Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3149869290', 'doi': None, 'title': 'Effectiveness of infliximab after adalimumab failure in Crohn's disease', 'display_name': 'Effectiveness of infliximab after adalimumab failure in Crohn's disease', 'publication_year': 2012, 'publication_date': '2012-01-01', 'ids': {'openalex': 'https://openalex.org/W3149869290', 'mag': '3149869290'}, 'language': 'zh-cn', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://www.cqvip.com/QK/84123X/201237/43535219.html', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306541008', 'display_name': '世界胃肠病学杂志:英文版', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035497314', 'display_name': 'Maria Fragaki', 'orcid': 'https://orcid.org/0000-0003-2246-8854'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Maria', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018501351', 'display_name': 'Chaparro', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Chaparro', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003342934', 'display_name': 'Montserrat', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Montserrat', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046902000', 'display_name': 'V Andreu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Andreu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082950236', 'display_name': 'Barreiro-de', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Barreiro-de', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069971844', 'display_name': 'Acosta', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Acosta', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012581632', 'display_name': 'Esther', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Esther', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5096571784', 'display_name': 'García-Planella', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Garcia-Planella', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101522061', 'display_name': 'Е. В. Иода', 'orcid': 'https://orcid.org/0000-0001-5414-0912'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Elena', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007880285', 'display_name': 'Wifredo Ricart', 'orcid': 'https://orcid.org/0000-0002-3452-9098'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ricart', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033112196', 'display_name': 'Eugeni', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Eugeni', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010248454', 'display_name': 'J R Domenech', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Domenech', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015693407', 'display_name': 'V Esteve', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Esteve', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101667117', 'display_name': 'О.Е. Фролова', 'orcid': 'https://orcid.org/0000-0002-7667-236X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Olga', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087457145', 'display_name': 'Merino', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Merino', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007092124', 'display_name': 'Pilar', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Pilar', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067104230', 'display_name': 'Nos', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Nos', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056551758', 'display_name': 'Mireia', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mireia', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5075179057', 'display_name': 'Penalva', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Penalva', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.597, 'has_fulltext': False, 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.847141, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '18', 'issue': '37', 'first_page': '5219', 'last_page': '5224'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10134', 'display_name': 'Genetics and Treatment of Inflammatory Bowel Disease', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10134', 'display_name': 'Genetics and Treatment of Inflammatory Bowel Disease', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13569', 'display_name': 'Epidemiology and Treatment of Microscopic Colitis', 'score': 0.9816, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11616', 'display_name': 'Hemophagocytic Lymphohistiocytosis and Related Disorders', 'score': 0.9622, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': "https://openalex.org/keywords/crohn's-disease", 'display_name': "Crohn's Disease", 'score': 0.445216}], 'concepts': [{'id': 'https://openalex.org/C2777138892', 'wikidata': 'https://www.wikidata.org/wiki/Q415264', 'display_name': 'Infliximab', 'level': 3, 'score': 0.97564244}, {'id': 'https://openalex.org/C2780132546', 'wikidata': 'https://www.wikidata.org/wiki/Q348260', 'display_name': 'Adalimumab', 'level': 3, 'score': 0.9666735}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.81272364}, {'id': 'https://openalex.org/C2779280984', 'wikidata': 'https://www.wikidata.org/wiki/Q1472', 'display_name': "Crohn's disease", 'level': 3, 'score': 0.50156236}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3751499}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.2506141}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://www.cqvip.com/QK/84123X/201237/43535219.html', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306541008', 'display_name': '世界胃肠病学杂志:英文版', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': [], 'abstract_inverted_index': {'瞄准:在': [0], 'adalimumab': [1, 7, 16, 31, 33, 43, 47], '失败以后在': [2], 'Crohns': [3, 12, 22], '疾病病人作为第二线的治疗评估': [4], 'infliximab': [5, 9, 18, 29, 35, 37, 41, 49, 53], '的有效性。方法:在一个基于社区的肠胃病学惯例的历史的队研究评估了在': [6], '失败以后与': [8], '(加维护的正式就职)': [10], '对待的': [11], '疾病病人。病人们用一个大西班牙的数据库(ENEIDA': [13], ')': [14], '被识别。结果:我们包括了在': [15], '失败以后收到了': [17], '的': [19, 44, 52], '15': [20], '个': [21], '疾病病人。五个病人由于反应的损失中止了': [23], 'adalimumab,': [24], '3': [25], '由于不利事件并且': [26], '7': [27, 45], '由于部分反应。在': [28], '治疗被开始以后,由于功效的损失打断了': [30], '的所有病人重获反应。由于不利事件中止了': [32], '的所有病人对': [34], '作出回应并且维持了这回答;这些病人之一在': [36], '上有一堂平静功课,但是': [38], '2': [39], '开发了不利事件。任何一个都没与': [40], '由于部分反应打断了': [42], '个病人到达宽恕。结论:从': [46], '切换到': [48], '可能在然而,开发反应的不利效果或损失的病人是有用的在主要': [50], 'nonresponders': [51], '的利益没被建立。': [54]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3149869290', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-19T14:41:36.898929', 'created_date': '2021-04-13'}