Publication Information

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1834, 1912, 1952, 2173, 2315, 2354], 'cells': [289, 777, 782, 2174, 2316], '(SMC)': [290], 'even': [291], 'though': [292], 'multiple': [293], 'drugs': [296], 'showed': [297], 'no': [298], 'comparable': [299], 'activity,': [300], 'suggesting': [301], 'there': [302], 'something': [304], 'special': [305], 'about': [306], '2': [308], 'medications.': [311], 'Nevertheless,': [312], 'matter': [314], 'seemed': [315], 'settled': [316], 'until': [317], 'belated': [319], 'realization': [320, 338], 'late': [323], 'stent': [324], 'thrombosis': [325], 'drug-eluting': [327], 'attributable': [329], 'delayed': [331], 'endothelial': [332, 381, 401, 491, 500, 557, 776, 1132, 1284, 1332, 1385, 1482, 1674, 1797], 'coverage': [333, 382, 402, 1133], 'stented': [335, 1156, 1688], 'surfaces': [336], 'brought': [337], 'need': [341], 'alternative': [343], 'approaches': [344, 358], 'better': [346], 'biology.In': [349], 'parallel': [350], 'efforts': [353], 'limit': [355], 'biological': [357], 'have': [359, 375, 470, 578, 712, 737, 931], 'focused': [360], 'processes': [364, 1119], 'driving': [365], 'neointimal': [366, 410, 448, 535, 616, 799, 826, 845, 1121, 1875, 2319], 'development': [367], 'stopping': [371], 'them.': [372], 'Early': [373], 'studies': [374, 418, 436], 'suggested': [376, 428, 443], 'loss': [379, 501], 'after': [383, 801, 1249, 1289, 1488, 1623, 1763, 1877, 2004, 2230], 'intraarterial': [385], 'injury': [386, 803, 869, 1490, 1765, 1879, 2232, 2347], 'exposed': [387], 'circulating': [390], 'growth': [391, 411, 1080, 1333, 1386, 1483, 1675, 1679, 1729, 1798], 'factors': [392, 1081], 'thereby': [393, 904, 1062], 'stimulating': [394], 'SMC': [395, 896, 929, 1073, 1091, 1184], 'migration.': [398], 'Therefore,': [399], 'restoring': [400], 'seen': [404], 'terminate': [409], 'removing': [413], 'stimulus.': [415], 'Indeed,': [416, 537], 'several': [417], 'Isner': [420, 1279], 'colleagues': [422], 'plasmid-mediated': [424], 'VEGF': [425, 445, 458, 564, 677, 720, 756, 819, 823, 860, 912, 922, 955, 965, 1031, 1061, 1998], 'gene': [426, 1291, 1388, 1758, 2302], 'transfer': [427, 1389, 1759, 2303], 'VEGF-driven': [430, 844], 'reendothelialization': [431, 1202], 'reduces': [432, 2095, 2227, 2269], 'restenosis.2': [433], 'However,': [434, 670], 'later': [435], 'failed': [437, 462], 'confirm': [439], 'findings': [441], 'treatment': [446, 1401], 'thus': [450], 'promoting': [451, 663, 1043], 'restenosis.3,4': [452], 'A': [453, 2034, 2375], 'clinical': [454], 'trial': [455], 'delivery': [459], 'show': [464], 'benefit.5': [466], 'Furthermore,': [467, 959], 'additional': [468, 1060], 'investigations': [469], 'shown': [471], 'neointima': [473, 1100, 1195, 1761, 2228], 'could': [475], 'be': [476, 849], 'induced': [477, 1310], 'absence': [480], 'endothelium,': [486], 'eg,': [487], 'intact': [490, 556], 'layer,': [492], 'further': [493, 579], 'questioning': [494], 'link': [496], 'between': [497, 592, 605, 623, 1997], 'luminal': [499, 1136, 1205], 'restenosis.6': [503], 'At': [504], 'same': [506, 796, 811], 'it': [508, 657, 1170], 'increasingly': [510], 'clear': [511], 'inflammatory': [514, 625, 1026], 'response': [515, 