379-388),': [1164], '1-Mar-2012.': [1168], '(2011)': [1174, 1213], 'Test': [1178], 'Reveals': [1179], 'Contribution': [1181], 'Body': [1183], 'Sodium-Volume': [1184], 'Content': [1185], '(V)': [1186], '(R)': [1189], 'Vasoconstriction': [1190], 'Long-Term': [1192], 'Blood': [1193], 'Pressure,': [1194], '10.1038/ajh.2011.171,': [1199], '24:11,': [1200], '(1164-1180),': [1201], '1-Nov-2011.': [1205, 1230], 'about': [1215], 'cardiovascular': [1219], 'mortality,': [1220], 'European': [1221], 'Journal,': [1223], '10.1093/eurheartj/ehr187,': [1224], '32:21,': [1225], '(2610-2612),': [1226], '(2010)': [1236], 'Response': [1237], '"Effective"': [1239], 'Blockers,': [1261], '55:3,': [1263], '(e17-e17),': [1264], '1-Mar-2010.': [1268], 'Kotovskaya': [1269], 'Y,': [1270], 'Kravtsova': [1271], 'O': [1272], 'Pavlova': [1274], 'PLASMA': [1277], 'RENIN': [1278], 'ASSESSMENT': [1279], 'AS': [1280], 'THE': [1281], 'STRATEGY': [1282], 'OF': [1283], 'HYPERTENSION': [1284], 'MANAGEMENT,': [1285], '"Arterial\'naya': [1286], 'Gipertenziya"': [1287], '("Arterial': [1288], 'Hypertension"),': [1289], '10.18705/1607-419X-2013-19-5-380-388,': [1290], '19:5,': [1291], '(380-388)': [1292], 'March': [1293], '2010Vol': [1294], 'Issue': [1296], '3': [1297], 'Advertisement': [1298, 1309], 'Article': [1299], 'InformationMetrics': [1300], 'https://doi.org/10.1161/HYPERTENSIONAHA.109.148023PMID:': [1301], '20083722': [1302], 'publishedJanuary': [1304], '2010': [1306], 'PDF': [1307], 'download': [1308], 'SubjectsClinical': [1310], 'StudiesDiagnostic': [1311], 'TestingPharmacology': [1312]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2113253442', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-16T12:20:43.123355', 'created_date': '2016-06-24'}