Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2112966993', 'doi': 'https://doi.org/10.1080/03009740510026887', 'title': 'Adalimumab (Humira®) restores clinical response in patients with secondary loss of efficacy from infliximab (Remicade®) or etanercept (Enbrel®): results from the STURE registry at Karolinska University Hospital', 'display_name': 'Adalimumab (Humira®) restores clinical response in patients with secondary loss of efficacy from infliximab (Remicade®) or etanercept (Enbrel®): results from the STURE registry at Karolinska University Hospital', 'publication_year': 2005, 'publication_date': '2005-10-19', 'ids': {'openalex': 'https://openalex.org/W2112966993', 'doi': 'https://doi.org/10.1080/03009740510026887', 'mag': '2112966993', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16234182'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/03009740510026887', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42124886', 'display_name': 'Scandinavian Journal of Rheumatology', 'issn_l': '0300-9742', 'issn': ['0300-9742', '1502-7732'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046718141', 'display_name': 'Marius C. Wick', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'M. C. Wick', 'raw_affiliation_strings': ['Departments of Rheumatology, Karolinska University Hospital, Solna'], 'affiliations': [{'raw_affiliation_string': 'Departments of Rheumatology, Karolinska University Hospital, Solna', 'institution_ids': ['https://openalex.org/I1335113835']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085603352', 'display_name': 'Sofia Ernestam', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129826125', 'display_name': 'Södertörn University', 'ror': 'https://ror.org/00d973h41', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I129826125']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'S. Ernestam', 'raw_affiliation_strings': ['Huddinge SE‐17176, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Huddinge SE‐17176, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I129826125']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046421321', 'display_name': 'Staffan Lindblad', 'orcid': 'https://orcid.org/0000-0001-7139-2580'}, 'institutions': [{'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'S. Lindblad', 'raw_affiliation_strings': ['Departments of Rheumatology, Karolinska University Hospital, Solna'], 'affiliations': [{'raw_affiliation_string': 'Departments of Rheumatology, Karolinska University Hospital, Solna', 'institution_ids': ['https://openalex.org/I1335113835']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031739976', 'display_name': 'Johan Bratt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I129826125', 'display_name': 'Södertörn University', 'ror': 'https://ror.org/00d973h41', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I129826125']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'J. Bratt', 'raw_affiliation_strings': ['Huddinge SE‐17176, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Huddinge SE‐17176, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I129826125']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071491614', 'display_name': 'Lars Klareskog', 'orcid': 'https://orcid.org/0000-0001-9601-6186'}, 'institutions': [{'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'L. Klareskog', 'raw_affiliation_strings': ['Departments of Rheumatology, Karolinska University Hospital, Solna'], 'affiliations': [{'raw_affiliation_string': 'Departments of Rheumatology, Karolinska University Hospital, Solna', 'institution_ids': ['https://openalex.org/I1335113835']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012009272', 'display_name': 'Ronald van Vollenhoven', 'orcid': 'https://orcid.org/0000-0001-6438-8663'}, 'institutions': [{'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'R. F. van Vollenhoven', 'raw_affiliation_strings': ['Departments of Rheumatology, Karolinska University Hospital, Solna'], 'affiliations': [{'raw_affiliation_string': 'Departments of Rheumatology, Karolinska University Hospital, Solna', 'institution_ids': ['https://openalex.org/I1335113835']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.629, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 124, 'citation_normalized_percentile': {'value': 0.864829, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '34', 'issue': '5', 'first_page': '353', 'last_page': '358'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11616', 'display_name': 'Autoimmune and Inflammatory Disorders Research', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11616', 'display_name': 'Autoimmune and Inflammatory Disorders Research', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11725', 'display_name': 'Immunodeficiency and Autoimmune Disorders', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780132546', 'wikidata': 'https://www.wikidata.org/wiki/Q348260', 'display_name': 'Adalimumab', 'level': 3, 'score': 0.9615698}, {'id': 'https://openalex.org/C2777138892', 'wikidata': 'https://www.wikidata.org/wiki/Q415264', 'display_name': 'Infliximab', 'level': 3, 'score': 0.9326408}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.93205446}, {'id': 'https://openalex.org/C2777226972', 'wikidata': 'https://www.wikidata.org/wiki/Q415343', 'display_name': 'Etanercept', 'level': 