552, 626, 1027], 'adventitia,': [518, 1126], 'presence': [522, 909], 'blood-derived': [524], 'mononuclear': [525, 781, 814], 'cells7': [526], 'accompanied': [528], 'adventitial': [530, 540, 581, 596, 645, 664, 1044, 1162], 'angiogenesis,8': [531], 'may': [532], 'significantly': [533], 'impact': [534], 'formation.': [536], 'stimulation': [538, 889, 1074], 'angiogenesis': [541, 562, 582, 597, 1165, 1513], 'VEGF,': [543, 661, 1077], 'FGF2,': [544, 1088], 'PR39': [546], 'led': [547], 'profound': [550], 'restenotic': [551], 'vessels': [554], 'coverage,': [558], 'suppression': [560], 'traps': [565], 'inhibitors': [567], 'FGF': [569], 'signaling': [570, 762, 820], 'greatly': [571], 'reduced': [572], 'it.6Several': [573], 'lines': [575], 'evidence': [577], 'linked': [580], 'direct': [587], 'demonstration': [588], 'correlation': [591, 604, 622], 'micro-CT–determined': [593], 'extent': [594, 600, 614, 797, 812], 'neointima,9–11': [602], 'magnitude': [607], 'stretch': [611], 'formation,1': [617], 'equally': [620], 'well-established': [621], 'angiogenesis.12': [628], 'Finally,': [629], 'one': [630], 'forgotten': [632], 'aspect': [633], 'is': [637, 744, 752, 763, 854, 957, 1004, 1141, 1171, 1902], 'vascularization': [640], 'neointima,13': [643], 'vasa': [646, 1104, 1544, 1726], 'vasorum': [647, 1545, 1727], 'being': [648], 'primary': [650], 'sources': [651], 'this': [653, 693, 708, 1084, 1115, 1168], '"intraarterial"': [654], 'vasculature.14': [655], 'Therefore': [656], 'looked': [658], 'plausible': [659, 1000], 'angiogenesis,': [665], 'would': [666], 'indeed': [667, 945], 'promote': [668], 'restenosis.': [669], 'although': [671, 920, 960], 'potential': [673], 'prorestenotic': [674, 967], 'effects': [675, 923, 1628, 1906], 'apparent,': [679], 'mechanism': [681, 885, 984], 'its': [683, 881], 'action': [684], 'remained': [685], 'unresolved.The': [686], 'paper': [687], 'Koga': [689, 977, 1738], 'et': [690], 'al': [691], 'issue': [694], 'Arteriosclerosis,': [696], 'Biology': [700], 'adds': [701], 'important': [702, 1143], 'information': [703], 'our': [705], 'biology.15': [709], 'authors': [711], 'used': [713], 'knock-in': [715], 'mouse': [716], 'line': [717], 'receptor': [721, 733, 743, 1957, 2184], '1': [722, 1236, 2120], '(VEGF-R1': [723], 'Flt-1)': [725], 'replaced': [726], 'truncated': [729], 'form': [730], 'does': [735], 'tyrosine': [738, 1632, 1768], 'kinase': [739, 1633, 1769, 2342], 'activity.': [740], 'mutant': [742, 792, 831], 'still': [745], 'expressed': [746], 'cell': [749, 788, 815, 1835, 1953, 2355], 'surface': [750, 1206], 'able': [753], 'bind': [755], 'high': [758], 'affinity': [759], 'but': [760, 778, 953], 'intracellular': [761], 'abolished.': [764], 'Flt-1': [765, 791, 830, 871, 1757], 'broad': [768], 'distribution': [769], 'expression': [771, 892, 1037, 2121, 2311], 'detectable': [772], 'only': [774], 'blood': [780], 'number': [785], 'types.': [789], 'mice': [793, 807, 1881], 'demonstrate': [794], 'wild-type': [806], 'exhibited': [809], 'infiltration.': [816], 'Blockade': [817, 1479], 'trap': [824], 'abolished': [825], 'both': [829, 911], 'control': [833], 'mice,': [834, 2235], 'consistent': [835], 'previous': [837], 'observations.': [838], 'Thus,': [839], 'entire': [841], 'appears': [847], 'independent': [850, 1443], 'Flt': [852], 'signaling.This': [853], 'unexpected': [855], 'ability': [858, 1181], 'induce': [862], 'monocyte': [863, 906, 1495, 1870], 'accumulation': [864, 1052], 'site': [867], 'via': [870, 895, 936], 'long': [873, 951], 'considered': [875], 'sine': [877], 'qua': [878], 'non': [879], 'biology.': [882], 'Instead,': [883], 'apparently': [886], 'involves': [887], 'VEGF-induced': [888], 'MCP1': [891], 'SMCs': [894, 900, 915, 1040, 1049], 'VEGF-R2.': [897], 'activated': [899], 'secrete': [902, 1059], 'MCP-1': [903, 941, 970, 1036, 1046, 1908, 2310], 'inducing': [905, 2176], 'accumulation.': [907], 'receptors': [913, 1800], 'well': [918], 'accepted16': [919], 'SMCs,': [925], 'induction': [927], 'migration,': [930], 'thought': [933], 'occur': [935, 1123], 'Flt-1.17': [937], 'role': [939, 962, 1329, 2180], 'restenosis18': [943], 'angiogenesis12': [947], 'also': [949, 1042], 'established,': [952], 'connection': [956], 'new.': [958], 'endogenous': [964], 'activity': [968, 1176, 1722], 'hinted': [973], 'previously,19': [975], 'study': [978], 'suggests': [979], 'more': [982], 'compelling': [983], 'action.Taken': [986], 'together': [987], 'evolving': [990], 'body': [991], 'knowledge': [993], 'sequence': [1001], 'events': [1003], 'illustrated': [1005], 'Figure.': [1008], 'adventitia': [1013, 1057], 'balloon': [1016, 1251], 'stretch/stent': [1017], 'expansion': [1018], 'leads': [1019, 1050, 1089], 'initiation': [1022], 'production': [1029, 1047], 'which,': [1032], 'turn,': [1034], 'induces': [1035, 1830, 2309], 'while': [1041], 'angiogenesis.': [1045], 'monocytes': [1054], 'leading': [1063], 'positive': [1066], 'amplification': [1067], 'cascade.': [1070], 'Together,': [1071], 'mitogenic': [1072, 1905], 'MCP-1,': [1076], 'present': [1082], 'niche': [1085], 'phenotypic': [1092, 1185], 'modulation': [1093, 1186], 'allows': [1095], 'migration': [1096, 1836, 2165], 'supported': [1101], 'adventitia-derived': [1103], 'vasorum.': [1105], 'Download': [1106], 'figureDownload': [1107], 'PowerPointFigure.': [1108], 'Figure': [1109], 'legend': [1110], 'text.The': [1111], 'key': [1112], 'points': [1113], 'paradigm': [1116], 'are': [1117], 'controlling': [1120], 'state': [1130], 'segment': [1137], 'artery': [1140, 2171], 'less': [1142], 'terms': [1145], 'previously': [1149], 'thought.': [1150], 'Ultimately,': [1151], 'management': [1154], 'arteries': [1157], 'will': [1158], 'require': [1159], 'inhibition': [1160, 2223], 'inflammation': [1163], '(and': [1166], 'context': [1169], 'interesting': [1172], 'note': [1174], 'antiangiogenic': [1175, 1721], 'paclitaxel)': [1178], 'prevent': [1183, 1194], '(a': [1187], 'newly': [1188], 'discovered': [1189], 'rapamycin20)': [1192], 'promotion': [1200], 'reduce': [1208], 'thrombosis.DisclosuresNone.FootnotesCorrespondence': [1209], 'Simons,': [1212], '333': [1222], 'Cedar': [1223], 'Street,': [1224], 'P.O.': [1225], 'Box': [1226], '208017,': [1227], 'CT': [1230], '06520-8017.': [1231], 'E-mail': [1232], '[email': [1233], 'protected]': [1234], 'References': [1235], 'Kuntz': [1237], 'RE,': [1238], 'Gibson': [1239], 'CM,': [1240], 'Nobuyoshi': [1241], 'M,': [1242, 