3, 'score': 0.92152643}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.7106128}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.32833153}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.29430073}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000068879', 'descriptor_name': 'Adalimumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015535', 'descriptor_name': 'Arthritis, Psoriatic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015535', 'descriptor_name': 'Arthritis, Psoriatic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068800', 'descriptor_name': 'Etanercept', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069285', 'descriptor_name': 'Infliximab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012042', 'descriptor_name': 'Registries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013548', 'descriptor_name': 'Sweden', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017211', 'descriptor_name': 'Treatment Failure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/03009740510026887', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42124886', 'display_name': 'Scandinavian Journal of Rheumatology', 'issn_l': '0300-9742', 'issn': ['0300-9742', '1502-7732'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16234182', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.74}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1672906812', 'https://openalex.org/W1966573516', 'https://openalex.org/W1979364075', 'https://openalex.org/W1985763670', 'https://openalex.org/W1997999969', 'https://openalex.org/W200629597', 'https://openalex.org/W2031092466', 'https://openalex.org/W2032613943', 'https://openalex.org/W2045485006', 'https://openalex.org/W2046628605', 'https://openalex.org/W2098767548', 'https://openalex.org/W2122265491', 'https://openalex.org/W2133541603', 'https://openalex.org/W2154432417', 'https://openalex.org/W2168698481', 'https://openalex.org/W2170601120', 'https://openalex.org/W2171341132', 'https://openalex.org/W2314052274', 'https://openalex.org/W2319957449', 'https://openalex.org/W2340084730', 'https://openalex.org/W3146223861'], 'related_works': ['https://openalex.org/W3149869290', 'https://openalex.org/W2980843199', 'https://openalex.org/W2755604283', 'https://openalex.org/W2318799791', 'https://openalex.org/W2236197927', 'https://openalex.org/W2162495586', 'https://openalex.org/W2116752853', 'https://openalex.org/W2075153701', 'https://openalex.org/W1992628263', 'https://openalex.org/W1588288904'], 'abstract_inverted_index': {'Objectives:': [0], 'To': [1], 'determine': [2], 'whether': [3], 'the': [4, 46, 83, 92, 107, 127, 145, 156, 168, 178, 195, 207], 'tumour': [5], 'necrosis': [6], 'factor‐α': [7], '(TNF‐α)': [8], 'antagonist': [9, 86], 'adalimumab': [10, 54, 81, 205, 216, 239], '(Humira®)': [11], 'can': [12, 240], 'be': [13], 'efficacious': [14], 'after': [15, 55], 'secondary': [16, 56, 229], 'loss': [17, 21, 57, 230], 'of': [18, 22, 58, 204, 231], 'efficacy': [19, 59, 232], '(i.e.': [20], 'clinical': [23, 31, 244], 'response': [24], 'in': [25, 217], 'patients': [26, 44, 76, 227], 'who': [27, 52, 77], 'had': [28], 'initially': [29], 'demonstrated': [30], 'response)': [32], 'to': [33, 60, 116, 131, 136, 165, 182, 186, 210, 238], 'infliximab': [34, 61, 100, 105, 119, 234], '(Remicade®)': [35], 'or': [36, 67, 235], 'etanercept': [37, 68, 149, 154, 170], '(Enbrel®).Patients': [38], 'and': [39, 74, 134, 185, 221], 'methods:': [40], 'We': [41], 'studied': [42], '36': [43], 'from': [45, 233], 'Stockholm': [47], 'TNF‐α': [48, 85], 'follow‐up': [49], 'registry': [50], '(STURE)': [51], 'received': [53], '(group': [62, 69, 87], 'A,': [63, 91, 219], 'n': [64, 71], '=': [65, 72], '27)': [66], 'B,': [70, 144, 220], '9),': [73], '26': [75], 'were': [78, 223], 'started': [79], 'on': [80, 125, 176], 'as': [82], 'first': [84], 'C).Results:': [88], 'In': [89, 142, 192], 'group': [90, 143, 193], 'baseline': [93, 146, 197], 'disease': [94], 'activity': [95], 'score': [96], '28': [97], '(DAS28)': [98], 'at': [99, 138, 148, 188], 'institution': [101, 150], 'was': [102, 111, 120, 151, 160, 171, 199], '5.5±0.2.': [103], 'During': [104, 153], 'treatment,': [106, 155], 'mean': [108, 128, 157, 179, 196], 'best': [109, 158], 'DAS28': [110, 129, 147, 159, 180, 198, 208], '3.7±0.2': [112], '(p<0.001),': [113], 'but': [114, 163], 'increased': [115, 164], '5.2±0.3': [117], 'when': [118], 'stopped.': [121, 172], 'After': [122, 173, 201], '3': [123, 174], 'months': [124, 140, 175, 190, 203], 'adalimumab,': [126, 177], 'decreased': [130, 181, 209], '4.5±0.3': [132], '(p<0.003),': [133], 'then': [135], '4.2±0.2': [137], '6': [139, 189, 202], '(p<0.001).': [141, 191, 212], '6.6±0.5.': [152], '4.6±0.5': [161], '(p<0.01),': [162], '5.7±0.4': [166], 'by': [167], 'time': [169], '4.8±0.3': [183], '(p<0.005),': [184], '4.1±0.2': [187], 'C,': [194], '5.6±0.3.': [200], 'therapy,': [206], '3.5±0.4': [211], 'ACR20': [213], 'responses': [214], 'with': [215, 228], 'groups': [218], 'C': [222], 'similar': [224], '(70–78%).Conclusions:': [225], 'For': [226], 'etanercept,': [236], 'switching': [237], 'restore': [241], 'a': [242], 'good': [243], 'response.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2112966993', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-08T23:02:21.297483', 'created_date': '2016-06-24'}