1272, 1346, 1350, 1374, 1427, 1464, 1466, 1474, 1476, 1506, 1665, 1701, 1717, 1745, 1747, 1753, 1791, 1855, 1863, 1929, 1941, 2021, 2106, 2199, 2294], 'Baim': [1243], 'DS.': [1244], 'Generalized': [1245], 'model': [1246], 'conventional': [1250], 'angioplasty,': [1252], 'directional': [1255], 'atherectomy.': [1256], 'J': [1257, 1317, 1560, 1635, 1805, 1915, 1962, 2117], 'Am': [1258, 1561, 1636, 1914], 'Coll': [1259, 1562, 1637], 'Cardiol.': [1260, 1563, 1638], '1993;': [1261], '21:': [1262, 1588, 1697], '15–25.CrossrefMedlineGoogle': [1263], 'Scholar2': [1264], 'Asahara': [1265], 'T,': [1266, 1303, 1595, 1741, 1865, 2112], 'Chen': [1267], 'D,': [1268, 2330], 'Tsurumi': [1269], 'Y,': [1270, 1470, 1785], 'Kearney': [1271], 'Rossow': [1273], 'S,': [1274, 1299, 1364, 1425, 1432, 1462, 1468, 1713, 1813, 1815, 1823, 1861, 1897, 2070, 2072, 2215, 2253, 2255, 2290], 'Passeri': [1275], 'J,': [1276, 1348, 1352, 1703, 1739, 1783, 2079, 2154, 2257], 'Symes': [1277], 'JF,': [1278, 1436, 1508], 'JM.': [1280], 'Accelerated': [1281], 'restitution': [1282], 'integrity': [1285], 'endothelium-dependent': [1287], 'function': [1288], 'phVEGF165': [1290], 'transfer.': [1292], 'Circulation.': [1293, 1340, 1415, 1448, 1498, 1520, 1651], '1996;': [1294], '94:': [1295], '3291–3302.CrossrefMedlineGoogle': [1296], 'Scholar3': [1297], 'Bhardwaj': [1298, 1424, 2289], 'Roy': [1300, 2073, 2250, 2291], 'H,': [1301, 1360, 2259, 2292, 2371], 'Heikura': [1302], 'Yla-Herttuala': [1304, 1375, 1431, 1670, 2298], 'S.': [1305, 1376, 1671], 'VEGF-A,': [1306], 'VEGF-D': [1307], 'VEGF-D(DeltaNDeltaC)': [1309], 'hyperplasia': [1312, 1876], 'carotid': [1314], 'arteries.': [1315, 1691], 'Eur': [1316], 'Clin': [1318], 'Invest.': [1319], '2005;': [1320, 1521, 1652], '35:': [1321], '669–676.CrossrefMedlineGoogle': [1322], 'Scholar4': [1323], 'Shiojima': [1324], 'I,': [1325, 1438, 1817, 2152], 'Walsh': [1326], 'K.': [1327, 1478, 1755], 'vascular': [1331, 1384, 1481, 1673, 1796, 1910, 1950, 2277, 2313, 2352], 'factor': [1334, 1387, 1484, 1676, 1799, 2226], 'restenosis:': [1336], 'controversy': [1338], 'continues.': [1339], '2004;': [1341, 1449, 1499, 1920], '110:': [1342, 1450, 1500], '2283–2286.LinkGoogle': [1343], 'Scholar5': [1344], 'Hedman': [1345, 1353], 'Hartikainen': [1347], 'Syvanne': [1349], 'Stjernvall': [1351], 'A,': [1354, 1356, 1368, 1532, 1599, 1659, 1711, 1781, 1891, 2019, 2027, 2148, 2150, 2205, 2207], 'Kivela': [1355, 1658], 'Vanninen': [1357], 'E,': [1358, 1362, 1430, 1749, 2068, 2077, 2081, 2261, 2334], 'Mussalo': [1359], 'Kauppila': [1361], 'Simula': [1363], 'Narvanen': [1365], 'O,': [1366, 1789], 'Rantala': [1367], 'Peuhkurinen': [1369], 'K,': [1370, 1454, 1456, 1458, 1472, 1661, 1669, 1707, 1743, 1751, 1819, 1821, 1847, 1853, 1859, 1981, 2025, 2201, 2203, 2332], 'Nieminen': [1371], 'MS,': [1372], 'Laakso': [1373], 'Safety': [1377], 'feasibility': [1379], 'catheter-based': [1381], 'intracoronary': [1383], 'prevention': [1392], 'postangioplasty': [1394], 'in-stent': [1396], 'chronic': [1403], 'myocardial': [1404, 1574], 'ischemia:': [1405], 'phase': [1406], 'II': [1407], 'results': [1408], 'Kuopio': [1411], 'Angiogenesis': [1412], 'Trial': [1413], '(KAT).': [1414], '2003;': [1416, 1587], '107:': [1417], '2677–2683.LinkGoogle': [1418], 'Scholar6': [1419], 'Khurana': [1420, 1503], 'R,': [1421, 1504, 1536, 1615, 2029, 2064, 2209, 2245], 'Zhuang': [1422], 'Z,': [1423, 1977, 1989, 2110], 'Murakami': [1426], 'De': [1428], 'Muinck': [1429], 'Ferrara': [1433], 'N,': [1434, 1597], 'Martin': [1435, 1507, 1924], 'Zachary': [1437, 1509], 'M.': [1440, 1644], 'Angiogenesis-dependent': [1441], 'phases': [1444], 'hyperplasia.': [1447], '2436–2443.LinkGoogle': [1451], 'Scholar7': [1452], 'Ohtani': [1453, 1852], 'Egashira': [1455, 1742, 1846], 'Hiasa': [1457], 'Zhao': [1459, 1848], 'Q,': [1460, 1849], 'Kitamoto': [1461], 'Ishibashi': [1463], 'Usui': [1465, 1854], 'Inoue': [1467, 1860], 'Yonemitsu': [1469], 'Sueishi': [1471, 1750], 'Sata': [1473], 'Shibuya': [1475, 1752, 1790, 2295], 'Sunagawa': [1477, 1754], 'suppresses': [1485], 'experimental': [1486], 'intraluminal': [1489], 'inhibiting': [1492], 'recruitment': [1493], 'lineage': [1496], 'cells.': [1497, 1804, 1913], '2444–2452.LinkGoogle': [1501], 'Scholar8': [1502], 'IC.': [1510], 'Role': [1511], 'cardiovascular': [1515], 'disease:': [1516], 'critical': [1518], 'appraisal.': [1519], '112:': [1522], '1813–1824.LinkGoogle': [1523], 'Scholar9': [1524], 'Kwon': [1525], 'HM,': [1526], 'Sangiorgi': [1527], 'G,': [1528, 1985, 2211], 'Ritman': [1529], 'EL,': [1530], 'Lerman': [1531], 'McKenna': [1533], 'C,': [1534, 1787, 1851, 2108, 2213, 2373], 'Virmani': [1535, 1614], 'Edwards': [1537], 'WD,': [1538], 'Holmes': [1539], 'DR,': [1540], 'Schwartz': [1541], 'RS.': [1542], 'Adventitial': [1543, 1620, 2088, 2301], 'balloon-injured': [1547], 'coronary': [1548, 1624, 1690, 2170], 'arteries:': [1549], 'visualization': [1550], 'quantitation': [1552], 'microscopic': [1555, 1582], 'three-dimensional': [1556, 1581], 'computed': [1557, 1578, 1583], 'tomography': [1558, 1579], 'technique.': [1559], '1998;': [1564], '32:': [1565], '2072–2079.CrossrefMedlineGoogle': [1566], 'Scholar10': [1567], 'Kantor': [1568], 'B,': [1569, 1611, 1709, 1983, 2062, 2074, 2247, 2251], 'Mohlenkamp': [1570], 'S': [1571, 2086, 2266, 2299], 'Imaging': [1572], 'microvasculature': [1575], 'fast': [1577], 'tomography.': [1584], 'Cardiol': [1585], 'Clin.': [1586], '587–605,': [1589], 'ix.CrossrefMedlineGoogle': [1590], 'Scholar11': [1591], 'Cheema': [1592], 'AN,': [1593], 'Hong': [1594], 'Nili': [1596], 'Segev': [1598], 'Moffat': [1600], 'JG,': [1601], 'Lipson': [1602], 'KE,': [1603], 'Howlett': [1604], 'AR,': [1605], 'Holdsworth': [1606], 'DW,': [1607], 'Cole': [1608], 'MJ,': [1609], 'Qiang': [1610], 'Kolodgie': [1612], 'F,': [1613], 'Stewart': [1616], 'DJ,': [1617, 1937], 'Strauss': [1618], 'BH.': [1619], 'microvessel': [1621], 'SU11218,': [1630], 'inhibitor.': [1634], '2006;': [1639], '47:': [1640, 1843], '1067–1075.CrossrefMedlineGoogle': [1641], 'Scholar12': [1642], 'Angiogenesis:': [1645], 'where': [1646], 'do': [1647], 'we': [1648], 'stand': [1649], 'now?': [1650], '111:': [1653], '1556–1566.LinkGoogle': [1654], 'Scholar13': [1655], 'Brasen': [1656], 'JH,': [1657], 'Roser': [1660], 'Rissanen': [1662], 'TT,': [1663], 'Niemi': [1664], 'Luft': [1666], 'FC,': [1667], 'Donath': [1668], 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